1,358 research outputs found
Deep grey matter volumetry as a function of age using a semi-automatic qMRI algorithm
Quantitative Magnetic Resonance has become more and more accepted for clinical trial in many fields. This technique not only can generate qMRI maps (such as T1/T2/PD) but also can be used for further postprocessing including segmentation of brain and characterization of different brain tissue. Another main application of qMRI is to measure the volume of the brain tissue such as the deep Grey Matter (dGM). The deep grey matter serves as the brain's "relay station" which receives and sends inputs between the cortical brain regions. An abnormal volume of the dGM is associated with certain diseases such as Fetal Alcohol Spectrum Disorders (FASD). The goal of this study is to investigate the effect of age on the volume change of the dGM using qMRI.
Thirteen patients (mean age= 26.7 years old and age range from 0.5 to 72.5 years old) underwent imaging at a 1.5T MR scanner. Axial images of the entire brain were acquired with the mixed Turbo Spin-echo (mixed -TSE) pulse sequence. The acquired mixed-TSE images were transferred in DICOM format image for further analysis using the MathCAD 2001i software (Mathsoft, Cambridge, MA). Quantitative T1 and T2-weighted MR images were generated. The image data sets were further segmented using the dual-space clustering segmentation. Then volume of the dGM matter was calculated using a pixel counting algorithm and the spectrum of the T1/T2/PD distribution were also generated. Afterwards, the dGM volume of each patient was calculated and plotted on scatter plot. The mean volume of the dGM, standard deviation, and range were also calculated.
The result shows that volume of the dGM is 47.5 ±5.3ml (N=13) which is consistent with former studies. The polynomial tendency line generated based on scatter plot shows that the volume of the dGM gradually increases with age at early age and reaches the maximum volume around the age of 20, and then it starts to decrease gradually in adulthood and drops much faster in elderly age. This result may help scientists to understand more about the aging of the brain and it can also be used to compare with the results from former studies using different techniques
Quantitative magnetic resonance image analysis via the EM algorithm with stochastic variation
Quantitative Magnetic Resonance Imaging (qMRI) provides researchers insight
into pathological and physiological alterations of living tissue, with the help
of which researchers hope to predict (local) therapeutic efficacy early and
determine optimal treatment schedule. However, the analysis of qMRI has been
limited to ad-hoc heuristic methods. Our research provides a powerful
statistical framework for image analysis and sheds light on future localized
adaptive treatment regimes tailored to the individual's response. We assume in
an imperfect world we only observe a blurred and noisy version of the
underlying pathological/physiological changes via qMRI, due to measurement
errors or unpredictable influences. We use a hidden Markov random field to
model the spatial dependence in the data and develop a maximum likelihood
approach via the Expectation--Maximization algorithm with stochastic variation.
An important improvement over previous work is the assessment of variability in
parameter estimation, which is the valid basis for statistical inference. More
importantly, we focus on the expected changes rather than image segmentation.
Our research has shown that the approach is powerful in both simulation studies
and on a real dataset, while quite robust in the presence of some model
assumption violations.Comment: Published in at http://dx.doi.org/10.1214/07-AOAS157 the Annals of
Applied Statistics (http://www.imstat.org/aoas/) by the Institute of
Mathematical Statistics (http://www.imstat.org
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Relationship Between Quantitative MRI Biomarkers and Patient-Reported Outcome Measures After Cartilage Repair Surgery: A Systematic Review.
Background:Treatment of articular cartilage injuries remains a clinical challenge, and the optimal tools to monitor and predict clinical outcomes are unclear. Quantitative magnetic resonance imaging (qMRI) allows for a noninvasive biochemical evaluation of cartilage and may offer advantages in monitoring outcomes after cartilage repair surgery. Hypothesis:qMRI sequences will correlate with early pain and functional measures. Study Design:Systematic review; Level of evidence, 3. Methods:A PubMed search was performed with the following search terms: knee AND (cartilage repair OR cartilage restoration OR cartilage surgery) AND (delayed gadolinium-enhanced MRI OR t1-rho OR T2 mapping OR dgemric OR sodium imaging OR quantitative imaging). Studies were included if correlation data were included on quantitative imaging results and patient outcome scores. Results:Fourteen articles were included in the analysis. Eight studies showed a significant relationship between quantitative cartilage imaging and patient outcome scores, while 6 showed no relationship. T2 mapping was examined in 11 studies, delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in 4 studies, sodium imaging in 2 studies, glycosaminoglycan chemical exchange saturation transfer (gagCEST) in 1 study, and diffusion-weighted imaging in 1 study. Five studies on T2 mapping showed a correlation between T2 relaxation times and clinical outcome scores. Two dGEMRIC studies found a correlation between T1 relaxation times and clinical outcome scores. Conclusion:Multiple studies on T2 mapping, dGEMRIC, and diffusion-weighted imaging showed significant correlations with patient-reported outcome measures after cartilage repair surgery, although other studies showed no significant relationship. qMRI sequences may offer a noninvasive method to monitor cartilage repair tissue in a clinically meaningful way, but further refinements in imaging protocols and clinical interpretation are necessary to improve utility
Factorised spatial representation learning: application in semi-supervised myocardial segmentation
The success and generalisation of deep learning algorithms heavily depend on
learning good feature representations. In medical imaging this entails
representing anatomical information, as well as properties related to the
specific imaging setting. Anatomical information is required to perform further
analysis, whereas imaging information is key to disentangle scanner variability
and potential artefacts. The ability to factorise these would allow for
training algorithms only on the relevant information according to the task. To
date, such factorisation has not been attempted. In this paper, we propose a
methodology of latent space factorisation relying on the cycle-consistency
principle. As an example application, we consider cardiac MR segmentation,
where we separate information related to the myocardium from other features
related to imaging and surrounding substructures. We demonstrate the proposed
method's utility in a semi-supervised setting: we use very few labelled images
together with many unlabelled images to train a myocardium segmentation neural
network. Specifically, we achieve comparable performance to fully supervised
networks using a fraction of labelled images in experiments on ACDC and a
dataset from Edinburgh Imaging Facility QMRI. Code will be made available at
https://github.com/agis85/spatial_factorisation.Comment: Accepted in MICCAI 201
Magnetization transfer effect on T1 relaxometry on 1.5T vs. 3T
PURPOSE: To assess the variability of incidental magnetization transfer effect (MT) by the number of slices and the magnetic field strength.
METHODS: Various magnetic resonance images (MRI) were obtained with a phantom containing a series of solutions of gadolinium (Gd) and sucrose in distilled water, agarose gel and two vials with olive oil and distilled water. A diffusion weighted image (DWI) sequence was acquired to determine diffusion coefficient for each component of the phantom. Several inversion recovery (IR) sequences having different TI values were run for single-slice and used to calculate T1 relaxation time with maximum precision and minimizing magnetization transfer effect. The T1 relaxation value resulting from processing IR sequences was used as reference value. The mixed-TSE sequences were used to calculate T1, T2 and PD values and to assess MT effect for single-slice as for multi-slice acquisition. All the DICOM MR images were processed using various algorithms programmed in Mathcad (version 2001i, PTC Needham, MA) by Dr. Hernan Jara. According with the potential of each sequences the programs generated the qMRI maps and values of T1, T2, PD were obtained for all the components of the phantom. Values resulted from Mathcad calculation were used for analysis. All the acquisitions, calculations and measurements were performed for 1.5T and 3T field strength
Characterizing aging in the human brainstem using quantitative multimodal MRI analysis.
Aging is ubiquitous to the human condition. The MRI correlates of healthy aging have been extensively investigated using a range of modalities, including volumetric MRI, quantitative MRI (qMRI), and diffusion tensor imaging. Despite this, the reported brainstem related changes remain sparse. This is, in part, due to the technical and methodological limitations in quantitatively assessing and statistically analyzing this region. By utilizing a new method of brainstem segmentation, a large cohort of 100 healthy adults were assessed in this study for the effects of aging within the human brainstem in vivo. Using qMRI, tensor-based morphometry (TBM), and voxel-based quantification (VBQ), the volumetric and quantitative changes across healthy adults between 19 and 75 years were characterized. In addition to the increased R2* in substantia nigra corresponding to increasing iron deposition with age, several novel findings were reported in the current study. These include selective volumetric loss of the brachium conjunctivum, with a corresponding decrease in magnetization transfer and increase in proton density (PD), accounting for the previously described âmidbrain shrinkage.â Additionally, we found increases in R1 and PD in several pontine and medullary structures. We consider these changes in the context of well-characterized, functional age-related changes, and propose potential biophysical mechanisms. This study provides detailed quantitative analysis of the internal architecture of the brainstem and provides a baseline for further studies of neurodegenerative diseases that are characterized by early, pre-clinical involvement of the brainstem, such as Parkinsonâs and Alzheimerâs diseases
The Role of Attorney Fee Shifting in Public Interest Litigation
BACKGROUND: Brain tissue segmentation of white matter (WM), grey matter (GM), and cerebrospinal fluid (CSF) are important in neuroradiological applications. Quantitative Mri (qMRI) allows segmentation based on physical tissue properties, and the dependencies on MR scanner settings are removed. Brain tissue groups into clusters in the three dimensional space formed by the qMRI parameters R1, R2 and PD, and partial volume voxels are intermediate in this space. The qMRI parameters, however, depend on the main magnetic field strength. Therefore, longitudinal studies can be seriously limited by system upgrades. The aim of this work was to apply one recently described brain tissue segmentation method, based on qMRI, at both 1.5 T and 3.0 T field strengths, and to investigate similarities and differences. METHODS: In vivo qMRI measurements were performed on 10 healthy subjects using both 1.5 T and 3.0 T MR scanners. The brain tissue segmentation method was applied for both 1.5 T and 3.0 T and volumes of WM, GM, CSF and brain parenchymal fraction (BPF) were calculated on both field strengths. Repeatability was calculated for each scanner and a General Linear Model was used to examine the effect of field strength. Voxel-wise t-tests were also performed to evaluate regional differences. RESULTS: Statistically significant differences were found between 1.5 T and 3.0 T for WM, GM, CSF and BPF (p<0.001). Analyses of main effects showed that WM was underestimated, while GM and CSF were overestimated on 1.5 T compared to 3.0 T. The mean differences between 1.5 T and 3.0 T were -66 mL WM, 40 mL GM, 29 mL CSF and -1.99% BPF. Voxel-wise t-tests revealed regional differences of WM and GM in deep brain structures, cerebellum and brain stem. CONCLUSIONS: Most of the brain was identically classified at the two field strengths, although some regional differences were observed
Algebraic Approach to q,t-Characters
Frenkel and Reshetikhin introduced q-characters to study finite dimensional
representations of quantum affine algebras. In the simply laced case Nakajima
defined deformations of q-characters called q,t-characters. The definition is
combinatorial but the proof of the existence uses the geometric theory of
quiver varieties which holds only in the simply laced case. In this article we
propose an algebraic general (non necessarily simply laced) new approach to
q,t-characters motivated by our deformed screening operators. The
t-deformations are naturally deduced from the structure of the quantum affine
algebra: the parameter t is analog to the central charge c. The q,t-characters
lead to the construction of a quantization of the Grothendieck ring and to
general analogues of Kazhdan-Lusztig polynomials in the same spirit as Nakajima
did for the simply laced case.Comment: 46 pages; accepted for publication in Advances in Mathematic
Biophysically motivated efficient estimation of the spatially isotropic R*2 component from a single gradientârecalled echo measurement
Purpose
To propose and validate an efficient method, based on a biophysically motivated signal model, for removing the orientationâdependent part of R*2 using a single gradientârecalled echo (GRE) measurement.
Methods
The proposed method utilized a temporal secondâorder approximation of the hollowâcylinderâfiber model, in which the parameter describing the linear signal decay corresponded to the orientationâindependent part of R*2. The estimated parameters were compared to the classical, monoâexponential decay model for R*2 in a sample of an ex vivo human optic chiasm (OC). The OC was measured at 16 distinct orientations relative to the external magnetic field using GRE at 7T. To show that the proposed signal model can remove the orientation dependence of R*2, it was compared to the established phenomenological method for separating R*2 into orientationâdependent and âindependent parts.
Results
Using the phenomenological method on the classical signal model, the wellâknown separation of R*2 into orientationâdependent and âindependent parts was verified. For the proposed model, no significant orientation dependence in the linear signal decay parameter was observed.
Conclusions
Since the proposed secondâorder model features orientationâdependent and âindependent components at distinct temporal orders, it can be used to remove the orientation dependence of R*2 using only a single GRE measurement
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