15,161 research outputs found
Effectiveness of an influenza vaccine programme for care home staff to prevent death, morbidity, and health service use among residents: cluster randomised controlled trial
Objective To determine whether vaccination of care home staff against influenza indirectly protects residents.Design Pair matched cluster randomised controlled trial.Setting Large private chain of UK care homes during the winters of 2003-4 and 2004-5.Participants Nursing home staff (n = 1703) and residents (n = 2604) in 44 care homes (22 intervention homes and 22 matched control homes).Interventions Vaccination offered to staff in intervention homes but not in control homes.Main outcome measures The primary outcome was all cause mortality of residents. Secondary outcomes were influenza-like illness and health service use in residents.Results In 2003-4 vaccine coverage in full time staff was 48.2% (407/884) in intervention homes and 5.9% (51/859) in control homes. In 2004-5 uptake rates were 43.2% (365/844) and 3.5% (28/800). National influenza rates were substaritially below average in 2004-5. In the 2003-4 period of influenza activity significant decreases were found in mortality of residents in intervention homes compared with control homes (rate difference - 5.0 per 100 residents, 95% confidence interval - 7.0 to - 2.0) and in influenza-like illness (P = 0.004), consultations with general practitioners for influenza-like illness (P = 0.008), and admissions to hospital with influenza-like illness (P = 0.009). No significant differences were found in 2004-5 or during periods of no influenza activity in 2003-4.Conclusions Vaccinating care home staff against influenza can prevent deaths, health service use, and influenza-like illness in residents during periods of moderate influenza activity
On Understanding Catastrophe â The Case of Highly Severe Influenza-Like Illness
Computational epidemiology is a form of spatiotemporal
reasoning in which social link structures
are employed, and spatially explicit models
are specified and executed. We point to issues thus
far addressed neither by engineers, nor scientists, in
the light of a use case focusing on catastrophic scenarios
that assume the emergence of a highly unlikely
but lethal and contagious strain of influenza.
Our conclusion is that important perspectives are
missing when dealing with policy issues resulting
from scenario execution and analyses in computational
epidemiology
Patterns of influenza-like illness and vaccination coverage on Liberty University\u27s campus
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Epidemiology of influenza-like illness in the Amazon Basin of Peru, 2008-2009.
BackgroundData addressing the incidence and epidemiology of influenza and influenza-like illness (ILI) in tropical regions of the world is scarce, particularly for the neotropics of South America.MethodsWe conducted active, population-based surveillance for ILI across 45 city blocks within the Amazon Basin city of Iquitos, Peru. Demographic data and household characteristics were collected for all participants, and participating households were visited three times weekly to inquire about ILI (fever plus cough or sore throat) among household residents. Nasal and oropharyngeal swabs were collected from participants with ILI and tested for influenza virus infection.ResultsBetween May 1, 2008 and July 8, 2009, we monitored 10,341 participants for ILI for a total of 11,569.5 person-years. We detected 459 ILI episodes, with 252 (54.9%) of the participants providing specimens. Age-adjusted incidence of ILI was estimated to be 46.7 episodes/1000 person-years. Influenza A and B viruses were detected in 25 (9.9%) and 62 (24.6%) specimens of ILI patients, respectively, for an estimated age-adjusted incidence rate of 16.5 symptomatic influenza virus infections/1000 person-years. Risk factors for ILI included age, household crowding, and use of wood as cooking fuel. For influenza virus infection specifically, age and use of wood as a cooking fuel were also identified as risk factors, but no effect of household crowding was observed.ConclusionsOur results represent the initial population-based description of the epidemiology of ILI in the Amazon region of Peru, which will be useful for developing region-specific strategies for reducing the burden of respiratory disease
Effectiveness of MF59âą Adjuvanted Influenza A(H1N1)pdm09 Vaccine in Risk Groups in the Netherlands
Background:The aim of the present study was to estimate the effectiveness of the MF59âą-adjuvanted influenza A(H1N1)pdm09 vaccine against medically attended influenza-like illness and RT-PCR confirmed influenza in the at-risk population and persons over 60 in the Netherlands.Methods:We conducted a retrospective cohort study in a Dutch based GP medical record database between 30 November 2009 and 1 March 2010 to estimate the vaccine effectiveness against influenza-like illness. Within the cohort we nested a test negative case-control study to estimate the effectiveness against laboratory confirmed influenza.Results:The crude effectiveness in preventing diagnosed or possible influenza-like illness was 17.3% (95%CI: -8.5%-36.9%). Of the measured covariates, age, the severity of disease and health seeking behaviour through devised proxies confounded the association between vaccination and influenza-like illness. The adjusted vaccine effectiveness was 20.8% (95%CI: -5.4%, 40.5%) and varied significantly by age, being highest in adults up to 50 years (59%, 95%CI: 23%, 78%), and non-detectable in adults over 50 years. The number of cases in the nested case control study was too limited to validly estimate the VE against confirmed influenza.Conclusions:With our study we demonstrated that the approach of combining a cohort study in a primary health care database with field sampling is a feasible and useful option to monitor VE of influenza vaccines in the future
Maritime conveyance cumulative influenza/influenza-like illness (ILI) form
CDC does not require that cruise ships traveling to or within U.S. waterways report individual cases of suspected or confirmed influenza. CDC requests the reporting of total influenza-like illness (ILI)/influenza cases (including zero) for each voyage by using this form. Cumulative ILI reporting is not requested from cargo ships. Please review the CDC recommendations Guidance for Cruise Ships on the Management of Influenza-like Illness available at: www.cdc.gov/quarantine/cruise/management/guidance-cruise-ships-influenza-updated.html.OMB Approved Control No. 0920-0134 Exp. 03/31/2022Publication date from document properties.maritime-conveyance-cumulative-influenza-influenza-like-illness-ili-form.pdf20191149
Enhancing Twitter Data Analysis with Simple Semantic Filtering: Example in Tracking Influenza-Like Illnesses
Systems that exploit publicly available user generated content such as
Twitter messages have been successful in tracking seasonal influenza. We
developed a novel filtering method for Influenza-Like-Illnesses (ILI)-related
messages using 587 million messages from Twitter micro-blogs. We first filtered
messages based on syndrome keywords from the BioCaster Ontology, an extant
knowledge model of laymen's terms. We then filtered the messages according to
semantic features such as negation, hashtags, emoticons, humor and geography.
The data covered 36 weeks for the US 2009 influenza season from 30th August
2009 to 8th May 2010. Results showed that our system achieved the highest
Pearson correlation coefficient of 98.46% (p-value<2.2e-16), an improvement of
3.98% over the previous state-of-the-art method. The results indicate that
simple NLP-based enhancements to existing approaches to mine Twitter data can
increase the value of this inexpensive resource.Comment: 10 pages, 5 figures, IEEE HISB 2012 conference, Sept 27-28, 2012, La
Jolla, California, U
Household-level risk factors for secondary influenza-like illness in a rural area of Bangladesh
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.Objective
To describe householdâlevel risk factors for secondary influenzaâlike illness (ILI), an important public health concern in the lowâincome population of Bangladesh.
Methods
Secondary analysis of control participants in a randomised controlled trial evaluating the effect of handwashing to prevent household ILI transmission. We recruited indexâcase patients with ILI â fever (<5 years); fever, cough or sore throat (â„5 years) â from health facilities, collected information on household factors and conducted syndromic surveillance among household contacts for 10 days after resolution of indexâcase patientsâ symptoms. We evaluated the associations between household factors at baseline and secondary ILI among household contacts using negative binomial regression, accounting for clustering by household.
Results
Our sample was 1491 household contacts of 184 indexâcase patients. Seventyâone percentage reported that smoking occurred in their home, 27% shared a latrine with one other household and 36% shared a latrine with >1 other household. A total of 114 household contacts (7.6%) had symptoms of ILI during followâup. Smoking in the home (RRadj 1.9, 95% CI: 1.2, 3.0) and sharing a latrine with one household (RRadj 2.1, 95% CI: 1.2, 3.6) or >1 household (RRadj 3.1, 95% CI: 1.8â5.2) were independently associated with increased risk of secondary ILI.
Conclusion
Tobacco use in homes could increase respiratory illness in Bangladesh. The mechanism between use of shared latrines and household ILI transmission is not clear. It is possible that respiratory pathogens could be transmitted through faecal contact or contaminated fomites in shared latrines
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