Een patient met gecompliceerd verlopende shigellose

Contains fulltext : 4436.pdf (publisher's version ) (Open Access

Treatment of invasive aspergillosis with itraconazole in a patient with chronic granulomatous disease

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Why Patients Miss Follow-Up Appointments: A Prospective Control-Matched Study

Objectives: To investigate missed appointments in a South African tertiary hospital. Study Design: Prospective, descriptive series with controls. Setting: The ENT/Oncology clinic at Tygerberg Academic Hospital, South Africa. Subjects: 305 patients with a head and neck malignancy who had follow-up appointments over 4 consecutive months between June and September 2006. A control group of 31 patients who attended the clinic was recruited in September 2006. Method: Analysis of the clinic attendance statistics to identify patients who missed follow-up appointments followed by a file review and interview of these patients. The results were compared with a control group. Outcome measures: 1) Incidence rate of failure to attend follow-up. 2) Causative factors Results: 51 (17%) booked patients missed their appointments. Non-attenders were most likely to miss their follow-up between 6 and 12 months (17/31) after treatment. No correlations were found between diagnosis, disease stage and missed appointments. Reasons include: transport (19 responses), ill-health (6) and financial constraints (5). State transport was unavailable to almost two-thirds of the responders who cited transport as a problem. Conclusions: The 17% missed appointment rate is largely due to transport constraints. The commonest time for patients to miss appointments is the 6-12 month follow-up period. The authors seek to identify patients at risk of missed appointments and suggest interventions to decrease this incidence

Protection of neutropenic mice from lethal Candida albicans infection by recombinant interleukin-1

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Biological and biochemical characterization of clinical isolates of herpes simplex virus type 2 resistant to acyclovir

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Титульні сторінки та зміст

The pharmaceutical industry is increasingly focusing on the development of biological therapeutics. These molecules generally cause no off-target toxicity and are highly species specific. Therefore, non-human primates (NHPs) are often the only relevant species in which to conduct regulatory safety testing to support clinical trials. However, species specificity and immunogenicity may negatively impact the predictive value of these ethically contentious animals and thus limits their value as a test species for drug development. To study what the value has been of 30 years of NHP testing in drug development, we investigated the drug registration files of all therapeutic monoclonal antibodies (mAbs) which were approved in the European Union to date. We analysed 30 mAbs of which 5 were diagnostic agents. As the industry moved towards the development of more human proteins, we observed that the average use of NHPs also increased. 16 registration files described studies in which anti-drug-antibodies caused increased clearance of the therapeutic and potentially confounded the study. Post mortem analysis in repeated-dose toxicity studies rarely revealed new or unexpected findings nor did embryofetal and peri-postnatal developmental toxicity studies. These issues limited the value of NHPs in the safety assessment of new monoclonal antibodies. To reduce the use of less relevant NHP studies in the development of new biological drugs, regulatory demands might be decreased, and manufacturers should be given incentives for successfully evaluating the safety of biological therapeutics using alternative technologies

Onderzoeksplan: Tussenrapportage vijf jaar na sluiting Referentiegebied Rottum

Het referentiegebied Rottum is een voor menselijke activiteiten gesloten gebied in de Nederlandse Waddenzee. In het kader van internationale afspraken wordt de natuurontwikkeling in het gebied gevolgd. In 2011 staat een tussentijdse rapportage gepland om een uitgebreider beeld te krijgen van de korte termijn ontwikkelingen in het gebied. Hiervoor is een uitgebreide bemonstering van het bodemleven, de vissen, biogene structuren en de bodemstructuur noodzakelijk. In dit rapport wordt een plan ontwikkeld voor deze uitgebreidere bemonstering, waarbij gebruik wordt gemaakt van statistische analyse van de gegevens die tot nu toe verzameld zijn

Development of Two-Dimensional Numerical Wave Flume for Wave Interaction with Rubble Mound Breakwaters

The numerical wave flume VOFbreak2 for simulation of wave interaction with a rubble mound breakwater is presented. The key innovations are a porous flow model and wave boundary conditions. The porous flow is implemented using a Forchheimer model. At the boundaries waves are generated using a combined wave generation-absorption technique and are absorped using a numerical sponge layer.

The efficacy of itraconazole against systemic fungal infections in neutropenic patients : a randomised comparative study with amphotericin B

Contains fulltext : 4533.pdf (publisher's version ) (Open Access

Visie op toekomstig onderzoek naar gasvormige emissies uit de Nederlandse veehouderij

De Nederlandse veehouderij bevindt zich op een belangrijk kruispunt: de veehouderij kan niet aan consumenten- en milieuwensen voldoen en tegelijkertijd voortgaan op de huidige weg. Een belangrijke vraag is hoe milieubelasting door gasvormige emissies (ammoniak, geur, broeikasgassen (lachgas, methaan en kooldioxide) en fijn stof) uit de veehouderij kan worden teruggedrongen in een nieuw vormgegeven veehouderij, die bijdraagt aan de ontwikkeling van een duurzame Nederlandse landbouw. Om inzicht te krijgen in de vraag welk onderzoek hiervoor noodzakelijk is een onderzoek uitgevoerd met als doel een visie te ontwikkelen op toekomstig onderzoek naar gasvormige emissies uit de Nederlandse Veehouderij. Belangrijke informatie voor de vorming van deze visie is verzameld uit interviews met verschillende maatschappelijke groeperingen