Nefropatía congénita en Schnauzer miniatura

Un Schnauzer miniatura, macho, de 13 meses de edad, presenta un cuadro de vómitos crónicos con historia clínica de gastritis. El examen físico y las pruebas complementarias permiten diagnosticar un cuadro compatible con la nefropatía familiar del Schnauzer miniatura. Se instauró dieta y tratamiento médico hasta que el animal empeoró a los dos meses y medio

Indicadores para la selección de talentos en el Atletismo, área de velocidad (vallas), categoría 13-14 años (Original).

Witch the results of this research, the selection system for sprinter talents velocity in Athletics is perfected, specifically in the hurdlers of the 13and 14 years old category in particular, its stages 2 and 3 corresponding to the entry into the school sports initiation school. Adaptations are proposed from the identification of more specific indicators in terms of their relationship with the particularities of the competitive of this discipline, which are locate by the nature in the technical and physical motor dimensions. Methods and research techniques of the theoretical, empirical and statistical levels were used that allowed to base the object and field of the investigation, determine the regularities from practice and theory, as well as process the data obtained. The need for these indicators is based on the diagnosis where is revealed, among other, that there are no dimensions or indicators by which by the speed race in the hundlers of the 13-14 years old category can be evaluated, it is in the interest of the national commission that document be written that can say how to determine a possible talent in the different disciplines that are related to the etalons of the 13-14 years old category, this category does not have a table where indicators appear to measure the performance of the athletes. The results achieved reveal the feasibility of improving the technical and physical motor indicator of speed races in short distance hurdlers of the 13-14 years old category.Con los resultados de esta investigación se perfecciona el sistema de selección de talentos velocistas en el Atletismo, específicamente para las carreras con vallas, categoría 13-14 años. Se elaboran indicadores específicos a partir de las exigencias de la disciplina y las particularidades de la actividad competitiva, que se ubican por su naturaleza en las dimensiones técnicas y físico-motrices. Se utilizaron métodos y técnicas de investigación de los niveles teóricos, empíricos y estadísticos que permitieron fundamentar el objeto y campo de la investigación, determinar las regularidades desde la práctica y la teoría; así como procesar los datos obtenidos. La necesidad de la investigación se sustenta a partir del diagnóstico, donde se revela la carencia de indicaciones específicas para favorecer la selección de futuro vallista de distancias cortas, categoría 13-14 años. Además es de interés para la comisión nacional de Atletismo, que se profundice en la elaboración de instrumentos, herramientas y formas para determinar un posible talento en la disciplina motivo de estudio, pues no cuenta con las normas para medir el rendimiento de los vallistas, así como otras herramientas, que le permitan evaluar la calidad de la ejecución técnica en estas edades. Los resultados alcanzados en la valoración teórica de la propuesta develan la funcionabilidad para su aplicación durante el proceso de selección de talento del velocista-vallista en la categoría 13-14 años

Barrett’s esophagus registries

The following on Barrett's esophagus registries contains commentaries on the data sets to be included, organizational issues, and the demographic, lifestyle, and diagnostic differences between the United States and Europe. The importance of collaborative studies is also discussed

Sea Bass Primary Cultures versus RTgill-W1 Cell Line: Influence of Cell Model on the Sensitivity to Nanoparticles

Determination of acute toxicity to vertebrates in aquatic environments is mainly performed following OECD test guideline 203, requiring the use of a large number of fish and with mortality as endpoint. This test is also used to determine toxicity of nanomaterials in aquatic environments. Since a replacement method for animal testing in nanotoxicity studies is desirable, the feasibility of fish primary cultures or cell lines as a model for nanotoxicity screenings is investigated here. Dicentrarchus labrax primary cultures and RTgill-W1 cell line were exposed to several concentrations (0.1 to 200 ug/mL) of different nanoparticles (TiO2, polystyrene and silver), and cytotoxicity, metabolic activity and reactive oxygen species formation were investigated after 24 and 48 h of exposure. Protein corona as amount of protein bound, as well as the influence of surface modification (-COOH, -NH2), exposure media (Leibovitz’s L15 or seawater), weathering and cell type were the experimental variables included to test their influence on the results of the assays. Data from all scenarios was split based on the significance each experimental variable had in the result of the cytotoxicity tests, in an exploratory approach that allows for better understanding of the determining factors affecting toxicity. Data shows that more variables significantly influenced the outcome of toxicity tests when the primary cultures were exposed to the different nanoparticles. Toxicity tests performed in RTgill-W1 were influenced only by exposure time and nanoparticle concentration. The whole data set was integrated in a biological response index to show the overall impact of nanoparticle exposures.This study was supported by a postdoctoral grant to AJ-R (Basque Government; POSDOC program 2017–2019), Basque Country, Spain; and Federal Ministry of Education and Research, BMBF (NanoUmwelt, grant agreement Nº 030150B), Germany

Análisis comparativo de subtítulos profesionales y fansubs en un capítulo de la serie “Riverdale”

La presente investigación tuvo como objetivo principal analizar los subtítulos profesionales y los fansubs, del primer capítulo de la primera temporada de la serie Riverdale. Para esto, se creó una ficha de análisis como instrumento, con la cual, se observó y analizó la muestra seleccionada. Este trabajo se basó en investigaciones de diferentes autores que se relacionaban con las variables, subtitulación profesional y fansub. Esta investigación tiene un enfoque cuantitativo, es un estudio descriptivo comparativo. Por lo tanto, se analizaron 200 subtítulos profesionales y 200 fansubs, ambos extraídos del primer capítulo de la primera temporada de la serie Riverdale. Se analizaron de acuerdo a 3 dimensiones: formato del subtítulo, convenciones ortotipográficas y la velocidad de lectura, teniendo en cuenta indicadores como: tipo de letra Arial, número de caracteres, posición en la pantalla, segmentación, ortografía, puntuación y caracteres por segundo (CPS). Se encontró que, en relación al formato del subtítulo, el fansub tuvo más errores que el subtítulo profesional especialmente en lo que refiere a la segmentación mientras que el subtítulo profesional solo tiene errores en el número de caracteres. Asimismo, en cuanto a las convenciones ortotipográficas, en el fansub se encontró errores en la puntuación y la ortografía. Además, el fansub se excedió en cuanto al número de caracteres permitidos para la velocidad de lectura, mientras que Netflix solo tuvo dos errores en este indicador

Assessment of iron oxide nanoparticle ecotoxicity on regeneration and homeostasis in the replacement model system Schmidtea mediterranea

Iron oxide nanoparticles (IONs) are used in a number of applications, from food to cosmetics, from medical applications to magnetic storage. In spite of the 550 tons produced each year in Europe alone, no effective dose limit recommendations are established and the overall risks connected to IONs are still debated. The incorporation of IONs in daily life raises a concern about their effects on the environment, on living organisms, and on human health. In this study, we used freshwater planarians to assess the nanoecotoxicity of IONs. Planarians are free-living invertebrates known for their astonishing regenerative ability. Because of their sensitivity to toxicants, they are often used to determine the effects of toxic, genotoxic and carcinogenic environmental compounds with an approach in line with the 3Rs (Reduce, Refine, Replace) principle. Planarians were exposed to IONs at concentrations up to 1 mg/mL and their effects were evaluated at the behavioral, morphofunctional and molecular levels, with a special emphasis on the regeneration process. Our results indicate that IONs did not affect the stem cell population dynamics, nor did they induce substantial changes in either homeostatic or regenerating planarians. As positive controls, gold nanoparticles coated with the pro-apoptotic anti-cancer drug hexadecylmethylammonium bromide, silver nanoparticles and highly concentrated polystyrene nanoparticles were used. These all elicited toxic effects. Therefore, we conclude that IONs at environmental concentrations are safe for planarians, and that the planarian is a powerful model system that can replace vertebrate animal models in nanoecotoxicology research and for nanoecotoxicology studies

MADNESS: A Multiresolution, Adaptive Numerical Environment for Scientific Simulation

MADNESS (multiresolution adaptive numerical environment for scientific simulation) is a high-level software environment for solving integral and differential equations in many dimensions that uses adaptive and fast harmonic analysis methods with guaranteed precision based on multiresolution analysis and separated representations. Underpinning the numerical capabilities is a powerful petascale parallel programming environment that aims to increase both programmer productivity and code scalability. This paper describes the features and capabilities of MADNESS and briefly discusses some current applications in chemistry and several areas of physics

Clinical and Complementary Diagnosis of Sinus Neoplasia in Horses

Background: Sinus neoplasms are reported as low frequency in horses. Its clinical characteristics are often nonspecific, depend on complementary methods for diagnosis, and when diagnosed, generally they are already advanced, limiting therapeutic possibilities. The objective of this case series was to detail clinical aspects and complementary exams for sinus neoplasms for early diagnosis, comparing them with the literature.Cases: Four horses were treated at the College of Veterinary Medicine and Animal Science of the University of São Paulo, with different clinical signs and previous diagnoses, which when evaluated by respiratory endoscopy, radiography, oral cavity evaluation and histopathological exams, revealed the diagnosis of anaplastic carcinoma, poorly differentiated carcinoma, ossifying fibroma and lymphoma. Previous diagnosis, based mainly on clinical signs, were sinusitis secondary to apical infection, ethmoidal hematoma, sinus cyst and sinusitis secondary to periapical disease. The cases of anaplastic carcinoma (case 1) and lymphoma (case 4) presented with an advanced degree of the disease with involvement and destruction of paranasal structures and adjacent tissues, in addition to a poor general condition, which made surgical treatment impossible and led to euthanasia. In these cases, previous treatment was made to apical infection and periodontal disease with secondary sinusitis, but negative evolution led to suspicion of neoplasia, confirmed by histopathological exam of incisional biopsy of the mass in oral cavity. Benign ossifying fibroma (case 3) presented with progressive respiratory difficulty due to occlusion of the lumen of some nasal meatus and radiographic signs of invasion and deformation of the adjacent bones, it was submitted for surgical excision and there was no recurrence until hospital discharge. The poorly differentiated carcinoma (case 2) was a multilobulate neoformation in the ethmoidal region, similar to ethmoid hematoma in endoscopic and radiographic evaluation, it was submitted for excision and two sessions of electrochemotherapy with bleomycin, associated with administration of piroxicam, which obtained a good result until the period of 1 year after discharge.Discussion: It was found that many characteristics are common with these types of neoplasms, and the clinical signs, such as nasal secretions, airway obstruction, increased facial volume, severe alterations in oral cavity, although unspecific, suggest the differential diagnosis for neoplasms. It is important to differentiate from other diseases noting the evolution and growth of these tumors, like in cases 1 and 4, especially the growth to internal tissues, using complementary methods described here, like endoscopic and radiographic examination. Late identification or even manipulation of neoplasms, without proper diagnosis, leads to a few prognoses regarding life. When it is possible to perform surgical excision, complementary methods are important to guide the procedure, and definitive diagnosis is made through histopathologic exam and some need immunohistochemistry analysis. Cases 2 and 3 had surgical access, were submitted to excision and treatment with good results, both with close monitoring in first months and prolonged quality of life. These results highlight the importance of complementary methods for early diagnosis, correct intervention and monitoring of evolution.Keywords: sinus neoplasia, paranasal sinus, tumor, head, horses