Panel 4 Paper 4.1: ICOMOS perspective on addressing CultureNature integration in the implementation of the SDGs

Rural landscapes with interconnected CultureNature heritage value have much to contribute to the resilience and sustainability of food production, use of renewable natural resources and overall well-being of communities. Rural landscapes are addressed in the UN Sustainable Development Goals (SDGs) in SDG 11 as a type of ‘human settlement’ and Target 11.4 calls for \u27strengthening efforts ‘to protect and safeguard the world’s cultural and natural heritage.’ Even so, to date, the contributions of rural landscapes have had limited recognition within the global framework for the UN SDGs and some reference in the UN-Habitat New Urban Agenda. This paper will provide the foundation for a panel discussion on how to more fully recognize the contributions from heritage values of rural landscapes and mainstream them within the SDGs and the New Urban Agenda. Presented in context with background on the ICOMOS doctrinal texts of rural landscape principles and the Culture-Nature Journey meetings, as well as reference to the urban-rural linkages in UN policy documents, this paper will offer insights from previous work to mainstream cultural heritage in sustainable territorial development, connecting key points on rural, historic urban and cultural landscapes, It thus also aims to inform on ways the ISC on Cultural Landscapes can work with ICOMOS, IUCN and others to advance consideration of rural landscapes

KC 4.1: Rural heritage and urban-rural linkages in the ICOMOS SDGs Policy Guidance

This Knowledge Café aims to provide a discussion platform to contribute to the drafting of a new ICOMOS SDGs Policy Guidance, from the perspective of rural heritage, landscapes and rural-urban linkages. While 50%-plus of global populations are urban dwellers, we tend to forget that the other half dwell in rural places. One of the 7 Priority Actions of the ICOMOS SDGs Working Group in 2018 is the preparation of a consolidated policy statement, as an effective tool for advocacy and communication to wider society and the development world. Based on the need to boost the role of cultural heritage in sustainable development processes, this would be a robust Policy Guidance document, serving to improve the recognition of the role of cultural heritage protection, particularly as defined by SDG 11.4 and the New Urban Agenda. The ICOMOS SDGs Working Group aims to launch this document at the 10th World Urban Forum in 2020 and at the High-Level Political Forum in 2021. The new Policy Guidance aims to emphasize “heritage as a resource, a strategic opportunity”, using the framework of the 3 dimensions of sustainability, economic, social, environmental, and propose adding the 4th dimension of ‘culture’ through an appropriate approach. The document should be based on solid scientific expertise sourced from ICOMOS membership. The Symposium on Rural Heritage: Landscapes and Beyond is a prime opportunity to involve some of this membership, ensuring a diverse and inclusive range of expertise in heritage informs the Policy Guidance. Rural heritage and landscapes, including rural-urban linkages, have great relevance for the intersection of cultural heritage and sustainable development, touching on many SDGs and issues raised in the New Urban Agenda, not to mention the Historic Urban Landscape Recommendation. To cite some examples of this inter-connectedness, the “inter-related categories of continuity and change” addressed during the Symposium, provide the following links: - under ‘Rural Culture’ to SDG 11.4 (change management for tangible rural heritage), SDG 1.5, 2.4, 11.5, 11.b, 13.1 (risk of loss of intangible rural traditions/ practices), SDG 8.9, SDG 12.b (rural cultural tourism), SDG 16.7, 16.a, 17.9, 17.15, 17.17 (identity of people and places); - under ‘Rural economics’ to SDG 1 (poverty eradication), SDG2 (food security), SDG3 (rural agricultural heritage), SDG 8 (improvement of markets and opportunities for rural traditional tools, techniques and rural heritage tourism), SDG 8 (infrastructure, services to small enterprises), SDG 11 (spatial form, territorial policies); - under ‘Rural Environment’ to SDG 6 (water), 13 and 15 (desertification, climate-induced severe weather events, biodiversity, forest management); and - under ‘Rural Society’ to SDG 1 (poverty alleviation) SDG 2 (agriculture), SDG 3.8, 3.c (health services), SDG 16, 17 (bottom-up governance). - Some case studies from ‘Moroccan Rural Heritage’ can be proposed during the session from participants who may have relevant knowledge, to demonstrate these links. The Knowledge Café will feature two speakers, Ege Yildirim and Patricia O’Donnell, giving the conceptual framework of the session, followed by Ilaria Rosetti presenting the method of open discussion, whereby breakout groups (e.g. 3-4 groups of 5-6) can discuss the links of rural heritage issues to the various 17 Goals and Targets under them, concluding with short reporting from each group, to be compiled and disseminated later by the conveners

The Our World Heritage Case Studies Approach to African Heritage, Social Capital and Participation

Context and backgroundThe Our World Heritage Foundation was created in 2020 as a global network to include different stakeholders in the review of the UNESCO World Heritage Convention, in its 50th anniversary. The Convention is in urgent need for a scientific-based participatory policy review, as it does not respond to the current global and regional challenges. With the world in crisis, threats from pandemics to economic depression, resource exploitation to politics, conflict to climate, development, disasters and more, today strain the very core of this treaty.Goal and Objectives:World Heritage is a medium to achieve our transformation into more locally empowered, just and resilient societies. The aim of this research is to generate scientific evidence with a participatory approach for policy recommendations for the UNESCO World Heritage Convention to adapt to the current challenges, threats, trends and strengths of World Heritage in general and African heritage in particular.Methodology:The paper focuses on the work and findings of the OWH Sustainability team in the 10 African World Heritage Sites selected, analysed and discussed within a global participatory process. The methodology involved self-assessment forms with a set of sustainability criteria and indicators, the parametrization of the data in a global barometer of the sustainable management of World Heritage for data analysis and visualization,  a focus group discussion with 10 African case study proponents, and a series of public debates with 109 international stakeholders.Results:Slow implementation processes in the management of African World Heritage is hindering sustainable development, due to the high urban development pressure, pollution, illegal hunting, poaching of wild life, logging, mining, population pressure, and climate change among other impacts on environmental sustainability of our African World heritage. However, inherent strengths of African culture could become key strategies to safeguard heritage, advance towards sustainable development and keep heritage alive, for which we provide recommendations

Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78

The pre- and postnatal environment may represent a window of opportunity for allergy and asthma prevention, and the hygiene hypothesis implies that microbial agents may play an important role in this regard. Using the cowshed-derived bacterium Acinetobacter lwoffii F78 together with a mouse model of experimental allergic airway inflammation, this study investigated the hygiene hypothesis, maternal (prenatal) microbial exposure, and the involvement of Toll-like receptor (TLR) signaling in prenatal protection from asthma. Maternal intranasal exposure to A. lwoffii F78 protected against the development of experimental asthma in the progeny. Maternally, A. lwoffii F78 exposure resulted in a transient increase in lung and serum proinflammatory cytokine production and up-regulation of lung TLR messenger RNA. Conversely, suppression of TLRs was observed in placental tissue. To investigate further, the functional relevance of maternal TLR signaling was tested in TLR2/3/4/7/9−/− knockout mice. The asthma-preventive effect was completely abolished in heterozygous offspring from A. lwoffii F78–treated TLR2/3/4/7/9−/− homozygous mother mice. Furthermore, the mild local and systemic inflammatory response was also absent in these A. lwoffii F78–exposed mothers. These data establish a direct relationship between maternal bacterial exposures, functional maternal TLR signaling, and asthma protection in the progeny

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

DIRECT CONVERSION OF HUMAN FIBROBLASTS INTO FUNCTIONAL OSTEOBLASTS BY SMALL MOLECULES

Ph.DDOCTOR OF PHILOSOPHY (SOM

Some results on the q-Beta function

In this article we find some results on the q-analogue of the beta function via using the concepts of neutrix and neutrix limit

KC 4.1: Rural heritage and urban-rural linkages in the ICOMOS SDGs Policy Guidance

Ege Yildirim is an urban planner specializing in heritage conservation and management, with over 20 years of experience working in Turkey and internationally. She was a Fulbright Scholar at Pratt Institute- New York and a Kaplan Fellow for Archaeological Heritage Management at Koç University. She has served as Heritage Site Manager of the Historic Guild Town of Mudurnu since 2015, and as Key Expert for Cultural Heritage in the EU-Turkey Anatolian Archaeology and Cultural Heritage Institute project (January-May 2019). She is currently the ICOMOS Focal Point for the SDGs, board member of ICOMOS Turkey and of Europa Nostra Turkey. Ilaria Rosetti is a researcher PhD candidate and a project developer in the heritage management field. She obtained her Master degree on Arts & Heritage: Policy, Management and Education at the Maastricht University. Her experience includes projects for public and private institutions, within fields of cultural policy, sustainable tourism, community engagement and strategies for the Sustainable Development Goals (SDGs). She’s the emerging professional representative of the ICOMOS SDGs Task Force and active member of ICOMOS Nederland. As member of the academic staff of the Antwerp University, she works towards the implementation of the UNESCO Recommendation on the Historic Urban Landscape. Patricia M. O’Donnell, preservation landscape architect and urban planner, founded Heritage Landscapes LLC in 1987. This professional firm has completed a diverse group of 500+ commissions that have received 87 awards to foster preservation and enable economic, environmental and societal sustainability for and places of value, particularly cultural landscapes. Her works at Heritage Landscapes, LLC apply planning and implementation expertise to the preservation and stewardship of places of regional, national and global importance. Currently serving as President of the ICOMOS IFLA International Scientific Committee on Cultural Landscapes, she fosters global collaboration to enhance cultural landscape preservation.This Knowledge Café aims to provide a discussion platform to contribute to the drafting of a new ICOMOS SDGs Policy Guidance, from the perspective of rural heritage, landscapes and rural-urban linkages. While 50%-plus of global populations are urban dwellers, we tend to forget that the other half dwell in rural places. One of the 7 Priority Actions of the ICOMOS SDGs Working Group in 2018 is the preparation of a consolidated policy statement, as an effective tool for advocacy and communication to wider society and the development world. Based on the need to boost the role of cultural heritage in sustainable development processes, this would be a robust Policy Guidance document, serving to improve the recognition of the role of cultural heritage protection, particularly as defined by SDG 11.4 and the New Urban Agenda. The ICOMOS SDGs Working Group aims to launch this document at the 10th World Urban Forum in 2020 and at the High-Level Political Forum in 2021. The new Policy Guidance aims to emphasize “heritage as a resource, a strategic opportunity”, using the framework of the 3 dimensions of sustainability, economic, social, environmental, and propose adding the 4th dimension of ‘culture’ through an appropriate approach. The document should be based on solid scientific expertise sourced from ICOMOS membership. The Symposium on Rural Heritage: Landscapes and Beyond is a prime opportunity to involve some of this membership, ensuring a diverse and inclusive range of expertise in heritage informs the Policy Guidance. Rural heritage and landscapes, including rural-urban linkages, have great relevance for the intersection of cultural heritage and sustainable development, touching on many SDGs and issues raised in the New Urban Agenda, not to mention the Historic Urban Landscape Recommendation. To cite some examples of this inter-connectedness, the “inter-related categories of continuity and change” addressed during the Symposium, provide the following links: - under ‘Rural Culture’ to SDG 11.4 (change management for tangible rural heritage), SDG 1.5, 2.4, 11.5, 11.b, 13.1 (risk of loss of intangible rural traditions/ practices), SDG 8.9, SDG 12.b (rural cultural tourism), SDG 16.7, 16.a, 17.9, 17.15, 17.17 (identity of people and places); - under ‘Rural economics’ to SDG 1 (poverty eradication), SDG2 (food security), SDG3 (rural agricultural heritage), SDG 8 (improvement of markets and opportunities for rural traditional tools, techniques and rural heritage tourism), SDG 8 (infrastructure, services to small enterprises), SDG 11 (spatial form, territorial policies); - under ‘Rural Environment’ to SDG 6 (water), 13 and 15 (desertification, climate-induced severe weather events, biodiversity, forest management); and - under ‘Rural Society’ to SDG 1 (poverty alleviation) SDG 2 (agriculture), SDG 3.8, 3.c (health services), SDG 16, 17 (bottom-up governance). - Some case studies from ‘Moroccan Rural Heritage’ can be proposed during the session from participants who may have relevant knowledge, to demonstrate these links. The Knowledge Café will feature two speakers, Ege Yildirim and Patricia O’Donnell, giving the conceptual framework of the session, followed by Ilaria Rosetti presenting the method of open discussion, whereby breakout groups (e.g. 3-4 groups of 5-6) can discuss the links of rural heritage issues to the various 17 Goals and Targets under them, concluding with short reporting from each group, to be compiled and disseminated later by the conveners