146 research outputs found
Sound-discrimination learning and auditory displays
Proceedings of the 9th International Conference on Auditory Display (ICAD), Boston, MA, July 7-9, 2003.Human listeners can learn to discriminate between sounds that are initially indistinguishable. To better understand the nature of this learning, we have been using behavioral techniques to examine training-induced improvements on basic auditory discrimination tasks. Here we report how multiple-hour training differentially affects the discrimination of sound frequency, intensity, location, and duration, and how learning on a given discrimination condition generalizes, or fails to generalize, to stimuli not encountered during training. We discuss how these data contribute to our understanding of discrimination learning and of the mechanisms underlying performance on particular trained tasks, and explore the implications of this learning for the design and evaluation of auditory displays
Atomic Hydrogen and Star Formation in the Bridge/Ring Interacting Galaxy Pair NGC 7714/7715 (Arp 284)
We present high spatial resolution 21 cm HI maps of the interacting galaxy
pair NGC 7714/7715. We detect a massive (2 x 10**9 M(sun)) HI bridge connecting
the galaxies that is parallel to but offset from the stellar bridge. A chain of
HII regions traces the gaseous bridge, with H-alpha peaks near but not on the
HI maxima. An HI tidal tail is also detected to the east of the smaller galaxy
NGC 7715, similarly offset from a stellar tail. The strong partial stellar ring
on the eastern side of NGC 7714 has no HI counterpart, but on the opposite side
of NGC 7714 there is a 10**9 M(sun) HI loop 11 kpc in radius. Within the NGC
7714 disk, clumpy HI gas is observed associated with star formation regions.
Redshifted HI absorption is detected towards the starburst nucleus. We compare
the observed morphology and gas kinematics with gas dynamical models in which a
low-mass companion has an off-center prograde collision with the outer disk of
a larger galaxy. These simulations suggest that the bridge in NGC 7714/7715 is
a hybrid between bridges seen in systems like M51 and the purely gaseous
`splash' bridges found in ring galaxies like the Cartwheel. The offset between
the stars and gas in the bridge may be due to dissipative cloud-cloud
collisions occuring during the impact of the two gaseous disks.Comment: 31 pages, Latex, 11 figures, to be published in the July 10, 1997
issue of the Astrophysical Journa
Measurement of Charged Pion Production Yields off the NuMI Target
The fixed-target MIPP experiment, Fermilab E907, was designed to measure the
production of hadrons from the collisions of hadrons of momenta ranging from 5
to 120 GeV/c on a variety of nuclei. These data will generally improve the
simulation of particle detectors and predictions of particle beam fluxes at
accelerators. The spectrometer momentum resolution is between 3 and 4%, and
particle identification is performed for particles ranging between 0.3 and 80
GeV/c using , time-of-flight and Cherenkov radiation measurements. MIPP
collected events of 120 GeV Main Injector protons striking a
target used in the NuMI facility at Fermilab. The data have been analyzed and
we present here charged pion yields per proton-on-target determined in bins of
longitudinal and transverse momentum between 0.5 and 80 GeV/c, with combined
statistical and systematic relative uncertainties between 5 and 10%.Comment: 15 pages, 13 figure
Funny walking : the rise, fall and rise of the Anglo-American comic eccentric dancer
This article will attempt to reposition comic eccentric dance as a metamorphic form that still, surprisingly, exists, and is to be found with reasonable ubiquity, in renewed incarna-tions within twenty first century media.
Tracing the origins of comic eccentric dance through examples of earlier comedy performance, and drawing from Bergson’s comic theory of body misalliance, this article will dis-cuss this particularly ludic fusion of music and comedy. Further changes to the form affected by modernist preoccupations during the new Jazz Age at the turn of the twentieth century will be suggested. Finally, ways in which the formulation lives on in twenty-first century in-carnations in the comedy work of, for instance, Jimmy Fallon and Ricky Gervase, and in popular television shows such as Strictly Come Dancing (BBC 2004 - ) and Britain’s Got Talent (ITV 2006 - ) will be posited
A study of a couple with type 2 diabetes: dyadic adjustment and psychological morbidity
Objective: this study assessed dyadic adjustment and psychological morbidity
in type 2 diabetic patients and their partners, focusing on the role of gender.
Methods: 214 diabetic patients and their partners participated in the cross-sectional
study and were assessed on psychological morbidity (HADS) and marital
adjustment (RDAS). Data was analyzed using dyadic analysis, a statistical process
that studies the patient/partner dyads simultaneously.
Results: results revealed that the negative relationship between dyadic adjustment
and psychological morbidity in female patients was stronger than in male
diabetic patients or in partners of male diabetic patients. On the other hand, the
relationship between dyadic adjustment and psychological morbidity in partners
of diabetic men was stronger than the same relationship in partners of diabetic
women.
Conclusion: since gender is a moderator, it is important to attend to the different
needs of female and male patients and the education of diabetic patients
should be centered on the patient/partner dyad.Fundação para a Ciência e a Tecnologia (FCT
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
Background
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy
Bovine Lactoferrin Counteracts Toll-Like Receptor Mediated Activation Signals in Antigen Presenting Cells
Lactoferrin (LF), a key element in mammalian immune system, plays pivotal roles in host defence against infection and excessive inflammation. Its protective effects range from direct antimicrobial activities against a large panel of microbes, including bacteria, viruses, fungi and parasites, to antinflammatory and anticancer activities. In this study, we show that monocyte-derived dendritic cells (MD-DCs) generated in the presence of bovine LF (bLF) fail to undergo activation by up-modulating CD83, co-stimulatory and major histocompatibility complex molecules, and cytokine/chemokine secretion. Moreover, these cells are weak activators of T cell proliferation and retain antigen uptake activity. Consistent with an impaired maturation, bLF-MD-DC primed T lymphocytes exhibit a functional unresponsiveness characterized by reduced expression of CD154 and impaired expression of IFN-γ and IL-2. The observed imunosuppressive effects correlate with an increased expression of molecules with negative regulatory functions (i.e. immunoglobulin-like transcript 3 and programmed death ligand 1), indoleamine 2,3-dioxygenase, and suppressor of cytokine signaling-3. Interestingly, bLF-MD-DCs produce IL-6 and exhibit constitutive signal transducer and activator of transcription 3 activation. Conversely, bLF exposure of already differentiated MD-DCs completely fails to induce IL-6, and partially inhibits Toll-like receptor (TLR) agonist-induced activation. Cell-specific differences in bLF internalization likely account for the distinct response elicited by bLF in monocytes versus immature DCs, providing a mechanistic base for its multiple effects. These results indicate that bLF exerts a potent anti-inflammatory activity by skewing monocyte differentiation into DCs with impaired capacity to undergo activation and to promote Th1 responses. Overall, these bLF-mediated effects may represent a strategy to block excessive DC activation upon TLR-induced inflammation, adding further evidence for a critical role of bLF in directing host immune function
Proceedings of Patient Reported Outcome Measure’s (PROMs) Conference Oxford 2017: Advances in Patient Reported Outcomes Research
A33-Effects of Out-of-Pocket (OOP) Payments and Financial Distress on Quality of Life (QoL) of People with Parkinson’s (PwP) and their Carer
- …