776 research outputs found
Contracture of the Infraspinatus Muscle in the Dog
A tentative diagnosis of contracture of the infraspinatus muscle was made in a dog with a foreleg shoulder lameness causing a positional deformity and characteristic abnormal gait in the affected limb. Contracture of the infraspinatus muscle most commonly involves hunting breeds, particularly actively working dogs
Analyticity of the Susceptibility Function for Unimodal Markovian Maps of the Interval
In a previous note [Ru] the susceptibility function was analyzed for some
examples of maps of the interval. The purpose of the present note is to give a
concise treatment of the general unimodal Markovian case (assuming real
analytic). We hope that it will similarly be possible to analyze maps
satisfying the Collet-Eckmann condition. Eventually, as explained in [Ru],
application of a theorem of Whitney [Wh] should prove differentiability of the
map restricted to a suitable set.Comment: 8 page
The Spitzer Survey of the Small Magellanic Cloud: Discovery of Embedded Protostars in the HII Region NGC 346
We use Spitzer Space Telescope observations from the Spitzer Survey of the
Small Magellanic Cloud (S3MC) to study the young stellar content of N66, the
largest and brightest HII region in the SMC. In addition to large numbers of
normal stars, we detect a significant population of bright, red infrared
sources that we identify as likely to be young stellar objects (YSOs). We use
spectral energy distribution (SED) fits to classify objects as ordinary (main
sequence or red giant) stars, asymptotic giant branch stars, background
galaxies, and YSOs. This represents the first large-scale attempt at blind
source classification based on Spitzer SEDs in another galaxy. We firmly
identify at least 61 YSOs, with another 50 probable YSOs; only one embedded
protostar in the SMC was reported in the literature prior to the S3MC. We
present color selection criteria that can be used to identify a relatively
clean sample of YSOs with IRAC photometry. Our fitted SEDs indicate that the
infrared-bright YSOs in N66 have stellar masses ranging from 2 Msun to 17 Msun,
and that approximately half of the objects are Stage II protostars, with the
remaining YSOs roughly evenly divided between Stage I and Stage III sources. We
find evidence for primordial mass segregation in the HII region, with the most
massive YSOs being preferentially closer to the center than lower-mass objects.
Despite the low metallicity and dust content of the SMC, the observable
properties of the YSOs appear consistent with those in the Milky Way. Although
the YSOs are heavily concentrated within the optically bright central region of
N66, there is ongoing star formation throughout the complex and we place a
lower limit on the star formation rate of 3.2 x 10^-3 Msun/yr over the last ~1
Myr.Comment: 13 pages, 5 figures (3 in color), 2 tables. Accepted for publication
in Ap
Race–Gender Differences in the Impact of History of Heavy Drinking on Current Alcohol Consumption during the Transition to Adulthood
American youth transitioning to adulthood consume more alcohol than in any other period of the life course. This high level of consumption can result in serious consequences, including lost productivity, death and disability, sexual assault, and addiction. Nevertheless, relatively little is known, especially by race and gender, about how prior history of heavy drinking (e.g., in late adolescence) impacts drinking in young adulthood. Utilizing data from the National Longitudinal Survey of Youth (1994-2004) for African Americans, Latinos, and Whites (N = 2,300), we found that Whites and Latinos drink more than African Americans, and men report drinking more than women. However, accounting for a history of heavy drinking introduces considerable variation in current drinking patterns by race–gender status. A history of heavy drinking more than doubles the number of drinks consumed by African American women, putting their drinking levels on par with African American men and White women and raising their level of drinking above Latinas. Further, African American women\u27s probability of heavy drinking becomes indistinguishable from that of African American men and White women, once accounting for a prior history of binge drinking. For Latinas with a history of heavy drinking, the probability of being a current binge drinker is equal to Latinos and White men and higher than African Americans and White women
Opposing synaptic regulation of amyloid-β metabolism by NMDA receptors in vivo
The concentration of amyloid-β (Aβ) within the brain extracellular space is one determinant of whether the peptide will aggregate into toxic species that are important in Alzheimer’s disease (AD) pathogenesis. Some types of synaptic activity can regulate Aβ levels. Here we demonstrate two distinct mechanisms that are simultaneously activated by NMDA receptors and regulate brain interstitial fluid (ISF) Aβ levels in opposite directions in the living mouse. Depending on the dose of NMDA administered locally to the brain, ISF Aβ levels either increase or decrease. Low doses of NMDA increase action potentials and synaptic transmission which leads to an elevation in synaptic Aβ generation. In contrast, high doses of NMDA activate signaling pathways that lead to ERK (extracellular-regulated kinase) activation, which reduces processing of APP into Aβ. This depression in Aβ via APP processing occurs despite dramatically elevated synaptic activity. Both of these synaptic mechanisms are simultaneously active, with the balance between them determining whether ISF Aβ levels will increase or decrease. NMDA receptor antagonists increase ISF Aβ levels, suggesting that basal activity at these receptors normally suppresses Aβ levels in vivo. This has implications for understanding normal Aβ metabolism as well as AD pathogenesis
Sensitive perception of a person’s direction of walking by 4-year-old children.
Watch any crowded intersection, and you will see how adept people are at reading the subtle movements of one another. While adults can readily discriminate small differences in the direction of a moving person, it is unclear if this sensitivity is in place early in development. Here, we present evidence that 4-year-old children are sensitive to small differences in a person's direction of walking (ϳ7°) far beyond what has been previously shown. This sensitivity only occurred for perception of an upright walker, consistent with the recruitment of high-level visual areas. Even at 4 years of age, children's sensitivity approached that of adults'. This suggests that the sophisticated mechanisms adults use to perceive a person's direction of movement are in place and developing early in childhood. Although the neural mechanisms for perceiving biological motion develop slowly, they are refined enough by age 4 to support subtle perceptual judgments of heading. These judgments may be useful for predicting a person's future location or even their intentions and goals
A geometric discretisation scheme applied to the Abelian Chern-Simons theory
We give a detailed general description of a recent geometrical discretisation
scheme and illustrate, by explicit numerical calculation, the scheme's ability
to capture topological features. The scheme is applied to the Abelian
Chern-Simons theory and leads, after a necessary field doubling, to an
expression for the discrete partition function in terms of untwisted
Reidemeister torsion and of various triangulation dependent factors. The
discrete partition function is evaluated computationally for various
triangulations of and of lens spaces. The results confirm that the
discretisation scheme is triangulation independent and coincides with the
continuum partition functionComment: 27 pages, 5 figures, 6 tables. in late
Spitzer IRAC observations of newly-discovered planetary nebulae from the Macquarie-AAO-Strasbourg H-alpha Planetary Nebula Project
We compare H-alpha, radio continuum, and Spitzer Space Telescope (SST) images
of 58 planetary nebulae (PNe) recently discovered by the Macquarie-AAO-Strasbo-
urg H-alpha PN Project (MASH) of the SuperCOSMOS H-alpha Survey. Using InfraRed
Array Camera (IRAC) data we define the IR colors of PNe and demonstrate good
isolation between these colors and those of many other types of astronomical
object. The only substantive contamination of PNe in the color-color plane we
illustrate is due to YSOs. However, this ambiguity is readily resolved by the
unique optical characteristics of PNe and their environs. We also examine the
relationships between optical and MIR morphologies from 3.6 to 8.0um and
explore the ratio of mid-infrared (MIR) to radio nebular fluxes, which is a
valuable discriminant between thermal and nonthermal emission. MASH emphasizes
late evolutionary stages of PNe compared with previous catalogs, enabling study
of the changes in MIR and radio flux that attend the aging process. Spatially
integrated MIR energy distributions were constructed for all MASH PNe observed
by the GLIMPSE Legacy Project, using the H-alpha morphologies to establish the
dimensions for the calculations of the Midcourse Space Experiment (MSX), IRAC,
and radio continuum (from the Molonglo Observatory Synthesis Telescope and the
Very Large Array) flux densities. The ratio of IRAC 8.0-um to MSX 8.3-um flux
densities provides a measure of the absolute diffuse calibration of IRAC at 8.0
um. We independently confirm the aperture correction factor to be applied to
IRAC at 8.0um to align it with the diffuse calibration of MSX. The result
agrees with the recommendations of the Spitzer Science Center and with results
from a parallel study of HII regions. These PNe probe the diffuse calibration
of IRAC on a spatial scale of 9-77 arcsec.Comment: 48 pages, LaTeX (aastex), incl. 18 PostScript (eps) figures and 3
tables. Accepted by Astrophysical Journa
Dust Settling in Magnetorotationally-Driven Turbulent Discs II: The Pervasiveness of the Streaming Instability and its Consequences
We present a series of simulations of turbulent stratified protostellar discs
with the goal of characterizing the settling of dust throughout a minimum-mass
solar nebula. We compare the evolution of both compact spherical grains, as
well as highly fractal grains. Our simulations use a shearing-box formulation
to study the evolution of dust grains locally within the disc, and collectively
our simulations span the entire extent of a typical accretion disc. The dust is
stirred by gas that undergoes MRI-driven turbulence. This establishes a steady
state scale height for the dust that is different for dust of different sizes.
This sedimentation of dust is an important first step in planet formation and
we predict that ALMA should be able to observationally verify its existence.
When significant sedimentation occurs, the dust will participate in a streaming
instability that significantly enhances the dust density. We show that the
streaming instability is pervasive in the outer disc. We characterize the scale
heights of dust whose size ranges from a few microns to a few centimeters. We
find that for spherical grains, a power-law relationship develops for the scale
height with grain size, with a slope that is slightly steeper than -1/2. The
sedimentation is strongest in the outer disc and increases for large grains.
The results presented here show that direct measurements of grain settling can
be made by ALMA and we present favorable conditions for observability. The
streaming instability should also be directly observable and we provide
conditions for directly observing it. We calculate collision rates and growth
rates for the dust grains in our simulations of various sizes colliding with
other grains, and find that these rates are significantly enhanced through the
density enhancement arising from the streaming instability.Comment: 39 pages, 13 figures, submitted to MNRAS. Abstract is abridge
Efficacy of individualised starting dose (isd) and fixed starting dose (fsd) of niraparib per investigator assessment (ia) in newly diagnosed advanced ovarian cancer (oc) patients
Niraparib is a poly(ADP-ribose) polymerase inhibitor approved for maintenance treatment of patients with
newly diagnosed or recurrent OC that responded to platinumbased chemotherapy and treatment in heavily-pretreated recurrent OC. Here we report efficacy in patients receiving the
FSD and ISD in the PRIMA/ENGOT-OV26/GOG-3012 trial
(NCT02655016)
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