Identifikation von Genen mit dem Potential zur Transformation von präkanzerösen Läsionen (Dysplasie) zu malignen Lebertumoren in einem transgenen Mausmodell

[no abstract

The Main Results of the Borexino Experiment

The main physical results on the registration of solar neutrinos and the search for rare processes obtained by the Borexino collaboration to date are presented.Comment: 8 pages, 8 figgures, To be published as Proceedings of the Third Annual Large Hadron Collider Physics Conference, St. Petersburg, Russia, 201

Acoustic telemetry in freshwater habitats: the influence of macrophytes on acoustic transmitter detection efficiency and identifying predation using novel transmitters

Acoustic telemetry is a popular tool to study the movements of animals and has resulted in substantial ecological knowledge gain. To effectively carry out acoustic telemetry studies, many technical and biological considerations must be made. This thesis aimed to fill gaps in knowledge pertaining to two common considerations in passive acoustic telemetry studies, particularly in nearshore freshwater habitats: understanding the influence of macrophytes on the detection efficiency and range of acoustic telemetry equipment and identifying whether or not tagged animals have been consumed by an aquatic predator. Through the application of detection range testing and hydroacoustic surveys, it was revealed that distance and macrophyte biovolume interact to significantly influence the detection efficiency of acoustic transmitters, and this influence varied significantly based on the seasonal growth and senescence of macrophytes. The distance at which 50% of transmissions were successfully detected ranged from 5.5 m (± 139.6 S.D.) to 186.8 m (± 114.4 S.D.) and was significantly correlated to seasonal fluctuations in macrophyte biovolume. One of the first field applications of novel transmitters that identify predation events of tagged individuals indicated that 31.7% of tagged fish (n = 60) were apparently predated, and variable detection patterns were demonstrated using spatial metrices to examine the transmitter movements before and after the apparent predation event. The novel information presented in this thesis regarding the significant seasonal influence of macrophytes on detection efficiency and range and the application of acoustic transmitters that identify predation events in the wild will inform and improve future acoustic telemetry studies

Spectroscopy of geo-neutrinos from 2056 days of Borexino data

We report an improved geo-neutrino measurement with Borexino from 2056 days of data taking. The present exposure is $(5.5\pm0.3)\times10^{31}$ proton$\times$yr. Assuming a chondritic Th/U mass ratio of 3.9, we obtain $23.7 ^{+6.5}_{-5.7} (stat) ^{+0.9}_{-0.6} (sys)$ geo-neutrino events. The null observation of geo-neutrinos with Borexino alone has a probability of $3.6 \times 10^{-9}$ (5.9$\sigma$). A geo-neutrino signal from the mantle is obtained at 98\% C.L. The radiogenic heat production for U and Th from the present best-fit result is restricted to the range 23-36 TW, taking into account the uncertainty on the distribution of heat producing elements inside the Earth.Comment: 4 pages, 4 figure

Rivaroxaban – an oral, direct Factor Xa inhibitor – lessons from a broad clinical study programme

Anticoagulants are recommended for the prevention and treatment of venous thromboembolism (VTE), prevention of stroke in patients with atrial fibrillation (AF) and secondary prevention in patients with acute coronary syndrome (ACS). There is a clinical need for novel anticoagulants offering improvements over current standard of care, such as fixed oral dosing and no need for routine monitoring. Rivaroxaban, an oral, once-daily, direct Factor Xa inhibitor, has recently completed the RECORD phase III programme for the prevention of VTE in patients undergoing total hip or knee replacement (THR or TKR), an indication for which it is approved in Europe and Canada. It is being investigated in large-scale phase III studies for VTE treatment and prevention of stroke in patients with AF, and phase III studies will soon commence for secondary prevention in patients with ACS. Phase I studies demonstrated that no routine anticoagulation monitoring was required, while phase II studies suggested that fixed daily doses had a wide therapeutic window. The four RECORD studies consistently showed that rivaroxaban was significantly more effective than enoxaparin in the prevention of VTE after THR and TKR, with a similar safety profile. This review describes the development of this novel anticoagulant, from bench to bedside

Agroecologia e o fortalecimento do sistema agrícola tradicional do Rio Negro, São Gabriel da Cachoeira, Amazonas

A agricultura familiar é a principal atividade desenvolvida pelos indígenas em São Gabriel da Cachoeira, alto rio Negro. O Sistema Agrícola Tradicional do Rio Negro é bem imaterial do país e como tal deve ser preservado. Contudo, nas comunidades na zona peri-urbana da cidade, deve-se fazer dessa agricultura fonte de renda económica, e não somente meio de subsistencia, uma demanda das proprias comunidades frente as condiçoes sócio ambientais e econômicas em que se encontram. A agroecologia pode atuar como ferramenta de afirmação e ampliação desse sistema, na medida em que fornece alternativas para combater as carencias naturais da agricultura indígena na amazonia sem interferir negativamente sobre as práticas culturais associadas. Apoiar e supri as demandas da agricultura tradicional praticada nessa região de forma adequada pressupõe a conservação da biodiversidade, da cultura indígena e da implemnetação de políticas publicas de desenvolvimento social.Eje: B1 Sistemas de producción de base agroecológica (Relatos de experiencias).Facultad de Ciencias Agrarias y Forestale

Agroecologia e o fortalecimento do sistema agrícola tradicional do Rio Negro, São Gabriel da Cachoeira, Amazonas

A agricultura familiar é a principal atividade desenvolvida pelos indígenas em São Gabriel da Cachoeira, alto rio Negro. O Sistema Agrícola Tradicional do Rio Negro é bem imaterial do país e como tal deve ser preservado. Contudo, nas comunidades na zona peri-urbana da cidade, deve-se fazer dessa agricultura fonte de renda económica, e não somente meio de subsistencia, uma demanda das proprias comunidades frente as condiçoes sócio ambientais e econômicas em que se encontram. A agroecologia pode atuar como ferramenta de afirmação e ampliação desse sistema, na medida em que fornece alternativas para combater as carencias naturais da agricultura indígena na amazonia sem interferir negativamente sobre as práticas culturais associadas. Apoiar e supri as demandas da agricultura tradicional praticada nessa região de forma adequada pressupõe a conservação da biodiversidade, da cultura indígena e da implemnetação de políticas publicas de desenvolvimento social.Eje: B1 Sistemas de producción de base agroecológica (Relatos de experiencias).Facultad de Ciencias Agrarias y Forestale