Structural concepts and experimental considerations for a versatile high-speed research airplane

Future aircraft may be hydrogen fueled and fly at hypersonic speeds. The resulting environments will require new structural concepts to satisfy performance goals. Large representative structures will have to be flight tested prior to commitment to a costly vehicle fleet. To perform flight tests, a versatile, economical, high-speed research airplane is defined. Results of this study including experimental considerations for a hypersonic research airplane are reported

Sexually Transmitted Disease and Male Infertility: A Systematic Review

Context Theoretically, sexually transmitted diseases (STDs) have the potential to disrupt male fertility; however, the topic remains controversial. Objective To describe the possible association between STDs and male infertility and to explore possible pathophysiologic mechanisms. Evidence acquisition We performed a systematic literature review in accordance with the PRISMA guidelines. PubMed, Embase, and the Cochrane Library were searched for articles published before January 1, 2016, using the MeSH terms for a variety of STDs and infertility. The search was restricted to human studies performed in men and published in English. Studies were included if they contained original data on a possible association or a cause-and-effect relationship between STD and male infertility. Studies were considered only if they included an appropriate control group and/or comprehensive laboratory data. Due to heterogeneity in the literature, a qualitative analysis was performed. Evidence synthesis Relevant studies on Chlamydia trachomatis, genital mycoplasmas, Neisseria gonorrhoeae, Trichomonas vaginalis, and viral infections were identified. For all pathogens, the studies were contradictory and generally of limited quality. In studies confirming an association, there was a tendency for authors to perform multiple analyses without appropriate corrections and to subsequently focus solely on outcomes that seemed to suggest a positive association; however, the body of literature that does not confirm an association between STDs and male infertility is also of inadequate quality. The data regarding possible pathophysiologic mechanisms are inconclusive. Conclusions There may be an association between STDs and male infertility of unknown genesis and possibly with different pathogenic mechanisms for different pathogens. Alternatively, some STDs may cause male infertility, whereas others may not; however, there is hardly a strong correlation. High-quality studies of the subject are needed. Patient summary Sexually transmitted diseases may cause male infertility through unknown mechanisms; however, from the available research, we cannot be sure that there is an association, and more studies are needed

The chemical evolution of galaxies within the IGIMF theory: the [alpha/Fe] ratios and downsizing

The chemical evolution of galaxies is investigated within the framework of the star formation rate (SFR) dependent integrated galactic initial mass function (IGIMF). We study how the global chemical evolution of a galaxy and in particular how [alpha/Fe] abundance ratios are affected by the predicted steepening of the IGIMF with decreasing SFR. We use analytical and semi-analytical calculations to evaluate the mass-weighted and luminosity-weighted [alpha/Fe] ratios in early-type galaxies of different masses. The models with the variable IGIMF produce a [alpha/Fe] vs. velocity dispersion relation which has the same slope as the observations of massive galaxies, irrespective of the model parameters, provided that the star formation duration inversely correlates with the mass of the galaxy (downsizing). These models also produce steeper [alpha/Fe] vs. sigma relations in low-mass early-type galaxies and this trend is consistent with the observations. Constant IMF models are able to reproduce the [alpha/Fe] ratios in large elliptical galaxies as well, but they do not predict this change of slope for small galaxies. In order to obtain the best fit between our results and the observations, the downsizing effect (i.e. the shorter duration of the star formation in larger galaxies) must be milder than previously thought.Comment: 13 pages, 18 figures, accepted for publication in Astronomy and Astrophysic

Effects of the integrated galactic IMF on the chemical evolution of the solar neighbourhood

The initial mass function determines the fraction of stars of different intial mass born per stellar generation. In this paper, we test the effects of the integrated galactic initial mass function (IGIMF) on the chemical evolution of the solar neighbourhood. The IGIMF (Weidner & Kroupa 2005) is computed from the combination of the stellar intial mass function (IMF), i.e. the mass function of single star clusters, and the embedded cluster mass function, i.e. a power law with index beta. By taking into account also the fact that the maximum achievable stellar mass is a function of the total mass of the cluster, the IGIMF becomes a time-varying IMF which depends on the star formation rate. We applied this formalism to a chemical evolution model for the solar neighbourhood and compared the results obtained by assuming three possible values for beta with the results obtained by means of a standard, well-tested, constant IMF. In general, a lower absolute value of beta implies a flatter IGIMF, hence a larger number of massive stars and larger metal ejection rates. This translates into higher type Ia and II supernova rates, higher mass ejection rates from massive stars and a larger amount of gas available for star formation, coupled with lower present-day stellar mass densities. (abridged) We also discuss the importance of the present day stellar mass function (PDMF) in providing a way to disentangle among various assumptions for beta. Our results indicate that the model adopting the IGIMF computed with beta ~2 should be considered the best since it allows us to reproduce the observed PDMF and to account for most of the chemical evolution constraints considered in this work.Comment: 22 pages, 19 figure

Testing the universal stellar IMF on the metallicity distribution in the bulges of the Milky Way and M31

We test whether the universal initial mass function (UIMF) or the integrated galaxial IMF (IGIMF) can be employed to explain the metallicity distribution (MD) of giants in the Galactic bulge. We make use of a single-zone chemical evolution model developed for the Milky Way bulge in the context of an inside-out model for the formation of the Galaxy. We checked whether it is possible to constrain the yields above 80 M_{\sun} by forcing the UIMF and required that the resulting MD matches the observed ones. We also extended the analysis to the bulge of M31 to investigate a possible variation of the IMF among galactic bulges. Several parameters that have an impact on stellar evolution (star-formation efficiency, gas infall timescale) are varied. We show that it is not possible to satisfactorily reproduce the observed metallicity distribution in the two galactic bulges unless assuming a flatter IMF ($x \leq 1.1$) than the universal one. We conlude that it is necessary to assume a variation in the IMF among the various environments.Comment: 9 pages, 4 figures, accepted for publication in A&

The aging male: investigation, treatment and monitoring of late-onset hypogonadism in males

Androgen deficiency in the aging male has become a topic of increasing interest and debate throughout the world. The demographics clearly demonstrate the increasing percentage of the population that is in the older age groups. The data also support the concept that testosterone falls progressively with age and that a significant percentage of men over the age of 60 years have serum testosterone levels that are below the lower limits of young adults (age 20-30 years) men. The principal questions raised by these observations are whether older hypogonadal men will benefit from testosterone treatment and what will be the risks associated with such intervention. The past decade has brought evidence of benefit of androgen treatment on multiple target organs of hypogonadal men and recent studies show short-term beneficial effects of testosterone in older men that are similar to those in younger men. Long-term data on the effects of testosterone treatment in the older population are limited and specific risk data on the prostate and cardiovascular systems are needed. Answers to key questions of functional benefits that may retard frailty of the elderly are not yet available. The recommendations described below were prepared for the International Society of Andrology (ISA) and the International Society for the Study of the Aging Male (ISSAM) following a panel discussion with active participation from the audience sponsored by the ISA on the topic at the 4th ISSAM Congress in Prague in February 2004.peer-reviewe