Pengaruh Intellectual Capital Terhadap Kinerja Keuangan Dan Nilai Pasar Perusahaan

The objective of this study was to investigate influence of firm’sintellectual capital on their financial performance and market value. The objects of this paper are manufacturing industries listed at the Indonesian Stock Exchange period 2007 to 2008. By using 41 companies sample using purposive sampling method. This study used simple regression to examinethe influence intellectual capital (Value added intellectual capital (VAIC)) to financial performances and company market value. To examine the influence of three component of intellectual capital (capital employed efficiency(VACA), human capital efficiency (VAHU) and structural capital efficiency (STVA) to financial performances and company market value, this study uses multiple regression. The results showed that only VAHU has significant influence to company market value and only STVA has significant influenceto financial performance

Improving the effectiveness of web application vulnerability scanning

Using web application vulnerability scanners is very appealing as they promise to detect vulnerabilities with minimal configuration effort. However, using them effectively in practice is often difficult. Two of the main reasons for this are limitations with respect to crawling capabilities and problems to perform authenticated scans. In this paper, we present JARVIS, which provides technical solutions that can be applied to a wide range of vulnerability scanners to overcome these limitations and to significantly improve their effectiveness. To evaluate JARVIS, we applied it to five freely available vulnerability scanners and tested the vulnerability detection performance in the context of seven deliberately insecure web applications. A first general evaluation showed that by using the scanners with JARVIS, the number of detected vulnerabilities can be increased by more than 100% on average compared to using the scanners without JARVIS. A significant fraction of the additionally detected vulnerabilities is security-critical, which means that JARVIS provides a true security benefit. A second, more detailed evaluation focusing on SQL injection and cross-site scripting vulnerabilities revealed that JARVIS improves the vulnerability detection performance of the scanners by 167% on average, without increasing the fraction of reported false positives. This demonstrates that JARVIS not only manages to greatly improve the vulnerability detection rate of these two highly security-critical types of vulnerabilities, but also that JARVIS is very usable in practice by keeping the false positives reasonably low. Finally, as the configuration effort to use JARVIS is small and as the configuration is scanner- independent, JARVIS also supports using multiple scanners in parallel in an efficient way. In an additional evaluation, we therefore analyzed the potential and limitations of using multiple scanners in parallel. This revealed that using multiple scanners in a reasonable way is indeed beneficial as it further increases the number of detected vulnerabilities without a significant negative impact on the reported false positives

Zur Beschäftigungsentwicklung in der Region Hannover – Ein Vergleich mit 12 deutschen Verdichtungsräumen

Der vorliegende Beitrag untersucht die Beschäftigungsentwicklung in der Region Hannover für den Zeitraum 1999 bis 2006 und stellt sie zwölf weiteren deutschen Verdichtungsräumen gegenüber. Unter Verwendung des Betriebs-Historik-Panels des Institutes für Arbeitsmarkt- und Berufsforschung (IAB) werden neben der Beschäftigungsentwicklung im Aggregat auch die dahinter liegenden Bruttoströme analysiert um somit auch Aussagen über die Dynamik der Beschäftigungsentwicklung treffen zu können. Insgesamt1 weist die Region Hannover zwischen 1999 und 2006 ein Nettobeschäftigungswachstum von 2,2 Prozent auf, was mit Blick auf die Vergleichsregionen als relativ ungünstig einzuschätzen ist. Zieht man die Bruttoströme zur Betrachtung hinzu, wird deutlich, dass hinter der relativ geringen Nettowachstumsrate eine beachtliche Dynamik an Beschäftigungsauf- und -abbau steht. So weist die Region Hannover eine Bruttowachstumsrate der Beschäftigung von 35,1 Prozent sowie eine Bruttoabbaurate der Beschäftigung von -32,9 Prozent auf. Im Vergleich zu den anderen Verdichtungsräumen zeigt sich, dass die relativ ungünstige Nettobeschäftigungsentwicklung in der Region Hannover insbesondere auf eine vergleichsweise geringe Bruttowachstumsrate zurückzuführen ist.Region Hannover, Beschäftigungsentwicklung, Paneldaten

Possible attacks on and countermeasures for secure multi-agent computation

In this paper we improve the model for secure multi-agent computation proposed by Endsuleit and Mie. We apply a recent protocol from Hirt and Maurer for secure multi-party computation to build Alliances of n agents that solve a common task. The protocol used is very efficient with a communication load of O(n^2 m) (where m is the number of multiplications). All computations within the Alliance are robust as less than n/3 agents are corrupted at the same time

Highly protein-loaded melt extrudates produced by small-scale ram and twin-screw extrusion - evaluation of extrusion process design on protein stability by experimental and numerical approaches

Understanding of generation, extent and location of thermomechanical stress in small-scale (< 3 g) ram and twin-screw melt-extrusion is crucial for mechanistic correlations to the stability of protein particles (lysozyme and BSA) in PEG-matrices. The aim of the study was to apply and correlate experimental and numerical approaches (1D and 3D) for the evaluation of extrusion process design on protein stability. The simulation of thermomechanical stress during extrusion raised the expectation of protein degradation and protein particle grinding during extrusion, especially when TSE was used. This was confirmed by experimental data on protein stability. Ram extrusion had the lowest impact on protein unfolding temperatures, whereas TSE showed significantly reduced unfolding temperatures, especially in combination with kneading elements containing screws. In TSE, the mechanical stress in the screws always exceeded the shear stress in the die, while mechanical stress within ram extrusion was generated in the die, only. As both extruder designs revealed homogeneously distributed protein particles over the cross section of the extrudates for all protein-loads (20–60%), the dispersive power of TSE revealed not to be decisive. Consequently, the ram extruder would be favored for the production of stable protein-loaded extrudates in small scale

Exploiting the potential of web application vulnerability scanning

Using automated web application vulnerability scanners so that they truly live up to their potential is difficult. Two of the main reasons for this are limitations with respect to crawling capabilities and problems to perform authenticated scans. In this paper, we present JARVIS, which provides technical solutions that can be applied to a wide range of vulnerability scanners to overcome these limitations. Our evaluation shows that by using JARVIS, the vulnerability detection performance of five freely available scanners can be improved by more than 100% compared to using them in their basic configuration. As the configuration effort to use JARVIS is small and the configurations are scanner-independent, JARVIS also allows to use multiple scanners in parallel in an efficient way. In an additional evaluation, we therefore analyzed the potential and limitations of using multiple scanners in parallel. This revealed that using multiple scanners in a reasonable way is indeed beneficial as it increases the number of detected vulnerabilities without a significant negative impact on the reported false positives

Virtue and the Health Professions

Presented to the WMU Center for the Study of Ethics in Society, February 8, 1991

Ketogenic diet does not promote triple-negative and luminal mammary tumor growth and metastasis in experimental mice

Vol.:(0123456789)1 3Clinical & Experimental Metastasis https://doi.org/10.1007/s10585-023-10249-z RESEARCH PAPER Ketogenic diet does not promote triple-negative and luminal mammary tumor growth and metastasis in experimental mice Meret Grube1 · Arno Dimmler2 · Anja Schmaus1 · Rafael Saup1 · Tabea Wagner 1 · Boyan K. Garvalov 1 · Jonathan P. Sleeman1,3 · Wilko Thiele 1 Received: 17 October 2023 / Accepted: 21 November 2023 © The Author(s) 2023 Abstract Ketogenic diets (KDs) can improve the well-being and quality of life of breast cancer patients. However, data on the effects of KDs on mammary tumors are inconclusive, and the influence of KDs on metastasis in general remains to be investigated. We therefore assessed the impact of a KD on growth and metastasis of triple negative murine 4T1 mammary tumors, and on the progression of luminal breast tumors in an autochthonous MMTV-PyMT mouse model. We found that KD did not influence the metastasis of 4T1 and MMTV-PyMT mammary tumors, but impaired 4T1 tumor cell proliferation in vivo, and also temporarily reduced 4T1 primary tumor growth. Notably, the ketogenic ratio (the mass of dietary fat in relation to the mass of dietary carbohydrates and protein) that is needed to induce robust ketosis was twice as high in mice as compared to humans. Surprisingly, only female but not male mice responded to KD with a sustained increase in blood β-hydroxybutyrate levels. Together, our data show that ketosis does not foster primary tumor growth and metastasis, suggesting that KDs can be safely applied in the context of luminal breast cancer, and may even be advantageous for patients with triple negative tumors. Furthermore, our data indicate that when performing experiments with KDs in mice, the ketogenic ratio needed to induce ketosis must be verified, and the sex of the mice should also be taken into account

Normative data and standard operating procedures for static and dynamic retinal vessel analysis as biomarker for cardiovascular risk

Retinal vessel phenotype is predictive for cardiovascular outcome. This cross-sectional population-based study aimed to quantify normative data and standard operating procedures for static and dynamic retinal vessel analysis. We analysed central retinal arteriolar (CRAE) and venular (CRVE) diameter equivalents, as well as retinal endothelial function, measured by flicker light‐induced maximal arteriolar (aFID) and venular (vFID) dilatation. Measurements were performed in 277 healthy individuals aged 20 to 82 years of the COmPLETE study. The mean range from the youngest compared to the oldest decade was 196 ± 13 to 166 ± 17 µm for CRAE, 220 ± 15 to 199 ± 16 µm for CRVE, 3.74 ± 2.17 to 3.79 ± 2.43% for aFID and 4.64 ± 1.85 to 3.86 ± 1.56% for vFID. Lower CRAE [estimate (95% CI): - 0.52 (- 0.61 to - 0.43)], CRVE [- 0.33 (- 0.43 to - 0.24)] and vFID [- 0.01 (- 0.26 to - 0.00)], but not aFID, were significantly associated with older age. Interestingly, higher blood pressure was associated with narrower CRAE [- 0.82 (- 1.00 to - 0.63)] but higher aFID [0.05 (0.03 to 0.07)]. Likewise, narrower CRAE were associated with a higher predicted aFID [- 0.02 (- 0.37 to - 0.01)]. We recommend use of defined standardized operating procedures and cardiovascular risk stratification based on normative data to allow for clinical implementation of retinal vessel analysis in a personalized medicine approach