New design parameters for biparabolic beach profiles (SW Cadiz, Spain)

165 profiles of seventy-one beaches along the Gulf of Cadiz (SW, Spain) were studied to improve the formulation of the beach profile in tidal seas. Maritime climate, degree of energy exposure and size of the sand grains were taken into account to study the two sections of the biparabolic profile. The objective of the study was the determination of more accurate formulations of the design parameters for the equilibrium profile that involves tidal seas. These formulations were modelled and validated based on existing profiles to quantify the error existing between the real profile and the modelling. This comparative analysis was extended by considering the formulations proposed by other authors. The best results were obtained with the proposal presented herein

A Design Parameter for Reef Beach Profiles—A Methodology Applied to Cadiz, Spain

The southwestern coast of Spain is in a tidal zone (mesotidal) which causes the equilibrium profile to be developed in two different sections: the breakage section and the swash section. These two sections give rise to the typical bi-parabolic profile existing in tidal seas. The existence of areas with reefs/rocks which interrupt the normal development of the typical bi-parabolic profile causes different types of beach profiles. The objective of this article is designing an easy methodology for determining new formulations for the design parameters of the equilibrium profile of beaches with reefs in tidal seas. These formulations are applied on 16 profiles to quantify the error between the real profile data and the modelling results. A comparative analysis is extended to the formulations proposed by other authors, from which it is found that better results are obtained with the new formulations

Wood Waste from Fruit Trees: Biomolecules and Their Applications in Agri-Food Industry

In the European Union (EU), a total of 11,301,345 hectares are dedicated to the cultivation of fruit trees, mainly olive orchards, grapevines, nut trees (almond, walnut, chestnut, hazelnut, and pistachio), apple and pear trees, stone fruit trees (peach, nectarine, apricot, cherry, and plum), and citrus fruit trees (orange, clementine, satsuma, mandarin, lemon, grapefruit, and pomelo). Pruning these trees, together with plantation removal to a lesser extent, produces a huge amount of wood waste. A theoretical calculation of the wood waste in the European Union estimates approximately 2 and 25 million tons from wood plantation removal and pruning, respectively, per year. This wood waste is usually destroyed by in-field burning or crushing into the soil, which result in no direct economic benefits. However, wood from tree pruning, which is enriched in high added-value mol-ecules, offers a wide spectrum of possibilities for its valorization. This review focuses on the contri-bution of wood waste to both sustainability and the circular economy, considering its use not only as biomass but also as a potential source of bioactive compounds. The main bioactive compounds found in wood are polyphenols, terpenes, polysaccharides, organic compounds, fatty acids, and alkaloids. Polyphenols are the most ubiquitous compounds in wood. Large amounts of hydroxyty-rosol (up to 25 g/kg dw), resveratrol (up to 66 g/kg dw), protocatechuic acid (up to 16.4 g/kg), and proanthocyanins (8.5 g/kg dw) have been found in the wood from olive trees, grapevines, almond trees and plum trees, respectively. The bioactivity of these compounds has been demonstrated at lower concentrations, mainly in vitro studies. Bioactive compounds present antioxidant, antimicro-bial, antifungal, biostimulant, anti-inflammatory, cardioprotective, and anticarcinogenic properties, among others. Therefore, wood extracts might have several applications in agriculture, medicine, and the food, pharmaceutical, nutraceutical, and cosmetics industries. For example, olive tree wood extract reduced thrombin-induced platelet aggregation in vitro; grapevine tree wood extract acts a preservative in wine, replacing SO2; chestnut tree wood extract has antifungal properties on post-harvest pathogens in vitro; and stone tree wood extracts are used for aging both wines and brandies. Moreover, the use of wood waste contributes to the move towards both a more sustainable development and a circular economy.Ministerio de Economía, Industria y Competitividad RTA2015-00005-C02-0

Isolation of Aspergillus spp. from the respiratory tract in critically ill patients: risk factors, clinical presentation and outcome

INTRODUCTION: Our aims were to assess risk factors, clinical features, management and outcomes in critically ill patients in whom Aspergillus spp. were isolated from respiratory secretions, using a database from a study designed to assess fungal infections. METHODS: A multicentre prospective study was conducted over a 9-month period in 73 intensive care units (ICUs) and included patients with an ICU stay longer than 7 days. Tracheal aspirate and urine samples, and oropharyngeal and gastric swabs were collected and cultured each week. On admission to the ICU and at the initiation of antifungal therapy, the severity of illness was evaluated using the Acute Physiology and Chronic Health Evaluation II score. Retrospectively, isolation of Aspergillus spp. was considered to reflect colonization if the patient did not fulfil criteria for pneumonia, and infection if the patient met criteria for pulmonary infection and if the clinician in charge considered the isolation to be clinically valuable. Risk factors, antifungal use and duration of therapy were noted. RESULTS: Out of a total of 1756 patients, Aspergillus spp. were recovered in 36. Treatment with steroids (odds ratio = 4.5) and chronic obstructive pulmonary disease (odds ratio = 2.9) were significantly associated with Aspergillus spp. isolation in multivariate analysis. In 14 patients isolation of Aspergillus spp. was interpreted as colonization, in 20 it was interpreted as invasive aspergillosis, and two cases were not classified. The mortality rates were 50% in the colonization group and 80% in the invasive infection group. Autopsy was performed in five patients with clinically suspected infection and confirmed the diagnosis in all of these cases. CONCLUSION: In critically ill patients, treatment should be considered if features of pulmonary infection are present and Aspergillus spp. are isolated from respiratory secretions

Beach Leveling Using a Remotely Piloted Aircraft System (RPAS): Problems and Solutions

The size and great dynamism of coastal systems require faster and more automated mapping methods like the use of a remotely piloted aircraft system (RPAS) or unmanned aerial vehicle (UAV). This method allows for shorter intervals between surveys. The main problem for surveying using low-altitude digital photogrammetry in beach areas is their visual homogeneity. Obviously, the fewer the homologous points defined by the program, the lower the accuracy. Moreover, some factors influence the error performed in photogrammetric techniques, such as flight height, flight time, percentage of frame overlap (side and forward), and the number of ground control points (GCPs). A total of 72 different cases were conducted varying these factors, and the results were analyzed. Among the conclusions, it should be highlighted that the error for noon flights is almost double that for the early morning flights. Secondly, there is no appreciable difference regarding the side overlap. But, on the other side, RMSE increased to three times (from 0.05 to 0.15 m) when forward overlap decreased from 85% to 70%. Moreover, relative accuracy is 0.05% of the flying height which means a significant increase in error (66%) between flights performed at 60 and 100 m height). Furthermore, the median of the error for noon flights (0.12 m) is almost double that for the early morning flights (0.07 m) because of the higher percentage of grids with data for early flights. Therefore, beach levelings must never be performed at noon when carried out by RPAS. Eventually, a new parameter has been considered: the relationship between the number of GCPs and the surface to be monitored. A minimum value of 7 GCP/Ha should be taken into account when designing a beach leveling campaign using RPAS.Fundacion Campus Tecnologico de Algeciras; Coastal Engineering Research group (University of Cadiz

Assessment of the differences in the phenolic composition and color characteristics of new strawberry (Fragaria x ananassa Duch.) cultivars by HPLC–MS and Imaging Tristimulus Colorimetry

The phenolic composition (by HPLC-DAD-MS) and color characteristics (by Imaging Tristimulus Colorimetry) of four strawberry cultivars that have shown good climate adaptation to subtropical area (Nikte, Zamorana, Jacona and Pakal) have been assessed. 24 monomeric phenolics were identified, including 15 anthocyanins, 5 phenolic acids, 1 flavanol and 4 flavonols. Nikte and Zamorana showed the highest phenolic potential mainly due to their higher content of anthocyanins, while Pakal was richer in phenolic acids. Regarding color, Nikte and Zamorana were the more similar cultivars having the lowest values of lightness and hue. On the contrary, the color of Pakal was quite different from all the rest, due to the specific distribution between pelargonidin and cyanidin. The inclusion of both phenolic and colorimetric information in the Linear Discriminant Analysis allowed reaching very good discriminations among cultivar

Un estudio sobre los jóvenes de Valencia : una nueva aproximación sociológica

Este trabajo se enmarca dentro de las políticas locales de juventud y pretende proporcionar algunos indicadores –en el sentido de indicios, de claves de comprensión– para las acciones que se inicien en el próximo Plan de Juventud de la ciudad de Valencia. La estructura del estudio responde básicamente al esquema organizativo planteado por el propio Plan Municipal de Juventud 2009-2012 en sus diferentes áreas y subáreas, pero adaptado a la nueva y reciente estructura con las que se quiere abordar el nuevo Plan Municipal de Juventud a partir de 2013. Por tanto, este estudio ha puesto el foco de atención en aquellas seis áreas que la Concejalía de Juventud del Ayuntamiento de Valencia considera prioritarias: áreas cuya suma e interrelación configuran una serie de políticas y prácticas de juventud. Las seis áreas son: empleo, vivienda, calidad de vida, ocio y tiempo libre, Formación, Información y participación.El estudio forma parte de un encargo de la Concejalía de Juventud del Ayuntamiento de Valencia, como marco teórico para un nuevo Plan de Juventud que se inicia en 2013

From ANAIS-25 towards ANAIS-250

The ANAIS (Annual modulation with NaI(Tl) Scintillators) experiment aims at the confirmation of the DAMA/LIBRA signal using the same target and technique at the Canfranc Underground Laboratory (LSC). 250 kg of ultra pure NaI(Tl) crystals will be used as target, divided into 20 modules, 12.5 kg mass each, and coupled to two high efficiency photomultiplier tubes from Hamamatsu. The ANAIS-25 set-up at the LSC consists of two prototypes, amounting 25 kg NaI(Tl), grown from a powder having a potassium level under the limit of our analytical techniques, and installed in a convenient shielding at the LSC. The background has been carefully analyzed and main results will be summarized in this paper, focusing on the alpha contamination identified in the prototypes and the related background contributions. Status of fulfillment of ANAIS experimental goals and prospects for the building of ANAIS-250 experiment will be also revised

Influence of the LILRA3 Deletion on Multiple Sclerosis Risk : Original Data and Meta-Analysis

Altres ajuts: Junta de Andalucía (JA)- Fondos Europeos de Desarrollo Regional (FEDER) (grant number CTS2704 to FM).Multiple sclerosis (MS) is a neurodegenerative, autoimmune disease of the central nervous system. Genome-wide association studies (GWAS) have identified over hundred polymorphisms with modest individual effects in MS susceptibility and they have confirmed the main individual effect of the Major Histocompatibility Complex. Additional risk loci with immunologically relevant genes were found significantly overrepresented. Nonetheless, it is accepted that most of the genetic architecture underlying susceptibility to the disease remains to be defined. Candidate association studies of the leukocyte immunoglobulin-like receptor LILRA3 gene in MS have been repeatedly reported with inconsistent results. In an attempt to shed some light on these controversial findings, a combined analysis was performed including the previously published datasets and three newly genotyped cohorts. Both wild-type and deleted LILRA3 alleles were discriminated in a single-tube PCR amplification and the resulting products were visualized by their different electrophoretic mobilities. Overall, this meta-analysis involved 3200 MS patients and 3069 matched healthy controls and it did not evidence significant association of the LILRA3 deletion [carriers of LILRA3 deletion: p = 0.25, OR (95% CI) = 1.07 (0.95-1.19)], even after stratification by gender and the HLA-DRB1*15 : 01 risk allele

The upper-airway microbiome as a biomarker of asthma exacerbations despite inhaled corticosteroid treatment.

BACKGROUND: The response to inhaled corticosteroids (ICS) in asthma is affected by the interplay of several factors. Among these, the role of the upper-airway microbiome has been scarcely investigated. We aimed to evaluate the association between the salivary, pharyngeal, and nasal microbiome with asthma exacerbations despite receipt of ICS. METHODS: Samples from 250 asthma patients from the Genomics and Metagenomics of Asthma Severity (GEMAS) study treated with ICS were analyzed. Control/case subjects were defined by the absence/presence of asthma exacerbations in the past 6 months despite being treated with ICS. The bacterial microbiota was profiled by sequencing the V3-V4 region of the 16S rRNA gene. Differences between groups were assessed by PERMANOVA and regression models adjusted for potential confounders. Afalse discovery rate (FDR) of 5% was used to correct for multiple comparisons. Classification models of asthma exacerbations despite ICS treatment were built with machine learning approaches based on clinical, genetic, and microbiome data. RESULTS: In nasal and saliva samples, case subjects had lower bacterial diversity (Richness, Shannon, and Faith indices) than control subjects (.007≤ P≤ .037). Asthma exacerbations accounted for 8% to 9% of the interindividual variation of the salivary and nasal microbiomes (.003≤ P≤ .046). Three, 4, and 11 bacterial genera from the salivary, pharyngeal, and nasal microbiomes were differentially abundant between groups (4.09*10-12≤ FDR≤ 0.047). Integrating clinical, genetic, and microbiome data showed good discrimination for the development of asthma exacerbations despite receipt of ICS (AUCtraining: 0.82 and AUCvalidation: 0.77). CONCLUSION: The diversity and composition of the upper-airway microbiome are associated with asthma exacerbations despite ICS treatment. The salivary microbiome has a potential application as a biomarker of asthma exacerbations despite receipt of ICS