Reading in Europe - Challenge and Case Studies of READ-IT Project

This paper aims to present the READ-IT project and the first set of case studies collected by DH and HSS researchers. Use-cases are key in the project’s strategy as they are essentials both to the definition and the validation of READ-IT data model and framework. The case studies include different sources, such as social media, students’ diaries and letters, from the 18th up to today, in Czech, French, German, Italian and Dutch. Each of them is supported by a specific dataset and a specific research question. In this context, this original validation process must be able to demonstrate the relevance, robustness and ability of both the general concept and the data model to process a wide variety of sources. Then, this model should be transferable to other DH projects where the experiential dimension is present

Modelling Changes in Diaries, Correspondence and Authors’ Libraries to support research on reading: the READ-IT approach

Diaries, correspondence and authors’ libraries provide important evidence into the evolution of ideas and society. Studying these phenomena is connected to understanding changes of perspective and values. In this paper we present the approach adopted by the READ-IT project in modelling changes in the contents of diaries, correspondence and authors’ libraries related to reading. By considering these three types of sources, we discuss the use of the data model to permit the study and increase the usability of sources containing evidence of reading experiences, highlighting common challenges and patterns related to changes to readers and to the medium of reading when confronting historical events

Reading in Europe—Challenges and lessons learned from the case studies of the READ-IT project

This article reflects on the challenges of combining humanistic and computational research perspectives within the framework of a multicultural and multilingual Digital Humanities project. It analyses the approach of Reading Europe Advanced Data Investigation Tool, a European project funded by JPI-CH, to the framing of its case studies within a wider perspective of interdisciplinary collaboration between humanities, digital humanities, and data science scholars. The analysis of sources ranging chronologically from the 18th century to the present and technologically from manuscript diaries to social media defines a new framework for the history of reading focused on the centrality of the human experience of the reader, and on the evolution of the medium through which reading is conducted. The interdisciplinary collaboration of the project develops a shared laboratory space where practices, languages, and research cultures converge to address both microscope and macroscope questions on the history of reading

The Transnational and the Text-Searchable: Digitized Sources and the Shadows They Cast

This working paper explores the consequences for historians' research practice of the twinned transnational and digital turns. The accelerating digitization of historians' sources (scholarly, periodical, and archival) and the radical shift in the granularity of access to information within them has radically changes historians' research practice. Yet this has incited remarkably little reflection regarding the consequences for individual projects or collective knowledge generation. What are the implications for international research in particular? This essay heralds the new kinds of historical knowledge-generation made possible by web access to digitized, text-searchable sources. It also attempts an accounting of all that we formerly, unwittingly, gained from the frictions inherent to international research in an analog world. What are the intellectual and political consequences of that which has been lost

Switch to maraviroc with darunavir/r, both QD, in patients with suppressed HIV-1 was well tolerated but virologically inferior to standard antiretroviral therapy: 48-Week results of a randomized trial

Objectives Primary study outcome was absence of treatment failure (virological failure, VF, or treatment interruption) per protocol at week 48. Methods Patients on 3-drug ART with stable HIV-1 RNA <50 copies/mL and CCR5-tropic virus were randomized 1:1 to maraviroc with darunavir/ritonavir qd (study arm) or continue current ART (continuation arm).Results In June 2015, 115 patients were evaluable for the primary outcome (56 study, 59 continuation arm). The study was discontinued due to excess of VF in the study arm (7 cases, 12.5%, vs 0 in the continuation arm, p = 0.005). The proportion free of treatment failure was 73.2% in the study and 59.3% in the continuation arm. Two participants in the study and 10 in the continuation arm discontinued therapy due to adverse events (p = 0.030). At VF, no emergent drug resistance was detected. Co-receptor tropism switched to non-R5 in one patient. Patients with VF reported lower adherence and had lower plasma drug levels. Femoral bone mineral density was significantly improved in the study arm. Conclusion Switching to maraviroc with darunavir/ritonavir qd in virologically suppressed patients was associated with improved tolerability but was virologically inferior to 3-drug therap

Cohort profile: The Observational cohort for the study of DOlutegravir in Antiretroviral Combination REgimens (ODOACRE)

The Observational cohort for the study of DOlutegravir in Antiretroviral Combination REgimens (ODOACRE) cohort was established in Italy in 2016 to evaluate the overall efficacy and tolerability of dolutegravir (DTG)-based antiretroviral (ARV) regimens in clinical practice

Switch to maraviroc with darunavir/r, both QD, in patients with suppressed HIV-1 was well tolerated but virologically inferior to standard antiretroviral therapy: 48-Week results of a randomized trial

Objectives: Primary study outcome was absence of treatment failure (virological failure, VF, or treatment interruption) per protocol at week 48. Methods: Patients on 3-drug ART with stable HIV-1 RNA <50 copies/mL and CCR5-tropic virus were randomized 1:1 to maraviroc with darunavir/ritonavir qd (study arm) or continue current ART (continuation arm). Results: In June 2015, 115 patients were evaluable for the primary outcome (56 study, 59 continuation arm). The study was discontinued due to excess of VF in the study arm (7 cases, 12.5%, vs 0 in the continuation arm, p = 0.005). The proportion free of treatment failure was 73.2% in the study and 59.3% in the continuation arm. Two participants in the study and 10 in the continuation arm discontinued therapy due to adverse events (p = 0.030). At VF, no emergent drug resistance was detected. Co-receptor tropism switched to non-R5 in one patient. Patients with VF reported lower adherence and had lower plasma drug levels. Femoral bone mineral density was significantly improved in the study arm. Conclusion: Switching to maraviroc with darunavir/ritonavir qd in virologically suppressed patients was associated with improved tolerability but was virologically inferior to 3-drug therapy

Reading in Europe - Challenge and Case Studies of READ-IT

Abstract of paper 0197 presented at the Digital Humanities Conference 2019 (DH2019), Utrecht , the Netherlands 9-12 July, 2019

Reading in Europe - Challenge and Case Studies of READ-IT

Abstract of paper 0197 presented at the Digital Humanities Conference 2019 (DH2019), Utrecht , the Netherlands 9-12 July, 2019