Effects of peripheral neuropathy on exercise capacity and quality of life in patients with chronic obstructive pulmonary diseases

Introduction: Chronic obstructive pulmonary diseases (COPD) have some systemic effects including systemic inflammation, nutritional abnormalities, skeletal muscle dysfunction, and cardiovascular, skeletal and neurological disorders. Some studies have reported the presence of peripheral neuropathy (PNP) at an incidence of 28-94% in patients with COPD. Our study aimed to identify whether PNP affects exercise performance and quality of life in COPD patients. Material and methods: Thirty mild-very severe patients with COPD (male/female = 29/1, mean age = 64 +/- 10 years) and 14 normal subjects (male/female = 11/5, mean age = 61 +/- 8 years) were included in the present study. All subjects underwent pulmonary function testing (PFT), cardiopulmonary exercise testing, electroneuromyography and short form 36 (SF-36). Results: Peak oxygen uptake (PeakVO(2)) was lower in COPD patients (115 +/- 0.53 l/min) than healthy subjects (2.02 +/- 0.46 l/min) (p = 0.0001). There was no PUP in healthy subjects while 16 (53%) of the COPD patients had PNP. Forced expiratory volume in 1 s (FEV1) and PeakVO(2) were significantly different between patients with PNP and those without (p = 0.009, p = 0.03 respectively). Quality of life of patients with PNP was lower than that of patients without PNP (p < 0.05). Conclusions: The present study demonstrates the exercise limitation in COPD patients with PUP Thus, presence of PNP has a poor effect on exercise capacity and quality of life in patients with COPD. Furthermore, treatment modalities for PNP can be recommended to these patients in order to improve exercise capacity and quality of life.Wo

Koah'lı hastalarda atak nedeni ile hastane yatışlarının maliyet analizi: Başkent Üniversitesi Ankara Hastanesi Örneği

Kronik Obstrüktif Akciğer hastalığı (KOAH) tüm dünyada kişiler ve toplumların ekonomik yükünün önemli bir parçasını oluşturan önemli bir mortalite ve morbidite nedenidir. KOAH önlenebilir ve tedavi edilebilir bir hastalık olmasına rağmen tekrarlayan semptomlar ve akut alevlenmelerle karakterizedir. 2010 yılında Amerika Birleşik Devletlerinde KOAH maliyeti 50 milyar dolar olarak tahmin edilmiştir. Maliyet hastalığın şiddeti ile artmaktadır ve hastane yatışı maliyetin önemli bir kısmını oluşturmaktadır. KOAH’ın Türkiye’deki mortalite ve morbiditesinin ekonomik maliyeti henüz iyi bilinmemektedir. Literatürde Ülkemizde KOAH’lı hastaların hastane yatışının ekonomik yükünü yansıtan birkaç bölgesel çalışma vardır. Bu çalışmada, KOAH akut ataklı hastaların yaklaşık hastane yatış maliyetini ortaya koymayı amaçladık. Ayrıca, hastane yatış maliyetini etkileyen faktörleri de ortaya koymayı hedefledik. Bu amaçla 1 Ocak 2011-31 Aralık 2013 tarihleri arasında Başkent Üniversitesi Hastanesi Göğüs Hastalıkları Kliniği’ne yatırılan KOAH atak’lı hastalar (n:90) retrospektif olarak çalışmaya dahil edildi. Bütün hastaların yaş, cins, hastanede yatış süresi gibi demografik özellikler kaydedildi. Ayrıca hastaların grip aşısı öyküsü, aldıkları antibiyotik tedavileri, mekanik ventilasyon uygulaması ve yoğun bakımda kalışları kaydedildi

Turkish Thoracic Society Experts Consensus Report: Recommendations for Pulmonary Function Tests During and After COVID 19 Pandemic

The recommendation of conducting pulmonary function tests (PFTs) from different societies during and after the coronavirus disease (COVID-19) pandemic was rated by the experts of the Turkish Thoracic Society (TTS) and presented as the TTS experts consensus report. Information about the topic has been provided

Effects of right ventricular dysfunction on exercise capacity and quality of life and associations with serum NT-proBNP levels in COPD: an observational study

Objective: During the course of chronic obstructive pulmonary disease (COPD), pulmonary hypertension (PH) and right ventricular (RV) failure may develop due to elevated afterload of the RV. In those patients, exercise capacity is reduced due to pulmonary and cardiac limitations. We investigated relationships between serum N-terminal of proB-type natriuretic peptide (NT-proBNP) and RV functions with exercise capacity and quality of life in patients COPD. Methods: An observational case-control study was conducted. We enrolled 31 moderate and severe COPD patients, and 20 subjects without chronic diseases as control group. Parameters reflecting the right ventricular diastolic and systolic functions by echocardiography along with serum NT-proBNP levels were assessed. Cardiopulmonary exercise testing and Short Form-36 (SF-36) were applied. Results: Serum NT-proBNP levels were higher in COPD patients than control group (p=0.003). Serum NT-proBNP level was found to be related with pulmonary arterial pressure. Serum NT-proBNP levels were negatively correlated with anaerobic threshold oxygen uptake (AT VO2) and peak oxygen uptake (PVO2) values. Early ventricular filling velocity (Em) was lower in COPD patients. Em wave was significantly correlated with O-2 pulse. There was a positive relationship between tricuspid E/A ratio and VO2 value at AT. SF-36 domains of physical functioning, general health and role limitation due to physical disorder were significantly correlated with AT VO2, PVO2 and O-2 pulse. Conclusion: Exercise limitation may be predicted by assessment of right ventricule functions and NT-proBNP levels and exercise limitation impairs quality of life in COPD patients

Characteristics and outcomes of end-stage renal disease patients with active tuberculosis followed in intensive care units

Tuberculosis (TB) remains a common problem in patients with chronic renal failure. In intensive care units, misdiagnosis or delayed diagnosis of TB is common. Therefore, a description of characteristics of active TB in patients with renal failure followed in intensive care units is important to reduce mortality and transmission of the disease. This study was performed to describe the characteristics of patients with renal failure admitted to the intensive care units and having active TB and evaluate predictive factors for in hospital mortality. The hospital records of 24 patients (11 women, 13 men) having ESRD and TB between 2001-2006 were reviewed. Clinical, radiological, and laboratory data on admission were recorded. Possible parameters contributing to in-hospital mortality were obtained from the medical records. In-hospital mortality rate was 66.6&#x0025;. Factors associated with mortality were decreased partial pressure of oxygen and malnutrition. Fever was reported in 8 patients and hemoptysis was reported in 3 patients. Eight patients had consolidation on chest radiograph, while 4 had normal findings Seventeen patients had pulmonary involvement, and 11 had extra pulmonary involvement. The mortality rate in TB patients followed in intensive care units is high, with 3 factors contributing to in-hospital mortality. Clinicians should consider active TB in renal failure patients being followed in the intensive care unit, even when results of a chest radiograph are normal especially in patients with unexplained poor general health or respiratory failure

Turkish Thoracic Society Consensus Report: Interpretation of Spirometry

Currently, the criteria for applying and evaluating spirometer measurements have been defined by American and European Respiratory Societies. Several pulmonary function test laboratories in Turkey as well as in the world use these standards. However, different interpretation results are observed in different pulmonary function test laboratories. This report is prepared to provide a basis for a standardized asssessment in our pulmonary function test in our country

370 Original Investigation

Effects of right ventricular dysfunction on exercise capacity and quality of life and associations with serum NT-proBNP levels in COPD: an observational stud

Exercise capasity and respiratory muscle strength responces to the cycle ergometer and calisthenic exercise training in chronic obstructive pulmonary diseases

WOS: 00020937040302

Cilazapril-induced pleural effusion: A case report and review of the literature

We describe an unusual case of lymphocytic pleural effusion associated with the use of cilazapril, a novel angiotensin-converting-enzyme inhibitor (ACEI). An 80-year-old male was prescribed cilazapril for hypertension. He subsequently presented with right chest pain and dry cough. He was found to have a lymphocytic pleural effusion on thoracentesis. Extensive workup, including open pleural biopsy, failed to reveal the etiology of the effusion. However, soon after the withdrawal of cilazapril, his clinical symptoms improved and the effusion disappeared. ACEI-induced pleural effusion has only been rarely reported. Drug-induced pleural effusion should be considered when formulating the differential diagnosis in a patient receiving ACEI