ARTICLE ABOUT THE NEGATIVE IMPACT OF ENVIRONMENTAL POLLUTION ON THE ECONOMIC INSTITUTION (PROSPECTS FOR THE YEAR 2035)

Regardless of their nature of operations, Economic institutions, strive for economic growth with the aim of maximizing their profits. However, in the process of conducting their activities, various negative effects on the environment occur, such as pollution and resource depletion. In order to integrate the environmental and social dimensions into the economic institution's strategy, governments have taken a series of measures and actions that align with the institution's activities and the achievement of sustainable development based on three fundamental principles: economic growth, social justice, and environmental protection. The external environmental assessment of the institution contributes to the effectiveness of its management, indicating the extent to which the institution is achieving its objectives by aligning its resources. This assessment allows for the identification of opportunities to exploit and threats or risks that can be faced or mitigated

THE IMPORTANCE OF ACTIVATING THE TECHNICAL BURIAL CENTERS FOR WASTE TO PRESERVE THE ENVIRONMENT AND ELIMINATE THE CRISIS OF RANDOM DUMPS: CONSTANTINE'S CASE

The projects of technical burial centers for waste, conversion units, sorting and passive dumps are of great importance and the only solution in the absence of parallel projects, or in the process of establishing them, such as the waste valuation project for the innovative project in partnership with the United Nations Development Program, which provides goals that are capable of providing and creating jobs In line with the principles of sustainable development, strengthening the circular economy, bringing financial returns and combating climate variables and global warming, by involving citizens and associations in the management and setting a budget of its own to finance it with sufficient space that would solve the Constantine crisis represented by the phenomenon of random hollows and the creation of wealth and work positions in the light of preserving The environment, by activating this project, which can eliminate the problem of waste that littered the state of Constantine in particular, and it helps that a very large amount of organic waste can be evaluated and recycled, and this is a positive thing for the state

THE DIGITAL CLOUD AS A REQUIREMENT FOR ESTABLISHING THE FOUNDATIONS OF THE DIGITAL ECONOMY AMID CONTEMPORARY TECHNOLOGICAL CHALLENGES - REFERENCE TO SERVICE MODELS IN ITS APPLICATIONS

The transition towards a digital economy constitutes a cornerstone in contemporary technological evolution, highlighting the role of the digital cloud as a crucial factor and catalyst for growth and innovation. The digital cloud, with its flexibility, speed, and efficiency in data storage and processing, offers new opportunities for both institutions and individuals to adapt to ongoing technological challenges. It provides effective solutions to these challenges through a flexible and secure infrastructure capable of handling and analyzing vast amounts of data efficiently.This investigation seeks to illuminate the critical role of cloud computing in laying the groundwork for the digital economy, demonstrating how cloud technology enhances operational efficiencies and augments adaptability for businesses within the digital commerce landscape. Cloud computing has emerged as the preeminent technology among information society professionals and workers, embodying a collection of services delivered by providers through the internet. This enables customers to tap into the providers' advanced capabilities and resources without the necessity of investing in costly infrastructure to achieve similar functionalities within their organizations

On the Dark Side of Therapies with Immunoglobulin Concentrates: The Adverse Events

Therapy by human immunoglobulin G (IgG) concentrates is a success story ongoing for decades with an ever increasing demand for this plasma product. The success of IgG concentrates on a clinical level is documented by the slowly increasing number of registered indication and the more rapid increase of the off-label uses, a topic dealt with in another contribution to this special issue of Frontiers in Immunology. A part of the success is the adverse event (AE) profile of IgG concentrates which is, even at life-long need for therapy, excellent. Transmission of pathogens in the last decade could be entirely controlled through the antecedent introduction by authorities of a regulatory network and installing quality standards by the plasma fractionation industry. The cornerstone of the regulatory network is current good manufacturing practice. Non-infectious AEs occur rarely and mainly are mild to moderate. However, in recent times, the increase in frequency of hemolytic and thrombotic AEs raised worrying questions on the possible background for these AEs. Below, we review elements of non-infectious AEs, and particularly focus on hemolysis and thrombosis. We discuss how the introduction of plasma fractionation by ion-exchange chromatography and polishing by immunoaffinity chromatographic steps might alter repertoire of specificities and influence AE profiles and efficacy of IgG concentrates

Nanorhéologie du contact sphère-plan avec couche mince interfaciale

LYON-Ecole Centrale (690812301) / SudocSudocFranceF

Singular elastostatic fields near the notch vertex of a Mooney–Rivlin hyperelastic body

International audienceWithin the framework of fully nonlinear fracture mechanics under plane deformation conditions, boundary value problem equations for the V-notch vertex problem in an incompressible Mooney-Rivlin material are deduced. Using an asymptotic procedure, the deformation, the Lagrange multiplier and stress fields near the notch vertex are computed and their principal properties are illustrated. First, it is shown that the singularity order depend on the V-notch angle. Second, a change of the singular term for a critical angle was revealed and a logarithmic singular term appears. Based on the results obtained, the deformed V-notch vertex lips near the tip was drawn. The V-notch vertex is shown to open, but not necessary in a symmetric manner. Analysis of the Cauchy stress tensor shows that the component σ 22 dominates the stress field. Some discrepancy with the linear theory have emmerged

Apoplexy in pituitary metastasis revealing a lung carcinoma

Abstract Pituitary metastasis (PM) is an uncommon manifestation of systemic malignant tumours. It is the least common site of intracranial metastases. As PM has no clinical or radiological pathognomonic features, their diagnosis is challenging. Herein, we present a rare case of a PM unveiling lung cancer. A 60‐year‐old male with no medical history of malignancy was admitted with a sudden headache, retro‐orbital pain, and a severe loss of both eyes' visual acuity. After proper investigations and endoscopic resection of the sellar mass, the diagnosis was confirmed to be pituitary metastasis of lung carcinoma. PM can be the initial presentation of an otherwise unknown malignancy. Their diagnosis and management are complex and depend on many factors. Endoscopic surgical resection provides histopathological proof, helps with symptomatic relief, and improves the quality of life but has no effect on survival

A comparison between intravenous lidocaine and ketamine on acute and chronic pain after open nephrectomy: A prospective, double-blind, randomized, placebo-controlled study

Background: Recently, there has been increasing interest in the use of analgesic adjuncts such as intravenous (IV) ketamine and lidocaine. Objectives: To compare the effects of perioperative IV lidocaine and ketamine on morphine requirements, pain scores, quality of recovery, and chronic pain after open nephrectomy. Study Design: A prospective, randomized, placebo-controlled, double-blind trial. Settings: The study was conducted in Charles Nicolle University Hospital of Tunis. Methods: Sixty patients were randomly allocated to receive IV lidocaine: bolus of 1.5 mg/kg at the induction of anesthesia followed by infusion of 1 mg/kg/h intraoperatively and for 24 h postoperatively or ketamine: bolus of 0.15 mg/kg followed by infusion of 0.1 mg/kg/h intraoperatively and for 24 h postoperatively or an equal volume of saline (control group [CG]). Measurements: Morphine consumption, visual analog scale pain scores, time to the first passage of flatus and feces, postoperative nausea and vomiting (PONV), 6-min walk distance (6MWD) at discharge, and the incidence of chronic neuropathic pain using the “Neuropathic Pain Questionnaire” at 3 months. Results: Ketamine and lidocaine reduced significantly morphine consumption (by about 33% and 42%, respectively) and pain scores compared with the CG (P < 0.001). Lidocaine and ketamine also significantly improved bowel function in comparison to the CG (P < 0.001). Ketamine failed to reduce the incidence of PONV. The 6 MWD increased significantly from a mean ± standard deviation of 27 ± 16.2 m in the CG to 82.3 ± 28 m in the lidocaine group (P < 0.001). Lidocaine, but not ketamine, reduced significantly the development of neuropathic pain at 3 months (P < 0.05). Conclusion: Ketamine and lidocaine are safe and effective adjuvants to decrease opioid consumption and control early pain. We also suggest that lidocaine infusion serves as an interesting alternative to improve the functional walking capacity and prevent chronic neuropathic pain at 3 months after open nephrectomy

The anti-plane shear elasto-static fields near a crack terminating at an isotropic hyperelastic bi-material interface

International audienc