725 research outputs found
Beat Cepheids as Probes of Stellar and Galactic Metallicity
The mere location of a Beat Cepheid model in a Period Ratio vs. Period
diagram (Petersen diagram) puts very tight constraints on its metallicity Z.
The Beat Cepheid Peterson diagrams are revisited with linear nonadiabatic
turbulent convective models, and their accuracy as a probe for stellar
metallicity is evaluated. They are shown to be largely independent of the
helium content Y, and they are also only weakly dependent on the
mass-luminosity relation that is used in their construction. However, they are
found to show sensitivity to the relative abundances of the elements that are
lumped into the metallicity parameter Z. Rotation is estimated to have but a
small effect on the 'pulsation metallicities'. A composite Petersen diagram is
presented that allows one to read off upper and lower limits on the metallicity
Z from the measured period P0 and period ratio P1/P0.Comment: 9 pages, 12 color figures (black and white version available from 1st
author's website). With minor revisions. to appear in Ap
Correction: Statistical modeling for selecting housekeeper genes
A correction to Statistical modeling for selecting housekeeper genes by Aniko Szabo, Charles M Perou, Mehmet Karaca, Laurent Perreard, John F Quackenbush, and Philip S Bernard. Genome Biology 2004, 5:R5
Circadian patterns of Wikipedia editorial activity: A demographic analysis
Wikipedia (WP) as a collaborative, dynamical system of humans is an
appropriate subject of social studies. Each single action of the members of
this society, i.e. editors, is well recorded and accessible. Using the
cumulative data of 34 Wikipedias in different languages, we try to characterize
and find the universalities and differences in temporal activity patterns of
editors. Based on this data, we estimate the geographical distribution of
editors for each WP in the globe. Furthermore we also clarify the differences
among different groups of WPs, which originate in the variance of cultural and
social features of the communities of editors
Hardness Assurance for Total Dose and Dose Rate Testing of a State-of-the-Art Off-Shore 32 nm SOI CMOS Processor
No abstract availabl
Human Monoclonal Antibody HCV1 Effectively Prevents and Treats HCV Infection in Chimpanzees
Hepatitis C virus (HCV) infection is a leading cause of liver transplantation and there is an urgent need to develop therapies to reduce rates of HCV infection of transplanted livers. Approved therapeutics for HCV are poorly tolerated and are of limited efficacy in this patient population. Human monoclonal antibody HCV1 recognizes a highly-conserved linear epitope of the HCV E2 envelope glycoprotein (amino acids 412-423) and neutralizes a broad range of HCV genotypes. In a chimpanzee model, a single dose of 250 mg/kg HCV1 delivered 30 minutes prior to infusion with genotype 1a H77 HCV provided complete protection from HCV infection, whereas a dose of 50 mg/kg HCV1 did not protect. In addition, an acutely-infected chimpanzee given 250 mg/kg HCV1 42 days following exposure to virus had a rapid reduction in viral load to below the limit of detection before rebounding 14 days later. The emergent virus displayed an E2 mutation (N415K/D) conferring resistance to HCV1 neutralization. Finally, three chronically HCV-infected chimpanzees were treated with a single dose of 40 mg/kg HCV1 and viral load was reduced to below the limit of detection for 21 days in one chimpanzee with rebounding virus displaying a resistance mutation (N417S). The other two chimpanzees had 0.5-1.0 log(10) reductions in viral load without evidence of viral resistance to HCV1. In vitro testing using HCV pseudovirus (HCVpp) demonstrated that the sera from the poorly-responding chimpanzees inhibited the ability of HCV1 to neutralize HCVpp. Measurement of antibody responses in the chronically-infected chimpanzees implicated endogenous antibody to E2 and interference with HCV1 neutralization although other factors may also be responsible. These data suggest that human monoclonal antibody HCV1 may be an effective therapeutic for the prevention of graft infection in HCV-infected patients undergoing liver transplantation
Earth-Affecting Solar Causes Observatory (EASCO): A mission at the Sun-Earth L5
Coronal mass ejections (CMEs) and corotating interaction regions (CIRs) as
well as their source regions are important because of their space weather
consequences. The current understanding of CMEs primarily comes from the Solar
and Heliospheric Observatory (SOHO) and the Solar Terrestrial Relations
Observatory (STEREO) missions, but these missions lacked some key measurements:
STEREO did not have a magnetograph; SOHO did not have in-situ magnetometer.
SOHO and other imagers such as the Solar Mass Ejection Imager (SMEI) located on
the Sun-Earth line are also not well-suited to measure Earth-directed CMEs. The
Earth-Affecting Solar Causes Observatory (EASCO) is a proposed mission to be
located at the Sun-Earth L5 that overcomes these deficiencies. The mission
concept was recently studied at the Mission Design Laboratory (MDL), NASA
Goddard Space Flight Center, to see how the mission can be implemented. The
study found that the scientific payload (seven remote-sensing and three in-situ
instruments) can be readily accommodated and can be launched using an
intermediate size vehicle; a hybrid propulsion system consisting of a Xenon ion
thruster and hydrazine has been found to be adequate to place the payload at
L5. Following a 2-year transfer time, a 4-year operation is considered around
the next solar maximum in 2025.Comment: 12 pages, 6 figures, 2 table
An overview of the higher level classification of Pucciniomycotina based on combined analyses of nuclear large and small subunit rDNA sequences
Mycologia, Vol. 98, nÂş6In this study we provide a phylogenetically
based introduction to the classes and orders of Pucciniomycotina (5Urediniomycetes), one of three subphyla of Basidiomycota. More than 8000 species of Pucciniomycotina have been described including putative saprotrophs and parasites of plants, animals and fungi. The overwhelming majority of these(,90%) belong to a single order of obligate plant
pathogens, the Pucciniales (5Uredinales), or rust fungi. We have assembled a dataset of previously published and newly generated sequence data from two nuclear rDNA genes (large subunit and small subunit) including exemplars from all known major groups in order to test hypotheses about evolutionary
relationships among the Pucciniomycotina. The
utility of combining nuc-lsu sequences spanning the entire D1-D3 region with complete nuc-ssu sequences
for resolution and support of nodes is discussed. Our study confirms Pucciniomycotina as a monophyletic
group of Basidiomycota. In total our results support eight major clades ranked as classes (Agaricostilbomycetes, Atractiellomycetes, Classiculomycetes,Cryptomycocolacomycetes,Cystobasidiomycetes, Microbotryomycetes,Mixiomycetes and Pucciniomycetes) and 18 orders
Agricultural livelihoods in coastal Bangladesh under climate and environmental change - A model framework
We describe a novel integrated modelling system aiming to approximate the impact of environmental change on farmers' livelihoods in Bangladesh.</p
Detection of solar-like oscillations from Kepler photometry of the open cluster NGC 6819
Asteroseismology of stars in clusters has been a long-sought goal because the
assumption of a common age, distance and initial chemical composition allows
strong tests of the theory of stellar evolution. We report results from the
first 34 days of science data from the Kepler Mission for the open cluster NGC
6819 -- one of four clusters in the field of view. We obtain the first clear
detections of solar-like oscillations in the cluster red giants and are able to
measure the large frequency separation and the frequency of maximum oscillation
power. We find that the asteroseismic parameters allow us to test
cluster-membership of the stars, and even with the limited seismic data in
hand, we can already identify four possible non-members despite their having a
better than 80% membership probability from radial velocity measurements. We
are also able to determine the oscillation amplitudes for stars that span about
two orders of magnitude in luminosity and find good agreement with the
prediction that oscillation amplitudes scale as the luminosity to the power of
0.7. These early results demonstrate the unique potential of asteroseismology
of the stellar clusters observed by Kepler.Comment: 5 pages, 4 figures, accepted by ApJ (Lett.
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