BENTHIC MACROFAUNA CONSUMPTION BY WATER BIRDS

The diversity and abundance of birds present in intertidal coastal ecosystems are closely related to the biomass of benthic invertebrates. The assessment of energy consumed compared with the available resource is one of the fundamental aspects of intertidal foodweb studies. The feeding of birds on benthic invertebrates was studied in the bay of Saint-Brieuc, a 2900ha tidal bay located on the Côtes d'Armor coast (Brittany). The consumption of the nine most numerous wader and duck species present on the site was valued at 1,9gAFDW/m²/yr. This is comparable with results observed in the Mont Saint-Michel bay but much lower than results from the Wadden sea. In order to further the understanding of the predator-prey system, the taking into account of local hypsometric singularities is relevant. Thus it is possible to determine an "average available foraging area" which takes into account the foreshore exposure frequency according to tidal conditions, which represents the real usage of the foreshore by birds. In the Bay of Saint-Brieuc foreshore, the available average surface is about 1115ha, i.e. a consumption of 4,9g/m²/yr. The use of this space by birds depends on the type, density and the accessibility of prey, the sediment characteristics, and the presence of events which can cause a disturbance. The distribution of the benthic macrofauna and spatial distribution of four wader species were studied to map the main feeding areas and the benthos they host. This data set will allow the study of potential feeding habitat compared with currently exploited habitat, and to analyse the compatibility of a complex benthic resources/birds/human activities system

Helicon wave-generated plasmas for negative ion beams for fusion

In the next generation of fusion reactors, such as DEMO, neutral beam injectors (NBIs) of high energy (0.8-1 MeV) deuterium atom swith high wall-plug efficiency (>50%) will be required to reach burning plasma conditions and to provide a significant amount of current drive.The present NBI system for DEMO assumes that 50 MW is delivered to the plasma by 3 NBIs. In the Siphore NBI concept, negative deuterium ions are extracted from a long, thin ion source 3 m high and 15 cm wide, accelerated and subsequently photo-neutralized. This requires the development of a new generation of negative ion sources. At the Swiss Plasma Center, a novel radio frequency helicon plasma source, based on a resonant network antenna source delivering up to 10 kW at 13.56 MHz, has been developed and is presently under study on the Resonant Antenna Ion Device (RAID). RAID is a linear device (1.9 m total length, 0.4 m diameter) and is equipped with an extensive set of diagnostics for full plasma characterization. In this work, the principles of operation of resonant antennas as helicon sources areintroduced. Wepresent absolute spectroscopy, Langmuir probe, and interferometry measurements on helicon plasmas. We characterize the performanceof the source in terms of hydrogen/deuterium dissociation and negative ion production as a function of the input power. Furthermore, first results with the helicon birdcage antenna installed on the Cybele negative ion source at CEA-IRFM arepresented, as a first step towards the validation of the Siphoreconcept

HIV Neuroinfection and Alzheimer’s Disease: Similarities and Potential Links?

Environmental factors such as chemicals, stress and pathogens are now widely believed to play important roles in the onset of some brain diseases, as they are associated with neuronal impairment and acute or chronic inflammation. Alzheimer’s disease (AD) is characterized by progressive synaptic dysfunction and neurodegeneration that ultimately lead to dementia. Neuroinflammation also plays a prominent role in AD and possible links to viruses have been proposed. In particular, the human immunodeficiency virus (HIV) can pass the blood-brain barrier and cause neuronal dysfunction leading to cognitive dysfunctions called HIV-associated neurocognitive disorders (HAND). Similarities between HAND and HIV exist as numerous factors involved in AD such as members of the amyloid and Tau pathways, as well as stress-related pathways or blood brain barrier (BBB) regulators, seem to be modulated by HIV brain infection, leading to the accumulation of amyloid plaques or neurofibrillary tangles (NFT) in some patients. Here, we summarize findings regarding how HIV and some of its proteins such as Tat and gp120 modulate signaling and cellular pathways also impaired in AD, suggesting similarities and convergences of these two pathologies

Brief Communication External globus pallidus stimulation modulates brain connectivity in Huntington's disease

Positron emission tomography with O-15-labeled water was used to study at rest the neurophysiological effects of bilateral external globus pallidus (GPe) deep brain stimulation in patients with Huntington's disease (HD). Five patients were compared with a control group in the on and off states of the stimulator. External globus pallidus stimulation decreased neuronal activity and modulated cerebral connectivity within the basal ganglia-thalamocortical circuitry, the sensorimotor, and the default-mode networks. These data indicate that GPe stimulation modulates functional integration in HD patients in accordance with the basal ganglia-thalamocortical circuit model

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

Un nouveau champ de pratiques du travail social : agir dans les espaces de transaction

La notion d’espaces de transaction dans l’intervention sociale incite tous les acteurs engagés dans l’intervention, qu’ils soient « eux » ou « nous », à développer l’entreprise participative, l’innovation dans les politiques publiques, la citoyenneté inclusive. Le modèle du positionnement social permet de situer les nouveaux rapports sociaux émergents entre un pôle formel (agir sur le mode des régulations normatives), un pôle informel (agir sur le mode de l’expérience innovante) et un pôle mixte (agir sur le mode coopératif ou associatif). Le modèle a pour caractéristiques de légitimer les individus porteurs de projets dans leur aptitude à occuper l’espace public, de situer les projets dans le mouvement dialectique entre l’instituant et l’institué et de mettre en rapport les transactions avec les enjeux démocratiques et le respect de l’environnement. On peut définir trois domaines de compétences requises pour mener à bien ce processus de développement local. Ils correspondent aux trois fonctions que devrait assumer l’agent de développement : un rôle de « passeur », un rôle de « tiers médian », un rôle d’« ingénieur démocratique ».The notion of transactional spaces in social intervention encourages all intervening actors, be it “they” or “we”, to develop the participative enterprise, the innovation in public policy, the inclusive citizenship. The social positioning model sets the new emerging social relations between a formal pole (acting in a normative regulation mode), an informal pole (acting in an innovative experience mode), and a combined pole (acting in a cooperative or associative mode). The characteristics of this model are: legitimizing individuals with projects in their ability to occupy the public space (transactional space), placing the projects in a dialectical movement between the instituting and the instituted; and establishing a relation between the transactions, on the one hand and democratic stakes and environmental respect, on the other. Three fields of competence are necessary to conduct this local development process, corresponding to the three functions that a development agent should assume : a “ferryman” role, a “middle third party” role, a “democratic engineer” role

Etude et developpement de la partie optique d'un detecteur permettant la mesure en monocoup de la forme temporelle d'une impulsion de lumiere tres breve (50 ps) issue du collisionneur LEP par effet Synchrotron

SIGLEAvailable from INIST (FR), Document Supply Service, under shelf-number : TD 80738 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc