The Role of trc in the Development of Glia in the Nervous System

Glial cells are vital components in the nervous system and are involved in the processes of axon ensheathment, axon targeting, and organ shape. These processes are crucial to a properly functioning nervous system. In previous research, the protein, Raw, was shown to reduce glial proliferation and migration in the developing eye disc of Drosophila. While Raw has been demonstrated to negatively regulate JNK signaling, its mechanism of action remains unclear. Studies in the context of dendrite adhesion and patterning in sensory neurons, have demonstrated that Raw interacts with Tricornered (Trc), an NDR family kinase. Trc is a component of the Hippo signaling pathway that regulates progression through the cell cycle. Even though Trc is placed in this pathway, its function is not well understood. We hypothesize that Trc functions cooperatively with Raw to regulate glial development. In order to explore the role of Trc in glia, knockdown experiments were performed. Trc knockdown in glia of the eye imaginal disc results in reduced numbers of glia. This reduction in glia could be due to glial cell death, reduced proliferation, or defects in glial migration. Preliminary data reveals low levels of cell death upon trc knockdown, suggesting the reduction in glial number is due to defects in proliferation or migration. Experiments are underway to test these possibilities. Future experiments will focus on the relationship of Raw, Trc, and Hippo signaling in the context of glial development

Scaling Down to Scale Up: Streamlining Production for Mass Digitization Efforts

Departments looking to increase their digitization efforts from start-up project mode to a maturing digital library program may encounter growing pains when it comes to reformatting and metadata production. Librarians from the University of Iowa\u27s Digital Library Services department will facilitate discussion about trade-offs and lessons learned associated with scaling up digital collection work. This preconference also will feature curators\u27 perspectives on the shift to a more comprehensive scanning treatment of archival collections and how this impacts scholars\u27 experience. Included in this presentation are tips for scaling up production through a collection-based approach, from practical tips on batch cataloging in a spreadsheet to a conceptual reorganization of digital collections to incorporate archival principles of hierarchical description

Max Kade Institute Friends Newsletter, Vol. 13, no. 4, Winter 2004

Quarterly Newsletter of the Max Kade Institute for German-American Studies, University of Wisconsin-MadisonContents: "Conference Explores Tales of Immigration" --- "Directors' Corner: MKI Resources Attracting Researchers" --- "Friend's Profile: Family Letters Inspired Ritsche to Write Novel" --- "Speaking of Language: Elias Molee and the Dream of an International Language" --- "Milwaukee's German-American Taverns in the 1940s" --- "Luxembourg-American Cultural Center in Ozaukee County" --- Collection Feature: Sehen Sie Amerika! Photographic Portfolios in German" --- "Book Review: Finding a German-American Family's Treasure in Milwaukee. A Mystery Novel for Children" --- "German-American Symposium in Bielefeld.

Global uncertainty in the diagnosis of neurological complications of SARS-CoV-2 infection by both neurologists and non-neurologists: An international inter-observer variability study

Introduction: Uniform case definitions are required to ensure harmonised reporting of neurological syndromes associated with SARS-CoV-2. Moreover, it is unclear how clinicians perceive the relative importance of SARSCoV-2 in neurological syndromes, which risks under- or over-reporting. Methods: We invited clinicians through global networks, including the World Federation of Neurology, to assess ten anonymised vignettes of SARS-CoV-2 neurological syndromes. Using standardised case definitions, clinicians assigned a diagnosis and ranked association with SARS-CoV-2. We compared diagnostic accuracy and assigned association ranks between different settings and specialties and calculated inter-rater agreement for case definitions as "poor" (kappa <= 0.4), "moderate" or "good" (kappa > 0.6). Results: 1265 diagnoses were assigned by 146 participants from 45 countries on six continents. The highest correct proportion were cerebral venous sinus thrombosis (CVST, 95.8%), Guillain-Barre ' syndrome (GBS, 92.4%) and headache (91.6%) and the lowest encephalitis (72.8%), psychosis (53.8%) and encephalopathy (43.2%). Diagnostic accuracy was similar between neurologists and non-neurologists (median score 8 vs. 7/10, p = 0.1). settings with few neurologists. However, encephalopathy, encephalitis, and psychosis were often misdiagnosed