233 research outputs found
Predicting the behavior of induction machine using motor-CAD and MATLAB packages
© 2018 IEEE. Design optimization of induction machines uses computer aided design. These machines are the most suitable choice for various and complex industrial applications and improved efficiency is a key point. Wound rotor induction machines have enjoyed a renascence as the generator in many commercial wind turbines. In this paper, both Motor-CAD and MATLAB packages are employed to predict the electromagnetic behavior of an induction machine during steady-state and transient-state. Finite element analysis of a three-phase, four-pole induction machine is carried by using Motor-CAD and MATLAB in order to complete the comparison. The graphical interfaces of Motor-CAD environment will be utilized to describe the machine geometry, winding harmonics, material properties, and air-gap flux. The predicted results are validated by the experiment. Power losses are calculated for the test machine, and then the results will be explained
HLA-DRB1 alleles in children with post-streptococcal acute glomerulonephritis
To investigate the association between HLA-DRB1 alleles and post-streptococcal acuteglomerulonephritis (PSAGN), 32 children withPSAGN and 380 healthy subjects from the samelocality were typed for DRB1alleles usingpolymerase chain-reverse hybridization technique.Patients with PSAGN have significantly increasedfrequency of both DRB1* 03011 (46.9 vs. 19.2% incontrols, P = 0.00025) and DRB1* 1105 (31.1 vs.15.6% in controls, P = 0.0097). However, aftercorrection of P values, only the difference for DRB1*03011 remains significant (P = 0.025). Their relativerisks are significantly high [3.71, confidence interval(Cl) = 1.8-7.8, and 3.57, Cl = 1.4-8.9 respectively].No significant differences in the frequency of bothalleles arc observed among patients with differentgrades of hypertension, proteinuria or hematuria.Conclusions: DRB1* 03011, and presumably 1105,alleles confer susceptibility to PSAGN. However theseverity of the disease is not determined by these twoalleles
Simultaneous voltammetric determination of antihypertensive drugs nifedipine and atenolol utilizing MgO nanoplatelet modified screen-printed electrodes in pharmaceuticals and human fluids
© 2017 The Authors. Nifedipine and atenolol dugs are conjugated in several anti-hypertensive pharmaceutical formulations. Herein, a reproducible and sensitive voltammetric procedure has been developed for the simultaneous analysis of nifedipine and atenolol for the first time using MgO − nanoplatelets modified screen-printed electrodes (MgO − SPEs) via differential pulse voltammetry (DPV). Two very well-resolved and reproducible signals/oxidation peaks with a voltammetric separation of 0.35 V were obtained in Britton–Robinson (BR) buffer (pH 9). The MgO NPLs are found to exhibit a high electrocatalytic activity and improved voltammetric response compared to unmodified (bare) SPEs. Under optimum pH conditions (pH 9), the DPV curves exhibit linear responses to nifedipine and atenolol over the concentration ranges of 0.2–104.41 μM and 6.66–909.09 μM with detection limits of 0.032 μM and 1.76 μM, respectively. The applicability of the MgO-SPEs is successfully utilized for simultaneous determination of nifedipine and atenolol in pharmaceutical tablets and human urine samples with good accuracy and precision, these results agreeing with independent high-performance liquid chromatography (HPLC)
Dynamics of Japanese encephalitis virus transmission among pigs in Northwest Bangladesh and the potential impact of pig vaccination.
BACKGROUND: Japanese encephalitis (JE) virus infection can cause severe disease in humans, resulting in death or permanent neurologic deficits among survivors. Studies indicate that the incidence of JE is high in northwestern Bangladesh. Pigs are amplifying hosts for JE virus (JEV) and a potentially important source of virus in the environment. The objectives of this study were to describe the transmission dynamics of JEV among pigs in northwestern Bangladesh and estimate the potential impact of vaccination to reduce incidence among pigs. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a comprehensive census of pigs in three JE endemic districts and tested a sample of them for evidence of previous JEV infection. We built a compartmental model to describe JEV transmission dynamics in this region and to estimate the potential impact of pig vaccination. We identified 11,364 pigs in the study area. Previous JEV infection was identified in 30% of pigs with no spatial differences in the proportion of pigs that were seropositive across the study area. We estimated that JEV infects 20% of susceptible pigs each year and the basic reproductive number among pigs was 1.2. The model suggest that vaccinating 50% of pigs each year resulted in an estimated 82% reduction in annual incidence in pigs. CONCLUSIONS/SIGNIFICANCE: The widespread distribution of historic JEV infection in pigs suggests they may play an important role in virus transmission in this area. Future studies are required to understand the contribution of pig infections to JE risk in humans and the potential impact of pig vaccination on human disease
Analysing the material suitability and concentration ratio of a solar-powered parabolic trough collector (PTC) using Computational Fluid Dynamics
This is the final version. Available on open access from MDPI via the DOI in this recordSolar-powered desalination is a sustainable solution for countries experiencing water scarcity. Several studies have presented different solutions to provide cleaner production in desalination systems. Parabolic trough collector (PTC) is one of these solutions that has proven to be superior among solar concentrators. Furthermore, a number of studies have investigated the use of PTC for distillation of saline water in response to water scarcity. In this study, a modified PTC model was developed, in which the heat exchanger was replaced by a condensation tube to reduce the energy consumption, and a black layer was introduced to the surface of the receiver to enhance its absorptance. As a reference case, the system productivity according to average solar intensities in Zagazig, located at 30°34′N 31°30′E in the North East of Egypt, is estimated. The results indicated that the maximum production rate that can be attained is 1.72 kg/hr. Then, the structure of the system is evaluated with the aid of Computational Fluid Dynamics (CFD) modelling, in order to enhance its productivity. Many materials are examined and the results recognised copper as the most suitable material amongst marine grade metals (i.e., aluminium, galvanised steel and stainless steel) to construct the receiver tube. This is due to its superior thermal performance, satisfactory corrosion resistance, and acceptable cost. Afterwards, the selected receiver tube was employed to identify the optimal Concentration Ratio (CR). Consequently, a CR of 90.56 was determined to be the optimum value for Zagazig and regions with similar solar radiation. As a result, the system’s productivity was enhanced drastically, as it was estimated that a maximum production rate of 6.93 kg/hr can be achieved.Science, Technology, and Innovation Funding. Authority (STIFA) of EgyptBritish Counci
Face Video Competition
The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-642-01793-3_73Person recognition using facial features, e.g., mug-shot images, has long been used in identity documents. However, due to the widespread use of web-cams and mobile devices embedded with a camera, it is now possible to realise facial video recognition, rather than resorting to just still images. In fact, facial video recognition offers many advantages over still image recognition; these include the potential of boosting the system accuracy and deterring spoof attacks. This paper presents the first known benchmarking effort of person identity verification using facial video data. The evaluation involves 18 systems submitted by seven academic institutes.The work of NPoh is supported by the advanced researcher fellowship PA0022121477of the Swiss NSF; NPoh, CHC and JK by the EU-funded Mobio project grant IST-214324; NPC and HF by the EPSRC grants EP/D056942 and EP/D054818; VS andNP by the Slovenian national research program P2-0250(C) Metrology and Biomet-ric System, the COST Action 2101 and FP7-217762 HIDE; and, AAS by the Dutch BRICKS/BSIK project.Poh, N.; Chan, C.; Kittler, J.; Marcel, S.; Mc Cool, C.; Rua, E.; Alba Castro, J.... (2009). Face Video Competition. En Advances in Biometrics: Third International Conference, ICB 2009, Alghero, Italy, June 2-5, 2009. Proceedings. 715-724. https://doi.org/10.1007/978-3-642-01793-3_73S715724Messer, K., Kittler, J., Sadeghi, M., Hamouz, M., Kostyn, A., Marcel, S., Bengio, S., Cardinaux, F., Sanderson, C., Poh, N., Rodriguez, Y., Kryszczuk, K., Czyz, J., Vandendorpe, L., Ng, J., Cheung, H., Tang, B.: Face authentication competition on the BANCA database. In: Zhang, D., Jain, A.K. (eds.) ICBA 2004. LNCS, vol. 3072, pp. 8–15. Springer, Heidelberg (2004)Messer, K., Kittler, J., Sadeghi, M., Hamouz, M., Kostin, A., Cardinaux, F., Marcel, S., Bengio, S., Sanderson, C., Poh, N., Rodriguez, Y., Czyz, J., Vandendorpe, L., McCool, C., Lowther, S., Sridharan, S., Chandran, V., Palacios, R.P., Vidal, E., Bai, L., Shen, L.-L., Wang, Y., Yueh-Hsuan, C., Liu, H.-C., Hung, Y.-P., Heinrichs, A., Muller, M., Tewes, A., vd Malsburg, C., Wurtz, R., Wang, Z., Xue, F., Ma, Y., Yang, Q., Fang, C., Ding, X., Lucey, S., Goss, R., Schneiderman, H.: Face authentication test on the BANCA database. In: Int’l. Conf. Pattern Recognition (ICPR), vol. 4, pp. 523–532 (2004)Phillips, P.J., Flynn, P.J., Scruggs, T., Bowyer, K.W., Chang, J., Hoffman, K., Marques, J., Min, J., Worek, W.: Overview of the Face Recognition Grand Challenge. In: IEEE Computer Society Conference on Computer Vision and Pattern Recognition, pp. 947–954 (2005)Bailly-Baillière, E., Bengio, S., Bimbot, F., Hamouz, M., Kittler, J., Marithoz, J., Matas, J., Messer, K., Popovici, V., Porée, F., Ruiz, B., Thiran, J.-P.: The BANCA Database and Evaluation Protocol. In: Kittler, J., Nixon, M.S. (eds.) AVBPA 2003. LNCS, vol. 2688. Springer, Heidelberg (2003)Turk, M., Pentland, A.: Eigenfaces for Recognition. Journal of Cognitive Neuroscience 3(1), 71–86 (1991)Martin, A., Doddington, G., Kamm, T., Ordowsk, M., Przybocki, M.: The DET Curve in Assessment of Detection Task Performance. In: Proc. Eurospeech 1997, Rhodes, pp. 1895–1898 (1997)Bengio, S., Marithoz, J.: The Expected Performance Curve: a New Assessment Measure for Person Authentication. In: The Speaker and Language Recognition Workshop (Odyssey), Toledo, pp. 279–284 (2004)Poh, N., Bengio, S.: Database, Protocol and Tools for Evaluating Score-Level Fusion Algorithms in Biometric Authentication. Pattern Recognition 39(2), 223–233 (2005)Martin, A., Przybocki, M., Campbell, J.P.: The NIST Speaker Recognition Evaluation Program, ch. 8. Springer, Heidelberg (2005
Post-Harvest Enhancing and Botrytis cinerea Control of Strawberry Fruits Using Low Cost and Eco-Friendly Natural Oils
This is the final version. Available from MDPI via the DOI in this record.This work investigates an experimental study for using low-cost and eco-friendly oils to increase the shelf life of strawberry fruit. Three natural oils were used: (i) Eucalyptus camaldulensis var obtuse, (ii) Mentha piperita green aerial parts essential oils (EOs), and (iii) Moringa oleifera seeds n-hexane fixed oil (FO). Furthermore, a mixture of EOs from E. camaldulensis var obtusa and M. piperita (1/1 v/v) was used. The treated fruits were stored at 5 °C and 90% relative humidity (RH) for 18 days. HPLC was used to analyse the changes in phenolic compounds during the storage periods. The effects of biofumigation through a slow-release diffuser of EOs (E. camaldulensis var obtusa and M. piperita), or by coating with M. oleifera FO, were evaluated in terms of control of post-harvest visual and chemical quality of strawberry fruits. The post-harvest resistance of strawberry fruits to Botrytis cinerea fungal infection was also evaluated. As a result, the EO treatments significantly reduced the change in visual and chemical quality of strawberry fruit. Additionally, changes in the titratable acidity of moringa FO-coated strawberry fruits were delayed. EO treatments improved total soluble solids, total phenols, ascorbic acid, antioxidants and peroxidase. E. camaldulensis var obtusa and M. piperita (1/1 v/v) EO-vapour fruit exhibited a slower rate of deterioration, compared to other treatments in all tested, in two experiments. The lowest colour change (ΔE) was observed inthe fruit treated with E. camaldulensis var obtusa EO and M. oleifera FO. HPLC showed changes in phenolic compounds’ concentration, where p-coumaric acid, caffeic acid, gallic acid, ferulic acid and ellagic acid were mostly identified in the fruits treated with the oils. SEM examination confirmed the potential decrease in fungal growth as the fruits were treated with EOs. In conclusion, the treatment of EOs during different storage periods showed promising characterisations for strawberry fruit quality.Deanship of Scientific Research, King Saud Universit
A randomized, open-label, comparative efficacy trial of artemether-lumefantrine suspension versus artemether-lumefantrine tablets for treatment of uncomplicated Plasmodium falciparum malaria in children in western Kenya
<p>Abstract</p> <p>Background</p> <p>Artemether/lumefantrine (AL) has been adopted as the treatment of choice for uncomplicated malaria in Kenya and other countries in the region. Six-dose artemether/lumefantrine tablets are highly effective and safe for the treatment of infants and children weighing between five and 25 kg with uncomplicated <it>Plasmodium falciparum </it>malaria. However, oral paediatric formulations are urgently needed, as the tablets are difficult to administer to young children, who cannot swallow whole tablets or tolerate the bitter taste of the crushed tablets.</p> <p>Methods</p> <p>A randomized, controlled, open-label trial was conducted comparing day 28 PCR corrected cure-rates in 245 children aged 6–59 months, treated over three days with either six-dose of artemether/lumefantrine tablets (Coartem<sup>®</sup>) or three-dose of artemether/lumefantrine suspension (Co-artesiane<sup>®</sup>) for uncomplicated falciparum malaria in western Kenya. The children were followed-up with clinical, parasitological and haematological evaluations over 28 days.</p> <p>Results</p> <p>Ninety three percent (124/133) and 90% (121/134) children in the AL tablets and AL suspension arms respectively completed followed up. A per protocol analysis revealed a PCR-corrected parasitological cure rate of 96.0% at Day 28 in the AL tablets group and 93.4% in the AL suspension group, p = 0.40. Both drugs effectively cleared gametocytes and were well tolerated, with no difference in the overall incidence of adverse events.</p> <p>Conclusion</p> <p>The once daily three-dose of artemether-lumefantrine suspension (Co-artesiane<sup>®</sup>) was not superior to six-dose artemether-lumefantrine tablets (Coartem<sup>®</sup>) for the treatment of uncomplicated malaria in children below five years of age in western Kenya.</p> <p>Trial registration</p> <p>ClinicalTrials.gov NCT00529867</p
Risk assessment for the spread of Serratia marcescens within dental-unit waterline systems using Vermamoeba vermiformis
Vermamoeba vermiformis is associated with the biofilm ecology of dental-unit waterlines (DUWLs). This study investigated whether V. vermiformis is able to act as a vector for potentially pathogenic bacteria and so aid their dispersal within DUWL systems. Clinical dental water was initially examined for Legionella species by inoculating it onto Legionella selective-medium plates. The molecular identity/profile of the glassy colonies obtained indicated none of these isolates were Legionella species. During this work bacterial colonies were identified as a non-pigmented Serratia marcescens. As the water was from a clinical DUWL which had been treated with Alpronâ„¢ this prompted the question as to whether S. marcescens had developed resistance to the biocide. Exposure to Alpronâ„¢ indicated that this dental biocide was effective, under laboratory conditions, against S. marcescens at up to 1x108 colony forming units/millilitre (cfu/ml). V. vermiformis was cultured for eight weeks on cells of S. marcescens and Escherichia coli. Subsequent electron microscopy showed that V. vermiformis grew equally well on S. marcescens and E. coli (p = 0.0001). Failure to detect the presence of S. marcescens within the encysted amoebae suggests that V. vermiformis is unlikely to act as a vector supporting the growth of this newly isolated, nosocomial bacterium
Pathogen- and Host-Directed Antileishmanial Effects Mediated by Polyhexanide (PHMB)
BACKGROUND:Cutaneous leishmaniasis (CL) is a neglected tropical disease caused by protozoan parasites of the genus Leishmania. CL causes enormous suffering in many countries worldwide. There is no licensed vaccine against CL, and the chemotherapy options show limited efficacy and high toxicity. Localization of the parasites inside host cells is a barrier to most standard chemo- and immune-based interventions. Hence, novel drugs, which are safe, effective and readily accessible to third-world countries and/or drug delivery technologies for effective CL treatments are desperately needed. METHODOLOGY/PRINCIPAL FINDINGS:Here we evaluated the antileishmanial properties and delivery potential of polyhexamethylene biguanide (PHMB; polyhexanide), a widely used antimicrobial and wound antiseptic, in the Leishmania model. PHMB showed an inherent antileishmanial activity at submicromolar concentrations. Our data revealed that PHMB kills Leishmania major (L. major) via a dual mechanism involving disruption of membrane integrity and selective chromosome condensation and damage. PHMB's DNA binding and host cell entry properties were further exploited to improve the delivery and immunomodulatory activities of unmethylated cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODN). PHMB spontaneously bound CpG ODN, forming stable nanopolyplexes that enhanced uptake of CpG ODN, potentiated antimicrobial killing and reduced host cell toxicity of PHMB. CONCLUSIONS:Given its low cost and long history of safe topical use, PHMB holds promise as a drug for CL therapy and delivery vehicle for nucleic acid immunomodulators
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