Del debate filosófico a la propuesta política: un intento de articulación de la obra de A. MacIntyre

En este trabajo se expone los rasgos principales de la obra de Alasdair MacIntyre. Se describe dos campos centrales de interés: la visión epistemológica y metodológica respecto de las tradiciones filosóficas y las posibilidades de sus debates, por un lado, y la posición política comunitarista, por el otro. Finalmente se presenta una interpretación que articula estos dos momentos como corolarios de una única propuesta teórica, sugiriendo especialmente a la figura del filósofo como aquella que más plenamente encarna y articula la propia tradición, al tiempo que la enfrenta con otras.This article presents the main characteristics of the work of Alasdair MacIntyre. The paper describes two central areas of interest: MacIntyre’s epistemological and methodological view about philosophical traditions and the possibilities of its debates, on one hand, and his communitarian political position, on the other. Finally, the author introduces an interpretation that articulates both aspects as corollaries of a single theoretical proposal, suggesting the role of the philosopher as the one who better represents and articulates his own tradition while confronting it with others.Fil: Saiz, Mauro Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Derecho. Departamento de Derecho Público. Cátedra de Teoría de Estado; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentin

Kinematic Analysis of a Flexible Tensegrity Robot

Conference Paper presented at The Joint International Conference of the XII International Conference on Mechanisms and Mechanical Transmissions (MTM) and the XXIII International Conference on Robotics (Robotics ’16)In the field of parallel kinematics few designs use highly deformable elements to obtain the end effector movement. Most compliant mechanisms rely on notches or shape changes to simulate a standard kinematic joint. In this work a kinematic model of a simple parallel continuum mechanism that combines a deformable element and cable is presented. The kinematic model is used to study the workspace of the manipulator and is validated by experimental measurements of a prototype.The authors wish to acknowledge the financial support received from the Spanish Government through the Ministerio de Economía y Competitividad (Project DPI2015-64450-R) and the Regional Government of the Basque Country through the Departamento de Educación, Universidades e Investigación (Project IT445-10) and UPV/EHU under program UFI 11/29

Novel Cardiac Mapping Approaches and Multimodal Techniques to Unravel Multidomain Dynamics of Complex Arrhythmias Towards a Framework for Translational Mechanistic-Based Therapeutic Strategies

[ES] Las arritmias cardíacas son un problema importante para los sistemas de salud en el mundo desarrollado debido a su alta incidencia y prevalencia a medida que la población envejece. La fibrilación auricular (FA) y la fibrilación ventricular (FV) se encuentran entre las arritmias más complejas observadas en la práctica clínica. Las consecuencias clínicas de tales alteraciones arrítmicas incluyen el desarrollo de eventos cardioembólicos complejos en la FA, y repercusiones dramáticas debido a procesos fibrilatorios sostenidos que amenazan la vida infringiendo daño neurológico tras paro cardíaco por FV, y que pueden provocar la muerte súbita cardíaca (MSC). Sin embargo, a pesar de los avances tecnológicos de las últimas décadas, sus mecanismos intrínsecos se comprenden de forma incompleta y, hasta la fecha, las estrategias terapéuticas carecen de una base mecanicista suficiente y poseen bajas tasas de éxito. Entre los mecanismos implicados en la inducción y perpetuación de arritmias cardíacas, como la FA, se cree que las dinámicas de las fuentes focales y reentrantes de alta frecuencia, en sus diferentes modalidades, son las fuentes primarias que mantienen la arritmia. Sin embargo, se sabe poco sobre los atractores, así como, de la dinámica espacio-temporal de tales fuentes fibrilatorias primarias, específicamente, las fuentes focales o rotacionales dominantes que mantienen la arritmia. Por ello, se ha desarrollado una plataforma computacional, para comprender los factores (activos, pasivos y estructurales) determinantes, y moduladores de dicha dinámica. Esto ha permitido establecer un marco para comprender la compleja dinámica de los rotores con énfasis en sus propiedades deterministas para desarrollar herramientas basadas en los mecanismos para ayuda diagnóstica y terapéutica. Comprender los procesos fibrilatorios es clave para desarrollar marcadores y herramientas fisiológica- y clínicamente relevantes para la ayuda de diagnóstico temprano. Específicamente, las propiedades espectrales y de tiempo-frecuencia de los procesos fibrilatorios han demostrado resaltar el comportamiento determinista principal de los mecanismos intrínsecos subyacentes a las arritmias y el impacto de tales eventos arrítmicos. Esto es especialmente relevante para determinar el pronóstico temprano de los supervivientes comatosos después de un paro cardíaco debido a fibrilación ventricular (FV). Las técnicas de mapeo electrofisiológico, el mapeo eléctrico y óptico cardíaco, han demostrado ser recursos muy valiosos para dar forma a nuevas hipótesis y desarrollar nuevos enfoques mecanicistas y estrategias terapéuticas mejoradas. Esta tecnología permite además el trabajo multidisciplinar entre clínicos y bioingenieros, para el desarrollo y validación de dispositivos y metodologías para identificar biomarcadores multi-dominio que permitan rastrear con precisión la dinámica de las arritmias identificando fuentes dominantes y atractores con alta precisión para ser dianas de estrategias terapeúticas innovadoras. Es por ello que uno de los objetivos fundamentales ha sido la implantación y validación de nuevos sistemas de mapeo en distintas configuraciones que sirvan de plataforma de desarrollo de nuevas estrategias terapeúticas. Aunque el mapeo panorámico es el método principal y más completo para rastrear simultáneamente biomarcadores electrofisiológicos, su adopción por la comunidad científica es limitada principalmente debido al coste elevado de la tecnología. Aprovechando los avances tecnológicos recientes, nos hemos enfocado en desarrollar, y validar, sistemas de mapeo óptico de alta resolución para registro panorámico cardíaco, utilizando modelos clínicamente relevantes para la investigación básica y la bioingeniería.[CA] Les arítmies cardíaques són un problema important per als sistemes de salut del món desenvolupat a causa de la seva alta incidència i prevalença a mesura que la població envelleix. La fibril·lació auricular (FA) i la fibril·lació ventricular (FV), es troben entre les arítmies més complexes observades a la pràctica clínica. Les conseqüències clíniques d'aquests trastorns arítmics inclouen el desenvolupament d'esdeveniments cardioembòlics complexos en FA i repercussions dramàtiques a causa de processos fibril·latoris sostinguts que posen en perill la vida amb danys neurològics posteriors a la FV, que condueixen a una aturada cardíaca i a la mort cardíaca sobtada (SCD). Tanmateix, malgrat els avanços tecnològics de les darreres dècades, els seus mecanismes intrínsecs s'entenen de forma incompleta i, fins a la data, les estratègies terapèutiques no tenen una base mecanicista suficient i tenen baixes taxes d'èxit. La majoria dels avenços en el desenvolupament de biomarcadors òptims i noves estratègies terapèutiques en aquest camp provenen de tècniques valuoses en la investigació de mecanismes d'arítmia. Entre els mecanismes implicats en la inducció i perpetuació de les arítmies cardíaques, es creu que les fonts primàries subjacents a l'arítmia són les fonts focals reingressants d'alta freqüència dinàmica i AF, en les seves diferents modalitats. Tot i això, se sap poc sobre els atractors i la dinàmica espaciotemporal d'aquestes fonts primàries fibril·ladores, específicament les fonts rotacionals o focals dominants que mantenen l'arítmia. Per tant, s'ha desenvolupat una plataforma computacional per entendre determinants actius, passius, estructurals i moduladors d'aquestes dinàmiques. Això va permetre establir un marc per entendre la complexa dinàmica multidomini dels rotors amb ènfasi en les seves propietats deterministes per desenvolupar enfocaments mecanicistes per a l'ajuda i la teràpia diagnòstiques. La comprensió dels processos fibril·latoris és clau per desenvolupar puntuacions i eines rellevants fisiològicament i clínicament per ajudar al diagnòstic precoç. Concretament, les propietats espectrals i de temps-freqüència dels processos fibril·latoris han demostrat destacar un comportament determinista important dels mecanismes intrínsecs subjacents a les arítmies i l'impacte d'aquests esdeveniments arítmics. Mitjançant coneixements previs, processament de senyals, tècniques d'aprenentatge automàtic i anàlisi de dades, es va desenvolupar una puntuació de risc mecanicista a la aturada cardíaca per FV. Les tècniques de cartografia òptica cardíaca i electrofisiològica han demostrat ser recursos inestimables per donar forma a noves hipòtesis i desenvolupar nous enfocaments mecanicistes i estratègies terapèutiques. Aquesta tecnologia ha permès durant molts anys provar noves estratègies terapèutiques farmacològiques o ablatives i desenvolupar mètodes multidominis per fer un seguiment precís de la dinàmica d'arrímies que identifica fonts i atractors dominants. Tot i que el mapatge panoràmic és el mètode principal per al seguiment simultani de paràmetres electrofisiològics, la seva adopció per part de la comunitat multidisciplinària d'investigació cardiovascular està limitada principalment pel cost de la tecnologia. Aprofitant els avenços tecnològics recents, ens centrem en el desenvolupament i la validació de sistemes de mapes òptics de baix cost per a imatges panoràmiques mitjançant models clínicament rellevants per a la investigació bàsica i la bioenginyeria.[EN] Cardiac arrhythmias are a major problem for health systems in the developed world due to their high incidence and prevalence as the population ages. Atrial fibrillation (AF) and ventricular fibrillation (VF), are amongst the most complex arrhythmias seen in the clinical practice. Clinical consequences of such arrhythmic disturbances include developing complex cardio-embolic events in AF, and dramatic repercussions due to sustained life-threatening fibrillatory processes with subsequent neurological damage under VF, leading to cardiac arrest and sudden cardiac death (SCD). However, despite the technological advances in the last decades, their intrinsic mechanisms are incompletely understood, and, to date, therapeutic strategies lack of sufficient mechanistic basis and have low success rates. Most of the progress for developing optimal biomarkers and novel therapeutic strategies in this field has come from valuable techniques in the research of arrhythmia mechanisms. Amongst the mechanisms involved in the induction and perpetuation of cardiac arrhythmias such AF, dynamic high-frequency re-entrant and focal sources, in its different modalities, are thought to be the primary sources underlying the arrhythmia. However, little is known about the attractors and spatiotemporal dynamics of such fibrillatory primary sources, specifically dominant rotational or focal sources maintaining the arrhythmia. Therefore, a computational platform for understanding active, passive and structural determinants, and modulators of such dynamics was developed. This allowed stablishing a framework for understanding the complex multidomain dynamics of rotors with enphasis in their deterministic properties to develop mechanistic approaches for diagnostic aid and therapy. Understanding fibrillatory processes is key to develop physiologically and clinically relevant scores and tools for early diagnostic aid. Specifically, spectral and time-frequency properties of fibrillatory processes have shown to highlight major deterministic behaviour of intrinsic mechanisms underlying the arrhythmias and the impact of such arrhythmic events. Using prior knowledge, signal processing, machine learning techniques and data analytics, we aimed at developing a reliable mechanistic risk-score for comatose survivors of cardiac arrest due to VF. Cardiac optical mapping and electrophysiological mapping techniques have shown to be unvaluable resources to shape new hypotheses and develop novel mechanistic approaches and therapeutic strategies. This technology has allowed for many years testing new pharmacological or ablative therapeutic strategies, and developing multidomain methods to accurately track arrhymia dynamics identigying dominant sources and attractors. Even though, panoramic mapping is the primary method for simultaneously tracking electrophysiological parameters, its adoption by the multidisciplinary cardiovascular research community is limited mainly due to the cost of the technology. Taking advantage of recent technological advances, we focus on developing and validating low-cost optical mapping systems for panoramic imaging using clinically relevant models for basic research and bioengineering.Calvo Saiz, CJ. (2022). Novel Cardiac Mapping Approaches and Multimodal Techniques to Unravel Multidomain Dynamics of Complex Arrhythmias Towards a Framework for Translational Mechanistic-Based Therapeutic Strategies [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/182329TESI

Essays on financial markets and corporate outcomes

These conflicting channels of influence raise an interesting empirical question regarding how bondholders, an important group of claimholders in the capital structure, view an active option market. In this paper, we address this open empirical question. Specifically, we study whether the volume of equity options written on the underlying asset increases or reduces firms' cost of debt. We find that a one-standard-deviation increase in options trading volume from its mean is associated with a 10-basis-point increase in the bond at-issue yield spread.Programa Oficial de Doctorado en Empresa y Finanzas / Business and FinancePresidente: Juan Ignacio Peña Sánchez de Rivera; Secretario: Santiago Carbó-Valverde; Vocal: Paolo Coll

Kinematic Analysis of a Continuum Parallel Robot

Conference Paper presented at EUCOMES 2016 held in Nantes, France, from 20 to 23 September 2016Continuum Parallel Robots are mechanical devices with closed loops where kinematic pairs have been eliminated and motion is obtained by large deformations of certain elements. Most compliant mechanisms use notches in thick elements to produce the effect of kinematic pairs. A few are designed so that slender elements can deform and produce the desired motion. Some microelectromechanical systems have used this principle to create bistable planar mechanisms. The purpose of this work is to extend such principle in the field of macro mechanisms for manipulation. The aim is to design the counterparts to some classical parallel manipulators solving the corresponding kinematic problems. In doing this, the authors will have to work out the most efficient way to solve a position problem where geometry and forces are involved. Such compliant mechanisms could be combined in the future with tensegrity systems to enhance the available workspace. In this first report, we will focus on the simplest planar parallel mechanism of two degrees of freedomThe authorswish to acknowledge the financial support received fromthe Spanish Government through theMinisterio de Economía y Competitividad (Project DPI2015-64450-R) and the Regional Government of the Basque Country through the Departamento de Educación, Universidades e Investigación (Project IT445-10) and UPV/EHU under program UFI 11/29. Also, the support of ERASMUS program is gratefully acknowledged by the fourth autho

Virtual slots: increasing power and reusability for user interface development languages

This is the author's version of the work. It is posted here for your personal use. Not for redistribution. The definitive Version of Record was published in CHI '95 Conference Companion on Human Factors in Computing Systems, http://dx.doi.org/10.1145/223355.223548Proceeding of CHI '95 Conference Companion on Human Factors in Computing SystemsAn extension to constraint-based user interface development languages is shown. It permits the abstract representation of constraints which must be applied to objects that are not accessible in the moment of the constraint definition. Using this mechanism, more modularity is achieved, as each part of information is stored where it is needed. Richer libraries of reusable objects can therefore be built in a natural way.Virtual Slots are a part of KIISS, a project funded by the National Research Plan of Spain. under grant No. TIC93-0268

KIISS: a system for visual specification of model-based user interfaces

Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. F. Saiz, J. Contreras, and R. Moriyón, “KIISS: a system for visual specification of model-based user interfaces”, in Computer Human Interaction Conference, 1998. Proceedings. 1998 Australasian, Adelaide, SA, 1998, pp. 306-313The appearance of model-based techniques for interface development has simplified the design of complex interactive applications, but this approach still requires from the designer a high knowledge level about the textual specification required. This paper presents a system, called KIISS (Knowledge-based Interactive Interface Surgery System), which allows the designer of an application to interactively define the model of its interface through visual specifications on an application example. Thus, the system enhances the model by allowing its use by designers who are not quite familiar with the textual specifications required for a user interface development. Moreover, reusability is preserved, since parts of existing applications can be both exchanged and modified interactivelyKIISS is partially supported by the Plan National de Investigation, Programa National de Tecnologia de Information y de las Comunicaciones, Spain, project number TIC93-0268, and a special grant from Comunidad de Madrid (Action Especial KIISS)

Power Control Optimization of an Underwater Piezoelectric Energy Harvester

Over the past few years, it has been established that vibration energy harvesters with intentionally designed components can be used for frequency bandwidth enhancement under excitation for sufficiently high vibration amplitudes. Pipelines are often necessary means of transporting important resources such as water, gas, and oil. A self-powered wireless sensor network could be a sustainable alternative for in-pipe monitoring applications. A new control algorithm has been developed and implemented into an underwater energy harvester. Firstly, a computational study of a piezoelectric energy harvester for underwater applications has been studied for using the kinetic energy of water flow at four different Reynolds numbers Re = 3000, 6000, 9000, and 12,000. The device consists of a piezoelectric beam assembled to an oscillating cylinder inside the water of pipes from 2 to 5 inches in diameter. Therefore, unsteady simulations have been performed to study the dynamic forces under different water speeds. Secondly, a new control law strategy based on the computational results has been developed to extract as much energy as possible from the energy harvester. The results show that the harvester can efficiently extract the power from the kinetic energy of the fluid. The maximum power output is 996.25 mu W and corresponds to the case with Re = 12,000.The funding from the Government of the Basque Country and the University of the Basque Country UPV/EHU through the SAIOTEK (S-PE11UN112) and EHU12/26 research programs, respectively, is gratefully acknowledged. The authors are very grateful to SGIker of UPV/EHU and European funding (ERDF and ESF) for providing technical and human

Contribution to the analisys of diffuse scattering in the indoor radio channel with 5G applications

Grado en Ingeniería de Tecnologías de Telecomunicació