The calculation of effective elastic constants in a composite with 3D orthogonal nonwoven fibers

The paper is devoted to the research of the effective characteristics of 3D orthogonal nonwoven fibers composites. The results were received via ANSYS software package. In this research a volume element of fibers in cubic unit cell is considered. The effective elastic properties of fiber reinforced composite have been defined by the numerical stress analysis of the unit cell

THE EFFICACY OF BIFOCAL RIGHT VENTRICULAR PACING IN CARDIAC RESYNCHRONIZATION THERAPY FOR THE TREATMENT OF HEART FAILURE

Background: It has been reported that bifocal pacing (BiFP) in the right ventricle (RV) may be an alternative to unsuccessful left ventricular (LV) lead implantation.Aim: This study seeks to assess the improvement in the clinical and hemodynamic parameters after long term BiFP in patients eligible for cardiac resynchronization therapy (CRT), in whom conventional biventricular (BiV) implantation was not feasible or failed.Methods: The three leads (right atrial appendage, RV apex and RV outflow tract) of a BiFP were implanted in 46 patients, among whom16 lost follow up within one month of BiFP implantation, so 30 patients (19 male/11 female) were enrolled in the study with the mean follow up period of 8.7 (± 6.7) months. All patients had heart failure refractory to medical therapy, New York Heart Association (NYHA) functional class of II, III and IV, ejection fraction (EF) ≤ 35 %, left bundle branch block (LBBB) with QRS duration ≥ 130 milliseconds and functional mitral regurgitation. The parameters (QRS duration, NYHA class, EF, and cardiomegaly) were evaluated before and 1, 3, 6, 12 and 24 months after BiFP implantation. A six minute walk test (6MWT) was performed on 7 patients, before and after implantation.Results: The results showed significant improvement in whole parameters, after both acute and long term BiFP. The improvement increased during subsequent follow up.Conclusions: The study concluded that BiFP is a feasible type of CRT in patients with refractory HF and can be used as an alternative to biventricular pacing when LV lead implantation is infeasible

slemany.x2017.xlsx

Climate data of Sulaimaniyah cit

Exploiting systems biology to investigate the gene modules and drugs in ovarian cancer: A hypothesis based on the weighted gene co-expression network analysis

Background Ovarian cancer (OC) is one of the worrisome gynecological cancers worldwide. Given its considerable mortality rate, it is necessary to investigate its oncogenesis. Methods In this study, we used systems biology approaches to describe the key gene modules, hub genes, and regulatory drugs associated with serous OC as the novel biomarkers using weighted gene co-expression network analysis (WGCNA). Findings Our findings have demonstrated that the blue module genes (r = 0.8, p-value = 1e-16) are involved in OC progression. Based on gene enrichment analysis, the genes in this module are frequently involved in biological processes such as the Cyclic adenosine monophosphate (cAMP) signaling pathway and the cellular response to transforming growth factor-beta stimulation. The co-expression network has been built using the correlated module's top hub genes, which are ADORA1, ANO9, CD24P4, CLDN3, CLDN7, ELF3, KLHL14, PRSS8, RASAL1, RIPK4, SERINC2, and WNT7A. Finally, a drug-target network has been built to show the interaction of the FDA-approved drugs with hub genes. Conclusions Our results have discovered that ADORA1, ANO9, SERINC2, and KLHL14 are hub genes associated with serous OC. These genes can be considered as novel candidate target genes for treating OC