4,374 research outputs found

    Multimarket contact in pharmaceutical markets

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    We analyze the effect of multimarket contact on the pricing behavior of pharmaceutical firms controlling for different levels of regulatory constraints using the IMS MIDAS database for the industry. Theoretically, under product differentiation, firms may find it profitable to allocate their market power among markets where they are operating, specifically from more collusive to more competitive ones. We present evidence for nine OECD countries suggesting the existence of a multimarket effect for more market friendly countries (U.S. and Canada) and less regulated ones (U.K., Germany, Netherlands), while the results are more unstable for highly regulated countries with some countries being consistent with the theory (France) while others contradicting it (Japan, Italy and Spain). A key result indicates that in the latter countries, price constraints are so intense, that there is little room for allocating market power. Thus equilibrium prices are expected in general to be lower in regulated countries.Pharmaceutical prices, Multimarket Contact, Regulation

    Multimarket Contact in Pharmaceutical Markets

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    The purpose of this paper is to analyze the effect of multimarket contact on the behavior of pharmaceutical firms controlling for different levels of regulatory constraints using IMS MIDAS database. Theoretically, firms that meet in several markets are expected to be capable of sustaining implicitly more profitable out- comes, even if perfect monitoring is not possible. Firms may find it profitable to redistribute their market power among markets where they are operating. We present evidence for nine OECD countries with different degrees of regulation and show that regulation affects the importance of economic forces on firms' price setting behavior. Furthermore, our results confirms the presence of the predictions of the multimarket theory for more market friendly countries (U.S. and Canada) and less regulated ones (U.K., Germany, Netherlands), in contrast, for highly regulated countries (Japan, France, Italy and Spain) the results are less clear with some countries beingPharmaceutical prices, Multimarket Contact, Regulation

    Deterministic constant-temperature dynamics for dissipative quantum systems

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    A novel method is introduced in order to treat the dissipative dynamics of quantum systems interacting with a bath of classical degrees of freedom. The method is based upon an extension of the Nos\`e-Hoover chain (constant temperature) dynamics to quantum-classical systems. Both adiabatic and nonadiabatic numerical calculations on the relaxation dynamics of the spin-boson model show that the quantum-classical Nos\`e-Hoover chain dynamics represents the thermal noise of the bath in an accurate and simple way. Numerical comparisons, both with the constant energy calculation and with the quantum-classical Brownian motion treatment of the bath, show that the quantum-classical Nos\`e-Hoover Chain dynamics can be used to introduce dissipation in the evolution of a quantum subsystem even with just one degree of freedom for the bath. The algorithm can be computationally advantageous in modeling, within computer simulation, the dynamics of a quantum subsystem interacting with complex molecular environments.Comment: Revised versio

    Improvement of the high-accuracy O 17 (p,α) N 14 reaction-rate measurement via the Trojan Horse method for application to O 17 nucleosynthesis

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    The O17(p,α)N14 and O17(p,γ)F18 reactions are of paramount importance for the nucleosynthesis in a number of stellar sites, including red giants (RGs), asymptotic giant branch (AGB) stars, massive stars, and classical novae. In particular, they govern the destruction of O17 and the formation of the short-lived radioisotope F18, which is of special interest for γ-ray astronomy. At temperatures typical of the above-mentioned astrophysical scenario, T=0.01-0.1 GK for RG, AGB, and massive stars and T=0.1-0.4 GK for a classical nova explosion, the O17(p,α)N14 reaction cross section is dominated by two resonances: one at about ERcm=65 keV above the F18 proton threshold energy, corresponding to the EX=5.673 MeV level in F18, and another one at ERcm=183 keV (EX=5.786 MeV). We report on the indirect study of the O17(p,α)N14 reaction via the Trojan Horse method by applying the approach recently developed for extracting the strength of narrow resonance at ultralow energies. The mean value of the strengths obtained in the two measurements was calculated and compared with the direct data available in literature. This value was used as input parameter for reaction-rate determination and its comparison with the result of the direct measurement is also discussed in the light of the electron screening effect

    The Lived Experiences of First-Generation College Students of Color Integrating into the Institutional Culture of a Predominantly White Institution

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    As many colleges and universities continue to increase their enrollment and diversification of their student body, the number of first-generation college students of color will continue to rise. Colleges have been charged with the challenge of not only enrolling this student population but also ensuring that they are connected to the university and persist to graduation. The purpose of this phenomenological qualitative study was to examine the lived experiences of first-generation college students of color at a Predominantly White Institution (PWI). This study utilized individual in-depth interviews and a focus group to examine how first-generation students of color experienced college at a PWI. Four major themes were revealed: a college degree is a means to a better lifestyle; money always matters; a heightened sense of safety concerns exists; and there is a desire for a supportive multicultural campus environment. The findings of this study may aid institutional leaders in understanding the first-generation college student of color experience at a PWI and assist in establishing and maintaining academic and social support programs that are geared towards these students

    On the Geometry and Entropy of Non-Hamiltonian Phase Space

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    We analyze the equilibrium statistical mechanics of canonical, non-canonical and non-Hamiltonian equations of motion by throwing light into the peculiar geometric structure of phase space. Some fundamental issues regarding time translation and phase space measure are clarified. In particular, we emphasize that a phase space measure should be defined by means of the Jacobian of the transformation between different types of coordinates since such a determinant is different from zero in the non-canonical case even if the phase space compressibility is null. Instead, the Jacobian determinant associated with phase space flows is unity whenever non-canonical coordinates lead to a vanishing compressibility, so that its use in order to define a measure may not be always correct. To better illustrate this point, we derive a mathematical condition for defining non-Hamiltonian phase space flows with zero compressibility. The Jacobian determinant associated with time evolution in phase space is altogether useful for analyzing time translation invariance. The proper definition of a phase space measure is particularly important when defining the entropy functional in the canonical, non-canonical, and non-Hamiltonian cases. We show how the use of relative entropies can circumvent some subtle problems that are encountered when dealing with continuous probability distributions and phase space measures. Finally, a maximum (relative) entropy principle is formulated for non-canonical and non-Hamiltonian phase space flows.Comment: revised introductio

    Cardiorespiratory coordination in repeated maximal exercise

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    Increases in cardiorespiratory coordination (CRC) after training with no differences in performance and physiological variables have recently been reported using a principal component analysis approach. However, no research has yet evaluated the short-term effects of exercise on CRC. The aim of this study was to delineate the behavior of CRC under different physiological initial conditions produced by repeated maximal exercises. Fifteen participants performed 2 consecutive graded and maximal cycling tests. Test 1 was performed without any previous exercise, and Test 2 6 min after Test 1. Both tests started at 0 W and the workload was increased by 25 W/min in males and 20 W/min in females, until they were not able to maintain the prescribed cycling frequency of 70 rpm for more than 5 consecutive seconds. A principal component (PC) analysis of selected cardiovascular and cardiorespiratory variables (expired fraction of O2, expired fraction of CO2, ventilation, systolic blood pressure, diastolic blood pressure, and heart rate) was performed to evaluate the CRC defined by the number of PCs in both tests. In order to quantify the degree of coordination, the information entropy was calculated and the eigenvalues of the first PC (PC1) were compared between tests. Although no significant differences were found between the tests with respect to the performed maximal workload (Wmax), maximal oxygen consumption (VO2 max), or ventilatory threshold (VT), an increase in the number of PCs and/or a decrease of eigenvalues of PC1 (t = 2.95; p = 0.01; d = 1.08) was found in Test 2 compared to Test 1. Moreover, entropy was significantly higher (Z = 2.33; p = 0.02; d = 1.43) in the last test. In conclusion, despite the fact that no significant differences were observed in the conventionally explored maximal performance and physiological variables (Wmax, VO2 max, and VT) between tests, a reduction of CRC was observed in Test 2. These results emphasize the interest of CRC evaluation in the assessment and interpretation of cardiorespiratory exercise testing

    Statistical Mechanics of Quantum-Classical Systems with Holonomic Constraints

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    The statistical mechanics of quantum-classical systems with holonomic constraints is formulated rigorously by unifying the classical Dirac bracket and the quantum-classical bracket in matrix form. The resulting Dirac quantum-classical theory, which conserves the holonomic constraints exactly, is then used to formulate time evolution and statistical mechanics. The correct momentum-jump approximation for constrained system arises naturally from this formalism. Finally, in analogy with what was found in the classical case, it is shown that the rigorous linear response function of constrained quantum-classical systems contains non-trivial additional terms which are absent in the response of unconstrained systems.Comment: Submitted to Journal of Chemical Physic
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