Ghosts in pure and hybrid formalisms of gravity theories: a unified analysis

In the first order formalism of gravitational theories, the spacetime connection is considered as an independent variable to vary together with the metric. However, the metric still generates its Levi-Civita connection that turns out to determine the geodesics of matter. Recently, "hybrid" gravity theories have been introduced by constructing actions involving both the independent Palatini connection and the metric Levi-Civita connection. In this study a method is developed to analyse the field content of such theories, in particular to determine whether the propagating degrees of freedom are ghosts or tachyons. New types of second, fourth and sixth order derivative gravity theories are investigated and the so called f(X) theories are singled out as a viable class of "hybrid" extensions of General Relativity.Comment: 9 page

Massive black hole binaries in LISA: multimessenger prospects and electromagnetic counterparts

In the next decade, the Laser Interferometer Space Antenna (LISA) will detect the coalescence of massive black hole binaries (MBHBs) in the range $[10^4, 10^8] \, \rm M_{\odot}$, up to $z\sim10$. Their gravitational wave (GW) signal is expected to be accompanied by an electromagnetic counterpart (EMcp), generated by the gas accreting on the binary or on the remnant BH. In this work, we present the number and characteristics (such as redshift and mass distribution, apparent magnitudes or fluxes) of EMcps detectable jointly by LISA and some representative EM telescopes. We combine state-of-the-art astrophysical models for the galaxies formation and evolution to build the MBHBs catalogues, with Bayesian tools to estimate the binary sky position uncertainty from the GW signal. Exploiting additional information from the astrophysical models, such as the amount of accreted gas and the BH spins, we evaluate the expected EM emission in the soft X-ray, optical and radio bands. Overall, we predict between 7 and 21 EMcps in 4 yrs of joint observations by LISA and the considered EM facilities, depending on the astrophysical model. We also explore the impact of the hydrogen and dust obscuration of the optical and X-ray emissions, as well as of the collimation of the radio emission: these effects reduce the number to EMcps to 2 or 3, depending on the astrophysical model, again in 4 yrs of observations. Most of the EMcps are characterised by faint EM emission, challenging the observational capabilities of future telescopes. Finally, we also find that systems with multi-modal sky position posterior distributions represent only a minority of cases and do not affect significantly the number of EMcps.Comment: 28 pages, 18 figures. Submitted to PR

Insight into the WNT system and its drug related response.

The WNT signalling pathway is a complex system for transferring information for DNA expression from the cell surface receptors to cytoplasm and then to the nucleus. It is based on several proteins that work together as agonists and antagonists in order to maintain homeostasys and to promote anabolic processes. The WNT system acts on all cellular lines involved in bone resorption and formation. WNT pathway can mainly be triggered by two different signalling cascades. The first is well known and is the so-called WNT-beta catenin system (or the canonical pathway), the second is known as the non canonical WNT pathway. WNT proteins form a superfamily of secreted glycoproteins. The association with surface receptors, called Frizzled, that are members of the G protein-coupled receptors superfamily and co receptors like low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) complete the WNT system. LRP5/6 show high affinity for WNT antagonists that modulate the activity of this pathway: DKK1 and sclerostin (SCL), that play a crucial role in modulating the WNT system. The WNT-pathway and in particular its antagonists SCL and DKK1 seems to play a key role in the regulation of bone remodeling during treatment with bone active agents such as bisphosphonates, but not only. Their effects become relevant especially in the course of long-term treatments

Role of Chlamydia Trachomatis infection in young men : what we need to know?

Chlamydia Trachomatis infections are the most common sexually transmitted bacterial infections worldwide: Because Chlamydia Trachomatis infections are asymptomatic in approximately 50% of infected men and 70% of infected women, there is a high risk for reproductive tract sequelae and high diffusion of the disease. Recently some studies improved the comprehension of this infection and its natural history highlighting the fact that severe complications can be avoided only by a proper early diagnosis and appropriate treatment. We reviewed the literature related to the new findings in the treatment of Chlamydia Trachomatis infection in sexually active young men. Articles from 1960-2014 were identified through a Medline search using the keywords "Chlamydia Trachomatis" combined with "urethritis", "epididymitis", "prostatitis" "treatment" or "management". Several studies highlighted that Chlamidia are only metabolically active in the host cell and therefore only targeted intracellularly by antibiotics. However, even if the standard therapy includes intracellularly-accumulated antibiotics such as tetracyclines or macrolides, recent evidences highlight the role of quinolones. In particular recent studies hilight the role of prulifloxacin in the treatment of chronic prostatitis patients for improving patient's quality of life and decreasing the IL-8 level. However, there is a need for future studies and to diffuse the knowledge about Chlamydia Trachomatis especially in urological clinical practice, in order to reduce the risk of diagnosis failure

Constraining the evolution of Newton's constant with slow inspirals observed from spaceborne gravitational-wave detectors

Spaceborne gravitational-wave (GW) detectors observing at milli-Hz and deci-Hz frequencies are expected to detect large numbers of quasi-monochromatic signals. The first and second time-derivative of the GW frequency ($\dot f_0$ and $\ddot f_0$) can be measured for the most favourable sources and used to look for negative post-Newtonian corrections, which can be induced by the source's environment or modifications of general relativity. We present an analytical, Fisher-matrix-based approach to estimate how precisely such corrections can be constrained. We use this method to estimate the bounds attainable on the time evolution of the gravitational constant $G(t)$ with different classes of quasi-monochromatic sources observable with LISA and DECIGO, two representative spaceborne detectors for milli-Hz and deci-Hz GW frequencies. We find that the most constraining source among a simulated population of LISA galactic binaries could yield $\dot G/G_0 \lesssim 10^{-6}\text{yr}^{-1}$, while the best currently known verification binary will reach $\dot G/G_0 \lesssim 10^{-4}\text{yr}^{-1}$. We also perform Monte-Carlo simulations using quasi-monochromatic waveforms to check the validity of our Fisher-matrix approach, as well as inspiralling waveforms to analyse binaries that do not satisfy the quasi-monochromatic assumption. We find that our analytical Fisher matrix produces good order-of-magnitude constraints even for sources well beyond its regime of validity. Monte-Carlo investigations also show that chirping stellar-mass compact binaries detected by DECIGO-like detectors at cosmological distances of tens of Mpc can yield constraints as tight as $\dot G/G_0 \lesssim 10^{-11}\text{yr}^{-1}$.Comment: 10 pages, 3 figure

The Jang equation reduction of the spacetime positive energy theorem in dimensions less than eight

We extend the Jang equation proof of the positive energy theorem due to R. Schoen and S.-T. Yau from dimension $n=3$ to dimensions $3 \leq n <8$. This requires us to address several technical difficulties that are not present when $n=3$. The regularity and decay assumptions for the initial data sets to which our argument applies are weaker than those of R. Schoen and S.-T. Yau. In recent joint work with L.-H. Huang, D. Lee, and R. Schoen we have given a different proof of the full positive mass theorem in dimensions $3 \leq n < 8$. We pointed out that this theorem can alternatively be derived from our density argument and the positive energy theorem of the present paper.Comment: All comments welcome! Final version to appear in Comm. Math. Phy

Observing GW190521-like binary black holes and their environment with LISA

Binaries of relatively massive black holes like GW190521 have been proposed to form in dense gas environments, such as the disks of Active Galactic Nuclei (AGNs), and they might be associated with transient electromagnetic counterparts. The interactions of this putative environment with the binary could leave a significant imprint at the low gravitational wave frequencies observable with the Laser Interferometer Space Antenna (LISA). We show that LISA will be able to detect up to ten GW190521-like black hole binaries, with sky position errors $\lesssim1$ deg$^2$. Moreover, it will measure directly various effects due to the orbital motion around the supermassive black hole at the center of the AGN, especially the Doppler modulation and the Shapiro time delay. Thanks to a careful treatment of their frequency domain signal, we were able to perform the full parameter estimation of Doppler and Shapiro-modulated binaries as seen by LISA. We find that the Doppler and Shapiro effects will allow for measuring the AGN parameters (radius and inclination of the orbit around the AGN, central black hole mass) with up to percent-level precision. Properly modeling these low-frequency environmental effects is crucial to determine the binary formation history, as well as to avoid biases in the reconstruction of the source parameters and in tests of general relativity with gravitational waves. <br

Constraining the evolution of Newton's constant with slow inspirals observed from spaceborne gravitational-wave detectors

Spaceborne gravitational-wave (GW) detectors observing at milli-Hz and deci-Hz frequencies are expected to detect large numbers of quasi-monochromatic signals. The first and second time-derivative of the GW frequency ($\dot f_0$ and $\ddot f_0$) can be measured for the most favourable sources and used to look for negative post-Newtonian corrections, which can be induced by the source's environment or modifications of general relativity. We present an analytical, Fisher-matrix-based approach to estimate how precisely such corrections can be constrained. We use this method to estimate the bounds attainable on the time evolution of the gravitational constant $G(t)$ with different classes of quasi-monochromatic sources observable with LISA and DECIGO, two representative spaceborne detectors for milli-Hz and deci-Hz GW frequencies. We find that the most constraining source among a simulated population of LISA galactic binaries could yield $\dot G/G_0 \lesssim 10^{-6}\text{yr}^{-1}$, while the best currently known verification binary will reach $\dot G/G_0 \lesssim 10^{-4}\text{yr}^{-1}$. We also perform Monte-Carlo simulations using quasi-monochromatic waveforms to check the validity of our Fisher-matrix approach, as well as inspiralling waveforms to analyse binaries that do not satisfy the quasi-monochromatic assumption. We find that our analytical Fisher matrix produces good order-of-magnitude constraints even for sources well beyond its regime of validity. Monte-Carlo investigations also show that chirping stellar-mass compact binaries detected by DECIGO-like detectors at cosmological distances of tens of Mpc can yield constraints as tight as $\dot G/G_0 \lesssim 10^{-11}\text{yr}^{-1}$