Cortical pain responses in human infants

Despite the recent increase in our understanding of the development of pain processing, it is still not known whether premature infants are capable of processing pain at a cortical level. In this study, changes in cerebral oxygenation over the somatosensory cortex were measured in response to noxious stimulation using real-time near-infrared spectroscopy in 18 infants aged between 25 and 45 weeks postmenstrual age. The noxious stimuli were heel lances performed for routine blood sampling; no blood tests were performed solely for the purpose of the study. Noxious stimulation produced a clear cortical response, measured as an increase in total hemoglobin concentration [HbT] in the contralateral somatosensory cortex, from 25 weeks (mean Delta[HbT] = 7.74 mu mol/L; SE, 1.10). Cortical responses were significantly greater in awake compared with sleeping infants, with a mean difference of 6.63 mu mol/L [95% confidence interval (CI) limits: 2.35, 10.91 mu mol/L; mean age, 35.2 weeks]. In awake infants, the response in the contralateral somatosensory cortex increased with age ( regression coefficient, 0.698 mu mol/L/week; 95% CI limits: 0.132, 1.265 mu mol/L/week) and the latency decreased with age (regression coefficient, -0.9861 mu mol/L/week; 95% CI limits: -1.5361, -0.4361 mu mol/L/week; age range, 25-38 weeks). The response was modality specific because no response was detected after non-noxious stimulation of the heel, even when accompanied by reflex withdrawal of the foot. We conclude that noxious information is transmitted to the preterm infant cortex from 25 weeks, highlighting the potential for both higher-level pain processing and pain-induced plasticity in the human brain from a very early age

Orbit selection study for pageos satellite final report

Orbit selection for PAGEOS geodetic satellit

Excavations at the Viking Barrow Cemetery at Heath Wood, Ingleby, Derbyshire

The cemetery at Heath Wood, Ingleby, Derbyshire, is the only known Scandinavian cremation cemetery in the British Isles. It comprises fifty-nine barrows, of which about one-third have been excavated on previous occasions, although earlier excavators concluded that some were empty cenotaph mounds. From 1998 to 2000 three barrows were examined. Our investigations have suggested that each of the barrows contained a burial, although not all contain evidence of a pyre. A full report of the 1998-2000 excavations is provided, alongside a summary of the earlier finds. The relationship of Heath Wood to the neighbouring site at Repton is examined, in order to understand its significance for the Scandinavian settlement of the Danelaw. It is concluded that Heath Wood may have been a war cemetery of the Viking Great Army of AD 873-8

Structural control interaction

The basic guidance and control concepts that lead to structural control interaction and structural dynamic loads are identified. Space vehicle ascent flight load sources and the load relieving mechanism are discussed, along with the the characteristics and special problems of both present and future space vehicles including launch vehicles, orbiting vehicles, and the Space Shuttle flyback vehicle. The special dynamics and control analyses and test problems apparent at this time are summarized

Recent progress on the accurate determination of the equation of state of neutron and nuclear matter

The problem of accurately determining the equation of state of nuclear and neutron matter at density near and beyond saturation is still an open challenge. In this paper we will review the most recent progress made by means of Quantum Monte Carlo calculations, which are at present the only ab-inito method capable to treat a sufficiently large number of particles to give meaningful estimates depending only on the choice of the nucleon-nucleon interaction. In particular, we will discuss the introduction of density-dependent interactions, the study of the temperature dependence of the equation of state, and the possibility of accurately studying the effect of the onset of hyperons by developing an accurate hyperon-nucleon and hyperon-nucleon-nucleon interaction.Comment: 3 figures, 1 table, to appear in the Proceedings of "XIII Convegno di Cortona su Problemi di Fisica Nucleare Teorica", Cortona (Italy), April 6-8, 201

The frequency of planets in multiple systems

The frequency of planets in binaries is an important issue in the field of extrasolar planet studies, because of its relevance in estimating of the global planet population of our Galaxy and the clues it can give to our understanding of planet formation and evolution. However, only preliminary estimates are available in the literature. We analyze and compare the frequency of planets in multiple systems to the frequency of planets orbiting single stars. We also try to highlight possible connections between the frequency of planets and the orbital parameters of the binaries (such as the periastron and mass ratio.) A literature search was performed for binaries and multiple systems among the stars of the sample with uniform planet detectability defined by Fischer & Valenti (2005), and 202 of the 850 stars of the sample turned out to be binaries, allowing a statistical comparison of the frequency of planets in binaries and single stars and a study of the run of the planet frequency as a function of the binary separation. We found that the global frequency of planets in the binaries of the sample is not statistically different from that of planets in single stars. Even conservatively taking the probable incompleteness of binary detection in our sample into account, we estimate that the frequency of planets in binaries can be no more than a factor of three lower than that of planets in single stars. There is no significant dependence of planet frequency on the binary separation, except for a lower value of frequency for close binaries. However, this is probably not as low as required to explain the presence of planets in close binaries only as the result of modifications of the binary orbit after the planet formation

The Gaia-ESO Survey: N-body modelling of the Gamma Velorum cluster

The Gaia-ESO Survey has recently unveiled the complex kinematic signature of the Gamma Velorum cluster: this cluster is composed of two kinematically distinct populations (hereafter, population A and B), showing two different velocity dispersions and a relative ~2 km s^-1 radial velocity (RV) shift. In this paper, we propose that the two populations of the Gamma Velorum cluster originate from two different sub-clusters, born from the same parent molecular cloud. We investigate this possibility by means of direct-summation N-body simulations. Our scenario is able to reproduce not only the RV shift and the different velocity dispersions, but also the different centroid (~0.5 pc), the different spatial concentration and the different line-of-sight distance (~5 pc) of the two populations. The observed 1-2 Myr age difference between the two populations is also naturally explained by our scenario, in which the two sub-clusters formed in two slightly different star formation episodes. Our simulations suggest that population B is strongly supervirial, while population A is close to virial equilibrium. We discuss the implications of our models for the formation of young star clusters and OB associations in the Milky Way.Comment: 12 pages, 7 figures, 2 tables, Astronomy and Astrophysics, in pres

The Gaia-ESO Survey: the selection function of the Milky Way field stars

The Gaia-ESO Survey was designed to target all major Galactic components (i.e., bulge, thin and thick discs, halo and clusters), with the goal of constraining the chemical and dynamical evolution of the Milky Way. This paper presents the methodology and considerations that drive the selection of the targeted, allocated and successfully observed Milky Way field stars. The detailed understanding of the survey construction, specifically the influence of target selection criteria on observed Milky Way field stars is required in order to analyse and interpret the survey data correctly. We present the target selection process for the Milky Way field stars observed with VLT/FLAMES and provide the weights that characterise the survey target selection. The weights can be used to account for the selection effects in the Gaia-ESO Survey data for scientific studies. We provide a couple of simple examples to highlight the necessity of including such information in studies of the stellar populations in the Milky Way.Comment: 18 pages, 19 figures, Accepted for publication in MNRAS (April 25, 2016

The Gaia-ESO Survey: Separating disk chemical substructures with cluster models

(Abridged) Recent spectroscopic surveys have begun to explore the Galactic disk system outside the solar neighborhood on the basis of large data samples. In this way, they provide valuable information for testing spatial and temporal variations of disk structure kinematics and chemical evolution. We used a Gaussian mixture model algorithm, as a rigurous mathematical approach, to separate in the [Mg/Fe] vs. [Fe/H] plane a clean disk star subsample from the Gaia-ESO survey internal data release 2. We find that the sample is separated into five groups associated with major Galactic components; the metal-rich end of the halo, the thick disk, and three subgroups for the thin disk sequence. This is confirmed with a sample of red clump stars from the Apache Point Observatory Galactic Evolution Experiment (APOGEE) survey. The two metal-intermediate and metal-rich groups of the thin disk decomposition ([Fe/H]>-0.25 dex) highlight a change in the slope at solar metallicity. This holds true at different radial regions. The distribution of Galactocentric radial distances of the metal-poor part of the thin disk ([Fe/H]<-0.25 dex) is shifted to larger distances than those of the more metal-rich parts. Moreover, the metal-poor part of the thin disk presents indications of a scale height intermediate between those of the thick and the rest of the thin disk, and it displays higher azimuthal velocities than the latter. These stars might have formed and evolved in parallel and/or dissociated from the inside-out formation taking place in the internal thin disk. Their enhancement levels might be due to their origin from gas pre-enriched by outflows from the thick disk or the inner halo. The smooth trends of their properties (their spatial distribution with respect to the plane, in particular) with [Fe/H] and [Mg/Fe] suggested by the data indicates a quiet dynamical evolution, with no relevant merger events