Carbon nanotube net as a conductive and transparent film for solar energy conversion

Vertically aligned silicon nanowires arrays have been grown through a metal-assisted chemical etching method, giving a heavily absorbing surface. Over this surface, a transparent and conductive net of carbon nanotubes has been formed by chemical vapour deposition. The optical characterisation of the net has been performed by the study of its hemispherical reflectance, and the electrical properties have been obtained by four-point probe method. A high transmittance of the net (over 99%) in the 300-900 nm range is reported. Also, a good sheet resistance value has been obtained (around 3 kΩ/□) for such a thin carbon nanotube netThis work was supported by MINECO research Project ENE2014-57977-C2-1-

Development and application of two novel monoclonal antibodies against overexpressed CD26 and integrin α3 in human pancreatic cancer.

Monoclonal antibody (mAb) technology is an excellent tool for the discovery of overexpressed cell surface tumour antigens and the development of targeting agents. Here, we report the development of two novel mAbs against CFPAC-1 human pancreatic cancer cells. Using ELISA, flow cytometry, immunoprecipitation, mass spectrometry, Western blot and immunohistochemistry, we found that the target antigens recognised by the two novel mAbs KU44.22B and KU44.13A, are integrin α3 and CD26 respectively, with high levels of expression in human pancreatic and other cancer cell lines and human pancreatic cancer tissue microarrays. Treatment with naked anti-CD26 mAb KU44.13A did not have any effect on the growth and migration of cancer cells nor did it induce receptor downregulation. In contrast, treatment with anti-integrin α3 mAb KU44.22B inhibited growth in vitro of Capan-2 cells, increased migration of BxPC-3 and CFPAC-1 cells and induced antibody internalisation. Both novel mAbs are capable of detecting their target antigens by immunohistochemistry but not by Western blot. These antibodies are excellent tools for studying the role of integrin α3 and CD26 in the complex biology of pancreatic cancer, their prognostic and predictive values and the therapeutic potential of their humanised and/or conjugated versions in patients whose tumours overexpress integrin α3 or CD26

Molecular Dynamics Simulation of Polymer-Metal Bonds

Molecular simulation is becoming a very powerful tool for studying dynamic phenomena in materials. The simulation yields information about interaction at length and time scales unattainable by experimental measurements and unpredictable by continuum theories. This is especially meaningful when referring to bonding between a polymer and a metal substrate. A very important characteristic of polymers is that their physical properties do not rely on the detailed chemical structure of the molecular chains but only on their flexibility, and accordingly they will be able to adopt different conformations. In this paper, a molecular simulation of the bonding between vinyl ester polymer and steel is presented. Four different polymers with increasing chain lengths have been studied. Atomic co-ordinates are adjusted in order to reduce the molecular energy. Conformational changes in the macromolecules have been followed to obtain the polymer pair correlation function. Radius of gyration and end-to-end distance distributions of the individual chains have been used as a quantitative measurement of their flexibility. There exists a correlation between flexibility of the molecular chains and the energy of adhesion between the polymer and the metal substrate. Close contacts between the two materials are established at certain points but every atom up to a certain distance from the interface contributes to the total value of the adhesion energy of the system

A Multi-Wavelength Analysis of Dust and Gas in the SR 24S Transition Disk

We present new Atacama Large Millimeter/sub-millimeter Array (ALMA) 1.3 mm continuum observations of the SR 24S transition disk with an angular resolution $\lesssim0.18"$ (12 au radius). We perform a multi-wavelength investigation by combining new data with previous ALMA data at 0.45 mm. The visibilities and images of the continuum emission at the two wavelengths are well characterized by a ring-like emission. Visibility modeling finds that the ring-like emission is narrower at longer wavelengths, in good agreement with models of dust trapping in pressure bumps, although there are complex residuals that suggest potentially asymmetric structures. The 0.45 mm emission has a shallower profile inside the central cavity than the 1.3 mm emission. In addition, we find that the $^{13}$CO and C$^{18}$O (J=2-1) emission peaks at the center of the continuum cavity. We do not detect either continuum or gas emission from the northern companion to this system (SR 24N), which is itself a binary system. The upper limit for the dust disk mass of SR 24N is $\lesssim 0.12\,M_{\bigoplus}$, which gives a disk mass ratio in dust between the two components of $M_{\mathrm{dust, SR\,24S}}/M_{\mathrm{dust, SR\,24N}}\gtrsim840$. The current ALMA observations may imply that either planets have already formed in the SR 24N disk or that dust growth to mm-sizes is inhibited there and that only warm gas, as seen by ro-vibrational CO emission inside the truncation radii of the binary, is present.Comment: Accepted for publication in Ap

Workplace wellbeing programmes and their impact on employees and their employing organisations: a scoping review of the evidence base

This report constitutes a scoping literature review that identifies and critically examines the evidence base surrounding health and wellbeing programmes conducted in the workplace and their impact on employees and their employing organisations. The review drew on a broad range of sources covering multiple sectors. However, the report additionally highlights evidence that relates specifically to the retail and construction industries. The review offers an analysis of the current evidence base and discusses the implications of implementing different types of workplace health and wellbeing schemes. Some recommendations for supporting and promoting the health and wellbeing of employees in organisations are made on the basis of this review and, where gaps in knowledge are identified, recommendations for further research are made

Scattered light images of spiral arms in marginally gravitationally unstable discs with an embedded planet

Scattered light images of transition discs in the near-infrared often show non-axisymmetric structures in the form of wide-open spiral arms in addition to their characteristic low-opacity inner gap region. We study self-gravitating discs and investigate the influence of gravitational instability on the shape and contrast of spiral arms induced by planet-disc interactions. Two-dimensional non-isothermal hydrodynamical simulations including viscous heating and a cooling prescription are combined with three-dimensional dust continuum radiative transfer models for direct comparison to observations. We find that the resulting contrast between the spirals and the surrounding disc in scattered light is by far higher for pressure scale height variations, i.e. thermal perturbations, than for pure surface density variations. Self-gravity effects suppress any vortex modes and tend to reduce the opening angle of planet-induced spirals, making them more tightly wound. If the disc is only marginally gravitationally stable with a Toomre parameter around unity, an embedded massive planet (planet-to-star mass ratio of $10^{-2}$) can trigger gravitational instability in the outer disc. The spirals created by this instability and the density waves launched by the planet can overlap resulting in large-scale, more open spiral arms in the outer disc. The contrast of these spirals is well above the detection limit of current telescopes.Comment: Accepted for publication in MNRAS; 13 pages, 8 figure

Visible spectroscopy of the new ESO Large Program on trans-Neptunian objects and Centaurs: final results

A second large programme (LP) for the physical studies of TNOs and Centaurs, started at ESO Cerro Paranal on October 2006 to obtain high-quality data, has recently been concluded. In this paper we present the spectra of these pristine bodies obtained in the visible range during the last two semesters of the LP. We investigate the spectral behaviour of the TNOs and Centaurs observed, and we analyse the spectral slopes distribution of the full data set coming from this LP and from the literature. We computed the spectral slope for each observed object, and searched for possible weak absorption features. A statistical analysis was performed on a total sample of 73 TNOs and Centaurs to look for possible correlations between dynamical classes, orbital parameters, and spectral gradient. We obtained new spectra for 28 bodies, 15 of which were observed for the first time. All the new presented spectra are featureless, including 2003 AZ84, for which a faint and broad absorption band possibly attributed to hydrated silicates on its surface has been reported. The data confirm a wide variety of spectral behaviours, with neutral--grey to very red gradients. An analysis of the spectral slopes available from this LP and in the literature for a total sample of 73 Centaurs and TNOs shows that there is a lack of very red objects in the classical population. We present the results of the statistical analysis of the spectral slope distribution versus orbital parameters. In particular, we confirm a strong anticorrelation between spectral slope and orbital inclination for the classical population. A strong correlation is also found between the spectral slope and orbital eccentricity for resonant TNOs, with objects having higher spectral slope values with increasing eccentricity.Comment: 11 pages, 9 figure

Testing particle trapping in transition disks with ALMA

We present new Atacama Large Millimeter/submillimeter Array (ALMA) continuum observations at 336GHz of two transition disks, SR21 and HD135344B. In combination with previous ALMA observations from Cycle 0 at 689GHz, we compare the visibility profiles at the two frequencies and calculate the spectral index ($\alpha_{\rm{mm}}$). The observations of SR21 show a clear shift in the visibility nulls, indicating radial variations of the inner edge of the cavity at the two wavelengths. Notable radial variations of the spectral index are also detected for SR21 with values of $\alpha_{\rm{mm}}{\sim}3.8-4.2$ in the inner region ($r<35$ AU) and $\alpha_{\rm{mm}}{\sim}2.6-3.0$ outside. An axisymmetric ring (which we call the ring model) or a ring with the addition of an azimuthal Gaussian profile, for mimicking a vortex structure (which we call the vortex model), is assumed for fitting the disk morphology. For SR21, the ring model better fits the emission at 336GHz, conversely the vortex model better fits the 689GHz emission. For HD135344B, neither a significant shift in the null of the visibilities nor radial variations of $\alpha_{\rm{mm}}$ are detected. Furthermore, for HD135344B, the vortex model fits both frequencies better than the ring model. However, the azimuthal extent of the vortex increases with wavelength, contrary to model predictions for particle trapping by anticyclonic vortices. For both disks, the azimuthal variations of $\alpha_{\rm{mm}}$ remain uncertain to confirm azimuthal trapping. The comparison of the current data with a generic model of dust evolution that includes planet-disk interaction suggests that particles in the outer disk of SR21 have grown to millimetre sizes and have accumulated in a radial pressure bump, whereas with the current resolution there is not clear evidence of radial trapping in HD135344B, although it cannot be excluded either.Comment: Minor changes after language edition. Accepted for publication in A&A (abstract slightly shortened for arXiv