Lactoferrin's anti-cancer properties. Safety, selectivity, and wide range of action

Despite recent advances in cancer therapy, current treatments, including radiotherapy, chemotherapy, and immunotherapy, although beneficial, present attendant side effects and long-term sequelae, usually more or less affecting quality of life of the patients. Indeed, except for most of the immunotherapeutic agents, the complete lack of selectivity between normal and cancer cells for radio- and chemotherapy can make them potential antagonists of the host anti-cancer self-defense over time. Recently, the use of nutraceuticals as natural compounds corroborating anti-cancer standard therapy is emerging as a promising tool for their relative abundance, bioavailability, safety, low-cost effectiveness, and immuno-compatibility with the host. In this review, we outlined the anti-cancer properties of Lactoferrin (Lf), an iron-binding glycoprotein of the innate immune defense. Lf shows high bioavailability after oral administration, high selectivity toward cancer cells, and a wide range of molecular targets controlling tumor proliferation, survival, migration, invasion, and metastasization. Of note, Lf is able to promote or inhibit cell proliferation and migration depending on whether it acts upon normal or cancerous cells, respectively. Importantly, Lf administration is highly tolerated and does not present significant adverse effects. Moreover, Lf can prevent development or inhibit cancer growth by boosting adaptive immune response. Finally, Lf was recently found to be an ideal carrier for chemotherapeutics, even for the treatment of brain tumors due to its ability to cross the blood-brain barrier, thus globally appearing as a promising tool for cancer prevention and treatment, especially in combination therapies

Site specific spin dynamics in BaFe2As2: tuning the ground state by orbital differentiation

The role of orbital differentiation on the emergence of superconductivity in the Fe-based superconductors remains an open question to the scientific community. In this investigation, we employ a suitable microscopic spin probe technique, namely Electron Spin Resonance (ESR), to investigate this issue on selected chemically substituted BaFe$_{2}$As$_{2}$ single crystals. As the spin-density wave (SDW) phase is suppressed, we observe a clear increase of the Fe 3$d$ bands anisotropy along with their localization at the FeAs plane. Such an increase of the planar orbital content interestingly occurs independently on the chemical substitution responsible for suppressing the SDW phase. As a consequence, the magnetic fluctuations combined with the resultant particular symmetry of the Fe 3$d$ bands are propitious ingredients to the emergence of superconductivity in this class of materials.Comment: 6 pages, 5 figure

Praktek Kolaborasi Dokter-perawat Terhadap Kepuasan Kerja Dokter Umum Di RSUD Nganjuk

Background: RSUD Nganjuk is a type B hospital. Patient care in RSUD Nganjuk inpatient unit is done by group of specialists from different disciplines, general practitioners, nurses, and other health personnel. But there are still many obstacles that occur in collaborative practice. Physician-Nurse interactions affect the quality of collaboration practices and physician's job satisfaction. Method: The study is a quantitative study with cross sectional approach. Populations consisted of all physicians in RSUD Nganjuk. The sampling method used in this study is total sampling. There are 18 respondents. Analysis of the data using multiple linear regression statistical test.Result and Discussion: The result of this study showed the value of F calculating (7,75) > t table value (4,221), and probability value was 0,02. That's means that the physician-nurse collaboration significantly influences physician's job satisfaction. Regression equivalent showed: Y = 0,267 X1 + 0,078 X2 + 0,452 X3 + 0,470 X3.Whereas determinant coefficient 0,614. This implied that physician-nurse collaboration simultaneously influence as much as 61,4% to physician's job satisfaction. Physician-nurse collaboration variable practice that influence physician's job satisfaction is mutual interest (p=0,03) The other factor: communication (p=0,17), scope of practice (p=0,77), and common goal (p=0,05) has not yet been influence in physician's job satisfaction. Conclusion: There was a significant influence among the collaboration variable practice consisting of communication (X1), the scope of practice (X2), mutual interests (X3), and a common goal (X4) simultaneously on physician's job satisfaction at the inpatient unit of RSUD Nganjuk. The most influential factor is the common goal

Possible unconventional superconductivity in substituted BaFe2_{2}As2_{2} revealed by magnetic pair-breaking studies

The possible existence of a sign-changing gap symmetry in BaFe$_{2}$As$_{2}$-derived superconductors (SC) has been an exciting topic of research in the last few years. To further investigate this subject we combine Electron Spin Resonance (ESR) and pressure-dependent transport measurements to investigate magnetic pair-breaking effects on BaFe$_{1.9}M_{0.1}$As$_{2}$ ($M=$ Mn, Co, Cu, and Ni) single crystals. An ESR signal, indicative of the presence of localized magnetic moments, is observed only for $M=$ Cu and Mn compounds, which display very low SC transition temperature ($T_{c}$) and no SC, respectively. From the ESR analysis assuming the absence of bottleneck effects, the microscopic parameters are extracted to show that this reduction of $T_{c}$ cannot be accounted by the Abrikosov-Gorkov pair-breaking expression for a sign-preserving gap function. Our results reveal an unconventional spin- and pressure-dependent pair-breaking effect and impose strong constraints on the pairing symmetry of these materials

Pressure and chemical substitution effects in the local atomic structure of BaFe2As2

The effects of K and Co substitutions and quasi-hydrostatic applied pressure (P<9 GPa) in the local atomic structure of BaFe2As2, Ba(Fe{0.937}Co{0.063})2As2 and Ba{0.85}K{0.15}Fe2As2 superconductors were investigated by extended x-ray absorption fine structure (EXAFS) measurements in the As K absorption edge. The As-Fe bond length is found to be slightly reduced (<~ 0.01 Angstroms) by both Co and K substitutions, without any observable increment in the corresponding Debye Waller factor. Also, this bond is shown to be compressible (k = 3.3(3)x10^{-3} GPa^{-1}). The observed contractions of As-Fe bond under pressure and chemical substitutions are likely related with a reduction of the local Fe magnetic moments, and should be an important tuning parameter in the phase diagrams of the Fe-based superconductors.Comment: 7 pages, 6 figure

Scaling of variables and the relation between noncommutative parameters in Noncommutative Quantum Mechanics

We consider Noncommutative Quantum Mechanics with phase space noncommutativity. In particular, we show that a scaling of variables leaves the noncommutative algebra invariant, so that only the self-consistent effective parameters of the model are physically relevant. We also discuss the recently proposed relation of direct proportionality between the noncommutative parameters, showing that it has a limited applicability.Comment: Revtex4, 4 pages; version to match the published on