Cross density of states and mode connectivity: Probing wave localization in complex media

We introduce the mode connectivity as a measure of the number of eigenmodes of a wave equation connecting two points at a given frequency. Based on numerical simulations of scattering of electromagnetic waves in disordered media, we show that the connectivity discriminates between the diffusive and the Anderson localized regimes. For practical measurements, the connectivity is encoded in the second-order coherence function characterizing the intensity emitted by two incoherent classical or quantum dipole sources. The analysis applies to all processes in which spatially localized modes build up, and to all kinds of waves

Correlation crises in insurance and finance, and the need for dynamic risk maps in ORSA

We explain why correlation crises may occur in insurance and finance. These phenomena are not taken into account in Solvency II standard formula. We show the importance of taking them into account in internal models or partial internal models. Given the variety of scenarios that could lead to correlation crises and their different potential impacts, we support the idea that ORSA (Own Risk and Solvency Assessment) reports of insurance companies should include dynamic and causal correlation crises analyzes.

The Casimir effect in the sphere-plane geometry

We present calculations of the Casimir interaction between a sphere and a plane, using a multipolar expansion of the scattering formula. This configuration enables us to study the nontrivial dependence of the Casimir force on the geometry, and its correlations with the effects of imperfect reflection and temperature. The accuracy of the Proximity Force Approximation (PFA) is assessed, and is shown to be affected by imperfect reflexion. Our analytical and numerical results at ambient temperature show a rich variety of interplays between the effects of curvature, temperature, finite conductivity, and dissipation.Comment: Proceedings of the 10th International Conference "Quantum Field Theory Under the Influence of External Conditions" (Benasque, Spain, 2011); 10 pages and 6 figure

Casimir interaction between a dielectric nanosphere and a metallic plane

We study the Casimir interaction between a dielectric nanosphere and a metallic plane, using the multiple scattering theory. Exact results are obtained with the dielectric described by a Sellmeier model and the metal by a Drude model. Asymptotic forms are discussed for small spheres, large or small distances. The well-known Casimir-Polder formula is recovered at the limit of vanishingly small spheres, while an expression better behaved at small distances is found for any finite value of the radius. The exact results are of particular interest for the study of quantum states of nanospheres in the vicinity of surfaces.Comment: 6 pages, 5 figure

Micro-scale finishing of the surface and form of a Ti-6Al-4V lightweight rotor obtained by laser powder bed fusion used for air bearing

The European Organisation for Nuclear Research, CERN, is in the process of designing and testing parts for the next generation of linear accelerators. In order to operate the experiments, the pre-alignment precision of the components of the two opposing accelerating complexes has placed increased demands on part tolerances, which are now approaching the micrometre. In order to meet these demanding requirements, improvements are necessary to the build processes, machining parameters and post-manufacture characterisation stages. One of the most promising methods for the production of these parts is Laser Powder Bed Fusion, and as such, this paper focuses on the manufacture of the lightweight air bearing rotor component and the micro-scale tolerance machining required by this part. The results demonstrate that despite being able to initially machine the part to a form tolerance approaching 2 μm, subsequent notch cutting and the release of residual stresses from the part obtained by Laser Powder Bed Fusion induces an 18 μm part misalignment which is larger than the tolerance limits of 5 μm required for operation. This demonstrates that further minimisation and understanding of the residual stresses induced during machining are required to facilitate the effective manufacture of high precision components of this type

A "core-complex-type structure" formed by superposed ductile and brittle extension followed by folding and high-angle normal faulting. The Santi Petri dome (western Betics, Spain)

The Santi Petri dome (western Betics, southern Spain) shows a core-complex-like structure, where migmatitic gneisses and schists outcrop below low-grade slates and phyllites, all of which form the basement of the Neogene Málaga basin. The migmatites and schists suffered a coaxial-flattening event during isothermal decompression and were later exhumed by ductile ESE non-coaxial stretching. Further exhumation was achieved by W- to SW-transport brittle low-angle normal faulting. Subsequently these extensional structures were gently folded in the core of a NE/SW-oriented antiform during the Tortonian. Finally the Santi Petri domal geometry was accentuated by the interference of orthogonal high-angle faults with ENE–WSW and NNW–SSE orientation. This core-complex-like structure, formed by superposition of extensional and compressive tectonic events, does not represent a classical, purely extensional core complex, which shows that metamorphic structure and geometry are not decisive criteria to define a core-complex

Evaluation of treatment response in adults with relapsing MOG-Ab-associated disease

Background: Myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) are related to several acquired demyelinating syndromes in adults, but the therapeutic approach is currently unclear. We aimed to describe the response to different therapeutic strategies in adult patients with relapsing MOG-Ab-associated disease. Methods: This is a retrospective study conducted in France and Spain including 125 relapsing MOG-Ab patients aged ≥ 18 years. First, we performed a survival analysis to investigate the relapse risk between treated and non-treated patients, performing a propensity score method based on the inverse probability of treatment weighting. Second, we assessed the annualised relapse rates (ARR), Expanded Disability Status Scale (EDSS) and visual acuity pre-treatment and on/end-treatment. Results: Median age at onset was 34.1 years (range 18.0-67.1), the female to male ratio was 1.2:1, and 96% were Caucasian. At 5 years, 84% (95% confidence interval [CI], 77.1-89.8) patients relapsed. At the last follow-up, 66 (52.8%) received maintenance therapy. Patients initiating immunosuppressants (azathioprine, mycophenolate mophetil [MMF], rituximab) were at lower risk of new relapse in comparison to non-treated patients (HR, 0.41; 95CI%, 0.20-0.82; p = 0.011). Mean ARR (standard deviation) was reduced from 1.05(1.20) to 0.43(0.79) with azathioprine (n = 11; p = 0.041), from 1.20(1.11) to 0.23(0.60) with MMF (n = 11; p = 0.033), and from 1.08(0.98) to 0.43(0.89) with rituximab (n = 26; p = 0.012). Other immunosuppressants (methotrexate/mitoxantrone/cyclophosphamide; n = 5), or multiple sclerosis disease-modifying drugs (MS-DMD; n = 9), were not associated with significantly reduced ARR. Higher rates of freedom of EDSS progression were observed with azathioprine, MMF or rituximab. Conclusion: In adults with relapsing MOG-Ab-associated disease, immunosuppressant therapy (azathioprine, MMF and rituximab) is associated with reduced risk of relapse and better disability outcomes. Such an effect was not found in the few patients treated with MS-DMD

An obesogenic feedforward loop involving PPARγ, acyl-CoA binding protein and GABAA receptor

Acyl-coenzyme-A-binding protein (ACBP), also known as a diazepam-binding inhibitor (DBI), is a potent stimulator of appetite and lipogenesis. Bioinformatic analyses combined with systematic screens revealed that peroxisome proliferator-activated receptor gamma (PPARγ) is the transcription factor that best explains the ACBP/DBI upregulation in metabolically active organs including the liver and adipose tissue. The PPARγ agonist rosiglitazone-induced ACBP/DBI upregulation, as well as weight gain, that could be prevented by knockout of Acbp/Dbi in mice. Moreover, liver-specific knockdown of Pparg prevented the high-fat diet (HFD)-induced upregulation of circulating ACBP/DBI levels and reduced body weight gain. Conversely, knockout of Acbp/Dbi prevented the HFD-induced upregulation of PPARγ. Notably, a single amino acid substitution (F77I) in the γ2 subunit of gamma-aminobutyric acid A receptor (GABAAR), which abolishes ACBP/DBI binding to this receptor, prevented the HFD-induced weight gain, as well as the HFD-induced upregulation of ACBP/DBI, GABAAR γ2, and PPARγ. Based on these results, we postulate the existence of an obesogenic feedforward loop relying on ACBP/DBI, GABAAR, and PPARγ. Interruption of this vicious cycle, at any level, indistinguishably mitigates HFD-induced weight gain, hepatosteatosis, and hyperglycemia

Nox2-deficient Tregs improve heart transplant outcomes via their increased graft recruitment and enhanced potency.

Nox2 is a ROS-generating enzyme, deficiency of which increases suppression by Tregs in vitro and in an in vivo model of cardiac remodelling. Since Tregs have emerged as a candidate therapy in autoimmunity and transplantation, we hypothesised that Nox2 deficiency in Tregs in recipient mice may improve outcomes in a heart transplant model. A novel B6129 mouse model with Treg-targeted Nox2 deletion (Nox2fl/flFoxP3Cre+) was generated and transplanted with hearts from CB6F1 donors. As compared to littermate controls, Nox2fl/flFoxP3Cre+ mice had lower plasma levels of alloantibodies and troponin-I, reduced levels of IFN-γ in heart allograft homogenates and diminished cardiomyocyte necrosis and allograft fibrosis. Single cell analyses of allografts revealed higher absolute numbers of Tregs and lower CD8+ T cell infiltration in Nox2-deficient recipients compared to Nox2-replete mice. Mechanistically, in addition to a greater suppression of CD8+CD25- T effector cell proliferation and IFN-γ production, Nox2-deficient Tregs expressed higher levels of CCR4 and CCR8, driving cell migration to allografts; this was associated with increased expression of miR214-3p. These data indicate that Nox2 deletion in Tregs enhances their suppressive ability and migration to heart allografts. Therefore, Nox2 inhibition in Tregs may be a useful approach to improve their therapeutic efficacy