435 research outputs found
Second reading of screening mammograms: results in the french national breast cancer screening programme (2004-2006)
ENSEMBLES: a new multi-model ensemble for seasonal-to-annual predictions: Skill and progress beyond DEMETER in forecasting tropical Pacific SSTs
A new 46-year hindcast dataset for seasonal-to-annual ensemble predictions has been created using a multi-model ensemble of 5 state-of-the-art coupled atmosphere-ocean circulation models. The multi-model outperforms any of the single-models in forecasting tropical Pacific SSTs because of reduced RMS errors and enhanced ensemble dispersion at all lead-times. Systematic errors are considerably reduced over the previous generation (DEMETER). Probabilistic skill scores show higher skill for the new multi-model ensemble than for DEMETER in the 4â6 month forecast range. However, substantially improved models would be required to achieve strongly statistical significant skill increases. The combination of ENSEMBLES and DEMETER into a grand multi-model ensemble does not improve the forecast skill further. Annual-range hindcasts show anomaly correlation skill of âŒ0.5 up to 14 months ahead. A wide range of output from the multi-model simulations is becoming publicly available and the international community is invited to explore the full scientific potential of these data
Genome sequences of Burkholderia sp. Strains CCGE1002 and H160, isolated from legume nodules in Mexico and Brazil.
The genome sequences of Burkholderia sp. strains CCGE1002 from Mexico and H160 from Brazil, isolated from legume nodules, are reported. Their gene contents in relation to plant-microbe interactions and xenobiotic degradation are discussed
Formation of a molecular Bose-Einstein condensate and an entangled atomic gas by Feshbach resonance
Processes of association in an atomic Bose-Einstein condensate, and
dissociation of the resulting molecular condensate, due to Feshbach resonance
in a time-dependent magnetic field, are analyzed incorporating non-mean-field
quantum corrections and inelastic collisions. Calculations for the Na atomic
condensate demonstrate that there exist optimal conditions under which about
80% of the atomic population can be converted to a relatively long-lived
molecular condensate (with lifetimes of 10 ms and more). Entangled atoms in
two-mode squeezed states (with noise reduction of about 30 dB) may also be
formed by molecular dissociation. A gas of atoms in squeezed or entangled
states can have applications in quantum computing, communications, and
measurements.Comment: LaTeX, 5 pages with 4 figures, uses REVTeX
An Improved Neutron Electric Dipole Moment Experiment
A new measurement of the neutron EDM, using Ramsey's method of separated
oscillatory fields, is in preparation at the new high intensity source of
ultra-cold neutrons (UCN) at the Paul Scherrer Institute, Villigen, Switzerland
(PSI). The existence of a non-zero nEDM would violate both parity and time
reversal symmetry and, given the CPT theorem, might lead to a discovery of new
CP violating mechanisms. Already the current upper limit for the nEDM
(|d_n|<2.9E-26 e.cm) constrains some extensions of the Standard Model.
The new experiment aims at a two orders of magnitude reduction of the
experimental uncertainty, to be achieved mainly by (1) the higher UCN flux
provided by the new PSI source, (2) better magnetic field control with improved
magnetometry and (3) a double chamber configuration with opposite electric
field directions.
The first stage of the experiment will use an upgrade of the RAL/Sussex/ILL
group's apparatus (which has produced the current best result) moved from
Institut Laue-Langevin to PSI. The final accuracy will be achieved in a further
step with a new spectrometer, presently in the design phase.Comment: Flavor Physics & CP Violation Conference, Taipei, 200
Measurement of the permanent electric dipole moment of the neutron
We present the result of an experiment to measure the electric dipole moment EDM) of the neutron at the Paul Scherrer Institute using Ramsey's method of separated oscillating magnetic fields with ultracold neutrons (UCN). Our measurement stands in the long history of EDM experiments probing physics violating time reversal invariance. The salient features of this experiment
were the use of a Hg-199 co-magnetometer and an array of optically pumped cesium vapor magnetometers to cancel and correct for magnetic field changes. The statistical analysis was performed on blinded datasets by two separate groups while the estimation of systematic effects profited from an
unprecedented knowledge of the magnetic field. The measured value of the neutron EDM is d_{\rm n} = (0.0\pm1.1_{\rm stat}\pm0.2_{\rmsys})\times10^{-26}e\,{\rm cm}
Finite Temperature Models of Bose-Einstein Condensation
The theoretical description of trapped weakly-interacting Bose-Einstein
condensates is characterized by a large number of seemingly very different
approaches which have been developed over the course of time by researchers
with very distinct backgrounds. Newcomers to this field, experimentalists and
young researchers all face a considerable challenge in navigating through the
`maze' of abundant theoretical models, and simple correspondences between
existing approaches are not always very transparent. This Tutorial provides a
generic introduction to such theories, in an attempt to single out common
features and deficiencies of certain `classes of approaches' identified by
their physical content, rather than their particular mathematical
implementation.
This Tutorial is structured in a manner accessible to a non-specialist with a
good working knowledge of quantum mechanics. Although some familiarity with
concepts of quantum field theory would be an advantage, key notions such as the
occupation number representation of second quantization are nonetheless briefly
reviewed. Following a general introduction, the complexity of models is
gradually built up, starting from the basic zero-temperature formalism of the
Gross-Pitaevskii equation. This structure enables readers to probe different
levels of theoretical developments (mean-field, number-conserving and
stochastic) according to their particular needs. In addition to its `training
element', we hope that this Tutorial will prove useful to active researchers in
this field, both in terms of the correspondences made between different
theoretical models, and as a source of reference for existing and developing
finite-temperature theoretical models.Comment: Detailed Review Article on finite temperature theoretical techniques
for studying weakly-interacting atomic Bose-Einstein condensates written at
an elementary level suitable for non-experts in this area (e.g. starting PhD
students). Now includes table of content
Evolutionary Toggling of Vpx/Vpr Specificity Results in Divergent Recognition of the Restriction Factor SAMHD1
SAMHD1 is a host restriction factor that blocks the ability of lentiviruses such as HIV-1 to undergo reverse transcription in myeloid cells and resting T-cells. This restriction is alleviated by expression of the lentiviral accessory proteins Vpx and Vpr (Vpx/Vpr), which target SAMHD1 for proteasome-mediated degradation. However, the precise determinants within SAMHD1 for recognition by Vpx/Vpr remain unclear. Here we show that evolution of Vpx/Vpr in primate lentiviruses has caused the interface between SAMHD1 and Vpx/Vpr to alter during primate lentiviral evolution. Using multiple HIV-2 and SIV Vpx proteins, we show that Vpx from the HIV-2 and SIVmac lineage, but not Vpx from the SIVmnd2 and SIVrcm lineage, require the C-terminus of SAMHD1 for interaction, ubiquitylation, and degradation. On the other hand, the N-terminus of SAMHD1 governs interactions with Vpx from SIVmnd2 and SIVrcm, but has little effect on Vpx from HIV-2 and SIVmac. Furthermore, we show here that this difference in SAMHD1 recognition is evolutionarily dynamic, with the importance of the N- and C-terminus for interaction of SAMHD1 with Vpx and Vpr toggling during lentiviral evolution. We present a model to explain how the head-to-tail conformation of SAMHD1 proteins favors toggling of the interaction sites by Vpx/Vpr during this virus-host arms race. Such drastic functional divergence within a lentiviral protein highlights a novel plasticity in the evolutionary dynamics of viral antagonists for restriction factors during lentiviral adaptation to its hosts. © 2013 Fregoso et al
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