146 research outputs found
Screening of Iberian Coinage in the 2(th)-1(th) BCE Period Using the Voltammetry of Immobilized Particles
This is the peer reviewed version of the following article: A. Doménech-Carbó, M. T. Doménech-Carbó, C. Álvarez-Romero, T. Pasíes, M. Buendía, Electroanalysis 2019, 31, 1164, which has been published in final form at https://doi.org/10.1002/elan.201900090. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.[EN] The voltammetry of immobilized particles (VIMP) was applied for grouping a series of 86 Iberian coins nominally minted in the cities of Iltirta, Castulo and Obulco in the 2(th)-1(th) BCE period for which there are no chronological data. Using characteristic signatures for the reduction of cuprite, tenorite and lead corrosion products in the patina of the coins, voltammetric grouping of coins was proposed. Voltammetric data were found to be consistent with textural and compositional properties of the surface and subsurface of selected coins using FIB-FESEM-EDX. The obtained data confirmed a clear separation between the productions of Iltirta on one side, and those of Castulo and Obulco on the other side, indicating the possibility to establish a rough chronology for these productions.Project CTQ2017-85317-C2-1-P, supported with Ministerio de Economia, Industria y Competitividad (MINECO), Fondo Europeo de Desarrollo Regional (ERDF) and Agencia Estatal de Investigacion (AEI), is gratefully acknowledged. The authors wish also to thank Mr. Manuel Planes and Dr. Jose Luis Moya, technical supervisors of the Electron Microscopy Service of the Universitat Politecnica de Valencia. Thanks to Manuel Gozalbes for his technical assistance in the numismatic domain and Gonzalo Cores and the Museu de Prehistrica de Valencia for facilitating the access to its collections.Doménech-Carbó, A.; Domenech Carbo, MT.; Álvarez-Romero, C.; Pasíes, T.; Buendía, M. (2019). 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(2011). ‘One-Touch’ Voltammetry of Microparticles for the Identification of Corrosion Products in Archaeological Lead. Electroanalysis, 23(6), 1391-1400. doi:10.1002/elan.201000739Doménech, A., Lastras, M., Rodríguez, F., & Osete, L. (2013). Mapping of corrosion products of highly altered archeological iron using voltammetry of microparticles. Microchemical Journal, 106, 41-50. doi:10.1016/j.microc.2012.05.002Doménech, A., Doménech-Carbó, M. T., & Martínez-Lázaro, I. (2010). Layer-by-layer identification of copper alteration products in metallic works of art using the voltammetry of microparticles. Analytica Chimica Acta, 680(1-2), 1-9. doi:10.1016/j.aca.2010.09.002DOMÉNECH-CARBÓ, A., DOMÉNECH-CARBÓ, M. T., PEIRÓ-RONDA, M. A., & OSETE-CORTINA, L. (2011). ELECTROCHEMISTRY AND AUTHENTICATION OF ARCHAEOLOGICAL LEAD USING VOLTAMMETRY OF MICROPARTICLES: APPLICATION TO THE TOSSAL DE SANT MIQUEL IBERIAN PLATE. 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Spontaneous synchronization to speech reveals neural mechanisms facilitating language learning
We introduce a deceptively simple behavioral task that robustly identifies two qualitatively different groups within the general population. When presented with an isochronous train of random syllables, some listeners are compelled to align their own concurrent syllable production with the perceived rate, whereas others remain impervious to the external rhythm. Using both neurophysiological and structural imaging approaches, we show group differences with clear consequences for speech processing and language learning. When listening passively to speech, high synchronizers show increased brain-to-stimulus synchronization over frontal areas, and this localized pattern correlates with precise microstructural differences in the white matter pathways connecting frontal to auditory regions. Finally, the data expose a mechanism that underpins performance on an ecologically relevant word-learning task. We suggest that this task will help to better understand and characterize individual performance in speech processing and language learning
Speech-to-Speech synchronization protocol to classify human participants as high or low auditory-motor synchronizers
The ability to synchronize a motor action to a rhythmic auditory stimulus is often considered an innate human skill. However, some individuals lack the ability to synchronize speech to a perceived syllabic rate. Here, we describe a simple and fast protocol to classify a single native English speaker as being or not being a speech synchronizer. This protocol consists of four parts: the pretest instructions and volume adjustment, the training procedure, the execution of the main task, and data analysis
Oxygen doping-induced photogeneration loss in P3HT:PCBM solar cells
This work investigates the loss in performance induced by molecular oxygen in bulk heterojunction solar cells. We observe that upon exposure to molecular oxygen both formation of P3HT+:O2− complex and metal oxidation at the interface between the active layer and metallic contact occur. These two different effects were separately investigated using NOBF4 as an oxidant. Our procedure has allowed studying p-doping of the active layer independently from contact degradation. A loss in photocurrent is associated with formation of P3HT+:O2− complex, which reduces the concentration of neutral P3HT present in the film in accordance with absorption and external quantum efficiency spectra. This complex is regarded as a source of a pathway of reversible degradation. Capacitance–voltage measurements allow for an accurate extraction of p-doping levels of the active layer produced by the presence of charged O2− species. In addition, one of the irreversible degradation pathways is identified to be oxidation of the metallic contact to form CaO. This oxide forms a thin dipole layer producing a voltage drop across the active layer/Ca interface, which has a direct impact on the open circuit voltage and fill factor
How the Charge-Neutrality Level of Interface States Controls Energy Level Alignment in Cathode Contacts of Organic Bulk-Heterojunction Solar Cells
Electronic equilibration at the metal–organic interface, leading to equalization of the Fermi levels, is a key process in organic optoelectronic devices. How the energy levels are set across the interface determines carrier extraction at the contact and also limits the achievable open-circuit voltage under illumination. Here, we report an extensive investigation of the cathode energy equilibration of organic bulk-heterojunction solar cells. We show that the potential to balance the mismatch between the cathode metal and the organic layer Fermi levels is divided into two contributions: spatially extended band bending in the organic bulk and voltage drop at the interface dipole layer caused by a net charge transfer. We scan the operation of the cathode under a varied set of conditions, using metals of different work functions in the range of 2 eV, different fullerene acceptors, and several cathode interlayers. The measurements allow us to locate the charge-neutrality level within the interface density of sates and calculate the corresponding dipole layer strength. The dipole layer withstands a large part of the total Fermi level mismatch when the polymer:fullerene blend ratio approaches 1:1, producing the practical alignment between the metal Fermi level and the charge-neutrality level. Origin of the interface states is linked with fullerene reduced molecules covering the metal contact. The dipole contribution, and consequently the band bending, is highly sensitive to the nature and amount of fullerene molecules forming the interface density of states. Our analysis provides a detailed picture of the evolution of the potentials in the bulk and the interface of the solar cell when forward voltage is applied or when photogeneration takes place
Scavenging Behaviour of Red Deer Cervus elaphus Linnaeus, 1758 (Artiodactyla: Cervidae) in Eastern Spain
A male red deer was repeatedly observed scavenging in eastern Spain. This is the first time this behaviour of the red deer being recorded by means of camera traps. Scavenging behaviour of herbivores may have implications for wildlife biologists and managers
Neural architectures of music – Insights from acquired amusia
The ability to perceive and produce music is a quintessential element of
human life, present in all known cultures. Modern functional
neuroimaging has revealed that music listening activates a large-scale
bilateral network of cortical and subcortical regions in the healthy
brain. Even the most accurate structural studies do not reveal which
brain areas are critical and causally linked to music processing. Such
questions may be answered by analysing the effects of focal brain
lesions in patients´ ability to perceive music. In this sense, acquired
amusia after stroke provides a unique opportunity to investigate the
neural architectures crucial for normal music processing. Based on the
first large-scale longitudinal studies on stroke-induced amusia using
modern multi-modal magnetic resonance imaging (MRI) techniques, such as
advanced lesion-symptom mapping, grey and white matter morphometry,
tractography and functional connectivity, we discuss neural structures
critical for music processing, consider music processing in light of the
dual-stream model in the right hemisphere, and propose a neural model
for acquired amusia.</p
Guía de práctica clínica para la elección del fluido de restauración volémica perioperatoria en los pacientes adultos intervenidos de cirugía no cardiaca
Esta Guía de Práctica Clínica responde a preguntas clínicas sobre seguridad en la elección de fluido (cristaloide, coloide o Hidroxietilalmidón 130) en pacientes que precisan restauración volémica en el periodo perioperatorio de cirugía no cardiaca. A partir del resumen de la evidencia, se elaboraron las recomendaciones siguiendo la metodología GRADE. En esta población se sugiere la fluidoterapia basada en la administración de cristaloides, (recomendación débil, calidad de la evidencia baja). En las situaciones en las que la restauración volémica no se alcance sólo con cristaloides, se sugiere utilizar coloides sintéticos (Hidroxietilalmidón 130 o gelatina fluida modificada) en lugar de Albúmina 5% (recomendación débil, calidad de la evidencia baja). La elección y dosificación de coloide deberán basarse en las características del producto, comorbilidad del paciente y experiencia del anestesiólogo
Political candidates in infotainment programmes and their emotional effects on Twitter: An analysis of the 2015 Spanish general elections pre-campaign season
This is an Accepted Manuscript of an article published by Taylor & Francis in Contemporary Social Science on 2019, available online: http://www.tandfonline.com/10.1080/21582041.2017.1367833.[EN] The infotainment format offers candidates an informal setting to show a more personal side of themselves to the electorate, opening themselves up to potential voters. An example of media hybridisation, social networks users can immediately comment on infotainment television programmes, a process known as second screening. These second screeners tend to be especially active in politics. This paper analyses the immediate emotional reaction of these users as they watch infotainment programmes that air during the campaign or pre-campaign seasons and feature political candidates as guests. We have confirmed that second screeners react more emotionally towards the candidate when his or her party is mentioned, and less emotionally when the host displays an aggressive attitude through his or her non-verbal communication. When issues related to the candidate¿s personal lives are discussed, users¿ emotional reactions improve slightly. The relevance of this research stems from the fact that we are witnessing the consolidation of a politics that increasingly strays from ideological questions, and instead focuses on more emotional and personal issues.This work was supported by the Ministerio de Economia y Competitividad under Grants CSO2013-43960-R and CSO2016-77331-C2-1-R.Baviera, T.; Peris, À.; Cano-Orón, L. (2019). Political candidates in infotainment programmes and their emotional effects on Twitter: An analysis of the 2015 Spanish general elections pre-campaign season. 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S., Van Thomme, J., Bialik, K., … Pevehouse, J. C. W. (2016). Dual Screening During Presidential Debates. American Behavioral Scientist, 60(14), 1816-1843. doi:10.1177/0002764216676245Sullivan, D. G., & Masters, R. D. (1988). «Happy Warriors»: Leaders’ Facial Displays, Viewers’ Emotions, and Political Support. American Journal of Political Science, 32(2), 345. doi:10.2307/2111127Thelwall, M., Buckley, K., Paltoglou, G., Cai, D., & Kappas, A. (2010). Sentiment strength detection in short informal text. Journal of the American Society for Information Science and Technology, 61(12), 2544-2558. doi:10.1002/asi.21416Vergeer, M., & Franses, P. H. (2015). Live audience responses to live televised election debates: time series analysis of issue salience and party salience on audience behavior. Information, Communication & Society, 19(10), 1390-1410. doi:10.1080/1369118x.2015.1093526Vilares, D., Thelwall, M., & Alonso, M. A. (2015). The megaphone of the people? Spanish SentiStrength for real-time analysis of political tweets. Journal of Information Science, 41(6), 799-813. doi:10.1177/0165551515598926Wohn, D. Y., & Na, E.-K. (2011). Tweeting about TV: Sharing television viewing experiences via social media message streams. First Monday. doi:10.5210/fm.v16i3.336
Dynamic soluble changes in sVEGFR1, HGF, and VEGF promote chemotherapy and bevacizumab resistance: A prospective translational study in the BECOX (GEMCAD 09-01) trial
Despite initial responsiveness, acquired resistance to both bevacizumab and chemotherapy in metastatic colorectal cancer is universal. We have recently published that in vitro, chronically oxaliplatin resistance upregulates soluble vascular endothelial growth factor receptor 1, downregulates vascular endothelial growth factor, and also promotes c-MET, b-ca catenin/transcription factor 4, and AKT activation. We tested whether variation in three serum biomarkers such as the natural c-MET ligand (hepatocyte growth factor), soluble vascular endothelial growth factor receptor 1, and vascular endothelial growth factor-A was associated with efficacy in metastatic colorectal cancer patients treated in the prospective BECOX study. Serum levels of vascular endothelial growth factor-A165, soluble vascular endothelial growth factor receptor 1, and hepatocyte growth factor were assessed by enzyme-linked immunosorbent assay method basally and every 3 cycles (at the time of computed tomography evaluation) in a preplanned translational study in the first-line BECOX trial in metastatic colorectal cancer patients treated with CAPOX plus bevacizumab. Response was evaluated by routine contrast-enhanced computed tomography by RECIST 1.1 by investigator assessment and by three blinded independent radiologists. Ratios between soluble vascular endothelial growth factor receptor 1/vascular endothelial growth factor-A and hepatocyte growth factor/vascular endothelial growth factor-A were established and variations through time were related to RECIST 1.1 by investigator assessment and independent radiologist. The
BECOX trial included 68 patients, and 27 patients were analyzed in the translational trial. A total of 80 RECIST 1.1 evaluations were done by investigator assessment and 56 by independent radiologist. We found that a 3.22-fold increase in soluble vascular endothelial growth factor receptor 1/vascular endothelial growth factor-A by investigator assessment
and a 3.06-fold increase in soluble vascular endothelial growth factor receptor 1/vascular endothelial growth factor-A by independent radiologist from previous determination were associated with responses compared with 1.38-fold increase by investigator assessment and 1.59 by independent radiologist in non-responders (p= 0.0009 and p = 0.03, respectively). Responders had a 3.36-fold increase in hepatocyte growth factor/vascular endothelial growth factor-A from previous determination by investigator assessment and 3.66-fold increase in hepatocyte growth factor/vascular endothelial growth factor-A by independent radiologist compared with 1.43-fold increase by investigator assessment and 1.53 by independent radiologist for non-responders (p = 0.002 and 0.003, respectively). In conclusion, a decrease
in vascular endothelial growth factor-A and an increase in soluble vascular endothelial growth factor receptor 1 during chemotherapy and bevacizumab exposure can contribute to both chemotherapy (due to c- MET/b-catenin activation) and bevacizumab (due to low vascular endothelial growth factor requirements) resistance. Because hepatocyte growth factor levels decrease also during acquired resistance, alternative strategies to hepatocyte growth factor–ligand inhibition should be investigatedThis work was supported by “beca SEOM a Jóvenes Investigadores 2009” and by the Emili Letang fellowship to Estela Pineda
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