A Case-Control Study of Cognitive Function in Patients with End-Stage Renal Disease Before and After Hemodialysis in Southern Spain

BACKGROUND: This single-center study aimed to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on modulation of thyroid hormone levels and cognition in the recovery stage of patients with cognitive dysfunction following stroke. MATERIAL AND METHODS: Seventy post-stroke patients who had cognitive impairment were randomly assigned to either the rTMS group or the control (sham) group. Both groups were administered basic treatment, with the rTMS group receiving rTMS (1 Hz, 90% MT, 1000 pulse/20 min, once a day for 5 days, for a total of 20 times), the stimulation site was the contralateral dorsolateral prefrontal cortex (DLPFC), and the sham group receiving sham stimulation which had the same stimulation parameters and site, except that the coil plane was placed perpendicular to the surface of the scalp. Cognitive function assessment and thyroid function tests were performed before and after 4 weeks of treatment. RESULTS: Serum levels of triiodothyronine (T3), free triiodothyronine (FT3), and thyroid stimulating hormone (TSH) showed a positive correlation with Montreal Cognitive Assessment (MoCA) scale score of stroke patients in the recovery phase. The post-treatment change in the scores of MoCA and Modified Barthel Index (MBI) and scores of 3 cognitive domains (visuospatial function, memory, and attention), as well as serum T3, FT3, and TSH levels, were improved more significantly in the rTMS group, and T3 and FT3 levels significantly affected the MoCA scores within the reference range. CONCLUSIONS: Serum T3, FT3, and TSH levels of stroke patients in the recovery phase were positively correlated with MoCA score. rTMS increased T3, FT3, and TSH levels and also improved MoCA and MBI of patients in the recovery phase of stroke

Characterization of Intact Proviruses in Blood and Lymph Node from HIV-Infected Individuals Undergoing Analytical Treatment Interruption.

The role of lymphoid tissue as a potential source of HIV-1 rebound following interruption of antiretroviral therapy (ART) is uncertain. To address this issue, we compared the latent viruses obtained from CD4+ T cells in peripheral blood and lymph nodes to viruses emerging during treatment interruption. Latent viruses were characterized by sequencing near-full-length (NFL) proviral DNA and env from viral outgrowth assays (VOAs). Five HIV-1-infected individuals on ART were studied, four of whom participated in a clinical trial of a TLR9 agonist that included an analytical treatment interruption. We found that 98% of intact or replication-competent clonal sequences overlapped between blood and lymph node. In contrast, there was no overlap between 205 latent reservoir and 125 rebound sequences in the four individuals who underwent treatment interruption. However, rebound viruses could be accounted for by recombination. The data suggest that CD4+ T cells carrying latent viruses circulate between blood and lymphoid tissues in individuals on ART and support the idea that recombination may play a role in the emergence of rebound viremia.IMPORTANCE HIV-1 persists as a latent infection in CD4+ T cells that can be found in lymphoid tissues in infected individuals during ART. However, the importance of this tissue reservoir and its contribution to viral rebound upon ART interruption are not clear. In this study, we sought to compare latent HIV-1 from blood and lymph node CD4+ T cells from five HIV-1-infected individuals. Further, we analyzed the contribution of lymph node viruses to viral rebound. We observed that the frequencies of intact proviruses were the same in blood and lymph node. Moreover, expanded clones of T cells bearing identical proviruses were found in blood and lymph node. These latent reservoir sequences did not appear to be the direct origin of rebound virus. Instead, latent proviruses were found to contribute to the rebound compartment by recombination

Evaluation of Convergent, Discriminant, and Criterion Validity of the Cuestionario Burnout Granada-University Students

Burnout is a health problem that affects professionals and students or professionals in training, especially those in health areas. For this reason, it is necessary that it is properly identified to prevent the impact it can have on the work and personal areas of the people who suffer from it. The aim of this work is to study the convergent, discriminant, and criterion validity of the Cuestionario Burnout Granada-University Students. The sample consisted of 463 undergraduate nursing students, selected by non-probabilistic convenience sampling, who participated voluntarily and anonymously in the study. The mean age of the participants was 21.9 (5.12) years, mostly female (74.1%), single (95.8%), and childless (95.6%). Information was collected face-to-face, and the instruments were completed on paper. Comparisons were made in the three dimensions of burnout of the CBG-USS between students with and without burnout, finding statistically significant differences in all three dimensions: Emotional Exhaustion (p < 0.001, d = 0.674), Cynicism (p < 0.001, d = 0.479), and Academic Efficacy (p < 0.001, d = −0.607). The Cuestionario Burnout Granada-University Students presents adequate reliability and validity indices, which demonstrates its usefulness in the identification of burnout. This syndrome has traditionally been measured in professionals, but students also present burnout, so it is necessary to have specific burnout instruments for students, since the pre-work situation and stressors of students are different from those of workers. In order to work on the prevention of university burnout, it is essential to have specific instruments for professionals in training that help in the detection of students with burnout

Complete Genome Sequences of Mycobacterium smegmatis Phages Chewbacca, Reptar3000, and Riparian, Isolated in Las Vegas, Nevada

Here, we present the complete genome sequences of Mycobacterium smegmatis phages Chewbacca, Reptar3000, and Riparian, isolated from soil in Las Vegas, NV. The phages were isolated and annotated by undergraduate students enrolled in the Phage Discovery course offered by the School of Life Sciences at the University of Nevada, Las Vega

Personality Factors as Predictors in Burnout Level Changes for Surgical Area Nurses

Surgical area nurses provide comprehensive care to patients throughout the surgical process. Increases in life expectancy lead to the appearance and development of diseases, translating into an increase in the number of necessary interventions. Increases in the workload can be another risk factor for the development of burnout in professionals in this area. Knowledge of psychological and personality-related variables provides relevant information of level changes in the dimensions of burnout syndrome. Three logistic regression models, based on a cross-sectional study with 214 nurses working in the surgical area in the Andalusian Health Service, Spain, were built for each dimension. These models included different variables related to depression and personality, with some being significant at the population level and consequently true risk or protection factors. Friendliness, responsibility and extraversion are protection factors for the personal accomplishment dimension, whilst neuroticism is a risk factor for this dimension. Friendliness is also a protection factor for depersonalization, whilst depression is a risk factor. Finally, neuroticism, responsibility and depression are risk factors for the emotional exhaustion dimension of burnout. These findings provide relevant information that makes anticipation of this syndrome in this group easier

Observation of γ-delayed 3α breakup of the 15.11 and 12.71 MeV states in 12C

6 pags., 4 figs., 2 tabs. -- PACS:27.20.+n25.55.Hp23.20.-g29.85.-cThe reactions 10B (3He, p α α α) at 4.9 MeV and 11B (3He, d α α α) at 8.5 MeV have been used to investigate the γ decay of states in 12C. By measuring the four-body final state in complete kinematics we are able to detect γ transitions indirectly. We find γ transitions from the 15.11 MeV state in 12C to the 12.71, 11.83, 10.3 and 7.65 MeV states followed by their breakup into three α particles. The relative γ-ray branching ratios obtained are (1.2 ± 0.3), (0.32 ± 0.12), (1.4 ± 0.2) and (4.4 ± 0.8) %, respectively, with the remaining (92.7 ± 1.0) % of the γ decays going to the bound states. We obtain Γα / Γ = (2.8 ± 1.2) % for the isospin-forbidden α decay of the 15.11 MeV state. From the 12.71 MeV state we find γ transitions to the 10.3 and 7.65 MeV states. The relative γ-ray branching ratios are (0.9- 0.5 + 0.6) and (2.6- 1.2 + 1.6) %, respectively, with the remaining (96.6- 1.3 + 1.7) % of the γ decays going to the bound states. Finally, we discuss the relation between the β decay of 12N and 12B to states in 12C and the γ decay of the 15.11 MeV analog in 12C to the same states. © 2009 Elsevier B.V.We would like to acknowledge the support of the Spanish CICYT research grant FPA2007-62170 and the MICINN Consolider Project CSD 2007-00042 as well as the support of the European Union VI Framework through RII3-EURONS/JRA4-DLEP (contract number 506065). D.G. is a Juan de la Cierva fellow

Nutritional value of Acacia amentacea and parkinsonia texana grown in semiarid conditions

In order to evaluate the nutritional value of Parkinsonia texana and Acacia amentacea, two leguminosae species of the Tamaulipan scrubland, Northeastern Mexico, two experiments were carried out: the first tested the effects of season and browse species on chemical composition as nutritional variable to small ruminants; the second tested the effect of the addition of polyethylene glycol (PEG) on fermentation parameters. Foliage samples were collected from three sites. Data of chemical composition were analysed using analysis of variance for a bi-factorial arrangement, whereas the effect of PEG was analysed by a strip plot design. Results of chemical composition were affected by interacting factors season*species as individually they were significantly different (P<0.001). Addition of PEG affected (P<0.001) fermentation parameters. Significantly higher values of neutral detergent fibre (42%), condensed tannins (19%), purines (9 μmol), partitioning factor (PF) (6.1) and gross energy losses (GEL=6.7%) were found in A. amentacea, while P. texana gave higher crude protein (18%), in vitro true organic matter digestibility (82%), metabolisable energy (ME) [2.1 Mcal/kg dry matter (DM)], A (183 mL), c (0.07/h) and L (0.86 h). Addition of PEG increased ME, and affected (P<0.001) fermentation parameters A and c, while purines and PF decreased. Results indicate that chemical composition and fermentation parameters vary according to seasons and species. PEG addition increases the fermentation parameters, which indicates that PEG counteracts the detrimental effects of secondary components of samples. Data suggest that using both species combined could supply necessary nutritional requirements to small ruminants in the Tamaulipan scrubland

The Spanish Infrared Camera onboard the EUSO-BALLOON (CNES) flight on August 24, 2014

The EUSO-Balloon (CNES) campaign was held during Summer 2014 with a launch on August 24. In the gondola, next to the Photo Detector Module (PDM), a completely isolated Infrared camera was allocated. Also, a helicopter which shooted flashers flew below the balloon. We have retrieved the Cloud Top Height (CTH) with the IR camera, and also the optical depth of the nonclear atmosphere have been inferred with two approaches: The first one is with the comparison of the brightness temperature of the cloud and the real temperature obtained after the pertinent corrections. The second one is by measuring the detected signal from the helicopter flashers by the IR Camera, considering the energy of the flashers and the location of the helicopter

The atmospheric science of JEM-EUSO

An Atmospheric Monitoring System (AMS) is critical suite of instruments for JEM-EUSO whose aim is to detect Ultra-High Energy Cosmic Rays (UHECR) and (EHECR) from Space. The AMS comprises an advanced space qualified infrared camera and a LIDAR with cross checks provided by a ground-based and airborne Global Light System Stations. Moreover the Slow Data Mode of JEM-EUSO has been proven crucial for the UV background analysis by comparing the UV and IR images. It will also contribute to the investigation of atmospheric effects seen in the data from the GLS or even to our understanding of Space Weather

National Prevalence and Trends of HIV Transmitted Drug Resistance in Mexico

BACKGROUND: Transmitted drug resistance (TDR) remains an important concern for the management of HIV infection, especially in countries that have recently scaled-up antiretroviral treatment (ART) access. METHODOLOGY/PRINCIPAL FINDINGS: We designed a study to assess HIV diversity and transmitted drug resistance (TDR) prevalence and trends in Mexico. 1655 ART-naïve patients from 12 Mexican states were enrolled from 2005 to 2010. TDR was assessed from plasma HIV pol sequences using Stanford scores and the WHO TDR surveillance mutation list. TDR prevalence fluctuations over back-projected dates of infection were tested. HIV subtype B was highly prevalent in Mexico (99.9%). TDR prevalence (Stanford score>15) in the country for the study period was 7.4% (95% CI, 6.2∶8.8) and 6.8% (95% CI, 5.7∶8.2) based on the WHO TDR surveillance mutation list. NRTI TDR was the highest (4.2%), followed by NNRTI (2.5%) and PI (1.7%) TDR. Increasing trends for NNRTI (p = 0.0456) and PI (p = 0.0061) major TDR mutations were observed at the national level. Clustering of viruses containing minor TDR mutations was observed with some apparent transmission pairs and geographical effects. CONCLUSIONS: TDR prevalence in Mexico remains at the intermediate level and is slightly lower than that observed in industrialized countries. Whether regional variations in TDR trends are associated with differences in antiretroviral drug usage/ART efficacy or with local features of viral evolution remains to be further addressed