Estudio de métodos y tiempos en el departamento de facturación de la empresa Audifarma S.A.

La idea de este proyecto surgió en el proceso de Facturación de la empresa Audifarma S.A. a raíz de la finalización de la prestación del servicio de dispensación de medicamentos con uno de sus clientes más importantes. El objetivo es analizar, evaluar y diseñar una nueva metodología que permita facturar la totalidad de fórmulas, de manera que se pueda cobrar el saldo pendiente. Se debe aclarar que por motivos de confidencialidad se llamara al cliente que será objeto de estudio Cliente X. El diseño de la nueva metodología estará contenido en una propuesta final donde se presentaran 3 puntos adicionales que permitirán controlar el proceso de todos los puntos posibles; el primero, y quizá el más importante, es el cálculo del recurso humano necesario para procesar la totalidad de fórmulas, para ello se debe tener en cuenta que desde el 6 de junio del año 2012, se contrataron 3 personas exclusivamente para realizar este proceso. El segundo punto es realizar un cálculo aproximado de los gastos salariales de los funcionarios requeridos con el fin de estimar el costo en el que se debe incurrir; y el tercero se refiere al diseño de una herramienta de control de las actividades que realiza cada uno de los funcionarios, lo que permitirá conocer las causas de incumplimiento y de esta manera se podrán ajustar detalles.The time and motion studies are an important tool, with this the companies can expect to make projections of both, human and monetary resources, to allow others to set and implement dynamic and consistent methodologies to process studied. They have to take into account an important factor, variability, and sometimes depending on the activities they want to standardize the methods and time study can become a double-edged sword, standards should respond to variability processes, otherwise, the results of the projections would not be the most successful and could be working under ambiguous parameters aimed at targets that very likely will not be met. So they should pay attention to every detail, every word or movement about the official system problems, the tools they use, everything is important and relevant to adjust and adapt the methodology to the process, in a more explicit study methods and time to design the mold in which they have to adjust the process and the “accurate” time. It is clear that companies standardize their processes are characterized because they are organized, methodical and with a substantial degree of control, which make them safe and reliable, so it is necessary to give the importance that it deserves, the responsibility of deliver a good product should not be taken as a risk due to inefficient and uncontrolled processes, they cannot contemplate risking customer confidence, which is a key factor when you lose it is very difficult to recover. For all this is true to say that the standardization process should become a required for companies and their staff have a guided culture and methodologies under the parameters that they set, so traceability can be done in time generating deviations avoiding rework and delays

Label-Free Detection of Post-translational Modifications with a Nanopore

Post-translational modifications (PTMs) of proteins play key roles in cellular processes. Hence, PTM identification is crucial for elucidating the mechanism of complex cellular processes and disease. Here we present a method for PTM detection at the single-molecule level using FraC biological nanopores. We focus on two major PTMs, phosphorylation and glycosylation, that mutually compete for protein modification sites, an important regulatory process that has been implicated in the pathogenic pathways of many diseases. We show that phosphorylated and glycosylated peptides can be clearly differentiated from nonmodified peptides by differences in the relative current blockade and dwell time in nanopore translocations. Furthermore, we show that these PTM modifications can be mutually differentiated, demonstrating the identification of phosphorylation and glycosylation in a label-free manner. The results represent an important step for the single-molecule, label-free identification of proteoforms, which have tremendous potential for disease diagnosis and cell biology

Domestic hot water consumption prediction models suited for dwellings in central-southern parts of Chile

Domestic hot water (DHW) consumption in dwellings can play a key role in the development of policies that are focused on energy poverty, and in improving energy efficiency, among other aspects. There is an important variability observed with DHW among different countries due to technical, sociological, climatic, and economic factors. Most studies that deal with DHW predictions are based on stochastic models, and only a few apply time series or statistical methods. In the case of Chile, the country is undergoing a policy development process, and there is little information about DHW consumption. As a result, it is fundamental to have DHW consumption prediction models that are focused on dwelling. For this reason, the study analysed the possibility of using time series models to make future estimations about monthly domestic hot water (DHW) consumption. To this end, consumption data obtained from 98 apartments between 2015 and 2021 were used, and 3 approaches were applied namely, exponential smoothing, basic structural model (BSM), and state-space model (SSM). The results showed that exponential smoothing and state-space methods allowed to obtain satisfactory results with regard to percentage error and confidence levels. Therefore, these models could be used to make future estimations of domestic hot water (DHW) consumption

Do we need complex and multidimensional indicators to assess energy poverty? The case of the Chilean indicator

Energy poverty is a multidimensional and complex phenomenon, and several indicators have been developed to evaluate and quantify it. However, often greater complexity does not mean greater precision. In the case of Chile, the Energy Poverty Network established the Three-dimensional and Territorial Indicator of Energy Poverty (EPTTI in Spanish) to assess the energy poverty situation of Chilean families. The EPTTI is based on a multidimensional approach with 10 indicators. Although, their evaluation involves resources that may hinder a practical application. This study analyzed the consistency between the individual responses of an indicator and the adapted EPTTI evaluation, using a database of 641 families. The results show that the excessive energy expenditure and the type and energy source of heating systems indicators are the variables with the greatest influence on energy poverty assessments. These results served to both propose simplified approaches for energy poverty assessment with the indicator, and establish policies of action that regional governments should address to reduce the situation of energy povertyNational Agency for Research and Development (ANID, in Spanish)Confort ambiental y pobreza energ´etica (+CO-PE)” of the University of the Bío-Bío, the Thematic Network 722RT0135 “Red Iberoamericana de Pobreza Energ´etica y Bienestar Ambiental” (RIPEBA)Thematic Networks of the CYTED Program for 2021Universidad de Granada / CBU

Thermal activation of catalytic microjets in blood samples using microfluidic chips

We demonstrate that catalytic microjet engines can out-swim high complex media composed of red blood cells and serum. Despite the challenge presented by the high viscosity of the solution at room temperature, the catalytic microjets can be activated at physiological temperature and, consequently, self-propel in diluted solutions of blood samples. We prove that these microjets self-propel in 10× diluted blood samples using microfluidic chips

Trapping self-propelled micromotors with microfabricated chevron and heart-shaped chips

We demonstrate that catalytic micromotors can be trapped in microfluidic chips containing chevron and heart-shaped structures. Despite the challenge presented by the reduced size of the traps, microfluidic chips with different trapping geometries can be fabricated via replica moulding. We prove that these microfluidic chips can capture micromotors without the need for any external mechanism to control their motion.The research leading to these results has received funding from S.S. and L.S. thank DFG (grant SA 2525/1-1) for financial support.European Community's Seventh Framework ProgramEuropean Commissio

Diseño de un diagnóstico de peligros y riesgos laborales de los trabajadores en el área de hospitalización, del Hospital San Pedro y San Pablo del municipio de La Virginia, durante el segundo semestre del año 2015

CD-T 363.15 A94; 89 pEl procedimiento de análisis de riesgos y peligros en el área de hospitalización del Hospital San Pedro y San Pablo, es novedoso porque es la base para promover la seguridad basada en comportamientos e inculcando una cultura de autocuidado para que sea trasmitida de una generación a otra, logrando que se viva una seguridad y salud laboral por convicción más no por obligación.Universidad Libre Seccional Pereir

The Effects of Organizational Culture on Employee Performance: A Study of the Edge Newspaper

This research aims to examine the effect of organizational culture on employee performance. The research was conducted by interviewing the Edge Newspaper Sdn Bhd Company’s top management and their employees. Apart from that, data collection will be based on observations from surveys and journals. These collected data were used to test our hypothesis that is ‘A good employee behaviour will increase business productivity, lower absenteeism, and achieve turnover”. It is proven that a positive relationship exists between organizational culture and employee behaviour. These findings provide new insights for the management of the effects of organizational culture on its employee performances. In addition, this research enhances the understanding of employee behaviour, possibly utilized by top management to encourage and manage their employees

Prototipo de incubadora neonatal

Las incubadoras neonatales proporcionan un entorno controlado para recién nacidos que necesitan cuidados especiales. Este prototipo ha sido diseñado para cubrir las necesidades mínimas en los hospitales, de modo que el personal médico pueda controlar el entorno del neonato. Este artículo reporta el diseño y construcción de un prototipo que incluyó una investigación con el fin de seleccionar y construir los elementos del prototipo: chasis, cúpula, portacolchón y una fuente de poder. Dentro de la incubadora se dispusieron sensores de temperatura, luminosidad, ruido, humedad y una alarma de apertura de la puerta; todos con el fin de garantizar el buen estado de salud del neonato. Con estos elementos, se pudo obtener un prototipo funcional, que se convierte en un primer paso para el desarrollo de incubadoras neonatales con tecnología apropiada.Newborn and premature infants incubators provide a controlled environment for infants which need special care. The constructed prototype has the potential to cover the minimal needs in a hospital, in a way that medical staff may control the newborn environment. This article reports the design and construction of the prototype included research for selecting and building the elements of the prototype: the chassis, hood, mattress case, and a power source. Different transducers were included in the incubator for measuring temperature, luminosity, noise, humidity, and a door alarm. The purpose of these was to guaranty the proper conditions for the newborn.The constructed prototype is fully functional and constitutes a first step for building newborn incubators with appropriated technology