Building Relationships With Our Island Home: Three Stories From Kindergarten in Hawaiʻi

As early childhood educators, we seek to create authentic and meaningful experiences for the children we learn alongside. We must remember that at its core, “education, in its highest form, liberates human potential through transformational teaching and learning experiences” (Meyer, Maeshiro, & Sumida, 2018, p. 17). As a Native Hawaiian early childhood educator in Hawaiʻi, I feel compelled to nurture the children’s emerging sense of place and self to empower them with a strong sense of connection and identity. Although not all the children in my care are Native Hawaiian by blood, they are being raised within a place and a culture that requires each of us to be cognizant of that place and culture. As Meyer (2016) stated, “what will be vital in this century is Culture––a way of being unique to place and people” (p. x). Meyer further clarified that “as a point of history, let it be known that we [Hawaiians] never did privilege” [ideas of race, ethnicity, and blood] as “points of separation” (p. x). There have been efforts to colonize and erase our Hawaiian language and culture for generations (Goodyear-Kaʻōpua, 2013; Kanaʻiaupuni, 2006). My hope as an educator is that each of us––children, educators, and families––will grow to embrace our kuleana, our responsibility and privilege, as people living in this unique and storied place

Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 May Help Downregulate TNF-Alpha, IL-6, IL-8, IL-10 and IL-12 (p70) in the Neurogenic Bladder of Spinal Cord Injured Patient with Urinary Tract Infections: A Two-Case Study

The management of urinary tract infection (UTI) in individuals with spinal cord injury (SCI) continues to be of concern, due to complications that can occur. An emerging concept that is a common underlying pathophysiological process is involved, wherein pathogens causing UTI have a role in inflammatory progression. We hypothesized that members of the commensal flora, such as lactobacilli, may counter this reaction through anti-inflammatory mediation. This was assessed in a pilot two-patient study in which probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri were administered to one patient and placebo to another, both along with antibiotics to treat acute UTI. Urinary TNF-alpha was significantly downregulated (P = .015) in the patient who received the probiotic and who used intermittent catheterization compared with patient on placebo and using an indwelling catheter. The extent to which this alteration resulted in improved well-being in spinal cord injured patients remains to be determined in a larger study

A systematic review of the association between dementia risk factors and cerebrovascular reactivity

Cumulative evidence suggests that impaired cerebrovascular reactivity (CVR), a regulatory response critical for maintaining neuronal health, is amongst the earliest pathological changes in dementia. However, we know little about how CVR is affected by dementia risk, prior to disease onset. Understanding this relationship would improve our knowledge of disease pathways and help inform preventative interventions. This systematic review investigates 59 studies examining how CVR (measured by magnetic resonance imaging) is affected by modifiable, non-modifiable, and clinical risk factors for dementia. We report that non-modifiable risk (older age and apolipoprotein ε4), some modifiable factors (diabetes, traumatic brain injury, hypertension) and some clinical factors (stroke, carotid artery occlusion, stenosis) were consistently associated with reduced CVR. We also note a lack of conclusive evidence on how other behavioural factors such as physical inactivity, obesity, or depression, affect CVR. This review explores the biological mechanisms underpinning these brain-behaviour associations, highlights evident gaps in the literature, and identifies the risk factors that could be managed to preserve CVR in an effort to prevent dementia

The distance to galactic globular clusters through RR Lyrae pulsational properties

By adopting the same approach outlined in De Santis & Cassisi (1999), we evaluate the absolute bolometric magnitude of the Zero Age Horizontal Branch (ZAHB) at the level of the RR Lyrae variable instability strip in selected galactic globular clusters. This allows us to estimate the ZAHB absolute visual magnitude for these clusters and to investigate its dependence on the cluster metallicity. The derived $M_V(ZAHB) - [Fe/H]$ relation, corrected in order to account for the luminosity difference between the ZAHB and the mean RR Lyrae magnitude, has been compared with some of the most recent empirical determinations in this field, as the one provided by Baade-Wesselink analyses, RR Lyrae periods, Hipparcos data for field variables and Main Sequence fitting based on Hipparcos parallaxes for field subdwarfs. As a result, our relation provides a clear support to the "long" distance scale. We discuss also another method for measuring the distance to galactic globular clusters. This method is quite similar to the one adopted for estimating the absolute bolometric magnitude of the ZAHB but it relies only on the pulsational properties of the Lyrae variables in each cluster. The reliability and accuracy of this method has been tested by applying it to a sample of globulars for which, due to the morphology of their horizontal branch (HB), the use of the commonly adopted ZAHB fitting is a risky procedure.Comment: 7 pages, 2 postscript figures, accepted for publication on MNRA

PCV54 Can A Cvd Polypill Save Money In The ‘Real World'?

Digitalitzat per Artypla

In-beam Tests of a Ring Imaging Cerenkov Detector With a Multianode Photomultiplier Readout

A ring-imaging \v{C}erenkov counter read out by a 100-channel PMT of active area 10$\times$10 cm$^2$ was operated successfully in a test beam at the BNL AGS with several radiator gases, including the heavy fluorocarbon C$_4$F$_{10}$. Ring radii were measured for electrons, muons, pions and kaons over the particle momentum range from 2 to 12 GeV/$c$, and a best resolution of $\sigma_r/r = 2.3\%$ was obtained.Comment: 11 pages (LaTeX) plus 7 figures in Postscript (gz-compressed and uuencoded

Detectability of Transiting Jupiters and Low-Mass Eclipsing Binaries in Sparsely Sampled Pan-STARRS-1 Survey Data

We present detailed simulations of the Pan-STARRS-1 (PS1) multi-epoch, multi-band 3-pi Survey in order to assess its potential yield of transiting planets and eclipsing binaries. This survey differs from dedicated transit surveys in that it will cover the entire Northern sky but provide only sparsely sampled light curves. Since most eclipses would be detected at only a single epoch, the 3-pi Survey will be most sensitive to deep eclipses (> 0.10 mag) caused by Jupiters transiting M dwarfs and eclipsing stellar/substellar binaries. The survey will also provide parallaxes for the ~400,000 stars within 100 pc which will enable a volume-limited eclipse search, reducing the number of astrophysical false positives compared to previous magnitude-limited searches. Using the best available empirical data, we constructed a model of the extended solar neighborhood that includes stars, brown dwarfs, and a realistic binary population. We computed the yield of deeply eclipsing systems using both a semi-analytic and a full Monte Carlo approach. We examined statistical tests for detecting single-epoch eclipses in sparsely sampled data and assessed their vulnerability to false positives due to stellar variability. Assuming a short-period planet frequency of 0.5% for M dwarfs, our simulations predict that about a dozen transiting Jupiters around low-mass stars (M < 0.3 Msun) within 100 pc are potentially detectable in the PS1 3-pi Survey, along with ~300 low-mass eclipsing binaries (both component masses < 0.5 Msun), including ~10 eclipsing field brown dwarfs. Extensive follow-up observations would be required to characterize these candidate eclipsing systems, thereby enabling comprehensive tests of structural models and novel insights into the planetary architecture of low-mass stars.Comment: ApJ, in pres

Boron Toxicity in Barley: Prospects for delivering a yield advantage

J.K. Eglington, R.J. Reid, J.E. Hayes, P. Davies, D. Jha and P. McDonal

Observation of laser pulse propagation in optical fibers with a SPAD camera

Recording processes and events that occur on sub-nanosecond timescales poses a difficult challenge. Conventional ultrafast imaging techniques often rely on long data collection times, which can be due to limited device sensitivity and/or the requirement of scanning the detection system to form an image. In this work, we use a single-photon avalanche detector array camera with pico-second timing accuracy to detect photons scattered by the cladding in optical fibers. We use this method to film supercontinuum generation and track a GHz pulse train in optical fibers. We also show how the limited spatial resolution of the array can be improved with computational imaging. The single-photon sensitivity of the camera and the absence of scanning the detection system results in short total acquisition times, as low as a few seconds depending on light levels. Our results allow us to calculate the group index of different wavelength bands within the supercontinuum generation process. This technology can be applied to a range of applications, e.g., the characterization of ultrafast processes, time-resolved fluorescence imaging, three-dimensional depth imaging, and tracking hidden objects around a corner. © The Author(s) 20171541sciescopu