The Fairness in Musical Licensing Act: The Tavern Bill Casts a Shadow

The Fairness in Musical Licensing Act, now pending before Congress, would allow restaurants owners and other businesses to play copyrighted music in their place of business without paying royalties or licensing fees to the copyright owner. This Article discusses the Fairness Act in the context of the 1976 Copyright Act and analyzes the effect of the Fairness Act on the future of the music industry if it passes into law. This Article also offers other possible solutions to the underlying conflicts that the Fairness Act seeks to remedy. The author concludes that the Fairness Act unreasonably exempts a large group of copyright users from paying licensing fees, and thus undermines the protection of copyrighted works the 1976 Act was designed to protect

EXPANDING HUMAN RIGHTS AND CIVIL RIGHTS VIOLATIONS IN THE UNITED STATES: SEE SOMETHING, SAY SOMETHING POLICY

According to the Bureau of Justice Statistics, almost 300,000 hate crimes occurred in 2012 in the United States. An astonishing 90% of these crimes were violent. Even more shocking are the 60% of hate crimes that are not reported to law enforcement (Wilson, 2014). In response to these dismal reporting statistics, the Department of Homeland Security (“DHS”) has adopted a policy (the “Policy”) and Congress introduced the “See Something, Say Something Act” (the “Act”), an amendment to the Homeland Security Act of 2002. The Policy and the Actencourage ordinary citizens to suspect and report someone based on perceived demeanor and/or overall appearance without the usual requirement of articulable suspicion (Terry, 1968). Due to the discriminatory nature of both the Policy and the Act, the proposed measures would be subject to strict scrutiny if challenged in court. Challenges to the Act would most likely revolve around civil rights violations. More importantly, basic human rights as outlined in the articles of The Universal Declaration of Human Rights (“UDHR”) are at issue.In practice, encouraging U.S. citizens to report each other without articulable suspicion opens the door for bias, prejudice, and intolerance. Even without these limitations, the Act may not achieve its ultimate goal of increasing reporting as only four percent of the 40% of hate crimes reported actually result in an arrest (Wilson, 2014). Increasing reporting of hate crimes, at best, may improve arrest rates into double digits

EXPANDING HUMAN RIGHTS AND CIVIL RIGHTS VIOLATIONS IN THE UNITED STATES: SEE SOMETHING, SAY SOMETHING POLICY

According to the Bureau of Justice Statistics, almost 300,000 hate crimes occurred in 2012 in the United States. An astonishing 90% of these crimes were violent. Even more shocking are the 60% of hate crimes that are not reported to law enforcement (Wilson, 2014). In response to these dismal reporting statistics, the Department of Homeland Security (“DHS”) has adopted a policy (the “Policy”) and Congress introduced the “See Something, Say Something Act” (the “Act”), an amendment to the Homeland Security Act of 2002. The Policy and the Actencourage ordinary citizens to suspect and report someone based on perceived demeanor and/or overall appearance without the usual requirement of articulable suspicion (Terry, 1968). Due to the discriminatory nature of both the Policy and the Act, the proposed measures would be subject to strict scrutiny if challenged in court. Challenges to the Act would most likely revolve around civil rights violations. More importantly, basic human rights as outlined in the articles of The Universal Declaration of Human Rights (“UDHR”) are at issue.In practice, encouraging U.S. citizens to report each other without articulable suspicion opens the door for bias, prejudice, and intolerance. Even without these limitations, the Act may not achieve its ultimate goal of increasing reporting as only four percent of the 40% of hate crimes reported actually result in an arrest (Wilson, 2014). Increasing reporting of hate crimes, at best, may improve arrest rates into double digits

The Normative Order of Reporting Police Misconduct: Examining the Roles of Offense Seriousness, Legitimacy, and Fairness

Using anonymous surveys of 3,235 officers in 30 police agencies, we tested hypotheses derived from prior policing research, legitimacy theory, and disciplinary fairness literature on the intentions of police officers to report acts of misconduct perpetrated by fellow officers. We examined features of the normative order involving peer reporting of police misconduct at both the individual agency and aggregate police subculture levels. Consistent with previous research, the perceived seriousness of the offense and legitimacy (endorsement) are consistently strong predictors of officers’ intentions to report misconduct. We also find that perceived fairness of discipline provides significant results, but the direction of the relationship depends on the perceived seriousness of the offense. It is clear that the majority of police officers participate in a shared normative culture of when to and when not to report misconduct. Finally, we note the importance of studying the reporting of police misconduct using a social psychological lens

Potent and Selective Inhibitors of the Inositol-requiring Enzyme 1 Endoribonuclease*

Inositol-requiring enzyme 1 (IRE1) is the most highly conserved signaling node of the unfolded protein response (UPR) and represents a potential therapeutic target for a number of diseases associated with endoplasmic reticulum stress. IRE1 activates the XBP-1 transcription factor by site-specific cleavage of two hairpin loops within its mRNA to facilitate its nonconventional splicing and alternative translation. We screened for inhibitors using a construct containing the unique cytosolic kinase and endoribonuclease domains of human IRE1α (hIRE1α-cyto) and a mini-XBP-1 stem-loop RNA as the substrate. One class compounds was salicylaldehyde analogs from the hydrolyzed product of salicylaldimines in the library. Salicylaldehyde analogs were active in inhibiting the site-specific cleavage of several mini-XBP-1 stem-loop RNAs in a dose-dependent manner. Salicyaldehyde analogs were also active in inhibiting yeast Ire1 but had little activity inhibiting RNase L or the unrelated RNases A and T1. Kinetic analysis revealed that one potent salicylaldehyde analog, 3-ethoxy-5,6-dibromosalicylaldehyde, is a non-competitive inhibitor with respect to the XBP-1 RNA substrate. Surface plasmon resonance studies confirmed this compound bound to IRE1 in a specific, reversible and dose-dependent manner. Salicylaldehydes inhibited XBP-1 splicing induced pharmacologically in human cells. These compounds also blocked transcriptional up-regulation of known XBP-1 targets as well as mRNAs targeted for degradation by IRE1. Finally, the salicylaldehyde analog 3-methoxy-6-bromosalicylaldehyde strongly inhibited XBP-1 splicing in an in vivo model of acute endoplasmic reticulum stress. To our knowledge, salicylaldehyde analogs are the first reported specific IRE1 endoribonuclease inhibitors

Association of Glycemia, Lipids, and Blood Pressure With Cognitive Performance in People With Type 2 Diabetes in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).

ObjectiveType 2 diabetes is a risk factor for cognitive impairment. We examined the relation of glycemia, lipids, blood pressure (BP), hypertension history, and statin use with cognition in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).Research design and methodsCross-sectional analyses from GRADE at baseline examined the association of glycemia (hemoglobin A1c [HbA1c]), LDL, systolic BP (SBP) and diastolic BP (DBP), hypertension history, and statin use with cognition assessed by the Spanish English Verbal Learning Test, letter and animal fluency tests, and Digit Symbol Substitution Test (DSST).ResultsAmong 5,047 GRADE participants, 5,018 (99.4%) completed cognitive assessments. Their mean age was 56.7 ± 10.0 years, and 36.4% were women. Mean diabetes duration was 4.0 ± 2.7 years. HbA1c was not related to cognition. Higher LDL was related to modestly worse DSST scores, whereas statin use was related to modestly better DSST scores. SBP between 120 and 139 mmHg and DBP between 80 and 89 mmHg were related to modestly better DSST scores. Hypertension history was not related to cognition.ConclusionsIn people with type 2 diabetes of a mean duration of <5 years, lower LDL and statin use were related to modestly better executive cognitive function. SBP levels in the range of 120-139 mmHg and DBP levels in the range of 80-89 mmHg, but not lower levels, were related to modestly better executive function. These differences may not be clinically significant

Rationale and Design for a GRADE Substudy of Continuous Glucose Monitoring

Background: The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) study has enrolled a racially and ethnically diverse population with type 2 diabetes, performed extensive phenotyping, and randomly assigned the participants to one of four second-line diabetes medications. The continuous glucose monitoring (CGM) substudy has been added to determine whether there are racial/ethnic differences in the relationship between average glucose (AG) and hemoglobin A1c (HbA1c). CGM will also be used to compare time in target range, glucose variability, and the frequency and duration of hypoglycemia across study groups. Methods: The observational CGM substudy will enroll up to 1800 of the 5047 GRADE study participants from the four treatment groups, including as many as 450 participants from each of 4 racial/ethnic minority groups to be compared: Hispanic White, non-Hispanic White, non-Hispanic African American, and non-Hispanic Other. CGM will be performed for 2 weeks in proximity to a GRADE annual visit, during which an oral glucose tolerance test will be performed and HbA1c and glycated albumin measured. Indicators of interindividual variation in red blood cell turnover, based on specialized erythrocyte measurements, will also be measured to explore the potential causes of interindividual HbA1c variations. Conclusions: The GRADE CGM substudy will provide new insights into whether differences exist in the relationship between HbA1c and AG among different racial/ethnic groups and whether glycemic profiles differ among frequently used diabetes medications and their potential clinical implications. Understanding such differences is important for clinical care and adjustment of diabetes medications in patients of different races or ethnicities