Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Razão e sensibilidade no ensino de administração: a literatura como recurso estético Sense and sensibility in management teaching: literature as an aesthetic resource

Este artigo problematiza o uso da literatura como recurso estético durante o processo de ensino da administração, com base em uma análise multidisciplinar dos trabalhos acadêmicos publicados, com a finalidade de: refletir sobre literatura e o papel da ficção no ensino, articulando a literatura com a existência humana; abordar a pesquisa em organizações e o uso de gêneros e estilos literários na produção do conhecimento; e discutir sobre os usos dos textos literários em ensino, pelo relato e discussão de práticas que utilizam a literatura. Tem especial destaque a dimensão estratégica da atividade de ensino que usa a literatura como recurso estético. A conclusão é de que o texto literário é um poderoso recurso de aprendizagem, pois tem como matéria-prima a palavra, o discurso, que é a essência da administração. E, também, que a integração entre administração e literatura pode ser uma estratégia fecunda, favorecendo criatividade e descoberta, pois possibilita o desenvolvimento de capacitações para sentir e conhecer.<br>The goal of this article is to challenge the use of literature as an aesthetic resource in management teaching-learning. The research is based on a multidisciplinary literature review in order to: think about fiction and its role in teaching, articulating fiction with human existence; explore organizational research and the use of literary genres and styles in knowledge production, and discuss about the use of literary texts in teaching through the presentation and discussion of practices using and capitalizing on fiction. Special attention is given to the strategic dimension of teaching activity that uses fiction as an aesthetic resource. The research's conclusion suggests that literary text is a powerful learning resource because it has as primary source accounts and discourse, these being the essence of management. Another conclusion is that the relationship between management and literature translates into a rich strategy, encouraging creativity and discovery as it allows the development of capabilities to feel and to know