226 research outputs found
Long-term outcomes of a 5-year follow up of patients with immune thrombocytopenic purpura after splenectomy
Baseline characteristics of people experiencing homelessness with a recent drug overdose in the PHOENIx pilot randomised controlled trial
Background: Drug-related deaths in Scotland are the highest in Europe. Half of all deaths in people experiencing homelessness are drug related, yet we know little about the unmet health needs of people experiencing homelessness with recent non-fatal overdose, limiting a tailored practice and policy response to a public health crisis.
Methods: People experiencing homelessness with at least one non-fatal street drug overdose in the previous 6 months were recruited from 20 venues in Glasgow, Scotland, and randomised into PHOENIx plus usual care, or usual care. PHOENIx is a collaborative assertive outreach intervention by independent prescriber NHS Pharmacists and third sector homelessness workers, offering repeated integrated, holistic physical, mental and addictions health and social care support including prescribing. We describe comprehensive baseline characteristics of randomised participants.
Results: One hundred and twenty-eight participants had a mean age of 42 years (SD 8.4); 71% male, homelessness for a median of 24 years (IQR 12–30). One hundred and eighteen (92%) lived in large, congregate city centre temporary accommodation. A quarter (25%) were not registered with a General Practitioner. Participants had overdosed a mean of 3.2 (SD 3.2) times in the preceding 6 months, using a median of 3 (IQR 2–4) non-prescription drugs concurrently: 112 (87.5%) street valium (benzodiazepine-type new psychoactive substances); 77 (60%) heroin; and 76 (59%) cocaine. Half (50%) were injecting, 50% into their groins. 90% were receiving care from Alcohol and Drug Recovery Services (ADRS), and in addition to using street drugs, 90% received opioid substitution therapy (OST), 10% diazepam for street valium use and one participant received heroin-assisted treatment. Participants had a mean of 2.2 (SD 1.3) mental health problems and 5.4 (SD 2.5) physical health problems; 50% received treatment for physical or mental health problems. Ninety-one per cent had at least one mental health problem; 66% had no specialist mental health support. Participants were frail (70%) or pre-frail (28%), with maximal levels of psychological distress, 44% received one or no daily meal, and 58% had previously attempted suicide.
Conclusions: People at high risk of drug-related death continue to overdose repeatedly despite receiving OST. High levels of frailty, multimorbidity, unsuitable accommodation and unmet mental and physical health care needs require a reorientation of services informed by evidence of effectiveness and cost-effectiveness.
Trial registration UK Clinical Trials Registry identifier: ISRCTN 10585019
Clinical Implications of Elevated Antiphospholipid Antibodies in Adult Patients with Primary Immune Thrombocytopenia
Health-related quality of life in children with chronic immune thrombocytopenia in China
Strengthening Biblical Historicity vis-a`-vis Minimalism, 1992–2008 and Beyond. Part 2.3: Some Commonalities in Approaches to Writing Ancient Israel’s History
This series of articles covers scholarly works in English which can, at least potentially, be associated with a generally positive view of biblical historicity regarding periods preceding the Israelites’ return from exile. Part 2 covers works that treat the methodological issues at the center of the maximalist–minimalist debate. Parts 2.1 and 2.2 selectively survey the works of 24 non-minimalist scholars during two decades. In the absence of consensus, this article analyzes the works in Parts 2.1 and 2.2, tracing elements of approach that are held in common, at least among pluralities of non-minimalists (possible majorities are not noted). The first commonality of approach is that history is provisional, not final. The second is that history should become fully multidisciplinary. The third commonality is that historians should receive all historical evidence on an equal footing before examination and cross-examination. The fourth and last is that historians should become increasingly sensitive to cultural aspects and coding in ancient Near Eastern materials
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