Senior Recital: Kyle Pridgen, percussion

This recital is presented in partial fulfillment of requirements for the degree Bachelor of Music in Music Education. Mr. Pridgen studies percussion with John Lawless.https://digitalcommons.kennesaw.edu/musicprograms/1528/thumbnail.jp

Percussion Ensemble Spring Concert

Kennesaw State University School of Music presents Percussion Ensemble Spring Concert.https://digitalcommons.kennesaw.edu/musicprograms/1406/thumbnail.jp

2014 Kennesaw State Festival of New Music

Kennesaw State University School of Music presents the 2014 Kennesaw State Festival of New Music with featured guest composer, Chen Yi.https://digitalcommons.kennesaw.edu/musicprograms/1374/thumbnail.jp

Choral Ensembles Spring Concert

Kennesaw State University School of Music presents Choral Ensembles Spring Concert.https://digitalcommons.kennesaw.edu/musicprograms/1363/thumbnail.jp

Choral Ensembles Spring Concert

Kennesaw State University School of Music presents Choral Ensembles Spring Concert.https://digitalcommons.kennesaw.edu/musicprograms/1405/thumbnail.jp

Holiday Concert, Home for the Holidays

Kennesaw State University School of Music presents Holiday Concert, Home for the Holidays.https://digitalcommons.kennesaw.edu/musicprograms/1433/thumbnail.jp

American Choral Directors Association Preview Concert with Guest Artist Ola Gjeilo, composer

Kennesaw State University School of Music presents the ACDA National Conference American Choral Directors Association Preview Concert with guest artist Ola Gjeilo, composer.https://digitalcommons.kennesaw.edu/musicprograms/1337/thumbnail.jp

Nanoparticle formulations of histone deacetylase inhibitors for effective chemoradiotherapy in solid tumors

Histone deacetylase inhibitors (HDACIs) represent a class of promising agents that can improve radiotherapy in cancer treatment. However, the full therapeutic potential of HDACIs as radiosensitizers has been restricted by limited efficacy in solid malignancies. In this study, we report the development of nanoparticle (NP) formulations of HDACIs that overcome these limitations, illustrating their utility to improve the therapeutic ratio of the clinically established first generation HDACI vorinostat and a novel second generation HDACI quisinostat. We demonstrate that NP HDACIs are potent radiosensitizers in vitro and are more effective as radiosensitizers than small molecule HDACIs in vivo using mouse xenograft models of colorectal and prostate carcinomas. We found that NP HDACIs enhance the response of tumor cells to radiation through the prolongation of γ-H2AX foci. Our work illustrates an effective method for improving cancer radiotherapy treatment