Mikrobiální dysbióza indukovaná opioidy

The aim of this bachelor thesis is to describe the consequences of opioids in relation to the gut microbiome. Chronic opioid use induces microbial dysbiosis in the gut, where both functional and structural changes in the composition of the microbiome occur. This disrupts gut homeostasis and leads to diseases. The diversity of microbial organisms decreases and the expression of neurotransmitters changes. Opioids interfere with the microbiomeň-gut-brain axis, which normally functions in symbiosis. They alter the composition of the gut microbiota, affect the function and structure of the gut epithelium and the expression of neurotransmitters in the nervous system. This thesis focuses primarily on the action of morphine, the action of which has been desribed the most. Keywords: opioids, microbiome, dysbiosis, microbiome-gut-brain axis, gut homeostasisCieľom tejto bakalárskej práce je popísať dôsledky opioidov v súvislosti s črevným mikrobiómom. Chronické užívanie opioidov vyvoláva v čreve mikrobiálnu dysbiózu, kedy nastáva funkčná aj štruktúrna zmena skladby mikrobiómu. To narúša črevnú homeostázu a vedie k vzniku ochorení. Diverzita mikrobiálnych organizmov klesá a mení sa expresia neurotransmitérov. Opioidy narúšajú na osu mikrobióm-črevo-mozog, ktorá za normálnych okolností funguje v symbióze. Menia zloženie črevných mikrobiot, ovplyvňujú funkciu a štruktúru epitelu čreva a expresiu neurotransmitérov v nervovej sústave. Práca sa zameriava predovšetkým na pôsobenie morfia, ktorého pôsobenie je najlepšie preskúmané. Kľúčové slová: opioidy, mikrobióm, dysbióza, os mikrobióm-črevo-mozog, črevná homeostázaDepartment of PhysiologyKatedra fyziologieFaculty of SciencePřírodovědecká fakult

Effect of insulin on carbon dioxide production in adipose tissue from immature rats

Es wurde der Einfluss von Insulin auf die CO 2 -Produktion im Fettgewebe unreifer Ratten mit einem Gewicht zwischen 35 und 90 g manometrisch bestimmt, wobei mit zunehmendem Gewicht bis zu 90 g eine vermehrte CO 2 -Produktion festgestellt werden konnte.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42239/1/18_2005_Article_BF02142277.pd

Opioid-induced microbial dysbiosis

The aim of this bachelor thesis is to describe the consequences of opioids in relation to the gut microbiome. Chronic opioid use induces microbial dysbiosis in the gut, where both functional and structural changes in the composition of the microbiome occur. This disrupts gut homeostasis and leads to diseases. The diversity of microbial organisms decreases and the expression of neurotransmitters changes. Opioids interfere with the microbiomeň-gut-brain axis, which normally functions in symbiosis. They alter the composition of the gut microbiota, affect the function and structure of the gut epithelium and the expression of neurotransmitters in the nervous system. This thesis focuses primarily on the action of morphine, the action of which has been desribed the most. Keywords: opioids, microbiome, dysbiosis, microbiome-gut-brain axis, gut homeostasi