War and dissociation : the case of futurist aesthetics

Thanks to their deliberate engagement in state propaganda Italian Futurists deserved a prominent spot in the history of military aesthetics in the 20th century. However, under what looked like an unequivocal expression of support for war, lied a deep philosophical disagreement concerning its existential and epistemological value. The bone of contention concerned the effects of warfare on perception and, consequently, the means of its depiction. The author analyses this intellectual disagreement within the group and focuses, in particular, on its philosophical implications

An innovative model for the sustainability of investments in the wind energy sector: the use of green sukuk in an Italian case study

In this paper we present the technical-energy-economic feasibility of wind power systems. An Italian 1 megawatt case study was considered to evaluate the importance of incentives in order to achieve the grid parity. Due to the severe reduction of incentives in the last years, in the present work we propose the use of Sukuk, a Shari’ah-compliant instrument used in the Islamic finance, as an alternative financial instrument used to limit the extent of leverage associated with financing. The building cost thresholds necessary to achieve the grid parity and a profitable and bankable project are presented with a sensitivity analysis. In the framework of the efforts against climate change and the emission of greenhouse gas, our results evidenced the importance of incentives and the applicability of the use of Shari’ah-compliant sukuk instruments in order to provide a feasible and sustainable investment in the wind energy sector

Metamodeling and metaquerying in OWL 2 QL

OWL 2 QL is a standard profile of the OWL 2 ontology language, specifically tailored to Ontology-Based Data Management. Inspired by recent work on higher-order Description Logics, in this paper we present a new semantics for OWL 2 QL ontologies, called Metamodeling Semantics (MS), and show that, in contrast to the official Direct Semantics (DS) for OWL 2, it allows exploiting the metamodeling capabilities natively offered by the OWL 2 punning. We then extend unions of conjunctive queries with both metavariables, and the possibility of using TBox atoms, with the purpose of expressing meaningful metalevel queries. We first show that under MS both satisfiability checking and answering queries including only ABox atoms, have the same complexity as under DS. Second, we investigate the problem of answering general metaqueries, and single out a new source of complexity coming from the combined presence of a specific type of incompleteness in the ontology, and of TBox axioms among the query atoms. Then we focus on a specific class of ontologies, called TBox-complete, where there is no incompleteness in the TBox axioms, and show that general metaquery answering in this case has again the same complexity as under DS. Finally, we move to general ontologies and show that answering general metaqueries is coNP-complete with respect to ontology complexity, Π2p-complete with respect to combined complexity, and remains AC0 with respect to ABox complexity

Defective Expression and Function of the Leukocyte Associated Ig-like Receptor 1 in B Lymphocytes from Systemic Lupus Erythematosus Patients

Systemic lupus erythematosus (SLE) is characterized by the production of a wide array of autoantibodies and dysregulation of B cell function. The leukocyte associated Immunoglobulin (Ig)-like receptor (LAIR)1 is a transmembrane molecule belonging to Ig superfamily which binds to different types of collagen. Herein, we have determined the expression and function of LAIR1 on B lymphocyte from SLE patients. LAIR1 expression in peripheral blood B lymphocytes from 54 SLE, 24 mixed connective tissue disease (MCTD), 20 systemic sclerosis (SSc) patients, 14 rheumatoid arthritis (RA) and 40 sex and age matched healthy donors (HD) have been analyzed by immunofluorescence. The effect of LAIR1 ligation by specific monoclonal antibodies, collagen or collagen producing mesenchymal stromal cells from reactive lymph nodes or bone marrow on Ig production by pokeweed mitogen and B cell receptor (BCR)-mediated NF-kB activation was assessed by ELISA and TransAM assay. The percentage of CD20+ B lymphocytes lacking or showing reduced expression of LAIR1 was markedly increased in SLE and MCTD but not in SSc or RA patients compared to HD. The downregulation of LAIR1 expression was not dependent on corticosteroid therapy. Interestingly, LAIR1 engagement by collagen or collagen-producing mesenchymal stromal cells in SLE patients with low LAIR1 expression on B cells delivered a lower inhibiting signal on Ig production. In addition, NF-kB p65 subunit activation upon BCR and LAIR1 co-engagement was less inhibited in SLE patients than in HD. Our findings indicate defective LAIR1 expression and function in SLE B lymphocytes, possible contributing to an altered control of B lymphocytes behavior

Temporal control of Wnt signaling is required for habenular neuron diversity and brain asymmetry

Precise temporal coordination of signaling processes is pivotal for cellular differentiation during embryonic development. A vast number of secreted molecules are produced and released by cells and tissues, and travel in the extracellular space. Whether they induce a signaling pathway and instruct cell fate, however, depends on a complex network of regulatory mechanisms, which are often not well understood. The conserved bilateral left-right asymmetrically formed habenulae of the zebrafish are an excellent model for investigating how signaling control facilitates the generation of defined neuronal populations. Wnt signaling is required for habenular neuron type specification, asymmetry and axonal connectivity. The temporal regulation of this pathway and the players involved have, however, remained unclear. We find that tightly regulated temporal restriction of Wnt signaling activity in habenular precursor cells is crucial for the diversity and asymmetry of habenular neuron populations. We suggest a feedback mechanism whereby the tumor suppressor Wnt inhibitory factor Wif1 controls the Wnt dynamics in the environment of habenular precursor cells. This mechanism might be common to other cell types, including tumor cells

Time measurements by means of digital sampling techniques: a study case of 100 ps FWHM time resolution with a 100 MSample/s, 12 bit digitizer

Abstract An application of digital sampling techniques is presented which can simplify experiments involving sub-nanosecond time-mark determinations and energy measurements with nuclear detectors, used for Pulse Shape Analysis and Time of Flight measurements in heavy ion experiments. The basic principles of the method are discussed as well as the main parameters that influence the accuracy of the measurements. The method allows to obtain both time and amplitude information with an electronic chain simply consisting of a charge preamplifier and a fast high resolution ADC (in the present application: 100 MSample/s , 12 bit ) coupled to an efficient on-line software. In particular an accurate Time of Flight information can be obtained by mixing a beam related time signal with the output of the preamplifier. Examples of this technique applied to Silicon detectors in heavy-ions experiments involving particle identification via Pulse Shape analysis and Time of Flight measurements are presented. The system is suited for applications to large detector arrays and to different kinds of detectors

Turbulent friction in flows over permeable walls

Peer reviewedPublisher PD

Molecular characterization of ‘Candidatus Phytoplasma prunorum’ in Cacopsilla pruni insect vector

Recent investigations on molecular characterization of the ‘Candidatus Phytoplasma prunorum’ (16SrX-B subgroup), causal agent of the European Stone Fruit Yellows (ESFY) syndrome, on the non ribosomal tuf gene resulted in the finding of two groups of isolates, named ‘type a’ and ‘type b’, both with a distinctive geographical distribution in Italian stone fruit growing areas (Ferretti et al., 2007 and 2008). Considering the role of Cacopsylla pruni (Scopoli) in the epidemiological cycle of the disease, the presence of the two groups of isolates has also been investigated in infected psyllid individuals from different Italian areas. Both types have been identified in C. pruni specimens collected on apricot, plum and wild Prunus species, confirming the geographical distribution and the percentages of spread of the two isolates.Keywords: ESFY, phytoplasma, characterization, tuf gene, insect vecto