Distribution System Reconfiguration with Variable Demands Using the Opt-aiNet Algorithm

This paper describes the application of the Opt-aiNet algorithm to the reconfiguration problem of distribution systems considering variable demand levels. The Opt-aiNet algorithm is an optimization technique inspired in the immunologic bio system and it aims at reproducing the main properties and functions of this system. The reconfiguration problem of distribution networks with variable demands is a complex problem that aims at identifying the most adequate radial topology of the network that complies with all technical constraints in every demand level while minimizing the cost of power losses along an extended operation period. This work includes results of the application of the Opt-aiNet algorithm to distribution systems with 33, 84, 136 and 417 buses. These results demonstrate the robustness and efficiency of the proposed approach

Estudos de neotectónica na falha de Carcavai, Algarve Oriental

Estudos levados a cabo na zona da falha de Carcavai revelaram a ocorrência de deformações (fracturação e filões detríticos) em sedimentos plio-quaternários, indicando actividade neotectónica. A generalidade das fracturas aparenta corresponder à expressão superficial secundária da actividade naquela zona de falha. Os dados adquiridos apontampara uma zona de falha complexa de desligamento esquerdo, com componente vertical inversa, desde o final do Mesozóico ou início do Cenozóico. Os filões detríticos foram interpretados como estruturas resultantes de liquefacção induzida sismicamente

A soil classification for seismic hazard assessment and mitigation of the Algarve

The Algarve province of Portugal is located near the E-W Eurasia-Africa plate boundary. It is characterized by a moderate seismicity, with some important historical earthquakes causing important damage and economical losses. Not only has it suffered the effects of large plate boundary events but also the impact of local onshore moderate-sized earthquake sources. The seismic hazard evaluation and mitigation of the area is therefore of great importance to the local populations and the large number of tourists that frequent the region. This paper focuses the evaluation of the most interesting and useful geotechnical near-surface parameters and a soil classification. The classification based upon the European Code 8 for civil engineering and SPT bedrock data, was carried out for land use planning and design of critical facilities. P-wave and S-wave seismic velocities were obtained through the acquisition, processing and interpretation refraction profiles. Hundreds of SPT parameters from available boreholes drilled for engineering and water supply were used and subsoil classification based on geophysical and geotechnical parameters is presented. Other parameters, such as Vp/Vs ratios and the Poisson coefficient were estimated and were computed to provide information for future site effect studies. The experimental procedure tested here is relatively fast, economical and easy to perform and can be useful to estimate soil microzoning and seismic hazard mapping in the absence of local earthquake records

Specialized genetic algorithm of Chu-Beasley applied to the Distribution System Reconfiguration problem considering several demand scenarios

This paper describes the application of the specialized genetic algorithm of Chu-Beasley to solve the Distribution System Reconfiguration, DSR, problem considering different demand scenarios. This algorithm is an approach inspired in the natural selection and evolution of species. The reconfiguration problem of distribution networks taking into account different demand scenarios aims at identifying the most adequate radial topology of a distribution system assuming that this topology is used for all demand scenarios under study. This search is driven by the minimization of the cost of energy losses in the network along a full operation year. The performance of the algorithm is evaluated considering test systems having 33, 70, 84 and 136 buses and a real system with 417 buses. The obtained results confirm the robustness and efficiency of the developed approach and its potential to be used in distribution control centers

Biological perspectives and current biofabrication strategies in osteochondral tissue engineering

From Springer Nature via Jisc Publications RouterHistory: received 2019-09-26, accepted 2020-06-29, registration 2020-06-29, pub-electronic 2020-07-09, online 2020-07-09, pub-print 2020-12Publication status: PublishedFunder: Engineering and Physical Sciences Research Council; doi: http://dx.doi.org/10.13039/501100000266; Grant(s): EP/L014904/1Funder: Fundação para a Ciência e a Tecnologia; doi: http://dx.doi.org/10.13039/501100001871; Grant(s): PTDC/MEC-GIN/29232/2017, 0245_IBEROS_1_EAbstract: Articular cartilage and the underlying subchondral bone are crucial in human movement and when damaged through disease or trauma impacts severely on quality of life. Cartilage has a limited regenerative capacity due to its avascular composition and current therapeutic interventions have limited efficacy. With a rapidly ageing population globally, the numbers of patients requiring therapy for osteochondral disorders is rising, leading to increasing pressures on healthcare systems. Research into novel therapies using tissue engineering has become a priority. However, rational design of biomimetic and clinically effective tissue constructs requires basic understanding of osteochondral biological composition, structure, and mechanical properties. Furthermore, consideration of material design, scaffold architecture, and biofabrication strategies, is needed to assist in the development of tissue engineering therapies enabling successful translation into the clinical arena. This review provides a starting point for any researcher investigating tissue engineering for osteochondral applications. An overview of biological properties of osteochondral tissue, current clinical practices, the role of tissue engineering and biofabrication, and key challenges associated with new treatments is provided. Developing precisely engineered tissue constructs with mechanical and phenotypic stability is the goal. Future work should focus on multi-stimulatory environments, long-term studies to determine phenotypic alterations and tissue formation, and the development of novel bioreactor systems that can more accurately resemble the in vivo environment

A Mouse to Human Search for Plasma Proteome Changes Associated with Pancreatic Tumor Development

Background: The complexity and heterogeneity of the human plasma proteome have presented significant challenges in the identification of protein changes associated with tumor development. Refined genetically engineered mouse (GEM) models of human cancer have been shown to faithfully recapitulate the molecular, biological, and clinical features of human disease. Here, we sought to exploit the merits of a well-characterized GEM model of pancreatic cancer to determine whether proteomics technologies allow identification of protein changes associated with tumor development and whether such changes are relevant to human pancreatic cancer. Methods and Findings: Plasma was sampled from mice at early and advanced stages of tumor development and from matched controls. Using a proteomic approach based on extensive protein fractionation, we confidently identified 1,442 proteins that were distributed across seven orders of magnitude of abundance in plasma. Analysis of proteins chosen on the basis of increased levels in plasma from tumor-bearing mice and corroborating protein or RNA expression in tissue documented concordance in the blood from 30 newly diagnosed patients with pancreatic cancer relative to 30 control specimens. A panel of five proteins selected on the basis of their increased level at an early stage of tumor development in the mouse was tested in a blinded study in 26 humans from the CARET (Carotene and Retinol Efficacy Trial) cohort. The panel discriminated pancreatic cancer cases from matched controls in blood specimens obtained between 7 and 13 mo prior to the development of symptoms and clinical diagnosis of pancreatic cancer. Conclusions: Our findings indicate that GEM models of cancer, in combination with in-depth proteomic analysis, provide a useful strategy to identify candidate markers applicable to human cancer with potential utility for early detection

Global perspectives on observing ocean boundary current systems

© The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Todd, R. E., Chavez, F. P., Clayton, S., Cravatte, S., Goes, M., Greco, M., Ling, X., Sprintall, J., Zilberman, N., V., Archer, M., Aristegui, J., Balmaseda, M., Bane, J. M., Baringer, M. O., Barth, J. A., Beal, L. M., Brandt, P., Calil, P. H. R., Campos, E., Centurioni, L. R., Chidichimo, M. P., Cirano, M., Cronin, M. F., Curchitser, E. N., Davis, R. E., Dengler, M., deYoung, B., Dong, S., Escribano, R., Fassbender, A. J., Fawcett, S. E., Feng, M., Goni, G. J., Gray, A. R., Gutierrez, D., Hebert, D., Hummels, R., Ito, S., Krug, M., Lacan, F., Laurindo, L., Lazar, A., Lee, C. M., Lengaigne, M., Levine, N. M., Middleton, J., Montes, I., Muglia, M., Nagai, T., Palevsky, H., I., Palter, J. B., Phillips, H. E., Piola, A., Plueddemann, A. J., Qiu, B., Rodrigues, R. R., Roughan, M., Rudnick, D. L., Rykaczewski, R. R., Saraceno, M., Seim, H., Sen Gupta, A., Shannon, L., Sloyan, B. M., Sutton, A. J., Thompson, L., van der Plas, A. K., Volkov, D., Wilkin, J., Zhang, D., & Zhang, L. Global perspectives on observing ocean boundary current systems. Frontiers in Marine Science, 6, (2010); 423, doi: 10.3389/fmars.2019.00423.Ocean boundary current systems are key components of the climate system, are home to highly productive ecosystems, and have numerous societal impacts. Establishment of a global network of boundary current observing systems is a critical part of ongoing development of the Global Ocean Observing System. The characteristics of boundary current systems are reviewed, focusing on scientific and societal motivations for sustained observing. Techniques currently used to observe boundary current systems are reviewed, followed by a census of the current state of boundary current observing systems globally. The next steps in the development of boundary current observing systems are considered, leading to several specific recommendations.RT was supported by The Andrew W. Mellon Foundation Endowed Fund for Innovative Research at WHOI. FC was supported by the David and Lucile Packard Foundation. MGo was funded by NSF and NOAA/AOML. XL was funded by China’s National Key Research and Development Projects (2016YFA0601803), the National Natural Science Foundation of China (41490641, 41521091, and U1606402), and the Qingdao National Laboratory for Marine Science and Technology (2017ASKJ01). JS was supported by NOAA’s Global Ocean Monitoring and Observing Program (Award NA15OAR4320071). DZ was partially funded by the Joint Institute for the Study of the Atmosphere and Ocean (JISAO) under NOAA Cooperative Agreement NA15OAR4320063. BS was supported by IMOS and CSIRO’s Decadal Climate Forecasting Project. We gratefully acknowledge the wide range of funding sources from many nations that have enabled the observations and analyses reviewed here