Geotechnical foundation conditions of Mesologion swimming pool center

Η επιλογή του καταλληλότερου τύπου θεμελίωσης εμπεριέχει την εξέταση ποικίλλων παραμέτρων. Στην περίπτωση του Κολυμβητηρίου Μεσολογγίου, έγινε μια προσπάθεια πρότασης ενός τύπου θεμελίωσης, κατάλληλου από γεωτεχνικής πλευράς, για ιζήματα που βρίσκονται πολύ κοντά στη θάλασσα. Το υπέδαφος εκεί, αποτελείται από μαλακά, λεπτόκοκκα, χαμηλής πλαστικότητας υλικά, CL μέχρι SL, με εναλλαγές υψηλής πλαστικότητας αργιλικών στρωμάτων CH. Επιπρόσθετα η στάθμη του υπόγειου υδροφόρου εντοπίζεται στα 0,8 μέτρα κάτω από την επιφάνεια του εδάφους. Ή δυσκολία εξασφάλισης αδιατάραχτων δειγμάτων λόγω κατάστασης υλικού, μας ανάγκασε να στηριχτούμε για τους υπολογισμούς των παραμέτρων στα αποτελέσματα των επί τόπου δοκιμών. Σκοπός της εργασίας αυτής είναι να παρουσιάσει τα υλικά των ιζημάτων, τις εδαφοτεχνικές τους παραμέτρους, τη μεθοδολογία, τους υπολογισμούς και την πρόταση θεμελίωσης για κολυμβητήριο Μεσολογγίου.Although geotechnical tests are standard and commonly used in determining the foundation type to be applied, in some cases the use ofin-situ tests are essential in order to obtain the correct values needed in the geotechnical calculations. In the case of the foundation of Mesologi Swimming-pool Center, an attempt was made to propose a foundation type, suitable from geotechnical point of view, for sediments that lie very close to the sea! The selection of the most suitable foundation type encloses the examination of several parameters. The subsoil there, consists of soft, fine grained, low plasticity materials, CL to SL with alternations of high plasticity clay layers CH. Additionally, the groundwater level is 0,8 meters under the soil surface, demonstrating constant saturation conditions. The combination of soft subsoil layers quality and the high level of groundwater leads to difficult foundation conditions in relation to immediate and secondary consolidation settlement. Geotechnical calculations and calculations of settlement were performed and the most suitable foundation type was semi-compensated mat foundation

THE OLVIOS, RETHIS AND INACHOS DRAINAGE SYSTEM EVOLUTION AND HUMAN ACTIVITIES INFLUNCE OF THEIR FUTURE EVOLUTION

Olvios, Rethis and Inachos Rivers are multistory drainage systems that occur in Northern Peloponnesus, and at the present day they have and a reversed, North to South, flow element. Dervenios, Skoupeikos and Fonissa Rivers are the misfit streams of Olvios and revealed as juvenile streams and discharge to the Corinth gulf. Agiorgitikos River is the misfit stream of Rethis River and Seliandros River is the juvenile stream. Asopos, Nemeas and Rachiani Rives are the misfit streams of Inachos River and they also discharge to the Corinth gulf. Asopos River characterized as re-established stream. Physical factors such as tectonic regime (active and inactive faults), lithology, erosion and distance from the source influenced the three drainage systems evolution and could be influence them also in the future. The increase of human activities both in their southern parts and in the distal parts close to the coast could be change the physical evolution of the studied drainages, producing a new wind gap in the coastal area and a lake or a lagoon backwards of the coastal area, destroying villages and towns

Investigating the entire course of telithromycin binding to Escherichia coli ribosomes

Applying kinetics and footprinting analysis, we show that telithromycin, a ketolide antibiotic, binds to Escherichia coli ribosomes in a two-step process. During the first, rapidly equilibrated step, telithromycin binds to a low-affinity site (KT = 500 nM), in which the lactone ring is positioned at the upper portion of the peptide exit tunnel, while the alkyl–aryl side chain of the drug inserts a groove formed by nucleotides A789 and U790 of 23S rRNA. During the second step, telithromycin shifts slowly to a high-affinity site (KT* = 8.33 nM), in which the lactone ring remains essentially at the same position, while the side chain interacts with the base pair U2609:A752 and the extended loop of protein L22. Consistently, mutations perturbing either the base pair U2609:A752 or the L22-loop hinder shifting of telithromycin to the final position, without affecting the initial step of binding. In contrast, mutation Lys63Glu in protein L4 placed on the opposite side of the tunnel, exerts only a minor effect on telithromycin binding. Polyamines disfavor both sequential steps of binding. Our data correlate well with recent crystallographic data and rationalize the changes in the accessibility of ribosomes to telithromycin in response to ribosomal mutations and ionic changes

Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI).

AIM: Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this double-blind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS: A total of 229 patients presenting with acute STEMI were randomized to receive either an i.v. infusion of 70 μmol sodium nitrite (n = 118) or matching placebo (n = 111) over 5 min immediately before primary percutaneous intervention (PPCI). Patients underwent cardiac magnetic resonance imaging (CMR) at 6-8 days and at 6 months and serial blood sampling was performed over 72 h for the measurement of plasma creatine kinase (CK) and Troponin I. Myocardial infarct size (extent of late gadolinium enhancement at 6-8 days by CMR-the primary endpoint) did not differ between nitrite and placebo groups after adjustment for area at risk, diabetes status, and centre (effect size -0.7% 95% CI: -2.2%, +0.7%; P = 0.34). There were no significant differences in any of the secondary endpoints, including plasma troponin I and CK area under the curve, left ventricular volumes (LV), and ejection fraction (EF) measured at 6-8 days and at 6 months and final infarct size (FIS) measured at 6 months. CONCLUSIONS: Sodium nitrite administered intravenously immediately prior to reperfusion in patients with acute STEMI does not reduce infarct size

Synthesis and Study of Fully Biodegradable Composites Based on Poly(butylene succinate) and Biochar

Biodegradable polymers offer a promising alternative to the global plastic problems and especially in the last decade, to the microplastics problems. For the first time, samples of poly(butylene succinate) (PBSu) biocomposites containing 1, 2.5, and 5 wt% biochar (BC) were prepared by in situ polymerization via the two-stage melt polycondensation procedure. BC was used as a filler for the PBSu to improve its mechanical properties, thermal transitions, and biodegradability. The structure of the synthesized polymers was examined by 1H and 13C nuclear magnetic resonance (NMR) and X-Ray diffraction (XRD) along with an estimation of the molecular weights, while differential scanning calorimetry (DSC) and light flash analysis (LFA) were also employed to record the thermal transitions and evaluate the thermal conductivity, respectively. It was found that the amount of BC does not affect the molecular weight of PBSu biocomposites. The fine dispersion of BC, as well as the increase in BC content in the polymeric matrix, significantly improves the tensile and impact strengths. The DSC analysis results showed that BC facilitates the crystallization of PBSu biocomposites. Due to the latter, a mild and systematic increase in thermal diffusivity and conductivity was recorded indicating that BC is a conductive material. The molecular mobility of PBSu, local and segmental, does not change significantly in the biocomposites, whereas the BC seems to cause an increase in the overall dielectric permittivity. Finally, it was found that the enzymatic hydrolysis degradation rate of biocomposites increased with the increasing BC content

Perceived exertion influences pacing among ultramarathon runners but post-race mood change is associated with performance expectancy

Objectives. This study investigated whether post-race mood changes among ultramarathon runners are associated with perceived exertion or the discrepancy between their actual and predicted performance times.Methods. Eight runners completed the Puffer ultramarathon, which is a challenging 73 km mountainous race across Table Mountain National Park in South Africa. Each runner completed a series of profile of mood state questionnaires (POMS) 2 days before the race (baseline), on the morning of the race (pre-race) and immediately after the race (post-race). Ratings of perceived exertion (RPE) were measured at 13 points during the race using the Borg 6-20 scale. The accuracy of performance expectationswas measured as the difference between runners’ actual and predicted race times.Results. Average completion time was 11:31:36±00:26:32 (h :mm:ss), average running speed was 6.4±2.2 km.hr-1 and averageRPE was 14.1±2.0. Increased POMS confusion was found before the race (33.30.7 v. 37.1±5.2, p=0.014; baseline v. pre-race). Post-race increases in POMS total mood disturbance (TMD) were found (168.3±20 v. 137.5±6.3, p=0.001; post race v. baseline) characterised by decreased vigour (43.3±4.0 v. 33.5±7.0, p=0.008; baseline v. post race), increased confusion (33.3±0.7 v. 38.5±4.8, p=0.006; baseline v. post race) and increased fatigue (37.8±4.8 v. 53.8±7.3, p=0.0003; baseline v. post race). A linear increase in RPE was found during the race (r=0.737, p=0.002).The magnitude of their post-race mood change (r=-0.704, p=0.026) was not found to be associated with runners’ average RPE but was found to be negatively correlated with accuracy of the performance predictions. A time series analysis indicated that POMS TMD would have taken 142±89 min to recover. Conclusions. The results show that RPE influences the wayultramarathon runners pace themselves more than performance expectancy but performance expectations have a greater influence on post-race mood. The magnitude of post-race mood change is associated with the extent of discrepancy between runners’ predicted and actual performance. This has implications for designing appropriate goals and pacing strategies for ultraendurance athletes.

Novel 3-nitrotriazole-based amides and carbinols as bifunctional anti-Chagasic agents.

3-Nitro-1H-1,2,4-triazole-based amides with a linear, rigid core and 3-nitrotriazole-based fluconazole analogs were synthesized as dual functioning antitrypanosomal agents. Such compounds are excellent substrates for type I nitroreductase (NTR) located in the mitochondrion of trypanosomatids and, at the same time, act as inhibitors of the sterol 14α-demethylase (T. cruzi CYP51) enzyme. Because combination treatments against parasites are often superior to monotherapy, we believe that this emerging class of bifunctional compounds may introduce a new generation of antitrypanosomal drugs. In the present work, the synthesis and in vitro and in vivo evaluation of such compounds is discussed.This work was supported in part by internal funds of the Radiation Medicine Department at NorthShore University HealthSystem. Experiments on T. cruzi CYP51 were funded by NIH (GM067871, to G.I.L.). In vitro screenings against parasites were funded by DNDi. For that project, DNDi received funding from the following donors: Department for Internationl Development (DFID), U.K.; Bill & Melinda Gates Foundation (BMGF), USA; Reconstruction Credit Institution-Federal Ministry of Education and Research (KfW-BMBF), Germany; and Directorate-General for International Cooperation (DGIS), The Netherlands. B.A.-V. acknowledges financial support by FONDECYT Postdoctorado 3130364