Vacaciones y permisos en el ámbito del empleo público

Este trabajo tiene por objeto analizar la regulación existente a efectos de vacaciones y otros permisos en el ámbito del empleo público en España. En este caso nos remontaremos a los inicios de la regulación de los permisos y las vacaciones de los que disfrutaban los trabajadores y como han ido evolucionando estos derechos. Podremos observar cómo se han ido ampliando en la mayoría de los casos, y sobre todo, como han ido desarrollando su regulación para no dar lugar a confusión y a disputa. En definitiva, este trabajo intentará explicar cómo se han llegado a conseguir los derechos individuales de las vacaciones y permisos para los empleados públicos y que diferencias existen entre los derechos que poseen los distintos tipos de trabajadores como los funcionarios de carrera, funcionarios interinos, el personal laboral y el personal eventual…si es que las hubiese.Grado en Relaciones Laborales y Recursos Humano

Melon Genome Regions Associated with TGR-1551-Derived Resistance to Cucurbit yellow stunting disorder virus

[EN] Cucurbit yellow stunting disorder virus(CYSDV) is one of the main limiting factors of melon cultivation worldwide. To date, no commercial melon cultivars resistant to CYSDV are available. The African accession TGR-1551 is resistant to CYSDV. Two major quantitative trait loci (QTLs) have been previously reported, both located near each other in chromosome 5. With the objective of further mapping the gene or genes responsible of the resistance, a recombinant inbred line (RIL) population derived from the cross between TGR-1551 and the susceptible cultivar 'Bola de Oro' was evaluated for resistance to CYSDV in five different assays and genotyped in a genotyping by sequencing (GBS) analysis. The major effect of one of the two QTLs located on chromosome 5 was confirmed in the multienvironment RIL assay and additionally verified through the analysis of three segregating BC(1)S(1)populations derived from three resistant RILs. Furthermore, progeny test using the offspring of selected BC(3)plants allowed the narrowing of the candidate interval to a 700 kb region. The SNP markers identified in this work will be useful in marker-assisted selection in the context of introgression of CYSDV resistance in elite cultivars.This research was funded by the Spanish Ministerio de Ciencia, Innovacion y Universidades, grant number AGL2017-85563-C2 (1-R and 2-R), and by the Conselleria d'Educacio, Investigacio, Cultura i Esports de la Generalitat Valenciana, grant number PROMETEO/2017/078 (to promote excellence groups, cofinanced with FEDER funds). M.L. is a recipient of a predoctoral fellowship (PRE2018-083466) of the Spanish Ministerio de Ciencia, Innovacion y Universidades.Pérez De Castro, AM.; López-Martín, M.; Esteras Gómez, C.; Garcés-Claver, A.; Palomares-Ríus, FJ.; Picó Sirvent, MB.; Gómez-Guillamón, ML. (2020). Melon Genome Regions Associated with TGR-1551-Derived Resistance to Cucurbit yellow stunting disorder virus. International Journal of Molecular Sciences. 21(17):1-17. https://doi.org/10.3390/ijms21175970S1172117Martelli, G. P., Agranovsky, A. A., Bar-Joseph, M., Boscia, D., Candresse, T., Coutts, R. H. A., … Yoshikawa, N. (2002). The family Closteroviridae revised. Archives of Virology, 147(10), 2039-2044. doi:10.1007/s007050200048Hassan, A., & Duffus, J. (1990). A review of a yellowing and stunting disorder of Cucurbits in the United Arab Emirates. Emirates Journal of Food and Agriculture, 2(1), 1. doi:10.9755/ejfa.v2i1.4989Wisler, G. C., Duffus, J. E., Liu, H.-Y., & Li, R. H. (1998). Ecology and Epidemiology of Whitefly-Transmitted Closteroviruses. Plant Disease, 82(3), 270-280. doi:10.1094/pdis.1998.82.3.270Desbiez, C., Lecoq, H., Aboulama, S., & Peterschmitt, M. (2000). First Report of Cucurbit yellow stunting disorder virus in Morocco. Plant Disease, 84(5), 596-596. doi:10.1094/pdis.2000.84.5.596cLouro, D., Vicente, M., Vaira, A. M., Accotto, G. P., & Nolasco, G. (2000). Cucurbit yellow stunting disorder virus (Genus Crinivirus) Associated with the Yellowing Disease of Cucurbit Crops in Portugal. Plant Disease, 84(10), 1156-1156. doi:10.1094/pdis.2000.84.10.1156aKao, J., Jia, L., Tian, T., Rubio, L., & Falk, B. W. (2000). First Report of Cucurbit Yellow Stunting Disorder Virus (Genus Crinivirus) in North America. Plant Disease, 84(1), 101-101. doi:10.1094/pdis.2000.84.1.101cBrown, J. K., Guerrero, J. C., Matheron, M., Olsen, M., & Idris, A. M. (2007). Widespread Outbreak of Cucurbit yellow stunting disorder virus in Melon, Squash, and Watermelon Crops in the Sonoran Desert of Arizona and Sonora, Mexico. Plant Disease, 91(6), 773-773. doi:10.1094/pdis-91-6-0773aKuo, Y.-W., Rojas, M. R., Gilbertson, R. L., & Wintermantel, W. M. (2007). First Report of Cucurbit yellow stunting disorder virus in California and Arizona, in Association with Cucurbit leaf crumple virus and Squash leaf curl virus. Plant Disease, 91(3), 330-330. doi:10.1094/pdis-91-3-0330bPolston, J. E., Hladky, L. L., Akad, F., & Wintermantel, W. M. (2008). First Report of Cucurbit yellow stunting disorder virus in Cucurbits in Florida. Plant Disease, 92(8), 1251-1251. doi:10.1094/pdis-92-8-1251bLiu, L. Z., Chen, Y. Y., & Zhu, W. M. (2010). First Report of Cucurbit yellow stunting disorder virus on Melon in China. Plant Disease, 94(4), 485-485. doi:10.1094/pdis-94-4-0485aTzanetakis, I. E., Martin, R. R., & Wintermantel, W. M. (2013). Epidemiology of criniviruses: an emerging problem in world agriculture. Frontiers in Microbiology, 4. doi:10.3389/fmicb.2013.00119Wintermantel, W. M., Gilbertson, R. L., Natwick, E. T., & McCreight, J. D. (2017). Emergence and epidemiology of Cucurbit yellow stunting disorder virus in the American Desert Southwest, and development of host plant resistance in melon. Virus Research, 241, 213-219. doi:10.1016/j.virusres.2017.06.004Wintermantel, W. M., Hladky, L. L., Cortez, A. A., & Natwick, E. T. (2009). A New Expanded Host Range of Cucurbit yellow stunting disorder virus Includes Three Agricultural Crops. Plant Disease, 93(7), 685-690. doi:10.1094/pdis-93-7-0685López-Sesé, A. I., & Gómez-Guillamón, M. L. (2000). Resistance to Cucurbit Yellowing Stunting Disorder Virus (CYSDV) in Cucumis melo L. HortScience, 35(1), 110-113. doi:10.21273/hortsci.35.1.110Lapidot, M., Legg, J. P., Wintermantel, W. M., & Polston, J. E. (2014). Management of Whitefly-Transmitted Viruses in Open-Field Production Systems. Advances in Virus Research, 147-206. doi:10.1016/b978-0-12-801246-8.00003-2McCreight, J. D., & Wintermantel, W. M. (2011). Genetic Resistance in Melon PI 313970 to Cucurbit yellow stunting disorder virus. HortScience, 46(12), 1582-1587. doi:10.21273/hortsci.46.12.1582Soria, C., López-Sesé, A. I., & Gómez-Guillamón, M. L. (1999). Resistance ofCucumis meloAgainstBemisia tabaci(Homoptera: Aleyrodidae). Environmental Entomology, 28(5), 831-835. doi:10.1093/ee/28.5.831Marco, C. F., Aguilar, J. M., Abad, J., Gómez-Guillamón, M. L., & Aranda, M. A. (2003). Melon Resistance to Cucurbit yellow stunting disorder virus Is Characterized by Reduced Virus Accumulation. Phytopathology®, 93(7), 844-852. doi:10.1094/phyto.2003.93.7.844Park, S. O., Crosby, K. M., & Mirkov, T. E. (2007). DETECTION OF LOCI FOR CUCURBIT YELLOW STUNTING DISORDER VIRUS RESISTANCE IN CUCUMIS MELO L. Acta Horticulturae, (763), 207-214. doi:10.17660/actahortic.2007.763.27Abrahamian, P. E., & Abou-Jawdah, Y. (2013). Whitefly-transmitted criniviruses of cucurbits: current status and future prospects. VirusDisease, 25(1), 26-38. doi:10.1007/s13337-013-0173-9Gil-Salas, F. M., Morris, J., Colyer, A., Budge, G., Boonham, N., Cuadrado, I. M., & Janssen, D. (2007). Development of real-time RT-PCR assays for the detection of Cucumber vein yellowing virus (CVYV) and Cucurbit yellow stunting disorder virus (CYSDV) in the whitefly vector Bemisia tabaci. Journal of Virological Methods, 146(1-2), 45-51. doi:10.1016/j.jviromet.2007.05.032Palomares-Rius, F. J., Garcés-Claver, A., Picó, M. B., Esteras, C., Yuste-Lisbona, F. J., & Gómez-Guillamón, M. L. (2018). ‘Carmen’, a Yellow Canary Melon Breeding Line Resistant to Podosphaera xanthii, Aphis gossypii, and Cucurbit Yellow Stunting Disorder Virus. HortScience, 53(7), 1072-1075. doi:10.21273/hortsci13013-18Pallas, V., & García, J. A. (2011). How do plant viruses induce disease? Interactions and interference with host components. Journal of General Virology, 92(12), 2691-2705. doi:10.1099/vir.0.034603-0Sáez, C., Esteras, C., Martínez, C., Ferriol, M., Dhillon, N. P. S., López, C., & Picó, B. (2017). Resistance to tomato leaf curl New Delhi virus in melon is controlled by a major QTL located in chromosome 11. Plant Cell Reports, 36(10), 1571-1584. doi:10.1007/s00299-017-2175-3Díaz-Pendón, J. A., Fernández-Muñoz, R., Gómez-Guillamón, M. L., & Moriones, E. (2005). Inheritance of Resistance to Watermelon mosaic virus in Cucumis melo that Impairs Virus Accumulation, Symptom Expression, and Aphid Transmission. Phytopathology®, 95(7), 840-846. doi:10.1094/phyto-95-0840Wintermantel, W. M., Gilbertson, R. L., McCreight, J. D., & Natwick, E. T. (2016). Host-Specific Relationship Between Virus Titer and Whitefly Transmission of Cucurbit yellow stunting disorder virus. Plant Disease, 100(1), 92-98. doi:10.1094/pdis-11-14-1119-reMaule, A. J., Escaler, M., & Aranda, M. A. (2000). Programmed responses to virus replication in plants. Molecular Plant Pathology, 1(1), 9-15. doi:10.1046/j.1364-3703.2000.00002.xPérez-de-Castro, A., Esteras, C., Alfaro-Fernández, A., Daròs, J.-A., Monforte, A. J., Picó, B., & Gómez-Guillamón, M. L. (2019). Fine mapping of wmv1551, a resistance gene to Watermelon mosaic virus in melon. Molecular Breeding, 39(7). doi:10.1007/s11032-019-0998-zGonzález, V. M., Aventín, N., Centeno, E., & Puigdomènech, P. (2013). High presence/absence gene variability in defense-related gene clusters of Cucumis melo. BMC Genomics, 14(1). doi:10.1186/1471-2164-14-782Villada, E. S., Gonzalez, E. G., Lopez-Sese, A. I., Castiel, A. F., & Gomez-Guillamon, M. L. (2009). Hypersensitive response to Aphis gossypii Glover in melon genotypes carrying the Vat gene. Journal of Experimental Botany, 60(11), 3269-3277. doi:10.1093/jxb/erp163Yuste-Lisbona, F. J., Capel, C., Gómez-Guillamón, M. L., Capel, J., López-Sesé, A. I., & Lozano, R. (2011). Codominant PCR-based markers and candidate genes for powdery mildew resistance in melon (Cucumis melo L.). Theoretical and Applied Genetics, 122(4), 747-758. doi:10.1007/s00122-010-1483-6González, V. M., Aventín, N., Centeno, E., & Puigdomènech, P. (2014). Interspecific and intraspecific gene variability in a 1-Mb region containing the highest density of NBS-LRR genes found in the melon genome. BMC Genomics, 15(1). doi:10.1186/1471-2164-15-1131Esteras, C., Formisano, G., Roig, C., Díaz, A., Blanca, J., Garcia-Mas, J., … Picó, B. (2013). SNP genotyping in melons: genetic variation, population structure, and linkage disequilibrium. Theoretical and Applied Genetics, 126(5), 1285-1303. doi:10.1007/s00122-013-2053-5Zeng, Z. B. (1994). Precision mapping of quantitative trait loci. Genetics, 136(4), 1457-1468. doi:10.1093/genetics/136.4.1457Joehanes, R., & Nelson, J. C. (2008). QGene 4.0, an extensible Java QTL-analysis platform. Bioinformatics, 24(23), 2788-2789. doi:10.1093/bioinformatics/btn52

Doñana, diversidad y ciencia

144 páginasLa biodiversidad es más que la suma de los elementos que componen el mundo vivo; también son biodiversidad las relaciones entre esos elementos, los procesos ecológicos que hacen posible su existencia y los procesos evolutivos que los han originado. […] Los seres humanos necesitamos a la biodiversidad más que ella a nosotros, ya que es la responsable de que la Tierra funcione de una manera satisfactoria. […] El entramado de la vida se ocupa de regular la composición de la atmósfera (y con ella, el clima), de depurar el aire y el agua, de hacer fértil al suelo, de evitar riadas y avalanchas, de polinizar las cosechas, de reducir las plagas, etc. Por todo ello es indispensable conservar la biodiversidad, hoy amenazada.” (Miguel Delibes) Doñana, diversidad y ciencia es un paseo conceptual por el espacio natural más emblemático de Europa. La esencia de un mito a través de decenas de fotografías… Un acercamiento respetuoso a la diversidad de sus conceptos, un paseo por la esencia de su historia y una curiosa aproximación a la ciencia que genera hoy en día. En este recorrido descubriremos el carácter distintivo de algunos de los parajes de la reserva, sus matices más interesantes, las texturas y las formas más sorprendentes de la naturaleza, sus colores y conjuntos, sus transformaciones en las últimas décadas y la influencia de la presencia humana en el privilegiado ecosistema de la Reserva Biológica de Doñana

New strategies for writing Degree Dissertations in English: pair-tutoring and teaching mini-videos

La redacción de textos académicos en inglés está íntimamente relacionada con la competencia lingüística que el alumnado universitario ha de desarrollar (B1 como requisito lingüístico mínimo previo a su graduación) y que, de manera lógica, está encadenada a la mejora de su empleabilidad (tanto a niveles nacionales como internacionales), de sus competencias comunicativas en segunda lengua y, por supuesto, la posibilidad de que los resultados de su trabajo académico trasciendan fronteras. El proyecto que aquí se presenta surge como evolución de un proyecto de innovación docente anterior, aprobado e implementado en la UCO (“La tutoría piramidal como estrategia para el diseño y desarrollo del trabajo final de grado en educación”, 2015-2-6011), y cuyo resultado ha permitido identificar la necesidad que con esta propuesta pretendemos cubrir. El objetivo final de este proyecto es enseñar al alumnado universitario a redactar sus TFG en inglés, al tiempo que el profesorado también participa en los seminarios, en los que se abordan también técnicas que faciliten la corrección de estos trabajos que se redactan en una lengua no materna o principal. La metodología se basa en seminarios participativos, así como en la elaboración de recursos, en los que alumnado (tutores y tutorizados) y profesorado (tutores y tutorizados) colaborarán para la consecución final del objetivo: la redacción y corrección de TFG, principalmente en lengua inglesa. Entre estos recursos, destacamos el diseño y la elaboración de minivídeos docentes modulares con la participación del profesorado implicado en el proyecto, así como del alumnado mentor, para explicar los aspectos clave de la elaboración de un TFG.Writing academic texts in English is closely related to the linguistic competence that university students need to develop (B1 level as a minimum linguistic requirement prior to their graduation). This competence entails an improvement of their future employability (both at the national and international levels), their communicative competences in a second language (L2), and obviously also the possibility that the results derived from their academic projects spill across national boundaries. This innovation project arises as the evolution of a previous innovation strategy, approved and implemented at the University of Córdoba (“La tutoría piramidal como estrategia para el diseño y desarrollo del trabajo final de grado en educación”, 2015-2-6011), whose results allowed the identification of the weaknesses that we aim to focus on during the development of this project. The final objective is to teach university students how to write their end-of-degree dissertations in English. At the same time teachers of the UCO also participate in a series of seminars to know different techniques about how to review these projects that are written in a language different from their mother tongue or main language. The methodology of this project is based on participative seminars, as well as on the development of resources, where students (mentors and mentees) and teachers (mentors and mentees) collaborate towards a common objective: writing and reviewing end-of-degree dissertations, mainly written in English. Among these resources, it can be highlighted the design and elaboration of teaching mini-videos, with the participation of the teachers involved in the project, as well as the mentor students, in order to explain the key aspects to be considered when writing an end-of-degree dissertation

Long-Term Real-World Effectiveness and Safety of Ustekinumab in Crohn’s Disease Patients: The SUSTAIN Study

Background Large real-world-evidence studies are required to confirm the durability of response, effectiveness, and safety of ustekinumab in Crohn’s disease (CD) patients in real-world clinical practice. Methods A retrospective, multicentre study was conducted in Spain in patients with active CD who had received ≥1 intravenous dose of ustekinumab for ≥6 months. Primary outcome was ustekinumab retention rate; secondary outcomes were to identify predictive factors for drug retention, short-term remission (week 16), loss of response and predictive factors for short-term efficacy and loss of response, and ustekinumab safety. Results A total of 463 patients were included. Mean baseline Harvey-Bradshaw Index was 8.4. A total of 447 (96.5%) patients had received prior biologic therapy, 141 (30.5%) of whom had received ≥3 agents. In addition, 35.2% received concomitant immunosuppressants, and 47.1% had ≥1 abdominal surgery. At week 16, 56% had remission, 70% had response, and 26.1% required dose escalation or intensification; of these, 24.8% did not subsequently reduce dose. After a median follow-up of 15 months, 356 (77%) patients continued treatment. The incidence rate of ustekinumab discontinuation was 18% per patient-year of follow-up. Previous intestinal surgery and concomitant steroid treatment were associated with higher risk of ustekinumab discontinuation, while a maintenance schedule every 12 weeks had a lower risk; neither concomitant immunosuppressants nor the number of previous biologics were associated with ustekinumab discontinuation risk. Fifty adverse events were reported in 39 (8.4%) patients; 4 of them were severe (2 infections, 1 malignancy, and 1 fever). Conclusions Ustekinumab is effective and safe as short- and long-term treatment in a refractory cohort of CD patients in real-world clinical practice

Using Interpretable Machine Learning to Identify Baseline Predictive Factors of Remission and Drug Durability in Crohn’s Disease Patients on Ustekinumab

Ustekinumab has shown efficacy in Crohn's Disease (CD) patients. To identify patient profiles of those who benefit the most from this treatment would help to position this drug in the therapeutic paradigm of CD and generate hypotheses for future trials. The objective of this analysis was to determine whether baseline patient characteristics are predictive of remission and the drug durability of ustekinumab, and whether its positioning with respect to prior use of biologics has a significant effect after correcting for disease severity and phenotype at baseline using interpretable machine learning. Patients' data from SUSTAIN, a retrospective multicenter single-arm cohort study, were used. Disease phenotype, baseline laboratory data, and prior treatment characteristics were documented. Clinical remission was defined as the Harvey Bradshaw Index <= 4 and was tracked longitudinally. Drug durability was defined as the time until a patient discontinued treatment. A total of 439 participants from 60 centers were included and a total of 20 baseline covariates considered. Less exposure to previous biologics had a positive effect on remission, even after controlling for baseline disease severity using a non-linear, additive, multivariable model. Additionally, age, body mass index, and fecal calprotectin at baseline were found to be statistically significant as independent negative risk factors for both remission and drug survival, with further risk factors identified for remission

Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.info:eu-repo/semantics/publishedVersio

Miradas y voces de la Investigación Educativa II : Curriculum y Diversidad. Innovación educativa con miras a la justicia social. Aportes desde la investigación educativa

Fil: Ferreyra, Horacio Ademar. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Sañudo Guerra, Lya. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Civarolo, María Mercedes.Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Pérez Moreno, Elena Silvia. Universidad Católica de Córdoba. Facultad de Educación; Argentin

Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain : Large-Scale Epidemiological Study

(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD-Crohn's disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)-during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31-56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery