Videoarte y tiempo

En el presente estudio se plantea dar cuenta de la relación intrínseca entre el tiempo y el arte, específicamente en el caso del videoarte. También se aborda de manera somera los principales conceptos que atañen a estos ámbitos. Asimismo analizamos las secuencias de la obra Fall (1970), de Bas Jan Ader, a partir de estos elementos

Hamiltonian analysis for new massive gravity

A detailed canonical analysis for three-dimensional massive gravity is performed. The construction of the fundamental Dirac brackets, the complete structure of the constraints and the counting of the physical degrees of freedom are reported. In addition, it is shown that the extended Hamiltonian is healed from Orstrogradki's instabilities

Influence of companion diagnostics on efficacy and safety of targeted anti-cancer drugs: systematic review and meta-analyses

This is an open-access article distributed under the terms of the Creative Commons Attribution License.-- et al.[Background]: Companion diagnostics aim to identify patients that will respond to targeted therapies, therefore increasing the clinical efficacy of such drugs. Less is known about their influence on safety and tolerability of targeted anti-cancer agents. [Methods and findings]: Randomized trials evaluating targeted agents for solid tumors approved by the US Food and Drug Administration since year 2000 were assessed. Odds ratios (OR) and and 95% confidence intervals (CI) were computed for treatment-related death, treatment-discontinuation related to toxicity and occurrence of any grade 3/4 adverse events (AEs). The 12 most commonly reported individual AEs were also explored. ORs were pooled in a meta-analysis. Analysis comprised 41 trials evaluating 28 targeted agents. Seventeen trials (41%) utilized companion diagnostics. Compared to control groups, targeted drugs in experimental arms were associated with increased odds of treatment discontinuation, grade 3/4 AEs, and toxic death irrespective of whether they utilized companion diagnostics or not. Compared to drugs without available companion diagnostics, agents with companion diagnostics had a lower magnitude of increased odds of treatment discontinuation (OR = 1.12 versus 1.65, p < 0.001) and grade 3/4 AEs (OR = 1.09 versus 2.10, p < 0.001), but no difference in risk of toxic death (OR = 1.40 versus 1.27, p = 0.69). Differences between agents with and without companion diagnostics were greatest for diarrhea (OR = 1.29 vs. 2.43, p < 0.001), vomiting (OR = 0.86 vs. 1.44, p = 0.005), cutaneous toxicity (OR = 1.82 vs. 3.88, p < 0.001) and neuropathy (OR = 0.64 vs. 1.60, p < 0.001). [Conclusions]: Targeted drugs with companion diagnostics are associated with improved safety, and tolerability. Differences were most marked for gastrointestinal, cutaneous and neurological toxicity.Ministry of Economy and Competitiveness of Spain (BFU2012-39151 and RD12/0036/0003 to AP), and the AECC (to AP). Fondo de Investigación Sanitaria (PI13/01444) and CRIS Cancer Foundation and ACEPAIN (to AO).Peer Reviewe

Cicloadiciones [3+2] asimétricas de alenos activados y 1,3- dipolos mediadas por un grupo p-tolilsulfinilo

Tesis doctoral inédita. Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Química Orgánica. Fecha de lectura: 04-07-201

Factores estratégicos en la constitución y tributación de las organizaciones sin fines de lucro en México

"El surgimiento de las Organizaciones civiles se da a partir de que algunas personas de bien decidieron agruparse para tratar de acortar la distancia entre lo que es una situación actual y la situación deseada. El papel fundamental de las organizaciones civiles es el desarrollo sostenible con la intención de desarrollar actividades sociales, comunitarias, culturales, o cualquier otra que promueva el bien común, todo esto sin perseguir fines económicos, al no aspirar a intereses económicos su trabajo se desempeña con la mejor intención del bienestar social descuidando los parámetros de legalidad que se deben aplicar para su creación así como el cumplimiento de sus obligaciones tributarias. El objetivo de esta investigación es proporcionar a las personas dedicadas a la filantropía un manual que cuente con los factores estratégicos que deben llevar a cabo, como lo son la constitución, mediante una asociación Civil el cumplimiento de las obligaciones que implica tributar en la LISR Título III con fines no lucrativos, mostrando con ello que conocer y aplicar las normas tributarias trae con sigo beneficios para trascender a través del tiempo con sus objetivos"

Applying Genetic Algorithms and RIA Technologies to the Development of Complex-VRP Tools in Real-World Distribution of Petroleum Products

Distribution problems had held a large body of research and development covering the VRP problem and its multiple characteristics, but few investigations examine it as an Information System, and far fewer as how it should be addressed from a development and implementation point of view. This paper describes the characteristics of a real information system for fuel distribution problems at country scale, joining the VRP research and development work using Genetic Algorithms, with the design of a Web based Information System. In this paper a view of traditional workflow in this area is shown, with a new approximation in which is based proposed system. Taking into account all constraint in the field, the authors have developed a VRPWeb-based solution using Genetic Algorithms with multiple web frameworks for each architecture layer, focusing on functionality and usability, in order to minimizing human error and maximizing productivity. To achieve these goals, authors have use SmartGWT as a powerful Web based RIA SPA framework with java integration, and multiple server frameworks and OSS based solutions, applied to development of a very complex VRP system for a logistics operator of petroleum products

Clay animation: animación en plastilina

Sólo visión Proyectabl

Identification of therapeutic targets in ovarian cancer through active tyrosine kinase profiling

This is an open-access article distributed under the terms of the Creative Commons Attribution License.The activation status of a set of pro-oncogenic tyrosine kinases in ovarian cancer patient samples was analyzed to define potential therapeutic targets. Frequent activation of HER family receptor tyrosine kinases, especially HER2, was observed. Studies in ovarian cancer cell lines confirmed the activation of HER2. Moreover, knockdown of HER2 caused a strong inhibition of their proliferation. Analyses of the action of agents that target HER2 indicated that the antibody drug conjugate trastuzumab-emtansine (T-DM1) caused a substantial antitumoral effect in vivo and in vitro, and potentiated the action of drugs used in the therapy of ovarian cancer. T-DM1 provoked cell cycle arrest in mitosis, and caused the appearance of aberrant mitotic spindles in cells treated with the drug. Biochemical experiments confirmed accumulation of the mitotic markers phospho-Histone H3 and phospho-BUBR1 in cells treated with the drug. Prolonged treatment of ovarian cancer cells with T-DM1 provoked the appearance of multinucleated cells which later led to cell death. Together, these data indicate that HER2 represents an important oncogene in ovarian cancer, and suggest that targeting this tyrosine kinase with T-DM1 may be therapeutically effective, especially in ovarian tumors with high content of HER2.Work supported by the Ministry of Economy and Competitiveness of Spain (BFU2012–39151), the Instituto de Salud Carlos III through the Spanish Cancer Centers Network Program (RD12/0036/0003), the scientific foundation of the AECC and the CRIS Foundation. JCM is a recipient of a Miguel Servet fellowship program. S. G-A is recipient of a doctoral contract from the MINECO. The Cancer Research Institute and the work carried out at A.P. laboratory receive support from the European Community through the regional development funding program (FEDER).Peer Reviewe

New inscriptions from Asido Caeserina

Los autores presentan tres nuevos epígrafes de la colonia Asido Caesarina, de difícil interpretación, aunque de notable singularidad, que vienen a enriquecer el ya amplio corpus epigráfico de la colonia.The authors present three new inscriptions from the colony Asido Caesarina, which are difficult to interpret, though of notable singularity. These inscriptions broaden the already wide epigraphic corpus of the colony

Antitumoral activity of the mithralog EC-8042 in triple negative breast cancer linked to cell cycle arrest in G2

This is an open-access article distributed under the terms of the Creative Commons Attribution License.Triple negative breast cancer (TNBC) is an aggressive form of breast cancer. Despite response to chemotherapy, relapses are frequent and resistance to available treatments is often observed in the metastatic setting. Therefore, identification of new therapeutic strategies is required. Here we have investigated the effect of the mithramycin analog EC-8042 (demycarosil-3D-β-D-digitoxosyl mithramycin SK) on TNBC. The drug caused a dose-dependent inhibition of proliferation of a set of TNBC cell lines in vitro, and decreased tumor growth in mice xenografted with TNBC cells. Mechanistically, EC-8042 caused an arrest in the G2 phase of the cell cycle, coincident with an increase in pCDK1 and Wee1 levels in cells treated with the drug. In addition, prolonged treatment with the drug also causes apoptosis, mainly through caspaseindependent routes. Importantly, EC-8042 synergized with drugs commonly used in the therapy of TNBC in vitro, and potentiated the antitumoral effect of docetaxel in vivo. Together, these data suggest that the mithralog EC-8042 exerts an antitumoral action on TNBC cells and reinforces the action of standard of care drugs used in the therapy of this disease. These characteristics, together with a better toxicology profile of EC-8042 with respect to mithramycin, open the possibility of its clinical evaluation.The Cancer Research Institute receives support from the European Community through the regional development funding program (FEDER), and from the Fundación Ramón Areces. Ministry of Economy and Competitiveness of Spain (BFU2009-07728 and BFU2012-39151), the Instituto de Salud Carlos III through the Spanish Cancer Centers Network Program (RD12/0036/0003) and the Scientific Foundation of the Spanish Association Against Cancer (AECC) and the CRIS Foundation to AP. JCM is a recipient of a Miguel Servet fellowship program (CP12/03073). The work carried out by A.O receives support by Instituto de Salud Carlos III; Fondo de Investigación Sanitaria (FIS), PI13/01444.Peer Reviewe