1,555 research outputs found
A kinematic study of the irregular dwarf galaxy NGC 2366 using HI and Halpha observations
Abridged. Context. The metal content of dwarf galaxies and the metal
enrichment of the intergalactic medium both suggest that mass loss from
galaxies is a significant factor for the chemical evolution history of
galaxies, in particular of dwarf galaxies. However, no clear evidence of a
blow-away in local dwarf galaxies has been found so far.
Aims. We therefore performed a detailed kinematic analysis of the neutral and
ionised gas in the nearby star-forming irregular dwarf galaxy NGC 2366 in order
to make predictions about the fate of the gas and to get a more complete
picture of this galaxy.
Methods. A deep Halpha image and Fabry-Perot interferometric data of NGC 2366
were obtained. They were complemented by HI synthesis data from the THINGS
survey. We searched for line-splitting both in Halpha and HI by performing a
Gaussian decomposition. To get an idea whether the expansion velocities are
high enough for a gas blow-away, we used the pseudo-isothermal halo model,
which gives us realistic values for the escape velocities of NGC 2366. The good
data quality also allowed us to discuss some peculiarities of the morphology
and the dynamics in NGC 2366.
Results. A large red-shifted outflow north west of the giant extragalactic
HII region with an expansion velocity of up to 50 km/s is found in Halpha, but
not in HI. Additionally, a blue-shifted component north of the giant
extragalactic HII region was detected both in Halpha and HI with an expansion
velocity of up to 30 km/s. A comparison with the escape velocities of NGC 2366
reveals that the gas does not have enough kinetic energy to leave the
gravitational potential.Comment: 15 pages, 14 figures, accepted for publication by A&
Trauma-induced coagulopathy
Acknowledgements E.E.M. and A.S. appreciate the generous support from the National Institutes of Health for their inflammation and coagulation research over the past 35 years (NIGMS: 1-6 P50 GM49222, 1-6 T32 GM08315, 1-2 U54 GM 62119, RM1 GM 131968 and NHLBI: UM1 HL120877). H.B.M. acknowledges the generous support from the National Institutes of Health (NHBLI: K99HL1518870) L.Z.K. acknowledges the generous support from the National Institutes of Health for her platelet biology research (NIGMS: K23GM130892-01). M.D.N. acknowledges the generous support by the National Institutes of Health (NIGMS: R35 GM119526 and NHLBI R01 HL141080).Peer reviewedPostprin
Plasma-based assays distinguish hyperfibrinolysis and shutdown subgroups in trauma-induced coagulopathy
BACKGROUND
Trauma patients with abnormal fibrinolysis have increased morbidity and mortality. Knowledge of mechanisms differentiating fibrinolytic phenotypes is important to optimize treatment. We hypothesized that subjects with abnormal fibrinolysis identified by whole blood viscoelastometry can also be distinguished by plasma thrombin generation, clot structure, fibrin formation, and plasmin generation measurements. METHODS
Platelet-poor plasma (PPP) from an observational cross-sectional trauma cohort with fibrinolysis shutdown (% lysis at 30 minutes [LY30] \u3c 0.9, n = 11) or hyperfibrinolysis (LY30 \u3e 3%, n = 9) defined by whole blood thromboelastography were studied. Noninjured control subjects provided comparative samples. Thrombin generation, fibrin structure and formation, and plasmin generation were measured by fluorescence, confocal microscopy, turbidity, and a fluorescence-calibrated plasmin assay, respectively, in the absence/presence of tissue factor or tissue plasminogen activator (tPA). RESULTS
Whereas spontaneous thrombin generation was not detected in PPP from control subjects, PPP from hyperfibrinolysis or shutdown patients demonstrated spontaneous thrombin generation, and the lag time was shorter in hyperfibrinolysis versus shutdown. Addition of tissue factor masked this difference but revealed increased thrombin generation in hyperfibrinolysis samples. Compared with shutdown, hyperfibrinolysis PPP formed denser fibrin networks. In the absence of tPA, the fibrin formation rate was faster in shutdown than hyperfibrinolysis, but hyperfibrinolysis clots lysed spontaneously; these differences were masked by addition of tPA. Tissue plasminogen activator–stimulated plasmin generation was similar in hyperfibrinolysis and shutdown samples. Differences in LY30, fibrin structure, and lysis correlated with pH. CONCLUSION
This exploratory study using PPP-based assays identified differences in thrombin generation, fibrin formation and structure, and lysis in hyperfibrinolysis and shutdown subgroups. These groups did not differ in their ability to promote tPA-triggered plasmin generation. The ability to characterize these activities in PPP facilitates studies to identify mechanisms that promote adverse outcomes in trauma
Reply to Bareille et al. Are Viscoelastometric Assays of Old Generation Ready for Disposal? Comment on Volod et al. Viscoelastic Hemostatic Assays: A Primer on Legacy and New Generation Devices
Stage progression and neurological symptoms in Trypanosoma brucei rhodesiense sleeping sickness: role of the CNS inflammatory response
Background: Human African trypanosomiasis progresses from an early (hemolymphatic) stage, through CNS invasion to the late (meningoencephalitic) stage. In experimental infections disease progression is associated with neuroinflammatory responses and neurological symptoms, but this concept requires evaluation in African trypanosomiasis patients, where correct diagnosis of the disease stage is of critical therapeutic importance.
Methodology/Principal Findings: This was a retrospective study on a cohort of 115 T.b.rhodesiense HAT patients recruited in Eastern Uganda. Paired plasma and CSF samples allowed the measurement of peripheral and CNS immunoglobulin and of CSF cytokine synthesis. Cytokine and immunoglobulin expression were evaluated in relation to disease duration, stage progression and neurological symptoms. Neurological symptoms were not related to stage progression (with the exception of moderate coma). Increases in CNS immunoglobulin, IL-10 and TNF-α synthesis were associated with stage progression and were mirrored by a reduction in TGF-β levels in the CSF. There were no significant associations between CNS immunoglobulin and cytokine production and neurological signs of disease with the exception of moderate coma cases. Within the study group we identified diagnostically early stage cases with no CSF pleocytosis but intrathecal immunoglobulin synthesis and diagnostically late stage cases with marginal CSF pleocytosis and no detectable trypanosomes in the CSF.
Conclusions: Our results demonstrate that there is not a direct linkage between stage progression, neurological signs of infection and neuroinflammatory responses in rhodesiense HAT. Neurological signs are observed in both early and late stages, and while intrathecal immunoglobulin synthesis is associated with neurological signs, these are also observed in cases lacking a CNS inflammatory response. While there is an increase in inflammatory cytokine production with stage progression, this is paralleled by increases in CSF IL-10. As stage diagnostics, the CSF immunoglobulins and cytokines studied do not have sufficient sensitivity to be of clinical value
On the Detectability of Galactic Dark Matter Annihilation into Monochromatic Gamma-rays
Monochromatic gamma-rays are thought to be the smoking gun signal for
identifying the dark matter annihilation. However, the flux of monochromatic
gamma-rays is usually suppressed by the virtual quantum effects since dark
matter should be neutral and does not couple with gamma-rays directly. In the
work we study the detection strategy of the monochromatic gamma-rays in a
future space-based detector. The monochromatic gamma-ray flux is calculated by
assuming supersymmetric neutralino as a typical dark matter candidate. We
discuss both the detection focusing on the Galactic center and in a scan mode
which detects gamma-rays from the whole Galactic halo are compared. The
detector performance for the purpose of monochromatic gamma-rays detection,
with different energy and angular resolution, field of view, background
rejection efficiencies, is carefully studied with both analytical and fast
Monte-Carlo method
Detecting the dark matter annihilation at the ground EAS detectors
In this paper we study the possibility of detecting gamma rays from dark
matter annihilation in the subhalos of the Milky Way by the ground based EAS
detectors within the frame of the minimal supersymmetric standard model. Based
on the Monte Carlo simulation we also study the properties of two specific EAS
detectors, the ARGO and HAWC, and the sensitivities of these detectors on the
detection of dark matter annihilation. We find the ground EAS detectors have
the possibility to observe such signals. Conversely if no signal observed we
give the constraints on the supersymmetric parameter space, which however
depends on the subhalos properties.Comment: 23 pages, 9 figures, accepted by NP
Sperm death and dumping in Drosophila
Mating with more than one male is the norm for females of many species. In addition to generating competition between the ejaculates of different males, multiple mating may allow females to bias sperm use. In Drosophila melanogaster, the last male to inseminate a female sires approximately 80% of subsequent progeny. Both sperm displacement, where resident sperm are removed from storage by the incoming ejaculate of the copulating male, and sperm incapacitation, where incoming seminal fluids supposedly interfere with resident sperm, have been implicated in this pattern of sperm use. But the idea of incapacitation is problematic because there are no known mechanisms by which an individual could damage rival sperm and not their own. Females also influence the process of sperm use, but exactly how is unclear. Here we show that seminal fluids do not kill rival sperm and that any 'incapacitation' is probably due to sperm ageing during sperm storage. We also show that females release stored sperm from the reproductive tract (sperm dumping) after copulation with a second male and that this requires neither incoming sperm nor seminal fluids. Instead, males may cause stored sperm to be dumped or females may differentially eject sperm from the previous mating
High-resolution mass models of dwarf galaxies from LITTLE THINGS
We present high-resolution rotation curves and mass models of 26 dwarf galaxies from LITTLE THINGS. LITTLE THINGS is a high-resolution Very Large Array HI survey for nearby dwarf galaxies in the local volume within 11 Mpc. The rotation curves of the sample galaxies derived in a homogeneous and consistent manner are combined with Spitzer archival 3.6 micron and ancillary optical U, B, and V images to construct mass models of the galaxies. We decompose the rotation curves in terms of the dynamical contributions by baryons and dark matter halos, and compare the latter with those of dwarf galaxies from THINGS as well as Lambda CDM SPH simulations in which the effect of baryonic feedback processes is included. Being generally consistent with THINGS and simulated dwarf galaxies, most of the LITTLE THINGS sample galaxies show a linear increase of the rotation curve in their inner regions, which gives shallower logarithmic inner slopes alpha of their dark matter density profiles. The mean value of the slopes of the 26 LITTLE THINGS dwarf galaxies is alpha =-0.32 +/- 0.24 which is in accordance with the previous results found for low surface brightness galaxies (alpha = -0.2 +/- 0.2) as well as the seven THINGS dwarf galaxies (alpha =-0.29 +/- 0.07). However, this significantly deviates from the cusp-like dark matter distribution predicted by dark-matter-only Lambda CDM simulations. Instead our results are more in line with the shallower slopes found in the Lambda CDM SPH simulations of dwarf galaxies in which the effect of baryonic feedback processes is included. In addition, we discuss the central dark matter distribution of DDO 210 whose stellar mass is relatively low in our sample to examine the scenario of inefficient supernova feedback in low mass dwarf galaxies predicted from recent Lambda SPH simulations of dwarf galaxies where central cusps still remain.Peer reviewe
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