189 research outputs found
Correction to the Moliere's formula for multiple scattering
The quasiclassical correction to the Moliere's formula for multiple
scattering is derived. The consideration is based on the scattering amplitude,
obtained with the first quasiclassical correction taken into account for
arbitrary localized but not spherically symmetric potential. Unlike the leading
term, the correction to the Moliere's formula contains the target density
and thickness not only in the combination (areal density). Therefore,
this correction can be reffered to as the bulk density correction. It turns out
that the bulk density correction is small even for high density. This result
explains the wide region of applicability of the Moliere's formula.Comment: 6 pages, RevTe
Retrieving Nuclear Information from Protons Propagating through A Thick Target
The multiple scattering of high-energy particles in a thick target is
fromulated in an impact parameter representation. A formalism similar but not
identical to that of Moliere is obtained. We show that calculations of particle
beam broadening due to multiple Coulomb scattering alone can be given in closed
form. The focus of this study is on whether or not the broadening of the
Coulomb angular distribution prevents the retrieval of nuclear-interaction
information from mesauring the angular distributions of charged partiles
scattered from a thick target. For this purpose, we study multiple scatterings
with both the nuclear and Coulomb interactions included and we do not make a
small-angle expansion. Condition for retrieving nuclear infomration from
high-energy protons propagating through a block of material are obtained.Comment: 29 pages, 13 figure
Cosmic ray tests of the D0 preshower detector
The D0 preshower detector consists of scintillator strips with embedded
wavelength-shifting fibers, and a readout using Visible Light Photon Counters.
The response to minimum ionizing particles has been tested with cosmic ray
muons. We report results on the gain calibration and light-yield distributions.
The spatial resolution is investigated taking into account the light sharing
between strips, the effects of multiple scattering and various systematic
uncertainties. The detection efficiency and noise contamination are also
investigated.Comment: 27 pages, 24 figures, submitted to NIM
Contribution of -terms to the total interaction cross sections of relativistic elementary atoms with atoms of matter
It is shown that the corrections of order to the total cross
sections for interaction of elementary hydrogen-like atoms with target atoms,
reported in the previously published paper [S.Mrowczynski, Phys.Rev. D36, 1520
(1987)], do not include some terms of the same order of magnitude. That results
in a significant contribution of these corrections in particular cases. The
full -corrections have been derived and it is shown that they are
really small and could be omitted for most practical applications.Comment: 5 page
Dynamics of the Pionium with the Density Matrix Formalism
The evolution of pionium, the hydrogen-like atom, while passing
through matter is solved within the density matrix formalism in the first Born
approximation. We compare the influence on the pionium break-up probability
between the standard probabilistic calculations and the more precise picture of
the density matrix formalism accounting for interference effects. We focus our
general result in the particular conditions of the DIRAC experiment at CERN.Comment: 14 pages, 2 figures, submitted to J. Phys. B: At. Mol. Phy
Extended Classical Over-Barrier Model for Collisions of Highly Charged Ions with Conducting and Insulating Surfaces
We have extended the classical over-barrier model to simulate the
neutralization dynamics of highly charged ions interacting under grazing
incidence with conducting and insulating surfaces. Our calculations are based
on simple model rates for resonant and Auger transitions. We include effects
caused by the dielectric response of the target and, for insulators, localized
surface charges. Characteristic deviations regarding the charge transfer
processes from conducting and insulating targets to the ion are discussed. We
find good agreement with previously published experimental data for the image
energy gain of a variety of highly charged ions impinging on Au, Al, LiF and KI
crystals.Comment: 32 pages http://pikp28.uni-muenster.de/~ducree
Exploring venlafaxine pharmacokinetic variability with a phenotyping approach, a multicentric french-swiss study (MARVEL study).
It is well known that the standard doses of a given drug may not have equivalent effects in all patients. To date, the management of depression remains mainly empirical and often poorly evaluated. The development of a personalized medicine in psychiatry may reduce treatment failure, intolerance or resistance, and hence the burden and costs of mood depressive disorders. The Geneva Cocktail Phenotypic approach presents several advantages including the "in vivo" measure of different cytochromes and transporter P-gp activities, their simultaneous determination in a single test, avoiding the influence of variability over time on phenotyping results, the administration of low dose substrates, a limited sampling strategy with an analytical method developed on DBS analysis. The goal of this project is to explore the relationship between the activity of drug-metabolizing enzymes (DME), assessed by a phenotypic approach, and the concentrations of Venlafaxine (VLX) + O-demethyl-venlafaxine (ODV), the efficacy and tolerance of VLX.
This study is a multicentre prospective non-randomized open trial. Eligible patients present a major depressive episode, MADRS over or equal to 20, treatment with VLX regardless of the dose during at least 4 weeks. The Phenotype Visit includes VLX and ODV concentration measurement. Following the oral absorption of low doses of omeprazole, midazolam, dextromethorphan, and fexofenadine, drug metabolizing enzymes activity is assessed by specific metabolite/probe concentration ratios from a sample taken 2 h after cocktail administration for CYP2C19, CYP3A4, CYP2D6; and by the determination of the limited area under the curve from the capillary blood samples taken 2-3 and 6 h after cocktail administration for CYP2C19 and P-gp. Two follow-up visits will take place between 25 and 40 days and 50-70 days after inclusion. They include assessment of efficacy, tolerance and observance. Eleven french centres are involved in recruitment, expected to be completed within approximately 2 years with 205 patients. Metabolic ratios are determined in Geneva, Switzerland.
By showing an association between drug metabolism and VLX concentrations, efficacy and tolerance, there is a hope that testing drug metabolism pathways with a phenotypical approach would help physicians in selecting and dosing antidepressants. The MARVEL study will provide an important contribution to increasing the knowledge of VLX variability and in optimizing the use of methods of personalized therapy in psychiatric settings.
ClinicalTrials.gov NCT02590185 (10/27/2015). This study is currently recruiting participants
DPM, a fast, accurate Monte Carlo code optimized for photon and electron radiotherapy treatment planning dose calculations
A new Monte Carlo (MC) algorithm, the `dose planning method' (DPM), and its associated computer program for simulating the transport of electrons and photons in radiotherapy class problems employing primary electron beams, is presented. DPM is intended to be a high-accuracy MC alternative to the current generation of treatment planning codes which rely on analytical algorithms based on an approximate solution of the photon/electron Boltzmann transport equation. For primary electron beams, DPM is capable of computing 3D dose distributions (in 1 mm3 voxels) which agree to within 1% in dose maximum with widely used and exhaustively benchmarked general-purpose public-domain MC codes in only a fraction of the CPU time. A representative problem, the simulation of 1 million 10 MeV electrons impinging upon a water phantom of 1283 voxels of 1 mm on a side, can be performed by DPM in roughly 3 min on a modern desktop workstation. DPM achieves this performance by employing transport mechanics and electron multiple scattering distribution functions which have been derived to permit long transport steps (of the order of 5 mm) which can cross heterogeneity boundaries. The underlying algorithm is a `mixed' class simulation scheme, with differential cross sections for hard inelastic collisions and bremsstrahlung events described in an approximate manner to simplify their sampling. The continuous energy loss approximation is employed for energy losses below some predefined thresholds, and photon transport (including Compton, photoelectric absorption and pair production) is simulated in an analogue manner. The δ-scattering method (Woodcock tracking) is adopted to minimize the computational costs of transporting photons across voxels.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/48969/2/m00815.pd
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