Possible Role of Tetracyclines on COVID-19: Recycling Well-Known Old Drugs from the Shelf

We are in the midst of a pandemic due to the novel coronavirus SARS-CoV-2. Innovative therapies are in the lookup around the world. Recently, chloroquine and hydroxychloroquine in addition to Azithromycin were proposed to be used in patients with severe disease even though strong evidence is lacking. We propose the use of tetracyclines in addition to anti-virals early in the curse of the disease in order to prevent the Cytokine Storm Syndrome associated with COVID-19 and prevent ARDS. The proposed mechanisms of tetracyclines are: 1) anti-apoptotic properties; 2) decrease the Myeloperoxidase and ROS releaser from immune cells; 3) decrease neutrophil and monocyte migration and chemotaxis; 4) decrease the secretion of pro-inflammatory and vasoactive cytokines from macrophages (IL-1 beta, IL-8, and TNF-alpha); 5) inhibition of iNOS expression; 6) inhibition of chemotaxis of peripheral monocytes; 7) inhibition of IL-6 production and its receptor system; 8) prevention of fibrosis; and 9) inhibition of metalloproteinases (particularly MMP-2 and 9). Tetracyclines are well-known drugs with lower costs, and are not associated with adverse effects like QT prolongation. Clinical trials are needed to test our hypothesis

Reconstrucción de aparato extensor en sarcoma fibromixoide de bajo grado en rodilla: reporte de caso

Introduction: Low-grade fibromyxoid sarcoma is a malignant tumor with a high risk of developing recurrence and metastasis, surgical resection with wide margins is the main treatment, limb preservation and reconstruction is in high demand for surgeons. Case of report: We present the case of a 67-year-old woman with a recurrence of a knee tumor that had been operated on two year earlier. Oncological resection of the tumor was performed with reconstruction of the knee joint with an Endo Model prosthesis and extensor mechanism reconstruction with a synthetic polypropylene mesh graft plus a semitendinosus and gracilis autograft. The patella was reconstructed with posterior femoral condyle autograft. At 16 months of patient follow-up, she is free of disease, with a score of 27 on the lower limb scale of the MSTS (Musculoskeletal Tumor Society). Conclusion: The combination of synthetic graft with hamstring autograft can reduce the failure rate of extensor mechanism reconstruction due to oncological resections.Introducción: El sarcoma fibromixoide de bajo grado es una tumoración maligna con alto riesgo de desarrollar recurrencia y metástasis, siendo la resección quirúrgica con márgenes amplios el tratamiento principal, la preservación de la extremidad y su reconstrucción es de alta demanda para los cirujanos. Reporte de caso: Presentamos el caso de una mujer de 67 años con recurrencia de tumoración en rodilla desde hace 12 meses, operado dos años antes. Se realizo resección oncológica de tumoración con reconstrucción de articulación de rodilla con prótesis Endo Model y reconstrucción de aparato extensor con injerto sintético de malla de polipropileno más autoinjerto de semitendinoso y gracilis. La patela se reconstruyó con autoinjerto de cóndilo femoral posterior. A los 16 meses de seguimiento la paciente se encuentra libre de enfermedad, con puntaje de 27 en la escala para miembro inferior de la MSTS (Musculoskeletal Tumour Society). Conclusión: La combinación de injerto sintético con autoinjerto de isquiotibiales puede disminuir la tasa de falla de la reconstrucción del aparato extensor por resecciones oncológicas

DISEÑO INTEGRAL DE LAS INSTALACIONES ELECTRICAS DE LA PLANTA INDUSTRIAL NORITSU AUTOMOTRIZ S.A.

SISTEMA ELÉCTRICO SISTEMA DE GENERACIÓN SISTEMA DE TRANSPORTE O TRANSMISIÓN SISTEMA DE DISTRIBUCIÓN SISTEMAS DE UTILIZACIÓN INSTALACIONES DE ACOMETIDAS DE BAJA Y MEDIA TENSIÓN CLASIFICACIÓN DE LOS SISTEMAS DE DISTRIBUCIÓN EN FUNCIÓN A LA CONEXION DEL NEUTRO ACOMETIDAS EN BAJA TENSIÓN TIPOS DE ACOMETIDAS ACOMETIDAS DE MEDIA TENSIÓN MATERIALES ELÉCTRICOS EN INSTALACIONES INTERIORES TABLEROS ELÉCTRICOS CONDUCTORES ELÉCTRICOS INTERRUPTORES DE PROTECCIÓN INTERRUPTORES TERMOMAGNÉTICOS DUCTERIA, BANDEJAS Y CANALETAS EMPALMES SISTEMAS DE PUESTA A TIERRA ILUMINACIÓN DE INTERIORES TIPOS DE LUMINARIAS CALCULO DE ILUMINACIÓN NORMATIVIDAD ELÉCTRICA RELACIONADA CON LOS SISTEMAS DE UTILIZACIÓ

Organización comunitaria que facilita el acceso al agua mediante el trabajo conjunto

La Comunidad Mapuche Felipin se asienta en la zona rural del Departamento Catán Lil (Centro de la Provincia del Neuquén). Dicha experiencia surge del trabajo conjunto de un grupo de crianceros de la Comunidad que practican históricamente la trashumancia en campos de veranada situados en la zona del Chachil y la invernada en los parajes de Chacayco sur y Agua del sapo. La aplicación de tecnologías sencillas y de muy rápida apropiación por parte de los productores es esencial en estos contextos. Pero más aún es determinante la organización del trabajo en contextos socioculturales donde el manejo y uso de los recursos naturales son comunitarios como es el caso de la comunidad Felipin. El acceso al agua genera impactos muy significativos, básicamente posibilitando la reproducción de la familia rural, abriendo posibilidades de mejorar la calidad de vida en todas sus dimensiones. Es importante la participación colectiva en el diseño y ejecución de estas obras, teniendo en cuenta que para la cultura Mapuche éstas fuentes de agua tienen un valor sagrado que requiere de un tratamiento de dialogo de los saberes campesinos y técnicos.Estación Experimental Agropecuaria BarilocheFil: Benitez, Pablo. Comunidad Mapuche Felipin/ Chacayco Sur; ArgentinaFil: Mena, Raul. Comunidad Mapuche Felipin/ Chacayco Sur; ArgentinaQuiroga, Horacio. Comunidad Mapuche Felipin/ Chacayco Sur; ArgentinaFil: Bascuñan, Rafael. Comunidad Mapuche Felipin/ Chacayco Sur; ArgentinaFil: Perez, Fidel. Comunidad Mapuche Felipin/ Chacayco Sur; ArgentinaFil: Navedo, Rodrigo Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Agencia de Extensión Rural Zapala; Argentin

Functional Enrichment Analysis of Regulatory Elements

This work has been partially supported by FEDER/Junta de Andalucia-Consejeria de Economia y Conocimiento/(grant CV20-36723), grant PID2020-119032RB-I00, MCIN/AEI/10.13039/501100011033 and FEDER/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades (Grant P20_00335).Statistical methods for enrichment analysis are important tools to extract biological information from omics experiments. Although these methods have been widely used for the analysis of gene and protein lists, the development of high-throughput technologies for regulatory elements demands dedicated statistical and bioinformatics tools. Here, we present a set of enrichment analysis methods for regulatory elements, including CpG sites, miRNAs, and transcription factors. Statistical significance is determined via a power weighting function for target genes and tested by theWallenius noncentral hypergeometric distribution model to avoid selection bias. These new methodologies have been applied to the analysis of a set of miRNAs associated with arrhythmia, showing the potential of this tool to extract biological information from a list of regulatory elements. These new methods are available in GeneCodis 4, a web tool able to perform singular and modular enrichment analysis that allows the integration of heterogeneous information.FEDER/Junta de Andalucia-Consejeria de Economia y Conocimiento CV20-36723MCIN/AEI PID2020-119032RB-I00FEDER/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades P20_0033

The new Physical Education curriculum in Ecuador

El objetivo del presente estudio, fue analizar el nuevo currículo de educación física en el Ecuador, el mismo que ha sido implementado por la subsecretaría de Fundamentos Educativos del Ministerio, argumentando que los cambios se adaptan al plan decenal sobre inclusión y atención a la diversidad; y que, además contiene una propuesta de capacitación presencial y en línea que brinda una metodología de flexibilidad para que el docente se adapte a las necesidades de los estudiantes. Para ello, se ha realizado un reajuste que simplifican la organización contemplada en la presentación de una planificación anual a un currículo por subnivel que abarcar tres años de estudio. La simplificación será implementada en educación básica donde existen cuatro subniveles: preparatoria, elemental, media y superior; donde por cada subnivel se contempla un plan analítico con sus respectivos objetivos de carácter obligatorio y opcional; mientras que lo mismo sucede a nivel de bachillerato también con una duración de tres años. El análisis contempló el impacto de la reforma, asignatura, el docente y los estudiantes, concluyendo que todo cambio representa nuevos retos identificando nuevas problemáticas y fortalezas que deben ser incididas a través de alternativas educativas enmarcadas en estrategias y técnicas incluyendo los estudiantes que tienen dificultades de aprendizaje.The objective of the present study, was to analyze the new physical education curriculum in Ecuador, which has been implemented by the Undersecretary of Educational Foundations of the Ministry, arguing that the changes are adapted to a ten-year plan on inclusion and attention to diversity; and that it also contains a proposal for face-to-face and online training that provides a flexibility methodology so that, the teacher adapts to the needs of the students. For this reason, a readjustment has been made that simplifies the organization contemplated in the presentation of an annual planning to a curriculum by sub-level that covers three years of study. The simplification will be implemented in basic education where there are four sublevels: preparatory, elementary, middle and higher; where for each sublevel an analytical plan is contemplated with its respective mandatory and optional objectives; while the same also happens at the baccalaureate level with a duration of three years. The analysis contemplated the impact of the reform, the subject, the teacher and the students, concluding that any change represents new challenges identifying new problems and strengths that must be influenced through educational alternatives framed in strategies and techniques including students who have difficulties in learnin

Simulating the detection of the global 21 cm signal with MIST for different models of the soil and beam directivity

The Mapper of the IGM Spin Temperature (MIST) is a new ground-based, single-antenna, radio experiment attempting to detect the global 21 cm signal from the Dark Ages and Cosmic Dawn. A significant challenge in this measurement is the frequency-dependence, or chromaticity, of the antenna beam directivity. MIST observes with the antenna above the soil and without a metal ground plane, and the beam directivity is sensitive to the electrical characteristics of the soil. In this paper, we use simulated observations with MIST to study how the detection of the global 21 cm signal from Cosmic Dawn is affected by the soil and the MIST beam directivity. We simulate observations using electromagnetic models of the directivity computed for single- and two-layer models of the soil. We test the recovery of the Cosmic Dawn signal with and without beam chromaticity correction applied to the simulated data. We find that our single-layer soil models enable a straightforward recovery of the signal even without chromaticity correction. Two-layer models increase the beam chromaticity and make the recovery more challenging. However, for the model in which the bottom soil layer has a lower electrical conductivity than the top layer, the signal can be recovered even without chromaticity correction. For the other two-layer models, chromaticity correction is necessary for the recovery of the signal and the accuracy requirements for the soil parameters vary between models. These results will be used as a guideline to select observation sites that are favorable for the detection of the Cosmic Dawn signal.Comment: Accepted for publication in the Astrophysical Journa

Teaching Energy Efficiency: A Cross-Border Public Class and Lesson Study in STEM

As part of an APEC educational project on the cross-cutting concept of energy, researchers and teachers from 6 countries spent 8 months designing, testing and implementing a pilot STEM public class with two schools from Chile and one from the US. One of the researchers taught a lesson from a school in Chile, with a live transmission to the other two schools via Skype. At the same time, the lesson was also broadcasted via video streaming. In addition to live questions and answers, students used individual devices to answer four open-ended questions that were commented on by the researcher as he received them. The experience demonstrated that Cross-Border Public Classes boost student engagement and represent a promising strategy for introducing a key 21st century skill: synchronous learning involving multiple teams across the world. It also revealed how Lesson Study and Public Classes integrated with ICT network technology can form a powerful learning ecosystem for regional development and social innovation