16 research outputs found
Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial.
- Author
- A Sarah Walker
- Abid Hussain
- Abiola Alli
- Abraham Gihawi
- Achyut Guleri
- Achyut Guleri
- Adam Jeans
- Adam Lewszuk
- Adam Mohamoodally
- Adam Wolstencroft
- Adele Marshall
- Adetunji Adedayo
- Adrian Lyons
- Agnieszka Skotnicka
- Ahalya Malachira
- Aiden Plant
- Alaric Colville
- Alex Chrdle
- Alex Peel
- Alex Szubert
- Alexander Szubert
- Ali Vaughn
- Alisha Beddoe
- Alison Eyre
- Alison Fair
- Alison Porges
- Alison Potter
- Alison Stolton
- Amanda Fife
- Amanda Moran
- Amandip Sahota
- Amita Patel
- Amy Driffill
- Amy Janvier
- Amy Murray
- Ana de Veciana
- Andrea Boyce
- Andree Evans
- Andrew Conbeer
- Andrew Flatt
- Andrew Potter
- Andrew Rosser
- Angela Cape
- Angela Dunne
- Angela Houston
- Angela King
- Angela McCadden
- Angela Parkin
- Ann Sarah Walker
- Anna L Goodman
- Anna McSkeane
- Anna Reyes
- Anna Sweeney
- Anne Anderson
- Anne Clarke
- Anthony Donnelly
- Antonia Scobie
- Antonio Querol-Rubiera
- Aodhan Breathnach
- Asha Mathews
- Atul Kotecha
- Avril Masdin
- Ayodele Ajayi
- Bala Subramanian
- Belinda Romans
- Ben Marks
- Benjamin Jeffs
- Bernadette Cook
- Bernadette Young
- Bernadette Young
- Bev Warner
- Bijal Patel
- Boingotlo Masake
- Brooke Jackson
- Cariad Evan
- Carlene Rowson
- Carlos DĂaz-Montaña
- Carmen Cantell
- Carol Brooks
- Carole McPherson
- Caroline Andrews
- Caroline Bedford
- Caroline Renton
- Carolyn Hemsley
- Carrie Ridley
- Catherine Aldridge
- Charley Higham
- Charlote Armer
- Charlotte Eglinton
- Charlotte Gibbs
- Charlotte Russell
- Cherrelle de Souza
- Cheryl Bailey
- Chi Kai Tam
- Chi Kai Tam
- Chiara Borg
- Chris Brewer
- Chris Smalley
- Christop Lohan
- Christopher Sim
- Claire Keatley
- Claire Williams
- Clare Hamson
- Clare Hutchison
- Clare James
- Clare Tarbotton
- Clive Graham
- Clive Graham
- Colin Brown
- Colin Walker
- Cordelia Watson
- Cressida Auckland
- Cressida Auckland
- Cristina Suarez
- Dai Griffiths
- Dakshika Jeyaratnam
- Dakshika Jeyaratnam
- Damien Mack
- Damilola Otiko
- Daniel Greaves
- Daniela Shackcloth
- Dave Osborne
- David A Price
- David Ashley Price
- David Chadwick
- David Harvey
- David Harvey
- Debbie Johnson
- Deborah Gilliam
- Deepa Nayar
- Denise Ward
- Denise Ward
- Diane Swift
- Dominika Wlazly
- Donna Palmer
- Duncan Wyncoll
- Ed Moran
- Edmund Ong
- Efisia Sais
- Elaine Strachan
- Elen Witness
- Elian Liu
- Elizabeth Foote
- Elizabeth Woodford
- Ella Foncel
- Ellen Adams
- Emily Hetherington
- Emma Folland
- Emma Foreman
- Emma Lawrence
- Emma Moore
- Emmanuel Nsutebu
- Emmanuel Nsutebu
- Faith Okhuoya
- Fiona Walters
- Fleur Hudson
- Fleur Hudson
- Fozia Ahmad
- Gagan Kaler
- Gavin Barlow
- Gavin Barlow
- Gaynor Notcheva
- Gayti Islam
- Gemma Pill
- Geoffrey Howell
- Georgina Shaw
- Giordana Sorrentino
- Gonzalez-Ruiz Armando
- Graham FitzGerald
- Gus Cardoso
- Guy E Thwaites
- Guy Thwaites
- Hannah Allsop
- Hannah Crowther
- Hannah Gott
- Helen Chesterfield
- Helen Fairlamb
- Helen Preedy
- Helen Reynolds
- Helen Vassallo
- Helen Webb
- Helen Wilson
- Helen Winslow
- Helen Wooldridge
- Helena Bond
- Helena White
- Hesther Wilson
- Hezron Greaves
- Hilary Pateman
- Holly Burton
- Ilias Mariolis
- Ines De Abreu
- Ingrid Emmerson
- Isobel Ramsay
- Jack Briggs
- Jackie Westcott
- James Calderwood
- James Fellows
- James Meiring
- James Millard
- James Price
- Jane Cunningham
- Jane Minton
- Jane Minton
- Jane Thompson
- Janet Andrews
- Janet Cairns
- Janet Cairns
- Janet Middle
- Janine Gradwell
- Jason Biswas
- Jason Howard
- Jason Wong
- Jennifer Fitzpatrick
- Jennifer Fitzpatrick
- Jennifer Harrison
- Jess Mandiza
- Jill Deane
- Jill Lyons
- Jim Anson
- Jo Studham
- Joanna Allen
- Joanna Flanagan
- Joanne Gordon
- Joanne Malkin
- Joanne Thorpe
- Joanne Williams
- Joby Cole
- John Humphries
- John Paul
- John Sloss
- John Widdrington
- John Williams
- John Williams
- Jonathan D Edgeworth
- Jonathan D Edgeworth
- Jonathan Folb
- Jonathan Wilson
- Jordan Ewing
- Joseph Lewis
- Josephine Marange
- Judith Chapman
- Judith Platt
- Judy Sercombe
- Julia Greig
- Julia Greig
- Julia Halpin
- Julian Sutton
- Julian Sutton
- Julie Frudd
- Julie Mitchell
- Julie Sorrell
- Karen Bisnauthsing
- Karen Brookes
- Karen Martin
- Kate Ellis
- Kate Maitland
- Kate Maloney
- Kate Ripalda
- Katherine Cullen
- Katherine Curley
- Katherine Pagett
- Kathryn Birchall
- Kathryn Louise Taylor
- Kathryn Potts
- Katie Wilkins
- Katy Marden
- Katy Moore
- Keith Yip
- Kelly Attack
- Kevin Cole
- Kim Cox
- Kim Ryalls
- Kirandip Mandar
- Kirsty Baillie
- Kirsty Gladas
- Kristian Warnes
- Kristine Criste
- Laura Behar
- Laura Butland
- Laura Latter
- Laura Makey
- Laura O'Neil
- Laura Ortiz-Ruiz de Gordoa
- Laura Shewan
- Laura Watson
- Leanne Carwithen
- Leanne Galloway-Browne
- Leila Bahadur
- Lemonia Ftika
- Lenka Strakova
- Leon Peto
- Leona Trainor
- Leona Yabsley
- Lesley Rigden
- Leslie Masters
- Lewis Jones
- Li-An Brown
- Lillian Tsang
- Linda March
- Lindsey Masters
- Lisa Burgess
- Lisa Hurley
- Lizzie Roberts
- Lois Mlemba
- Louise Barrett
- Louise Robinson
- Louise Wright
- Luis Cotter
- Luke Anson
- Luke Bedford
- Lydia Rylance-Knight
- Lynne Smart
- Lynne Whitehead
- Lynsey Goodwin
- Lynsey Stephenson
- M Estee Török
- M Estée Török
- Maggie Cole
- Maggie Kalita
- Manish Pareek
- Manju Joy
- Manuel Fenech
- Maria Edwards
- Maria Hayes
- Maria Nadolski
- Marie-Claire Hoyle
- Marie-Claire West
- Marina Morgan
- Mark Bolton
- Mark Wallis
- Martin J Llewelyn
- Martin Llewelyn
- Martin Wiselka
- Martin Wiselka
- Martyn Cain
- Mary Wands
- Matthew Scarborough
- Matthew Scarborough
- Maxine Hough
- Mazhar Alam
- Mel Baxter
- Melanie Ekani
- Melanie Harrison
- Melanie Hutchings
- Melinda Munang
- Melody Smith
- Michael Ankcorn
- Michelle A Graver
- Michelle Wood
- Mike Marner
- Miranda Kean
- Mirriam Sangombe
- Muge Cevik
- Musa Kamfose
- N Claire Gordon
- Nadine Abberley
- Natalia Waddington
- Naval Vyse
- Neil Jenkins
- Neil Jenkins
- Neil Stone
- Nicholas Beeching
- Nicola Claire Gordon
- Nicola Ridley
- Nicola Smith
- Nicolas Cortes
- Nisa Khan
- Noah Yogo
- Orla Brady
- Pankaj Lal
- Pankaj Lal
- Paul Chadwick
- Paul Jones
- Paul McWhinney
- Paul McWhinney
- Paul R Chadwick
- Paul Roberts
- Paula Harlow
- Paula Sharratt
- Pauline Lambert
- Pavithra Natarajan
- Peter Flegg
- Peter Moss
- Peter Wilson
- Peter Wilson
- Polly Tarrant
- Rachel Abrahams
- Rachel Austin-Hutchison
- Rachel Bousfield
- Rachel Vincent
- Rahul Kurup
- Rajesh Jarghese
- Rakhee Chahuan
- Rasha Said
- Rashmi Sharma
- Rebecca B Saunderson
- Rebecca Palmer
- Rebecca Tagney
- Rebecca Warren
- Reni Jacob
- Richard Bellamy
- Richard Cunningham
- Richard Nendick
- Rob Porter
- Rob Wosley
- Robert Porter
- Robert Reed
- Robert Tilley
- Robert Tilley
- Roderick Balancio-Tolentino
- Rosie Fok
- Rosie Fok
- Ruth Millett
- Ruth Moroney
- Saadia Rahman
- Saba Qaiser
- Sally Batham
- Samantha Crossman
- Sani Aliyu
- Sanuki Perera
- Sara Taiyari
- Sarah A Wyllie
- Sarah Birchall
- Sarah Dyas
- Sarah Glover
- Sarah Meisner
- Sarah Meisner
- Sarah Moll
- Sarah Rippon
- Sarah Stevenson
- Sarah Thornthwaite
- Sarah Wyllie
- Scott Prentice
- Sebastien Martin
- Senait Haile
- Sephora Shaw
- Sergio Muñoz-Villaverde
- Sharon Sheehan
- Shirley Cooper
- Shirley Todd
- Shona Hughes
- Simon Matthews
- Simon Warren
- Sophie Collier
- Sophie Whiteley
- Stacey Donaldson
- Stacey Valentine
- Stephen Booth
- Stephen Coleman
- Stephen K Glass
- Stephen Mepham
- Stephen Morris-Jones
- Sue Kimachia
- Sue Williams
- Suryabrata Banerjee
- Susan Hopkins
- Susan Hopkins
- Susan Lord
- Suzanne Price
- Tamara Mitchell
- Tamika Chapter
- Tat Yam
- Tenessa Sargent
- Teresa Pettifer
- Theodore Gouliouris
- Tim Kemp
- Tim Planche
- Tim Planche
- Tina Burdett
- Tiphanie Clarke
- Tracey Dobson
- Tracey Mynes
- Tracey Platt
- Tracy Matheson-Smith
- Tristan Clark
- Una Poultney
- Veena Raviprakash
- Veenu Kollipara
- Vicki Lowthorpe
- Vicky Chu
- Victoria Dean
- Vusumuzi Shabangu
- Weronika Szypura
- Yvonne Jackson
- Zaheer Islam
- Zoe Martin
- Zoe Prime
- Zoe Swann
- Publication venue
- Lancet
- Publication date
- 14/12/2017
- Field of study
BACKGROUND: Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, or death, by enhancing early S aureus killing, sterilising infected foci and blood faster, and reducing risks of dissemination and metastatic infection. METHODS: In this multicentre, randomised, double-blind, placebo-controlled trial, adults (â„18 years) with S aureus bacteraemia who had received â€96 h of active antibiotic therapy were recruited from 29 UK hospitals. Patients were randomly assigned (1:1) via a computer-generated sequential randomisation list to receive 2 weeks of adjunctive rifampicin (600 mg or 900 mg per day according to weight, oral or intravenous) versus identical placebo, together with standard antibiotic therapy. Randomisation was stratified by centre. Patients, investigators, and those caring for the patients were masked to group allocation. The primary outcome was time to bacteriologically confirmed treatment failure or disease recurrence, or death (all-cause), from randomisation to 12 weeks, adjudicated by an independent review committee masked to the treatment. Analysis was intention to treat. This trial was registered, number ISRCTN37666216, and is closed to new participants. FINDINGS: Between Dec 10, 2012, and Oct 25, 2016, 758 eligible participants were randomly assigned: 370 to rifampicin and 388 to placebo. 485 (64%) participants had community-acquired S aureus infections, and 132 (17%) had nosocomial S aureus infections. 47 (6%) had meticillin-resistant infections. 301 (40%) participants had an initial deep infection focus. Standard antibiotics were given for 29 (IQR 18-45) days; 619 (82%) participants received flucloxacillin. By week 12, 62 (17%) of participants who received rifampicin versus 71 (18%) who received placebo experienced treatment failure or disease recurrence, or died (absolute risk difference -1·4%, 95% CI -7·0 to 4·3; hazard ratio 0·96, 0·68-1·35, p=0·81). From randomisation to 12 weeks, no evidence of differences in serious (p=0·17) or grade 3-4 (p=0·36) adverse events were observed; however, 63 (17%) participants in the rifampicin group versus 39 (10%) in the placebo group had antibiotic or trial drug-modifying adverse events (p=0·004), and 24 (6%) versus six (2%) had drug interactions (p=0·0005). INTERPRETATION: Adjunctive rifampicin provided no overall benefit over standard antibiotic therapy in adults with S aureus bacteraemia. FUNDING: UK National Institute for Health Research Health Technology Assessment
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
- Akbar Maha Ghulam
- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
- Akkaya Ege Nur
- Akpamgbo Chukwunonso Nnamdi
- Akwaisah Ayoub
- Al Hammoud Amr
- Al Rawashdeh Toka â â
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safaâ
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
- Al-Touny Shimaa
- Al-zawaydeh Alia
- Alaa Ali
- Alabed Ebtihal
- Alagelli Fatma
- Alagoz Ahmet Can
- Alameen Hind
- Alameen Maram
- Alamlih Laith
- Alaqoubi Retaj
- Alarabi Rehab
- Alariby Fatima
- Alatefi Dawood
- Alathameen Nassar
- Albakosh Bashir Abobaker
- Albanopoulos Konstantinos
- Albarhomy Osama
- Albarki Aisha
- Albashaireh Alaa
- Albatni Safa Sasi
- Albayadi Eslam
- Alboon Mosab
- Alboridy Muneera
- Alboueishi Asraa Ali
- Aldeges Marwan
- Aldreawi Mohammed
- Alflite Asil Omar Saleh
- Alfrijat Tamam
- Alfrjani Tariq
- Algabbasi Salima
- Algatanesh Nassib
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhaleem Ayah
- Alhaleeq Saif
- Alharam Abtisam
- Alhashimi Abdulhadi Mohammed Alhadi
- Alhassan Monzer
- Alhudhairy Sara
- Ali Ahmed
- Ali Aml
- Ali Doua
- Ali Eithar M
- Ali Iqra Fatima Munawar
- Ali Maab
- Ali Manal
- Ali Muhammad
- Ali Radwa
- Ali Rawan Alsheikh
- Ali Rzan Ali Hamedelneel
- Ali Shehroz
- Aliosin Oleg
- Aljamal Mohammad
- Aljamal Sarah
- Alkaraja Layth
- Alkaseek Akram
- Alkazali Mustafa
- Alkchr Hayat Ben Hasan Mohamed A A
- Alkhatib Abed Alazeez
- Allam Shereen
- Almahroush Marin
- Almakki Doha Mohammed Ahmed
- Alnajjar Lara
- Alnajjar Majjd
- Alnatsheh Wesam
- Alnour Ammar
- Alomar Rabiaa
- Alomari Yazan
- Alqaarh Aya
- Alragig Zahra
- Alrifae Ghaliya Mohamed H
- Alrosan Risan
- Alsagoff Sharifah Nor Amirah Syed Abdul Latiff
- Alsaid Hamza
- Alsaify Esmat
- Alsaih Sawsan
- Alsari Najah
- Alshareea Entisar
- Alshawadfy Abdelrhman
- Alshawesh Aisha
- Alsheik Ahmad
- Alsori Mohamed
- Alsoudani Ali
- Altabbaa Hashem
- Altahir Mohamed
- Altair Mawadda
- Altaweel Ahmad
- Altughar Bushra
- Alvarez Matias
- Alvarez-Lozada Luis Adrian
- Alvarez-Lozada Luis Adrian
- Alwahaib Anas
- Alwash Mohammed
- Alzarga Ali
- Alzarouq Ebtisam
- Alzarroug Amal
- Alzghoul Bader
- Alzyoud Osama
- Amarasekara Mishka
- Amary Marwa
- Ametov Amet
- Amin Mostafa K
- Aminu Bashiru
- Aminu Muhammad Baffah
- Ammar Ahmed Siddique
- Amro Dana
- Ananthapadmanabhan Shravankrishna
- Anderson Paul
- Andrew Paul Chimezie
- Andriani Adelaide
- Anestiadou Elissavet
- Angelis Fragkiskos
- Angeslis Fragkiskos
- Aqeel Syed Talha Bin
- Aral Canan
- Arebi Jaber
- Arnaoutoglou Eleni
- Arslangilay Mert
- Arvanitaki Alexandra
- Asadyari-Lupo Shadie
- Ashar Nur Ayuni Khirul
- Ashour Amira
- Ashraf Hamza
- Ashur Abir Ben
- Asjad Imran
- Askar Aamal
- Askin Abdullah Emre
- Aslam Muhammad Nadeem
- Aslan Merve
- Aslangilay Mert
- Astal Mohammed
- Asudo Felicia
- Atadag Yildiz Buyukdereli
- Atef Dina
- Athamneh Tayseer
- Athanasiadis Apostolos
- Ather M Hammad
- Atherton Kristy
- Atia Ahmed
- Atici Semra Demirli
- Atilhan Ridvan
- Atim Terkaa
- Atiq Tabish
- Atta Raneem
- Attia Mohamed
- Attiya Omar
- Awad Hasan
- Awadallah Safaa
- Awoyinka Babatunde
- Ayasrah Salem
- Aydin Cemil
- AydogÌdu Erhan Onur
- Ayogu Emeka
- Ayoub Kerillos
- Ayyad Alaa
- Azboy Ibrahim
- Azer Armia
- Azhari Malaz
- Aziz Aliya Begum
- Babalola Olakunle
- Babar Daniyal
- Babekir Enas Mohammedtom Abdulhameed
- Babiker Afra
- Bacariza Loreto
- Baccar Marwen
- Badawy Asmaa
- Badi Hussameddin
- Badr Karim
- Badri Danniel
- Bagazi Doaa
- Bailey Ashley
- Bakare Adewumi
- Bakari Maisaratu A
- Bakeer Hibah Bileid
- Bakeer Mohammed
- Balciscueta Zutoia
- Ballah Shirahn
- Balogh Zsolt
- Baltacı Zeynep Hazal
- Banaga Essam Eldien Abuobaida
- Banerjee Arnab
- Banihani Farah
- Barbara Silvia Jasmine
- Barbaro Antonio
- Bareka Metaxia
- Bariun Yara
- Barka Sharf
- Barker John
- Barker Sally
- Barsoum Fady
- Basam Aya
- Basam Aya
- Bassam Ahmad
- Bassey Asi-oqua
- Bataineh Saad
- Bature Stephen Bodam
- Bayram Cigdem
- Baysallar Duygu
- Baziotis-Kalfas Kristian
- Beatson Nicholas
- Bei Michael
- Bektas Sebnem
- Bell David
- Benamor Oumayma
- Benek Duygu Ece
- Benham Emily
- Benismai Israa
- Bensalem Marya
- Bensalem Serien Hossain
- Benyani Simran Vinod
- Bernabei Massimiliano
- Betts Aisling
- Bezweek Adel
- Bhikha Jainey
- Bindra Randipsingh
- Binnawara Muhannud
- Bird Katie
- Bisgin Tayfun
- Bitsianis Stefanos
- Blake Jessica
- Bland Laura
- Blassey Aneel
- Blundell Jian
- Bobba Sriya
- Bockxmeer John Van
- Bolam Scott Matthew
- Bolton Damien
- Bosi Simone
- Bouaoud Souad
- Bouchenak Kamel
- Boussahel Ikram Fatima Zohra
- Bowman Sarah
- Boyd Theresa
- Boyes Hamish
- Boyley Jessica
- Bozhko Maxim
- Bozkir Haktan Ovul
- Bozkurt Mehmet Abdussamet
- Bresadola Vittorio
- Brewster Dani
- Brooke Kenya
- Brown Georgia
- Brown Matthew
- Buari Taiwo
- Buhavac Milos
- Bunjo Zachary
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- Burruso Luca
- Busaidi Ibrahim S Al
- Bushaala Hassan
- Butterworth Yasmine
- Butyrskii Aleksandr
- Cabalag Carlos
- Cade Richard
- Cakcak Ibrahim Ethem
- Cakir Niyazi
- Calini Giacomo
- Calini Giacomo
- Camkıran Elifsu
- Canavese Anna
- Candan Mert
- Canny Mitch
- Canton Joshua
- Capar Mehmet Ali
- Cardelli Stefano
- Carlos Angela
- Carnuccio Emma
- Carre Xenia
- Casciola Francesca
- Castagnini Francesco
- Catalioto Caterina
- Cepe Hale
- Cerinic Pietro Matucci
- Certel Alperen Taha
- Cetınkaya Zeynep Sahan
- Chakroun Sawssen
- Chambers Jessica
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- Chan Alex
- Chan Ashley
- Chan Juliet
- Chan Justin
- Chan Nicholas
- Chand Namisha
- Chandiok Karan
- Chandler Callum
- Chandra Pooja
- Chang Jared
- Chang Kelvin
- Changati Varun
- Chao Phoebe
- Chau Michelle
- Chau Michelle
- Chauhan Karanjeet
- Chawla Tabish
- Chen Andrew
- Chen Brian
- Chen Paul
- Chen Yan
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- Cheng Felicity
- Cheung Aiden
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- Chidambaram Seevakan
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- Clanfield Matthew
- Clarnette Nick
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- Cobden Andrew
- Colaco Ashley
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- Collins Josh
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- Coomber Grace
- Copertino Nicolas
- Cordingley Timothy
- Cornwell Charlotte
- Cornwell Charlotte
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- Crossman Mason
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- Cuneo Beatriz
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- Çolak Eli Ìf
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- Das Ankita
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- Daudu Davina
- Davies Lily
- Dawod Nimatee
- Dawood Ali
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- Dawson Amanda
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- Yodkitydomying Chatnapa
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- Yoon Si Woo
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- Young Stevie
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- Yousif Fatima Imad
- Yousri Mohamed
- Youssef Ahmed A
- Youssef Arkan
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- Yue Bosco
- Yue Tiffany
- Yunos Mohamed Haseef Mohamed
- Yusuf Stephen
- Yuzgec Ayse Nilufer
- Zachomitros Fotios
- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- âAladna âAbdallah
- âAljoumaa âAbdullah
- âNawfal âHamdi
- âNiazi âAmmar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study
- Author
- 't Hart Ellen P.
- ?a?inkovĂĄ Pavla
- Aaserud Olaf
- Abbruzzese Giovanni
- Acharya T.
- Akhtar Shahbana
- Albanese Alberto
- Alegre Javier
- Alegre Javier
- Allain Philippe
- Alusi Sundus
- Amico Enrico
- Andrade Carlos
- Andrews S. C.
- Andrews Thomasin
- Andrews Thomasin
- Anheim Mathieu
- Antczak Jakub
- Armstrong Matthew
- Armstrong Richard
- Arques Penelope Navas
- Arran N.
- Arran Natalie
- Artiga MarĂa JosĂ© Saiz
- Axelson E.
- Azulay Jean-Philippe
- Baake Verena
- Babiloni Blandine
- Bachoud-LĂ©vi Anne-Catherine
- Banaszkiewicz Krzysztof
- Bandmann Oliver
- Barbera Miquel Aguilar
- Bardinet E.
- Barker Roger A.
- Barrero Francisco
- Barth Katrin
- Barth Katrin
- Barthélémy Rekha
- Bas Jordi
- Bascuñana Mónica
- Bechtel N.
- Bechtel Natalie
- Beckmann Heike
- Bek Judith
- Bellonet Marcellin
- Bentivoglio Anna Rita
- Bentivoglio Rita
- Berglund Peter
- Berna C.
- Berrissoul Hassan
- Bertini Elisabetta
- Betz Sabrina
- Biunno Ida
- BjĂžrgo Kathrine
- BjĂžrnevoll Inga
- Blaszcyk Magdalena
- Blin Stéphanie
- Bocwinska Dorota
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen S.
- Bohlen Stefan
- Bojakowska-Jaremek Kamila
- Bolwijn J. J. W.
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- Bonelli Raphael M.
- Bonneau Dominique
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- Boogaerts Andrea
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- Bos Reineke
- Bos Reineke
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- Swain Rachel
- Szczudlik Andrzej
- Szczygiel Elzbieta
- Szinwelski Michal
- SĂĄnchez Vicenta
- SĂŒĂmuth Sigurd
- t'Hart E. P.
- Tabrizi Sarah
- Tabrizi Sarah
- Tabrizi Sarah J.
- Tacik Pawel
- Tan Louis
- Taylor Cat
- Taylor Rachel
- Thibault-Tanchou Stéphanie
- Thomas Gareth
- Thompson Catherine
- Thompson Jennifer
- Thomson Aileen
- Tidswell Katherine
- Timewell Erika
- Tobin A.
- Tomasello Chiara
- Torres MarĂa Martirio Antequera
- Toscano Jean
- Townhill Jenny
- Townhill Jenny
- TRACK-HD investigators
- Tranchant Christine
- Trautmann Sonja
- Trender-Gerhard Iris
- Tuuha Katri
- Uhrova Tereza
- Ullah Jasmin
- Ure Alexandra
- ValabrĂšgue R.
- Valadas Anabela
- Valentine Ruth
- van den Bogaard S. J. A.
- van den Bogaard Simon J. A.
- van der Grond J.
- van Hout Monique S. E.
- van Oostrom J. C. H.
- van Paemel Dominique
- van Reijen Dimphna
- van Vugt Jeroen P. P.
- van Walsem Marleen R.
- van Walsem Marleen R.
- Vandenberghe Wim
- Vandenberghe Wim
- Vargas-GonzĂĄlez Laura
- Vaughan Vivien
- Ventura Marta FatĂĄs
- Verellen-Dumoulin Christine
- Verellen-Dumoulin Christine
- Verhoeven Marloes E.
- Verny Christophe
- Verstappen C. C. P.
- Verstraelen Nichola
- Viladrich Celia Mareca
- Vilaplana Garcia Carmen PeirĂł
- Villanueva Clara
- Vinther-Jensen Tua
- Vuillaume Isabelle
- Wahlström Jan
- Wahlström Jan
- Wang C.
- Wannepain Sandrine
- Warner Thomas
- Wasielewska Anna
- Weber Zaugg Sabine
- Weber Natalia
- Wehus Ragnhild
- Weindl Adolf
- Wenning Gregor
- Wentzel Magnus
- Werner Cornelius J.
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Whalstedt Carina
- Whitehead D.
- Whitlock K.
- Wiedemann Alexandra
- Wikström Birgitta
- Wild E.
- Wild Edward
- Wild Sue
- Wild Sue
- Winkelmann Juliane
- Witjes-Ane M.-N.
- Witjes-Ané Marie-Noelle
- Witkowski Grzegorz
- Witkowski Grzegorz
- Wolz Annett
- Wolz Martin
- Wright Abigail
- Wright Abigail
- Wright Jan
- WĂłjcik Magdalena
- Yardumian Pam
- Yardumian Pam
- Yates Shona
- Zaremba Jacek
- Zaremba Jacek
- Zdzienicka Elzbieta
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Daniel
- Zielonka Eugeniusz
- Zieora-Jakutowicz Karolina
- Zimmermann Marie-Agathe
- Zinzi Paola
- Zinzi Paola
- Zittel Simone
- Zucker Birgit
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008â11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003â13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 Ă 10â10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 Ă 10â8 DHFR p=8·37 Ă 10â7 MTRNR2L2 p=2·15 Ă 10â9) and to a lesser extent in REGISTRY (MSH3 p=9·36 Ă 10â4 DHFR p=8·45 Ă 10â4 MTRNR2L2 p=1·20 Ă 10â3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 Ă 10â8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16â0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06â0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation
E-cadherin loss of function in the murine intestine
- Publication venue
- Publication date
- 01/01/2012
- Field of study
E-cadherin (Cdh1), is a major component of epithelial adherens junctions, binds the Wnt pathway effector ÎČ-catenin and is lost at the invasive edge of colon cancers. Crypt stem cells give rise to 4 cell lineages that, with the exception of Paneth cells, travel along the crypt-villus axis over 3 days and are shed by anoikis. Gain of function of the Wnt pathway by a mutation in Adenomatous Polyposis Coli (Apc) disrupts enterocyte turnover to result in adenoma formation. Homozygote null Cdh1 is embryonic lethal, and heterozygote Cdh1 can promote Apc1638N induced adenoma formation, but we lack models that assess additional functions of Cdh1 in the adenoma to carcinoma transition. The aim of this thesis was to evaluate the effect of Cdh1 loss of function in the murine intestine, including in the setting of Wnt pathway activation. To do this, germline and intestinal specific conditional Cdh1 loss of function models were generated. Conditional homozygous deletion of Cdh1 resulted in embryonic lethality using Villin-Cre. In adults, homozygous Cdh1 loss using the tamoxifen inducible Villin-CreERT2 led to intestinal inflammation, bacteraemia and disrupted crypt-villus architecture. Combined conditional homozygous deletion of Cdh1 and Apc resulted in Wnt pathway upregulation assessed by ÎČ-catenin immunolabelling. Strain dependent effects of Cdh1 heterozygosity were apparent on the Apc heterozygote background: ApcMin/+ Cdh1+/- (C57BL/6J) had no effect on survival or adenoma phenotype compared to littermate ApcMin/+; Cdh1+/fl increased adenoma burden in Apc+/fl Vil-Cre animals (B6D2/C57BL/6J). Low frequency recombination of Apcfl/fl using Lgr5-EGFP-IRES-CreERT2 bypasses the loss of heterozygosity event relied on in heterozygous Apc tumour models achieving a large adenoma burden within 4 weeks. Cdh1 loss did not alter survival or adenoma phenotype in this model, including the development of large caecal tumours. Immunolabelling of tumours from Apcfl/fl Cdh1fl/fl animals showed persistent E-cadherin protein expression, suggesting incomplete recombination or that double homozygote enterocytes failed to survive. In vitro adenoma culture was used to test whether E-cadherin loss was incompatible with enterocyte survival in the setting of Wnt activation. Apcfl/fl Cdh1+/+ and Apcfl/fl Cdh1fl/fl adenoma were cultured in matrigel and treated with an adenovirus expressing Cre recombinase under a CMV promoter (Ad-Cre). Ad-Cre had no effect on Apcfl/fl Cdh1+/+ adenoma growth. Ad-Cre treated Apcfl/fl Cdh1fl/fl adenoma organoids showed cells where Eâcadherin loss resulted in Wnt pathway upregulation as assessed by nuclear ÎČ-catenin and Axin2 expression, and epithelial mesenchymal transition shown by upregulation of fibronectin, twist and vimentin. This work supports a role for E-cadherin in modulation of the Wnt pathway. Further investigation is required to define the cell adhesion versus Wnt regulatory functions of E-cadherin
Stratified analyses refine association between TLR7 rare variants and severe COVID-19
- Author
- A. Gulati
- Aaron Butler
- Aayesha Kazi
- Abdelhakim Altabaibeh
- Abdul Kayani
- Abhinav Gupta
- Abigail Crew
- Abigail Knighton
- Abigail Short
- Abigail Taylor
- Abiola Harrison
- Adam Brayne
- Adam Brown
- Adam Loveridge
- Adama Fofano
- Aditya Kuravi
- Adriana Botello
- Adriana Palom
- Agilan Kaliappan
- Agilan Kaliappan
- Agnieszka Kubisz-Pudelko
- AgustĂn Albillos
- Ahmed Zaki
- Ailbhe Brady
- Ailsa Golightly
- Ailstair Nichol
- Ainhi Mac
- Ajay Raithatha
- Alain Vuylsteke
- Alan Maclean
- Alan Morrison
- Alan Neal
- Alasdair Bamford
- Alasdair Hay
- Alastair McGregor
- Alastair Rose
- Alastair Thomas
- Aled Morgan
- Alessandra Bandera
- Alessio Gerussi
- Alex Howlett
- Alex Lyon
- Alex McCurdy
- Alex Puxty
- Alexander Hoischen
- Alexandra Metcalfe
- Alexandra Williams
- Alexandre C. Pereira
- Alfredo Serrano-Ruiz
- Alice Harvey
- Alice Michael Mitchell
- Alice Nicholson
- Alice Poole
- Alice Thomas
- Alicia A.C. Waite
- Alicia Knight
- Alicia Price
- Alison Brown
- Alison Brown
- Alison Durie
- Alison Ghosh
- Alison Harrison
- Alison Lewis
- Alison Lye
- Alison Quinn
- Alison Turnbull
- Alison Williams
- Alison Wilson
- Alissa Kent
- Alistair Gales
- Alistair Hughes
- Alistair Meikle
- Alistair Nichol
- Alistair Roy
- Allison Daniels
- Alun Rees
- Amanda Ayers
- Amanda Cowton
- Amanda Lyle
- Amanda McGregor
- Amanda Sanderson
- Amanda Tyler
- Amanda Whileman
- Amber Cox
- Amber Ford
- Ambreen Tariq
- Amelia Daniel
- Amelia Stacey
- Ami Wilkinson
- Amie Reddy
- Amit Patel
- Amitaa Maharajh
- Amro Katary
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- Amy Gardner
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- Ana Alvaro
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- Andre Franke
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- Andrea Kay
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- Andrew Higham
- Andrew Higham
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- Andy Law
- Anelise C. Zborowski
- Aneta Bociek
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- Angela Allan
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- Anil Hormis
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- Annalisa Dance
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- Anne Nicholson
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- Anne Todd
- Anne Zak
- Annette Hilldrith
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- Armorel Salberg
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- Arunkumar Ganesan
- Ascanio Tridente
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- Asifa Ali
- Atideb Mitra
- Atul Garg
- Audrey Coutts
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- Avril Donaldson
- Axel Schmidt
- Ayaa Eltayeb
- Ayesha Javaid
- Azmerelda Abraheem
- Baird Tracy
- Bally Purewal
- Balvinder Baines
- Barbara Winter-Goodwin
- Barney Scholefield
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- Beatriz Nafria
- Becky Lenagh
- Beena David
- Beena Eapen
- Belinda Roberts
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- Carlos Castro Delgado
- Carly Price
- Carmel Stuart
- Carole Hays
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- Carter David
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- Chenqing Zheng
- Cheryl Finch
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- Chunda Sri-Chandana
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- Dabheoc Coleman
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- Dawn Collier
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- Debbie Hamilton
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- Dee Mullan
- Dee Mullan
- Deepak Subramanian
- Deirdre Fottrell-Gould
- Delordson Kallon
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- Dhanalakshmi Bakthavatsalam
- Dhaneesha Senaratne
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- J. Kenneth Baillie
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- James Scriven
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- Janine Mallinson
- Jannik Boos
- Jasmine Egan
- Jasmine Medhora
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- Jaspret Gill
- Javier Fernandez
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- Jayachandran Radhakrishnan
- Jayaprakash Singh
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- Jen Service
- Jenkins Samuel
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- Jennifer Valentine
- Jennifer Whitbread
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- Jenny Ritzema
- Jeremy Bewley
- Jeremy Scanlon
- Jerik Verula
- Jeronimo Moreno-Cuesta
- Jess Caterson
- Jess Perry
- Jessica Jones
- Jessica Pendlebury
- Jessica Reynolds
- Jessica Thrush
- Jesus M. Banales
- Jez Pinnell
- Jiantao Chen
- Jill Greig
- Jisha Mathew
- Jo Dasgin
- Jo Fletcher
- Jo Singleton
- Jo Stickley
- Jo-Anna Conyngham
- Joachim L. Schultze
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- Jocelyn Keshet-Price
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- Jordi Barretina
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- Joshua Cooper
- Josie Goodsell
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- Karen Reid
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- Kat Rhead
- Katarina Manso
- Katarzyna Hafezi
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- Kate Colette Tatham
- Kate Darlington
- Kate Hammerton
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- Kate Long
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- Katerina Stroud
- Katharine Duffy
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- Katherine Schon
- Kathleen Holding
- Kathryn Birchall
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- Kathryn Norman
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- Sinead Kelly
- Siobhain Carmody
- Sivarupan Selvanayagam
- Sohphie Birch
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- Sophie Kennedy-Hay
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- Sophie Packham
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- Stephen Cole
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- Sweyn Garrioch
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- Tammy Gilchrist
- Tara McHugh
- Tatiana Pogreban
- Taya Anderson
- Teishel Joefield
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- Teresa Scott
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- Tim Smith
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- Timothy Walsh
- Tina Coventry
- Tinashe Samakomva
- Tobias Rankin
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- Tonicha Nortcliffe
- Tony Wackett
- Toran Williams
- Tracey Cosier
- Tracey Hodgkiss
- Tracie Arden
- Tracy Duncan
- Tracy Hazelton
- Tracy Lewis
- Tracy Marsden
- Tracy Wood
- Trevor Paterson
- Una Poultney
- Val Irvine
- Valeria Rimoldi
- Valerie Beech
- Valerie Joan Page
- Valli Ratnam
- Vanessa Linnett
- Vanessa Rivers
- Varun Sarathy
- Veronica Wagstaff
- Veronika Pristopan
- Vicky Martinson
- Vicky Thomas
- Vicky Thwaites
- Vicky Thwaites
- Victoria Bastion
- Victoria Bridgett
- Victoria Clark
- Victoria Frost
- Victoria Lake
- Victoria Maynard
- Victoria Maynard
- Victoria Parris
- Victoria Parris
- Victoria Slater
- Victoria Tuckey
- Victoria Turner
- Victoria Waugh
- Vidya Kasipandian
- Vikki Crickmore
- Vikram Anumakonda
- Vinodh Krishnamurthy
- Vinodh Krishnamurthy
- Vishal Amin
- Wall Alanna
- Waqas Khaliq
- Waqas Khaliq
- Watkins Claire
- Wendy Goddard
- Wendy Harrison
- Wendy McCormick
- West Joe
- Wiesia Woodyatt
- Wild Laura
- William James Hurt
- Wilna Oosthuyzen
- Xavier Farré
- Xinyi Qiu
- Yasmin Choudhury
- Yasmin Death
- Yasmin Hussain
- Yolanda Baird
- Yusuf Cheema
- Yvette Thirlwall
- Yvonne Jackson
- Zahira Maqsood
- Zakaula Belagodu
- Zena Bradshaw
- Ziortza Fernandez
- Zoe Alldis
- Zoe Coton
- Zoe Daly
- Zoe Garland
- Zoe Lamond
- Zoe Prime
- Zoe Scott
- Zohra Omar
- Zohreh Farzad
- Publication venue
- Elsevier
- Publication date
- 01/10/2024
- Field of study
Summary: Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence were sequenced in 1,772 severe COVID-19 cases and 5,347 population-based controls from Spain/Italy. Rare deleterious TLR7 variants were present in 2.4% of young (<60 years) cases with no reported clinical risk factors (n = 378), compared to 0.24% of controls (odds ratio [OR] = 12.3, p = 1.27 Ă 10â10). Incorporation of the results of either functional assays or protein modeling led to a pronounced increase in effect size (ORmax = 46.5, p = 1.74 Ă 10â15). Association signals for the X-chromosomal gene TLR7 were also detected in the female-only subgroup, suggesting the existence of additional mechanisms beyond X-linked recessive inheritance in males. Additionally, supporting evidence was generated for a contribution to severe COVID-19 of the previously implicated genes IFNAR2, IFIH1, and TBK1. Our results refine the genetic contribution of rare TLR7 variants to severe COVID-19 and strengthen evidence for the etiological relevance of genes in the interferon signaling pathway
Clinical manifestations of intermediate allele carriers in Huntington disease
- Author
- A Marit de Weert
- Aakta Patel
- Abigail Wright
- Abigail Wright
- Adriana Prundean
- Adrien Come
- Adrienne Curtis
- Agata Stenwak
- Agnieszka Gorzkowska
- Agnieszka Konkel
- Aicha Ghenam
- Alain Kaelin
- Aleksandra Kaczmarczyk
- Alessandro Roca
- Alexander MĂŒnchau
- Alexandra Ure
- Alexandre Eusebio
- Alice Seris
- Alison Kraus
- Alma Sikiric
- Alyson Andrew
- Alyson Bradbury
- Alzbeta MĂŒhlbĂ€ck
- Amaia GonzĂĄlez
- Amy Palmer
- Ana Calado
- Ana GarcĂa
- Ana Maria Finisterra
- Ana Maria Finisterra
- Ana Rojo SebastiĂĄn
- Ana Rojo SebastiĂĄn
- Ana Salgueiro
- Anabela Valadas
- Andrea Buck
- Andrea Ginestroni
- Andrea H Nemeth
- Andrea Horta-Barba
- Andrea Kesse
- Andrea Sollom
- Andrew Parkinson
- Andrzej Szczudlik
- Aneta Klimberg
- Angel MartĂnez Pueyo
- Anke Niess
- Anna Ciesielska
- Anna Gogol
- Anna Kaminska
- Anna Maria Romoli
- Anna Rita Bentivoglio
- Anna Rita Dellomonaco
- Anna SuĆek
- Anna Wasielewska
- Anne Kampstra
- Anne Rosser
- Anne Schoonderbeek
- Anne-Catherine Bachoud-LĂ©vi
- Annunziata De Nicola
- Antonella Muroni
- Antonia Campolongo
- Antonio Herranz BĂĄrcenas
- Antonio Villa Riballo
- Ariane Schneider
- Artur Dziadkiewicz
- Arvid Heiberg
- Arvid Heiberg
- ArĂĄnzazu Gorospe
- Ashok Krishnamoorthy
- Ashok Raman
- AsunciĂłn MartĂnez Descals
- AsunciĂłn MartĂnez-Descals
- Audrey Olivier
- Baldev Singh
- Barbara D'Alessio
- Barbara JasiĆska-Myga
- Barbara Kaminski
- Barbara Vives Pastor
- BartĆomiej WiĆniewski
- Beate Rindal
- Beatriz Tijero Merino
- Beatriz Udaeta
- Belén Frades
- Bernhard Landwehrmeyer
- Beverley Hayward
- Beverley Soltysiak
- Bianca Kramer
- Blandine Babiloni
- Bénédicte Gohier
- Calvo S.
- Camille Genoves
- Carina Hvalstedt
- Carlo Rinaldi
- Carlos Salvador
- Carmen AntĂșnez Almagro
- Carmen DurĂĄn Herrera
- Carole Clayton
- Carolin Geitner
- Carolina Mendez Lucena
- Carolina Villa
- Caroline Hallam
- Caroline Peacy
- Carsten Saft
- Cat Taylor
- Caterina Bartoli
- Catherine Bourdet
- Catherine Clenaghan
- Catherine Taylor
- Cecilie Haggag Johannessen
- Charlotte Duché
- Charlotte Eddy
- Charlotte Golding
- Cheryl Stopford
- Chiara Esposito
- Christelle Chabot
- Christian Sass
- Christian Sass
- Christiane Schlangen
- Christina Vangsted-Hansen
- Christine Garreau
- Christine Held
- Christine Held
- Christine Leypold
- Christine Verellen-Dumoulin
- Christine Verellen-Dumoulin
- Christoph Michael Kosinski
- Christoph Schrader
- Christophe Verny
- Christos Ganos
- Cici Feliz Feliz
- Cinzia Valeria Russo
- Claire Thiriez
- Clara Villanueva
- Clarisse Scherer-Gagou
- Claudia Cormio
- Claudia Lamanna
- Claudia Mechi
- Claudia Serpino
- Cornelius J Werner
- Cristina JanuĂĄrio
- Cristina Melgar Fernandez
- Cristina Semedo
- Cubo E.
- Cynthia Butcher
- Cyril Goizet
- CĂšlia Mareca Viladrich
- CĂ©cile Focseneanu
- CĂ©cile Minet
- Daniel Ecker
- Daniel Ecker
- Daniel Stompel
- Daniel Zielonka
- Daniel Zielonka
- Daniela Monza
- Daniela Probst
- Daniela Rae
- Daniela Schwenk
- Danielle LafoucriĂšre
- Danuta Ryglewicz
- David Craufurd
- David Harrison
- Davina Hensman
- Dawn Freire- Patino
- Dawn Rogers
- Dawn Rogers
- Deena Gallantree
- Dirk Dressler
- Dolors Badenes Guia
- Dominique Bonneau Marie Bost
- Dominique Van Paemel
- Dorota BoÄwiĆska
- Edward Wild
- Elena Bellosta Diago
- Elena Ghelli
- Elena LĂłpez
- Elena Salvatore
- Elisabeth Dramstad
- Elisabeth Rosser
- Elisabetta Bertini
- Elizabeth Coulthard
- Elizaveta Yudina
- Ellen P 't Hart
- Elvina Chu
- Elvira Roca
- Elzbieta Zdzienicka
- ElĆŒbieta SzczygieĆ
- Emilia Sitek
- Emma Hobson
- Emma Oughton
- Erika Timewell
- Esther Cubo
- Eugeniusz Zielonka
- Eva Hölzner
- Eva Milkereit
- Eva Pacheco Cortegana
- Eve M Dumas
- Ewa NaroĆŒaĆska
- Ewelina Ciach-Wysocka
- Ewelina Kubowicz
- Fabienne Calvas
- Farideh Badei
- Ferdinando Squitieri
- Fernanda Fortunato
- Fernando Alonso Frech
- Fernando Alonso-Frech
- Filipa JĂșlio
- Fiona Summers
- Flverly Francis
- Francesca De Gregorio
- Francesca Elifani
- Francesca Lovo
- Francesco Marrosu
- Francisco Castera Brugada Carmen PeirĂł Vilaplana
- Franziska Lezius
- Frédérique Fluchere
- Fuensanta Noguera Perea
- FĂĄtima Damas Hermoso
- G Bernhard Landwehrmeyer
- Gabriela KĆodowska-Duda
- Gabriele Diercks
- Gareth Thomas
- Gemma Tome Carruesco
- Gil-Polo CAnne-Catherine Bachoud-LĂ©vi
- Gill Siuda
- Ginette Cass
- Gioia Jacopini
- Giovanni Franco
- Giovanni Ristori
- Gisa Ellrichmann
- Giulia Coarelli
- Giuseppe De Michele
- Graça Morgado
- Grzegorz Opala
- Grzegorz Witkowski
- Grzegorz Witkowski
- Guillermo GarcĂa Ribas
- Gunnel Fredlund
- Halina Sienkiewicz-Jarosz
- Hanan Khalil
- Hannah Musgrave
- Hannele Hypponen
- Heather Dipple
- Heike Beckmann
- Heike Gorzolla
- Helen Fairtlough
- Helen Gundersen
- Helen Murphy
- Helene Padieu
- Heli Hiivola
- Herwig Lange
- Hubert Kwiecinski
- Hugh Rickards
- Husam Samara
- HĂ©lĂšne Grosjean
- Ida Biunno
- Ida Unmack Larsen
- Idaira MartĂn
- Ines Goerendt
- Inés Legarda Ramirez
- Irene Mazzante
- Irene Romero
- Iris Trender-Gerhard
- Isabella Foustanos
- Itziar Gaston
- Ivana Markova
- Iwona StÄpniak
- Jacek AnioĆa Anna Bryl
- Jacek Zaremba
- Jacek Zaremba
- Jaime Kulisevsky Bojarsky
- Jakub Antczak
- Jamie Levey
- Jan Coebergh
- Jan Frich
- Jan Lewerenz
- Jan Lewerenz
- Jan Wahlström
- Jan Wahlström
- Jan Wright
- Jaroslaw Slawek
- Javier Del Val Fernandez
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- Jenny Townhill
- Jeremy Cosgrove
- Jeroen P P van Vugt
- Jerzy Marcinkowski
- Jesus Perez Perez
- JesĂșs Miguel Ruiz Idiago
- Jette Stockholm
- Jill Davison
- Jillian Foster
- Joana Morgado
- Joaquim J Ferreira
- Joaquim J Ferreira
- Johannes Schiefer
- John O Donovan
- John Piedad
- Jordi Bas
- Josh Williams
- Josh Wood
- José Chacón Peña
- José Luis López-Sendón Moreno
- JosĂ© Manuel GarcĂa Moreno
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- Joy Read
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- Juan GarcĂa Caldentey
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- Jutta Rummel
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- JĂžrgen Nielsen
- Kai Boelmans
- Kamila Bojakowska-Jaremek
- Karen Doherty
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- Karolina Ziora-Jakutowicz
- Kasia Sieradzan
- Katarzyna Jachinska
- Katherine Tidswell
- Kathleen Fuller
- Kathleen Price
- Kathrin Reetz
- Kathrine BjĂžrgo
- Kathrine Haggag
- Kathryn Dixon
- Katia Youssov
- Katri Tuuha
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- Kerstin Koppers
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- Kingsley Powell
- Kirsti Martikainen
- Kirsty Matheson
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- Kirsty O'Donovan
- Koldo Berganzo Corrales
- Krzysztof Banaszkiewicz
- Laetitia Jameau
- Laetitia Vervoitte
- Lars RetterstĂžl
- Lars Stubbe
- Laura Casas Hernanz
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- Laura Mundler
- Laura Vivancos Moreau
- Laurent Cléret
- Laurent Marquine
- Laurent Paterski
- Laurie Lemoine
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- Leanne Timings
- Lena Hjermind
- Lennard Herrmann
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- Lisanne MĂŒtze
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- Marleen van Walsem
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- Martinez-Horta S.
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- Mette Gilling
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- Nadia Peppa
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- Olivia J Handley
- Pablo SĂĄnchez Lozano
- Pam Yardumian
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- Paola Zinzi
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- Patricia Trigo Cubillo
- Patrick Weydt
- Patrocinio Garcia Moreno
- Paul Gill
- Pavla Ć aĆĄinkovĂĄ
- Pawel Tacik
- Pedro JosĂ© GarcĂa RuĂz
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- Rachel Edwards
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- Radu Constantinescu
- Rafal Rola
- Ragnhild Wehus
- Rainer Hoffmann
- Ralf Marquard
- Ralf Reilmann
- Ramon Fernandez de Bobadilla
- Ramos-Arroyo M. A.
- Raphael M Bonelli
- Raymund A C Roos
- Raymund A C Roos
- Rebecca Minschke
- Reineke Bos
- Reineke Bos
- René Ribacoba
- Richard Armstrong
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- Roisin Jack
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- Rupert Noad
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- Ruth Fullam
- Ruth Fullam
- Ruth Valentine
- Sabine Gayde-Stephan
- Sabine Weber Zaugg
- Sabrina Betz
- Sabrina Debruxelles
- Salman Haider
- Salvadora Manzanares
- Samia Cheriet
- Sandra Gutierrez Romero
- Sandra Large
- Sandrine Rolland
- Sandro Sorbi
- Sara Minster
- Sara Minster
- Sarah Hunt
- Sarah J Tabrizi
- Sarah Rose
- Sarah Tabrizi
- Saul Martinez-Horta
- Saul Martinez-Horta
- Selene Capodarca
- Serge JaumĂ Classen
- Shahbana Akhtar
- Sharon McDonnell
- Sheila A Simpson
- Shona Yates
- Sigrun Schepers
- Sigurd SĂŒssmuth
- Silke Rumpf
- Silvia Piacentini
- Silvia Pradella
- Silvia Romano
- Silvio Peluso
- Simon J A van den Bogaard
- Simone Zittel
- Solveig Nepper
- Sonia Arribas Pardo
- Sonia GonzĂĄlez
- Sonja Trautmann
- Stefan Bohlen
- Stefania Bruno
- Stefanie Brown
- Stefanie Rohm
- Stephan Klebe
- Stephanie Hamer
- Stephen B Dunnett
- Stephen Dunnett
- Stuart Jamieson
- Sue McKenzie
- Sue Wild
- Suresh Komati
- Susan Huson
- Susana Pro Koivisto
- Susana Pro Koivisto
- Suzanne Lindquist
- SĂ©bastien Charpentier
- Tecla Tucci
- Tereza Uhrova
- Thomas Musacchio
- Thomas Warner
- Thomasin Andrews
- Tiago Mendes
- Tiago Mestre
- Tiago Mestre
- Tiziana Martino
- Torsten Illmann
- Tua Vinther-Jensen
- Ulrika HĂžsterey-Ugander
- Umberto Spampinato
- Una Jones
- Uruj Anjum
- Ute Hidding
- Valentina Codella
- Valeria Piras
- Valérie Vaquie
- Verena Baake
- Verena Baake
- Veronica Puertas Martin
- Verónica Mañanes Barral
- Vicenta SĂĄnchez
- Vittorio Sciruicchio
- Vivien Vaughn
- Walburgis Heinicke
- Wildson Vieira da Silva
- Wim Vandenberghe
- Wioletta Krysa
- Witold Soltan
- Yanik Stebler
- Yuri Seliverstov
- Zeid Mohammed
- Zosia Miedzybrodzka
- Zygmunt Jamrozik
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2016
- Field of study
Objective: There is controversy about the clinical consequences of intermediate alleles (IAs) in Huntington disease (HD). The main objective of this study was to establish the clinical manifestations of IA carriers for a prospective, international, European HD registry. Methods: We assessed a cohort of participants at risk with <36 CAG repeats of the huntingtin (HTT) gene. Outcome measures were the Unified Huntington's Disease Rating Scale (UHDRS) motor, cognitive, and behavior domains, Total Functional Capacity (TFC), and quality of life (Short Form-36 [SF-36]). This cohort was subdivided into IA carriers (27-35 CAG) and controls (<27 CAG) and younger vs older participants. IA carriers and controls were compared for sociodemographic, environmental, and outcome measures. We used regression analysis to estimate the association of age and CAG repeats on the UHDRS scores. Results: Of 12,190 participants, 657 (5.38%) with <36 CAG repeats were identified: 76 IA carriers (11.56%) and 581 controls (88.44%). After correcting for multiple comparisons, at baseline, we found no significant differences between IA carriers and controls for total UHDRS motor, SF-36, behavioral, cognitive, or TFC scores. However, older participants with IAs had higher chorea scores compared to controls (p 0.001). Linear regression analysis showed that aging was the most contributing factor to increased UHDRS motor scores (p 0.002). On the other hand, 1-year follow-up data analysis showed IA carriers had greater cognitive decline compared to controls (p 0.002). Conclusions: Although aging worsened the UHDRS scores independently of the genetic status, IAs might confer a late-onset abnormal motor and cognitive phenotype. These results might have important implications for genetic counseling. ClinicalTrials.gov identifier: NCT01590589
Cognitive decline in Huntington's disease expansion gene carriers
- Author
- Aanonsen Nils Olaf
- Aaserud Olaf
- Abbruzzese Giovanni
- Akhtar Shahbana
- AlarcĂłn Moreau MarĂa Dolores
- Albanese Alberto
- Allain Philippe
- Almagro Carmen AntĂșnez
- Alonso-Frech Fernando
- Andrade Carlos
- Andrews Thomasin
- Andrich JĂŒrgen
- Anheim Mathieu
- Anjum Uruj
- Annic AgnĂšs
- Antczak Jakub
- Arbelo JosĂ© MatĂas
- Arkuszewski MichaĆ
- Armstrong Richard
- Arntsen Vibeke
- Arques Penelope Navas
- Arran Natalie
- Artiga MarĂa JosĂ© Sainz
- Azulay Jean-Philippe
- Baake Verena
- Babiloni Blandine
- Bachmeier Michael
- Bachoud-LĂ©vi Anne-Catherine
- Badei Farideh
- Banaszkiewicz Krzysztof
- Bandmann Oliver
- Barbera Miquel Aguilar
- Barker Roger A.
- Barral Verónica Mañanes
- Barrero Francisco
- Barth Katrin
- Barthélémy Recka
- Bartoli Caterina
- Barun Nadia
- Bas Jordi
- Bascuñana Mónica
- Bechtel Natalie
- Beckmann Heike
- Bek Judith
- Bellonet Marcellin
- Benaich Sandra
- Benoit Alexandra
- Bentivoglio Anna Rita
- Bentivoglio Anna-Rita
- Berglund Maria
- Berglund MĂ„ns
- Berglund Peter
- Bergmann Ulrike
- Bernard TomĂĄĆĄ
- Berrisoul Hassan
- Bertini Elisabetta
- Bethwaite Pamela
- Betz Sabrina
- Beuth Markus
- Bioux Sandrine
- Biunno Ida
- BjĂžrgo Kathrine
- BjĂžrnevoll Inga
- Bliaux Evangeline
- Blin Stéphanie
- Blinkenberg Ellen Ăkland
- Blondeau Leily
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen Stefan
- Boissé Marie-Françoise
- Bojakowska-Jaremek Kamila
- Bojarsky Jaime Kulisevsky
- Bonelli Raphael M.
- Bonneau Dominique
- BorgeĂžd Nancy
- Bos Reineke
- Bosca Maria
- Bosredon Cecile
- Bost Marie
- Boster Sarah
- Boudali Lotfi
- Bove Francesco
- BoÄwiĆska Dorota
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brice Alexis
- Brockie Peter
- Bronzova Juliana
- Brown Pauline
- Brown Stefanie
- Brugger Florian
- Bruno Stefania
- Bruycker Christelle De
- Bryl Jacek AnioĆa Anna
- Buchanan Lindsay
- Buck Andrea
- Buongiorno MarĂa Teresa
- Buratti Lisa
- Burguera Juan Andres
- Burgunder Jean-Marc
- Burrows Liz
- Busquets NĂșria
- Busse Monica
- Butcher Cynthia
- BĂĄrcenas Antonio Herranz
- Böringer Regina
- BĂŒrk Katrin
- BĆaszczyk Magdalena
- Cabaret Maryline
- Calandra-Buonaura Giovanna
- Caldentey Juan GarcĂa
- Callaghan Jenny
- Calopa Matilde
- Calvas Fabienne
- Calzado Noemi
- Campolongo Antonia
- Cannella Milena
- Capellari Sabina
- Capetian Philipp
- Capodarca Selene
- Carette Anne-Sophie
- CarriĂšre Nicolas
- Carruesco Gemma Tome
- Cass Ginette
- Castagliuolo Simona
- Castaldo Anna
- Catalli Claudio
- Catena Judit LĂłpez
- Cavaco Sara
- Cação Gonçalo
- Chabot Christelle
- Charles Perrine
- Cheriet Samia
- Chiara Piccininni
- Chu Carol
- Chu Elvina
- Ciach-Wysocka Ewelina
- Ciesielska Anna
- Classen Serge JaumĂ
- Clayton Carole
- Clenaghan Catherine
- Coarelli Giulia
- Codella Valentina
- Coebergh Jan
- Coelho Miguel
- Come Adrien
- Connemann Julia
- Constantinescu Radu
- Cormio Claudia
- Cortegana Eva MarĂa Pacheco
- Cortelli Pietro
- Cosgrove Jeremy
- Costa Andreia
- Coulthard Elizabeth
- Courtin Françoise
- Couttier Julien
- Craufurd David
- Crooks Jenny
- Cubillo Patricia Trigo
- Cubo Esther
- Curtis Adrienne
- D'Alessio Barbara
- Da Silva Vieira
- DamĂĄsio Joana
- Das Purkayastha Debasish
- Davidson Lynn
- Davison Jill
- De Bobadilla Ramon Fernandez
- De Gregorio Francesca
- De La Cerda Santa MarĂa AndrĂ©s
- De Langavant Laurent Cleret
- De Michele Giuseppe
- De Molina RocĂo Malo
- De Nicola Annunziata
- De Souza Jenny
- De Tommaso Marina
- De Weert A. Marit
- Debilly BĂ©rengĂšre
- Debruxelles Sabrina
- Dec MaĆgorzata
- Decorte Eric
- DedichĂĄ Nadia RodrĂguez
- Defebvre Luc
- Deith Catherine
- Dekker Meike
- Del Mar Fenollar MarĂa
- Del Val Fernandez Javier
- Del ValleLoarte MarĂa
- Delabaere HelĂšne
- Delaigue Christine
- Delfini Marie
- Delliaux Marie
- Delval Arnaud
- Demonet Jean-François
- Depelchin Alizé
- Descals AsunciĂłn MartĂnez
- Destee Alain
- Dewulf-Pasz Nelly
- Deyebenes Justo GarcĂa
- Di Bella Daniela
- Di Donato Stefano
- Di Giacopo Raffaella
- Di Maio Luigi
- Di Maria Emilio
- Di Poggio Monica Bandettini
- Di Renzo Martina
- Dieguez Esther
- Diercks Gabriele
- Difruscolo Olimpia
- Dipple Heather
- Dixon Kathryn
- Doherty Karen
- Dondaine Thibaut
- Donovan John O.
- Dose Matthias
- Dougherty Andrew
- Downie Lorna
- Dramstad Elisabeth
- Dressler Dirk
- Duché Charlotte
- Duda Gabriela KĆodowska E.
- Dugauquier Florence
- Duits Annelien
- Dujardin Kathy
- Dumas Eve M.
- Dunnett Stephen
- Dunnett Stephen B.
- Dupuis Michel
- Durif Franck
- Durr Alexandra
- Duru CĂ©cile
- Dziadkiewicz Artur
- DĂaz-Zorita Juan Pablo Tartari
- Ecker Daniel
- Eddy Charlotte
- Edwards Maureen
- Edwards Rachel
- Eklund Pia
- Ekwall Camilla
- Elifani Francesca
- Ellrichmann Gisa
- Esposito Chiara
- Eusebio Alexandre
- Evans Carole
- Ewenczyk Claire
- Fairtlough Helen
- Fannemel Madeleine
- Fasano Alfonso
- Fasquel VĂ©ronique
- Feliz Cici Feliz
- Fernandes Joana
- Ferraldeschi Michela
- Ferrandes Giovanna
- Ferreira Joaquim J.
- Ferrer Pilar Quiléz
- Figuerola Begoña Jeweinat
- Fillingham Kay
- Finisterra Ana Maria
- Fisher Kate
- Flament MĂ©lanie
- Fletcher Amy
- Fluchere Frédérique
- Fortuna Lorenza
- Fortunato Fernanda
- Foster Jillian
- Foustanos Isabella
- Frades Belén
- Francis Flverly
- Francisque HĂ©lĂšne
- Franco Giovanni
- Frech Fernando Alonso
- Fredlund Gunnel
- Freire-Patino Dawn
- Frich Jan
- Frich Jan C.
- Frontali Marina
- Fullam Ruth
- Fuller Kathleen
- Fullerton Neil
- Gago Miguel
- Gallantree Deena
- Gallassi Roberto
- Gallentree Deena
- Ganos Christos
- Garcia-Amigot Fermin
- GarcĂa Ana
- GarcĂa RocĂo GarcĂa-Ramos
- Garreau Christine
- Garrett Carolina
- Gaston Itziar
- Gayde-Stephan Sabine
- Geitner Carolin
- Gelderblom Harald
- Gellera Cinzia
- Genitrini Silvia
- Genoves Camille
- Gerrtiz Anna
- Gethin Louise
- Ghelli Elena
- Gill Paul
- Gilling Mette
- Ginestroni Andrea
- Girard Carole
- Giuliano Joe
- Godefroy Olivier
- Goerendt Ines
- Gogol Anna
- Gohier Bénédicte
- Goizet Cyril
- Golding Charlotte
- GonzĂĄlez Sonia
- Goodman Anna
- Gorospe ArĂĄnzazu
- Gorzkowska Agnieszka
- Gorzolla Heike
- Goudie David
- Gowers Lesley
- Grabska Natalia
- Grosjean HĂ©lĂšne
- Guedes Leonor Correia
- Guenam Aicha
- Guia Dolors Badenes
- Guidubaldi Arianna
- GuimarĂŁes Joana
- Guisasola Luis Menéndez
- Guyant-Maréchal Lucie
- Guzman Natalie Valle
- Guérid Marie-Anne
- Göller Marie-Lousie
- Göpfert Nicole
- GĂžrvell Per F.
- Haggag Kathrine
- Haider Salman
- Hallam Caroline
- Hamer Stephanie
- Hametner Eva-Maria
- Handley Olivia J.
- Hannequin Didier
- Hannier VĂ©ronique
- Harding Alison
- Hare Marianne
- Harrison David
- Harrower Timothy
- Hartikainen Paivi
- Haug Marte GjĂžl
- Hauge Erik
- Hayward Beverley
- Hecht Karen
- Heiberg Arvid
- Heinicke Walburgis
- Held Christine
- Hensman Davina
- Hepperger Caroline
- Hermoso FĂĄtima Damas
- Hernanz Laura Casas
- Herranhof Brigitte
- Herrera Carmen Duran
- Herrmann Lennard
- Hidding Ute
- Hiivola Heli
- Hill Susan
- Ho Carrie
- Hobson Emma
- Hoffmann Rainer
- Hofstetter Nina
- Holas Christiane
- Holl Anna
- Holmes Katrina
- Hopes Lucie
- Hotter Anna
- Howard Liz
- Hughes Max
- Hunger Ulrike
- Hunt Sarah
- Huson Susan
- Hussl Anna
- Hvalstedt Carina
- Hyppönen Hannele
- Hölzner Eva
- HĂžsterey-Ugander Ulrika
- Ialongo Tamara
- Idiago JesĂșs Miguel Ruiz
- Illarioshkin Sergey
- Illmann Torsten
- Ireland Jane
- Irvine Sarah
- Jachinska Katarzyna
- Jack Roisin
- Jacopini Gioia
- Jameau Laetitia
- Jamieson Stuart
- Jamrozik Zygmunt
- Janik Piotr
- JanuĂĄrio Cristina
- JasiĆska-Myga Barbara
- Jauffret CĂ©line
- Johannessen Cecilie Haggag
- Johns Nicola
- Johnson Liz
- Jones Lesley
- Jones Mary
- Jones Una
- Jourdain SĂ©verine
- Jung Hans H.
- Justo Damian
- JĂșlio Filipa
- Kaczmarczyk Aleksandra
- Kaelin Alain
- Kaminska Anna
- Kaminski Barbara
- Kammel Gerit
- Kampstra Anne
- Kapfhammer Hans-Peter
- Kassar Abdulrahman
- Kavalier Fred
- Kazoka Mbombe
- Kesse Andrea
- Khalil Hanan
- Klebe Stephan
- KlempĂr JirĂ
- Klimberg Aneta
- Klooster Jesper
- Knight Caroline
- Kohl Zacharias
- Koivisto Susana Pro
- Komati Suresh
- Konkel Agnieszka
- Koppers Kerstin
- Koppitz Michael
- Kosinski Christoph Michael
- Kozay Christina
- Kramer Bianca
- Kraus Alison
- Kraus Peter
- Krawczyk Malgorzata
- Kremer Berry
- Krishnamoorthy Ashok
- Krysa Wioletta
- Krystkowiak Pierre
- Kubowicz Ewelina
- Kwiecinski Hubert
- Ladurner Gunther
- LafoucriĂšre Danielle
- Lagha-Boukbiza Ouhaid
- Lahiri Nayana
- Laing Hana
- Lamanna Claudia
- Lambeck Johann
- Landwehrmeyer Bernhard
- Landwehrmeyer G. Bernhard
- Lange Herwig
- Larcher Barbara
- Large Sandra
- Lashwood Alison
- Lau Puay Ngoh
- LaurĂ Matilde
- Laver Fiona
- Leenders Nico
- Legendre Perrine
- Lemaire Marie-Helene
- Lemoine Laurie
- Lesne Fabien
- Levey Jamie
- Lewerenz Jan
- Lewin Kajsa
- Lewis Monica
- Lezius Franziska
- Ligon-Auer Maria
- Lilek Sabine
- Lilek Stefan
- Linnsand Petra
- Loiseau Sylvie
- Longato Nadine
- Longinus Bernhard
- Longthorpe Mandy
- Lopera Monica Rodriguez
- Loria Giovanna
- Loureiro Rui
- Loutfi Ghada
- Lovo Francesca
- Lozano Pablo SĂĄnchez
- Lucena Carolina Mendez
- LĂłpez Rosa Guerrero
- Löhle Matthias
- LĂŒsebrink Antje
- Maass Antonia
- MagalhĂŁes Marina
- Magnet Markus
- Mahlknecht Philipp
- Maiwald Robert
- Majeed Tahir
- MajerovĂĄ Veronika
- Malec-Litwinowicz Michalina
- MaltĂȘte David
- Mandich Paola
- Manouvrier Sylvie
- Mantaux BĂ©atrice
- Manzanares Salvadora
- Marcel Christophe
- Marchese Roberta
- Marcinkowski Jerzy
- Mariotti Caterina
- Mariscal Natividad
- Markova Ivana
- Marquard Ralf
- Martikainen Kirsti
- Martin Veronica Puertas
- Martinez-Horta Saul
- Martinez-Jaurrieta Maria Dolores
- Martino Tiziana
- MartĂn Idaira
- MartĂnez Noelia RodrĂguez
- MartĂnez-Descals AsunciĂłn
- Mason Sarah
- Massano JoĂŁo
- Massarelli Marco
- Matheson Kirsty
- Mazzante Irene
- Mcdonnell Sharon
- Mcentagart Meriel
- Mcfadyen Paula
- Mcgill Marie
- Mckenzie Sue
- Mclean Tim
- Mechi Claudia
- Meier Simone
- Meireles Joana
- Mendes Tiago
- Mestre Tiago
- Middleton Julia
- Miedzybrodzka Zosia
- Mihaylova Violeta
- Milani Paolo
- Milkereit Eva
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- Minschke Rebecca
- Minster Sara
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- Mohammed Zeid
- Monin Marie-Lorraine
- Monteiro Ana
- Monza Daniela
- Morales Blas
- Moreira InĂȘs
- Moreno José Luis Lópeze-Sendón
- Moreno JosĂ© Manuel GarcĂa
- Moreno Patrocinio Garcia
- Morgado Graca
- Morgan Karen
- Mundler Laura
- Murphy Helen
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- Muñoz Juan MarĂn
- MĂ€chtel Miriam
- Möller Carsten
- MĂŒhlau Mark
- MĂŒhlbĂ€ck Alzbeta
- MĂŒller Christoph
- MĂŒller Nicole
- MĂŒnchau Alexander
- MĂŒnkel Kristina
- MĂŒtze Lisanne
- Nanetti Lorenzo
- NarozaĆska Ewa
- Neleborn-LingefjÀrd Liselotte
- Nemeth Andrea H.
- Nepper Solveig
- Nevitt Louise
- Nielsen JĂžrgen E.
- NiemelÀ Valter
- Niess Anke
- Novak Marianne
- Nowak Malgorzata
- Nowak Marielle
- O'Donovan Kirsty
- O'Keefe Deidre
- O'Neill Mari
- Oehmen Martin
- Olivier Audrey
- Ollokainen Mari
- Olofsson Carina
- Oosterloo Mayke
- Opala Grzegorz
- Orth Michael
- Ossig Christiana
- Otti Daniela
- Oughton Emma
- Owen Michael
- Padieu Helene
- Paganini Marco
- Pagonabarraga Javier
- Painold Annamaria
- Palanca Paloma Millan
- Palmer Amy
- Panzeri Marta
- Pardo Sonia Arribas
- Paridi Dominga
- Pariente Jérémie
- Parkinson Andrew
- Partington-Jones Lucy
- Pastor Barbara Vives
- Patel Aakta
- Paterski Laurent
- Patton Michael
- Peacy Caroline
- Pearson Pauline
- Peinemann Alexander
- Peluso Silvio
- Peppa Nadia
- Perea Fuensanta Noguera
- Perez Jesus Perez
- Periañez Juan Manuel
- Peter Mireille
- Petersen Jens A.
- Peterson Maria
- Petersén à sa
- Petracca Martina
- Petrollini Martina
- Peña José Chacón
- Phillipps Clélie
- Phillips Michelle
- Piacentini Silvia
- Piano Carla
- Pica Emmanuel
- Piedad John
- Pierre MichĂšle
- Pinter Bernadette
- Playe Alicia
- Plomhause Lucie
- Poda Roberto
- Poewe Werner
- Polo Cecilia Gil
- Porteous Mary
- Pouliquen Dorothée
- Powell Kingsley
- Pradella Silvia
- Price Kathleen
- Prieto Marta Para
- Priller Josef
- Probst Daniela
- Prouzet Julie
- Prundean Adriana
- PrĂŒĂ Harald
- Pueyo Angel MartĂnez
- PÀivÀrinta Markku
- PĂ„lhagen Sven
- Quaranta Davide
- Quarrell Oliver
- Rae Daniela
- Rakowicz Maryla
- Raman Ashok
- Ramirez Inés Legarda
- Ramos-Arroyo Maria
- Ramos-Arroyo Maria Antonia
- Raseta Rolland
- Redondo Luis
- Reetz Kathrin
- Reijntjes Robert H. A. M.
- Reilmann Ralf
- Reimer Jan
- Reisinger Karin
- Reiter Eva-Magdalena
- RetterstĂžl Lars
- Ribacoba René
- Riballo Antonio Villa
- Ribas Guillermo GarcĂa
- RibaĂŻ Pascale
- Ribbat Michael
- Ribosa Roser
- Richter Przemyslaw
- Rickards Hugh
- Rijntjes Michel
- Rinaldi Carlo
- Rindal Beate
- Ristori Giovanni
- Ritchie Stuart
- Robert Misericordia Floriach
- Robertson Dene
- Robertson Nicola
- Robowski Piotr
- Roca Alessandro
- Roca Elvira
- Rogers Dawn
- Rohm Stefanie
- Rola Rafal
- Rolland Sandrine
- Romano Silvia
- Romero Irene
- Romero Sandra Gutierrez
- Romoli Anna Maria
- Roos Raymund A. C.
- Rose Sarah
- Rosser Anne
- Rosser Elisabeth
- Roth Jan
- Rothery Jean
- Roussel Martine
- Rowett Liz
- Roze Emmanuel
- Ruddy Deborah
- Rudolf Gabrielle
- RudziĆska Monika
- Rummel Jutta
- Rumpf Silke
- Russo Cinzia Valeria
- RuĂz Pedro JosĂ© GarcĂa
- Ryglewicz Danuta
- RĂžren Niini
- RĂžsby Oddveig
- SablonniĂšre Bernard
- Saft Carsten
- Salgueiro Ana
- Salvador Carlos
- Salvatore Elena
- Samara Husam
- Sando Sigrid Botne
- Santacruz Pilar
- Santala Maire
- Santhouse Alastair
- Sass Christian
- Savage Lois
- Scaglione Cesa
- Scheibl Monika
- Schepers Sigrun
- Scherer-Gagou Clarisse
- Schiefer Johannes
- Schlangen Christiane
- Schmalfeld Jenny
- Schmidt Simone
- Schneider Ariane
- Schoonderbeek Anne
- Schrader Christoph
- Schwenk Daniela
- Schöggl Helmut
- SchĂŒler BĂ©atrice
- SchĂŒpbach Michael
- Sciruicchio Vittorio
- SebastiĂĄn Ana Rojo
- SempoĆowicz Justyna
- Seppi Klaus
- Serpino Claudia
- Sevilla Maria Ascension Zea
- Sienkiewicz-Jarosz Halina
- Sieradzan Kasia
- Sikiric Alma
- Silva Mark
- Simonelli Maria
- Simonin Clémence
- Simpson Sheila A.
- Sinadinosa Daniela
- Singh Baldev
- Sitek Emilia
- Siuda Gill
- Slawek Jaroslaw
- Snowden Julie
- Soleti Francesco
- Solito Marcella
- Soliveri Paola
- Sollom Andrea
- Soltan Witold
- Soltysiak Beverley
- SolĂs Pilar
- Sorbi Sandro
- Sorrentino Pierpaolo
- Spadaro Maria
- Spagnolo Francesca
- Spampinato Umberto
- Sprenger Fabienne
- Spruth Eike
- Squitieri Ferdinando
- Staffen Wolfgang
- Stamm Christiane
- Stattin Eva-Lena
- Stebler Yanik
- Steinmetz GisĂšle
- Stenwak Agata
- Stokke Bodil
- Stompel Daniel
- Stopford Cheryl
- Storch Alexander
- Stubbe Lars
- StÀdtler Michael
- StĂžrseth Hanna Haugan
- Stȩpniak Iwona
- Summers Fiona
- Sundblom Jimmy
- SuĆek Anna
- Swain Rachel
- Szczudlik Andrzej
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- Szinwelski Michal
- SĂĄnchez Vicenta
- SĂĄnchez Violeta SĂĄnchez
- SĂŒssmuth Sigurd
- T Hart Ellen P.
- Tabrizi Sarah
- Tabrizi Sarah J.
- Tacik Pawel
- Tan Louis
- Tard CĂ©line
- Taroni Franco
- Tataru Alina
- Taylor Anne-Marie
- Taylor Cat
- Taylor Rachel
- Tchikviladzé Maya
- Thibault-Tanchou Stéphanie
- Thiel Silvia
- Thomas Gareth
- Thompson Jennifer
- Thompson Jennifer C.
- Thomson Aileen
- Tidswell Katherine
- Timewell Erika
- Timings Leanne
- Tir MĂ©lissa
- Tomasello Chiara
- Tonner Alison
- Torlizzi Flavia
- Torres MarĂa Martirio Antequera
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- Udaeta Beatriz
- Uhrova Tereza
- Ulla Miguel
- Ullah Jasmin
- Ure Alexandra
- Valadas Anabela
- Valentine Ruth
- Van Den Bogaard Simon J. A.
- Van Hout Monique S. E.
- Van Oostrom Joost
- Van Paemel Dominique
- Van Vugt Jeroen P. P.
- Van Walsem Marleen
- Van Walsem Marleen R
- Vandenberghe Wim
- Vaughan Vivien
- Ventura Marta FatĂĄs
- Verellen-Dumoulin Christine
- Verhoeven Marloes
- Verny Christophe
- Verstraelen Nichola
- Verstraelen Nicola
- Vezza Maurizio
- Vidal Tiphaine
- Viladrich CĂšlia Mareca
- Vilaplana Francisco Castera Brugada Carmen PeirĂł
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- Villanueva Marina Ăvila
- Vivancos Laura
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- Vuillaume Isabelle
- Waber Mirella
- Wagner Caroline
- Wahlström Jan
- Walleczek Anna Maria
- Wannepain Sandrine
- Warner Thomas
- Wasielewska Anna
- Weber Nathalia
- Wehus Ragnhild
- Weindl Adolf
- Wenning Gregor
- Werner Cornelius J.
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Widner HĂ„kan
- Wikström Birgitta
- Wild Edward
- Wild Sue
- Wildson SĂ©bastien Charpentier
- Williams Josh
- Winkelmann Juliane
- Winkler JĂŒrgen
- Witjes-Ané Marie-Noelle
- Witkowski Grzegorz
- WiĆniewski BartĆomiej
- Wolz Annett
- Wolz Martin
- Wood Josh
- Wright Abigail
- Wright Jan
- WĂłjcik Magdalena
- Yardumian Pam
- Yates Shona
- Youssov Katia
- Zaremba Jacek
- Zaugg Sabine Weber
- Zdzienicka Elzbieta
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Eugeniusz
- Zimmermann Marie-Agathe
- Zinzi Paola
- Ziora-Jakutowicz Karolina
- Zittel Simone
- Zucker Birgit
- Ć aĆĄinkovĂĄ Pavla
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Optimization of adsorptive removal of α-toluic acid by CaO2 nanoparticles using response surface methodology
- Author
- 't Hart Ellen P.
- Aaserud Olaf
- Abbruzzese Giovanni
- Aguilar Barbera Miquel
- Albanese Alberto
- Allain Philippe
- Alonso-Frech Fernando
- Andrews Thomasin
- Andrews Thomasin
- Andrich JĂŒrgen
- Antczak Jakub
- Antequera Torres MarĂa Martirio
- Arran Natalie
- Azulay Jean-Philippe
- Babiloni Blandine
- Bachoud-LĂ©vi A. C.
- Badenes Guia Dolors
- Banaszkiewicz Krzysztof
- Bandettini di Poggio Monica
- Bandmann Oliver
- Barker Roger A.
- Barnes Kathy
- Barrero Francisco
- Barth Katrin
- Barth Katrin
- Bas Jordi
- Bascuñana Garde Mónica
- Bascuñana Garde Mónica
- Bastida Antonio MartĂn
- Bate Louise
- Bechtel Natalie
- Beckmann Heike
- Beister Antonie
- Bellonet Marcellin
- Bentivoglio A. R.
- Bentivoglio Anna Rita
- Bertini Elisabetta
- Bisson Jonathan
- Biunno I.
- Björn Yvonne
- BjĂžrgo Kathrine
- BjĂžrnevoll Inga
- Blinkenberg Ellen Ăkland
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen Stefan
- Bolwijn J. J. W.
- Bonelli Raphael M.
- Bonelli Raphael M.
- Bonelli Raphael M.
- Boogaerts Andrea
- BorgerĂžd Nancy
- Bos Reineke
- Bos Reineke
- Bosca Maria
- Bourne Colin
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brockie Peter
- Brugger Florian
- Bruno Stefania
- Bryl Anna
- Buck Andrea
- Buongiorno Maria Teresa
- Buratti Lisa
- Burg Sabrina
- Burguera Juan Andrés
- Burgunder J. M.
- Burgunder Jean-Marc
- Burgunder Yvonne
- Burn John
- Burns Peter
- Burrows Liz
- Busquets NĂșria
- Busse Monica
- BĂŒrk Kathrin
- Callaghan Jenny
- Calopa Matilde
- Calvas Fabienne
- Campos Garcia Anabel
- Cannella Milena
- Capellari Sabrina
- Carette Anne-Sophie
- Carrillo FĂĄtima
- Casas Hernanz Laura
- Catalli Claudio
- Causley Aaron
- Cavaco Sara
- Chabot Christelle
- Chacón Peña José
- Cheriet Samia
- Chu Carol
- Chu Carol
- Chu Elvina
- Ciesielska Anna
- Clapton Jackie
- Clayton Carole
- Clenaghan Catherine
- Codella Valentina
- Coelho Miguel
- Coleman Caroline
- Connemann Julia
- Constantinescu Radu
- Cormio Claudia
- Correia Guedes Leonor
- Correia Guedes Leonor
- Cortelli Pietro
- Costa Cristina
- Craufurd David
- Crooks Jenny
- Cubo Esther
- Curtis Adrienne
- CĂĄceres MarĂa Teresa
- Dalmau Elorza Marina
- DamĂĄsio Joana
- de Bruycker Christelle
- de Gregorio Francesca
- de Michele Giuseppe
- de Nicola Nunzia
- de Raedt Sylvie
- de Souza Jenny
- de Tommaso Marina
- de Weert A. Marit
- Debruxelles Sabrina
- Dec Malgorzata
- Decorte Eric
- Dekker M.
- Delliaux Marie
- Delphini Marie
- Delval Arnaud
- di Bella Daniela
- di Donato Stefano
- di Giacopo Raffaella
- di Maio Luigi
- di Maria Emilio
- di Pietro Anna
- Diercks Gabriele
- Difruscolo Olimpia
- Dinca Avarvarei Luminita
- Dipple Heather
- Doherty Karen
- Dose Matthias
- Dougherty Andrew
- Dujardin Kathy
- Dumas Eve M.
- Dunnett S. B.
- Dunnett Stephen B.
- Duru CĂ©cile
- DurĂĄn Herrera Carmen
- DurĂĄn-Sindreu Terol Santiago
- DĂ©monet Jean-Francois
- DĂez-Aja LĂłpez CristĂłbal
- Ecker Daniel
- Ecker Daniel
- Edwards Maureen
- Ekwall Camilla
- Ellison-Rose Lynda
- Eschenbach Carolin
- Esmaeilzadeh Mona
- European Huntington's Disease Network
- Eusebio Alexandre
- Evans Carole
- Fairtlough Helen
- Fannemel Madelein
- Fasano Alfonso
- FatĂĄs Ventura Marta
- Fenollar MarĂa
- FernĂĄndez Recio Maria
- Ferrandes Giovanna
- Ferreira J. J.
- Ferreira Joaquim J.
- Fillingham Kay
- Finisterra Ana Maria
- Fisher Kate
- Flamez Anja
- Fletcher Amy
- Floriach Robert Misericordia
- Foster Jillian
- Foustanos Isabella
- Fredlund Gunnel
- Frich Jan
- Friedrich Andrea
- Frontali Marina
- Fullam Ruth
- Gago Miguel
- Galitzky Monique
- Gallassi Roberto
- Ganos Christos
- Garcia Moreno José Manuel
- GarcĂa de YĂ©benes Justo
- GarcĂa Ribas Guillermo
- GarcĂa RuĂz Pedro J.
- GarcĂa-Ramos GarcĂa RocĂo
- Garrett Carolina
- GarzĂłn RuĂz BelĂ©n
- Gaston Itziar
- Gelderblom Harald
- Gellera Cinzia
- Genitrini Silvia
- Ghelli Elena
- Gill Paul
- Ginestroni Andrea
- Giuliano J.
- Gohier Bénédicte
- Goizet Cyril
- Golding Charlotte
- Golding Charlotte
- GonzĂĄlez Casado Ana
- GonzĂĄlez GonzĂĄlez Sonia
- Goodman Anna
- Gorospe AranzazĂș
- Gorzolla Heike
- Grant Janet
- Grosjean HĂ©lĂšne
- Gross Diana
- Guerra Maria RosĂĄlia
- Guidubaldi Arianna
- Guérid Marie-Anne
- GĂžller Marie-Louise
- GĂžrvell Per
- Hallam Caroline
- Hamer Stephanie
- Hametner Eva-Maria
- Hammer Kathrin
- Handley Olivia J.
- Handley Olivia J.
- Handley Olivia J.
- Handley Olivia J.
- Harding Alison
- Haro MartĂnez Isabel
- Harrison David
- Harrower Timothy
- Hasholt Lis
- Hauge Erik
- Hayward Beverley
- Hecht Karen
- Heiberg Arvid
- Heiberg Arvid
- Heinicke Walburgis
- Held Christine
- Held Christine
- Henley Susie
- Hepperger Caroline
- Herranhof Brigitte
- Hidding Ute
- Hiivola Heli
- Hill Susan
- Hjermind Lena E.
- Hobson Emma
- Hoffmann Rainer
- Holas Christiane
- Holl Anna
- Hotter Anna
- Howard Liz
- Howcroft Debbie
- Hughes Max
- Hughes Teresa
- Hunger Ulrike
- Hunt Sarah
- Huson Susan
- Hussl Anna
- Höglund Arja
- Hölzner Eva
- HĂžsterey-Ugander Ulrika
- Ialongo Tamara
- Ignatius Jaakko
- Illmann T.
- Illmann T.
- Jachinska Katarzyna
- Jack Roisin
- Jacopini Gioia
- Jakobsen Oda
- Jamieson Stuart
- Jamrozik Zygmunt
- Janik Piotr
- JanuĂĄrio Cristina
- Jasinska-Myga Barbara
- Johansson Anders
- Johns Nicola
- Jurgens Caroline K.
- JĂșlio Filipa
- Kaelin Alain
- Kalbarczyk Anna
- Kapfhammer Hans-Peter
- Kavalier Fred
- Kershaw Ann
- Kieni Janina
- KlempĂ JirĂ
- Klimberg Aneta
- Klodowska-Duda Gabriela
- Koppers Kerstin
- Koppitz Michael
- Kosinski Christoph Michael
- Kraus Peter H.
- Krawczyk Malgorzata
- Kremer Berry
- Krysa Wioletta
- Krystkowiak Pierre
- KucharĂk Martin
- Kwiecinski Hubert
- KÀrppÀ Mikko
- Ladurner Gunther
- LafoucriĂšre Danielle
- Lahiri Nayana
- Lama Suarez MarĂa JosĂ©
- Lambeck Johann
- Lambord Nicol
- Landwehrmeyer Bernhard Georg
- Landwehrmeyer G. Bernhard
- Landwehrmeyer G. Bernhard
- Lange Herwig
- Lange Herwig
- Lashwood Alison
- LaurĂ Mathilde
- Laver Fiona
- Leenders K. L.
- Legarda Inés
- Levey J.
- Lewerenz Jan
- Leythaeuser Gabriele
- Lezius Franziska
- Lilek Sabine
- Lilek Stefan
- Longinus Bernhard
- Lorenza Fortuna
- Loria Giovanna
- Loutfi Ghada
- LĂłpez Catena Judit
- LĂłpez del Val Javier
- López-Sendón Moreno José Luis
- Löhle Matthias
- MagalhĂŁes Marina
- Magnet Markus
- Mahlknecht Philipp
- Mair Katharina
- Majeed Tahir
- Mandich Paola
- Marchese Roberta
- Marcinkowski Jerzy T.
- Mareca Viladrich Celia
- Mariotti Caterina
- Mariscal Natividad
- Markova Ivana
- Markova Ivana
- Marquard Ralf
- Martikainen Kirsti
- Martino Tiziana
- MartĂnez Martinez Laura
- MartĂnez-Descals AsunciĂłn
- MartĂnez-Descals AsunciĂłn
- Mason Sarah
- Massaro Francesca
- Matheson Kirsty
- McGill Marie
- McKenzie Sue
- McLean Tim
- Mechi Claudia
- Mendes Tiago
- Menéndez Guisasola Luis
- Mestre Tiago
- Mestre Tiago
- Middleton Julia
- Miedzybrodzka Zosia
- Milkereit Eva
- Miller Joanne
- Miller Julie
- Minster Sara
- Mir Pablo
- Modoni Anna
- Monza Daniela
- Monza Daniela
- Morales Blas
- Moreno Garcia Patrocinio
- Morez V.
- Mundler Laura
- Murch Ann
- Muth Sabine
- Muñoz Esteban
- Möller Jens Carsten
- MĂŒller Nicole
- MĂŒnchau Alexander
- Nanetti Lorenzo
- Navas Arques Penelope
- Neleborn-LingefjÀrd Liselotte
- Nemeth Andrea H.
- Nepper Solveig
- Nielsen J. E.
- Nielsen JĂžrgen
- Niess Anke
- Nocker Michael
- Noguera Perea MarĂa Fuensanta
- Novak Marianne
- Nowak Marielle
- NĂžrremĂžlle Anne
- O'Donovan Kirsty
- Olivier Audrey
- Olofsson Carina
- Opala Gregorz
- Orth Michael
- Orth Michael
- Orth Michael
- Orth Michael
- Orth Michael
- Otti Daniela
- Oughton Emma
- Overland Torborg
- Padieu Helene
- Paganini Marco
- Painold Annamaria
- Paridi Dominga
- Parkinson Andrew
- Partington-Jones Lucy
- Pate Louise
- Patel Aakta
- Paterski Laurent
- Paterson Nicole
- Patino Dawn
- Patton Michael
- Paucar Martin
- Pearson Pauline
- Peinemann Alexander
- Peippo Maarit
- Peppa Nadia
- Peppa Nadia
- Peter Mireille
- Petersen Asa
- Peterson Maria
- Piacentini Silvia
- Piano Carla
- Piccininni Chiara
- Pin Quiroga Purificacion
- Plomhouse Lucie
- Poda Roberto
- Poewe Werner
- Pons i CĂ rdenas Regina
- Porteous Mary
- Pradella Silvia
- Prehn Christian
- Price Kathleen
- Priller Josef
- Pro Koivisto Susana
- Pro Koivisto Susana
- Probst Daniela
- Prundean Adriana
- PrĂŒss Harald
- PÀivÀrinta M.
- PĂ„lhagen Sven E.
- Quaranta Davide
- Quarrell Oliver
- Quiléz Ferrer Pilar
- Raab Tina
- Rabasa Perez Maria
- Rae Daniela
- Rakowicz Maria
- Raman Ashok
- Ramos-Arroyo Maria A.
- Rankin Julia
- Raymond Lucy
- Read Joy
- Redondo Vergé Luis
- Reilmann Ralf
- Reimer Jan
- Reinante Gema
- Reisinger Karin
- RetterstĂžl Lars
- Reza-Soltani Tina Walldén
- Rialland Amandine
- RibaĂŻ Pascale
- Ribbat Michael
- Richter Przemyslaw
- Richter Sven
- Rickards Hugh
- Rinaldi Carlo
- Rissling Ida
- Ritchie Stuart
- Rizzo Giovanni
- Robertson Dene
- Roca Elvira
- Rohm Stefanie
- Roig Llesoy Joan
- Rojo SebastiĂĄn Ana
- Romano Silvia
- Romero Irene
- Romoli Anna Maria
- Roos R. A.
- Roos Raymund A.
- Rose Sarah
- Rosser Anne
- Rosser Elisabeth
- Roth Jan
- Rothery Jean
- Roussel Martine
- Ruddy Deborah
- Rudolf Gabrielle
- Rudzinska Monika
- Rumpf Silke
- Russo Cinzia Valeria
- RuĂz Idiago JesĂșs Miguel
- RuĂz Vergara Mar
- Ryglewicz Danuta
- RĂžren Ninni
- Saft Carsten
- Saiz Artiga MarĂa JosĂ©
- Salmen Stephan
- Salvador Carlos
- Salvatore Elena
- Samara Husam
- Sanchez JesĂșs
- Sando Sigrid Botne
- Sandström Britta
- Santala Maire
- SasinkovĂĄ Pavla
- Sass Christian
- Say Miranda
- Scaglione Cesa
- Scheibl Monika
- Schepers Sigrun
- Scherer-Gagou Clarisse* Gagou, Clarisse Scherer-
- Schiefer Johannes
- Schlangen Christiane
- Schmalfeld Jenny
- Schmidt Simone
- Schrader Christoph
- Schrenk Caroline
- Schuierer Michele
- Schwenke C.
- Schwenke Carsten
- Schöggl Helmut
- SchĂŒpbach Michael
- Sciruicchio Vittorio
- SebastiĂĄn A. R.
- Selimbegovic-Turkovic Amina
- Sempolowicz Justyna
- SenkĂĄrovĂĄ Zuzana
- Seppi Klaus
- Serpino Claudia
- Sieradzan Kasia
- Silva Mark
- Simonelli Maria
- Simonin Clémence
- Simpson Sheila
- Sinadinosa Daniela
- Sipponen Marjatta
- Sitek Emilia
- Siuda Gill
- Slawek Jaroslaw
- Smith Paul
- Snowden Julie
- Soleti Francesco
- Solis Pilar
- Soliveri Paola
- Sollom Andrea
- Soltan Witold
- Soltani Riza
- Soltysiak Beverley
- Sorbi Sandro
- Soriano GarcĂa Socorro
- Spadaro Maria
- Spruth Eike Jakob
- Squitieri Ferdinando
- Staffen Wolfgang
- Stamm Christiane
- Stattin Eva-Lena
- Stebler Yanik
- Steiner Tanja
- Steinmetz GisĂšle
- Stokholm Jette
- Stokke Bodil
- Stopford Cheryl
- Storch Alexander
- Strassburger Katrin
- Stubbe Lars
- StÀdtler Michael
- SuarĂ©z San MartĂn Esther
- Sulek Anna
- Summers Fiona
- Svenningsson Per
- Szczudlik Andrzej
- SĂĄnchez SĂĄnchez Violeta
- SĂĄnchez Vicenta
- SĂžrensen Sven Asger
- SĂŒĂmuth Sigurd
- Tabrizi S. J.
- Tabrizi Sarah
- Tabrizi Sarah
- Taylor Rachel
- Tedroff Joakim
- Thibault-Tanchou Stéphanie
- Thomas Gareth
- Thompson Jennifer
- Thomson Aileen
- Thomson Jenny
- Tidswell Katherine
- TimĂłteo Angela
- Tomasello Chiara
- Tome Carruesco Gemma
- Torres RodrĂguez MarĂa JosĂ©
- Toscano Jean
- Townhill Jenny
- Townhill Jenny
- Tranchant Christine
- Trautmann Sonja
- Trender-Gerhad Iris
- Trigo Cubillo Patricia
- Trigo Cubillo Patricia
- Tritsch Christine
- Tucci Tecla
- Tuuha Katri
- Tyvoll Hilde
- Uhrova T.
- Ullah Jasmin
- Ure Alexandra
- Valadas Anabela
- Vale José
- van den Bogaard Simon J. A.
- van Hout Monique S.
- van Kammen D.
- van Oostrom J. C. H.
- van Reijen Dimphna
- van Vugt Jeroen P.
- van Walsem Marleen R.
- van Walsem Marlene R.
- Vandenberghe Wim
- Vandenberghe Wim
- Verellen-Dumoulin Christine
- Verellen-Dumoulin Christine
- Verny Christophe
- Verstappen C. C. P.
- Verstraelen Nichola
- Verstraelen Nichola
- Villa Riballo Antonio
- Villanueva Clara
- Vivancos Moreau Laura
- Vives Barbara
- VĂĄzquez Rivera Susana
- Wagner Caroline
- Wahlström J.
- Wahlström Jan
- Walleczek Anna Maria
- Wallner M.
- Wannepain Sandrine
- Warner Thomas
- Weber Zaugg Sabine
- Wehus Raghild
- Weindl Adolf
- Wenning Gregor
- Werner Cornelius Johannes
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Widner Hakan
- Wiedemann Alexandra
- Wiklund Leif
- Wikström Birgitta
- Wild E. J.
- Wild Edward
- Wild Sue
- Winnberg Elisabeth
- Witjes-Ané Marie-Noelle
- Witjes-Ané Marie-Noelle
- Witkowski Grzegorz
- Wolf Elisabeth
- Wolz Annett
- Wolz Martin
- Wright Abigail
- Wright Jan
- WĂłjcik Magdalena
- Yardumian Pam
- Yates Shona
- Yudina Elizaveta
- Zangerl Anja
- Zaremba J.
- Zaremba Jacek
- Zdzienicka Elzbieta
- Zeman Adam
- Zielonka Daniel
- Zielonka Daniel
- Zielonka Eugeniusz
- Zimmermann Marie-Agathe
- Zinzi Paola
- Zinzi Paola
- Zittel Simone
- Zucker Birgit
- Ă man Jaana
- Publication venue
- Elsevier
- Publication date
- 01/01/2011
- Field of study
The present work addresses the optimization of process parameters for adsorptive removal of α-toluic acid by calcium peroxide (CaO2) nanoparticles using response surface methodology (RSM). CaO2 nanoparticles were synthesized by chemical precipitation method and confirmed by Transmission electron microscopy (TEM) and high-resolution TEM (HRTEM) analysis which shows the CaO2 nanoparticles size range of 5â15ânm. A series of batch adsorption experiments were performed using CaO2 nanoparticles to remove α-toluic acid from the aqueous solution. Further, an experimental based central composite design (CCD) was developed to study the interactive effect of CaO2 adsorbent dosage, initial concentration of α-toluic acid, and contact time on α-toluic acid removal efficiency (response) and optimization of the process. Analysis of variance (ANOVA) was performed to determine the significance of the individual and the interactive effects of variables on the response. The model predicted response showed a good agreement with the experimental response, and the coefficient of determination, (R2) was 0.92. Among the variables, the interactive effect of adsorbent dosage and the initial α-toluic acid concentration was found to have more influence on the response than the contact time. Numerical optimization of process by RSM showed the optimal adsorbent dosage, initial concentration of α-toluic acid, and contact time as 0.03âg, 7.06âg/L, and 34âmin respectively. The predicted removal efficiency was 99.50%. The experiments performed under these conditions showed α-toluic acid removal efficiency up to 98.05%, which confirmed the adequacy of the model prediction
Reduced Cancer Incidence in Huntington's Disease: Analysis in the Registry Study
- Author
- \u160a\u161inkov\ue1 Pavla
- \u160enk\ue1rov\ue1 Zuzana
- \uc5man Jaana
- Aaserud Olaf
- Abbruzzese Giovanni
- Agarwal Veena
- Akhtar Shahbana
- Alarc\uf3n Moreau Mar\ueda Dolores
- Albanese Alberto
- Allain Philippe
- Almagro Carmen Ant\ufanez
- Almeida Manuel
- Alonso-Frech Fernando
- Alusi Sundus
- Anderson Mary
- Andersson Christian
- Andrade Carlos
- Andrew Alyson
- Andrews Thomasin
- Andrich J\ufcrgen
- Angeles Maria
- Aniola Jacek
- Anjum Uruj
- Annic Agn\ue8s
- Antczak Jakub
- Arbelo Jos\ue9 Mat\uedas
- Arkuszewski Michal
- Armstrong Richard
- Arntsen Vibeke
- Arques Penelope Navas
- Arran Natalie
- Artiga Mar\ueda Jos\ue9 Sainz
- Azulay Jean-Philippe
- B\ue1rcenas Antonio Herranz
- B\uf6ringer Regina
- Baake Verena
- Babiloni Blandine
- Bachmeier Michael
- Bachoud-L\ue9vi Anne-Catherine
- Badei Farideh
- Bailey Wendy
- Banaszkiewicz Krzysztof
- Bandmann Oliver
- Barbera Miquel Aguilar
- Barker Roger A.
- Barral Ver\uf3nica Ma\uf1anes
- Barrero Francisco
- Barth Katrin
- Barth\ue9l\ue9my Recka
- Bas Jordi
- Bechtel Natalie
- Beckmann Heike
- Bek Judith
- Bellonet Marcellin
- Benaich Sandra
- Benoit Alexandra
- Bentivoglio Anna Rita
- Berglund Maria
- Berglund Peter
- Bergmann Ulrike
- Berrisoul Hassan
- Bertini Elisabetta
- Bethwaite Pamela
- Betz Sabrina
- Beuth Markus
- Bioux Sandrine
- Biunno Ida
- Bj\uf6rnsson Elisabeth
- Bj\uf8rgo Kathrine
- Bj\uf8rnevoll Inga
- Blaszczyk Magdalena
- Bliaux Evangeline
- Blin St\ue9phanie
- Blinkenberg Ellen 8kland
- Blondeau Leily
- Bo\u107wi\u144ska Dorota
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen Stefan
- Boiss\ue9 Marie-Fran\ue7oise
- Bojakowska-Jaremek Kamila
- Bojarsky Jaime Kulisevsky
- Bonelli Raphael M.
- Bonneau Dominique
- Boogaerts Andrea
- Borge\uf8d Nancy
- Bos Reineke
- Bosca Maria
- Bosredon Cecile
- Bost Marie
- Boudali Lotfi
- Bove Francesco
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brice Alexis
- Brockie Peter
- Bronzova Juliana
- Brugada Francisco Castera
- Brugger Florian
- Bruno Stefania
- Bryl Anna
- Buchanan Lindsay
- Buck Andrea
- Buongiorno Mar\ueda Teresa
- Buratti Lisa
- Burguera Juan Andres
- Burgunder Jean-Marc
- Burn John
- Burrows Liz
- Busquets N\ufaria
- Busse Monica
- Butcher Cynthia
- Cabaret Maryline
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- Calandra-Buonaura Giovanna
- Caldentey Juan Garc\ueda
- Callaghan Jenny
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- Cannella Milena
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- Capetian Philipp
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- Carette Anne-Sophie
- Carri\ue8re Nicolas
- Carrillo F\ue1tima
- Carruesco Gemma Tome
- Casado Roc\uedo Villagr\ue1n
- Cass Ginette
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- Castaldo Anna
- Catalli Claudio
- Catena Judit L\uf3pez
- Chabot Christelle
- Charles Perrine
- Charpentier S\ue9bastien
- Cheriet Samia
- Chu Carol
- Chu Elvina
- Ciach-Wysocka Ewelina
- Ciesielska Anna
- Classen Serge Jaum\ue1
- Clayton Carole
- Clenaghan Catherine
- Coarelli Giulia
- Codella Valentina
- Coebergh Jan
- Coelho Miguel
- Coleman Caroline
- Come Adrien
- Connemann Julia
- Constant Eric
- Constantinescu Radu
- Cormio Claudia
- Corrales Koldo Berganzo
- Cortegana Eva Mar\ueda Pacheco
- Cortelli Pietro
- Costa Andreia
- Costa Cristina
- Coulthard Elizabeth
- Courtin Fran\ue7oise
- Couttier Julien
- Craufurd David
- Craven Janet
- Crooks Jenny
- Cubillo Patricia Trigo
- Cubo Esther
- Curtis Adrienne
- D\ucdaz-Zorita Juan Pablo Tartari
- Da Silva Wildson Vieira
- Das Purkayastha Debasish
- Davidson Lynn
- Davies Rhys
- Davison Jill
- De Bobadilla Ramon Fernandez
- De Bruycker Christelle
- De Gregorio Francesca
- De La Cerda Santa Mar\ueda Andr\ue9s
- De Langavant Laurent Cleret
- De Michele Giuseppe
- De Molina Roc\uedo Malo
- De Nicola Annunziata
- De Souza Keylock Jenny
- De Tommaso Marina
- De Weert A. Marit
- De Y\ue9benes Justo Garc\ueda
- Debilly B\ue9reng\ue8re
- Debruxelles Sabrina
- Dec Malgorzata
- Decorte Eric
- Dedich\ue1 Nadia Rodr\uedguez
- Defebvre Luc
- Deith Catherine
- Dekker Meike
- Del Mar Fenollar Mar\ueda
- Del Valle Loarte Mar\ueda
- Delabaere Hel\ue8ne
- Delaigue Christine
- Delfini Marie
- Delliaux Marie
- Delval Arnaud
- Demonet Jean-Fran\ue7ois
- Depelchin Aliz\ue9
- Destee Alain
- Dewulf-Pasz Nelly
- DI Bella Daniela
- DI Donato Stefano
- DI Giacopo Raffaella
- DI Maio Luigi
- DI Maria Emilio
- DI Pietro Anna Gerrtiz
- DI Poggio Monica Bandettini
- DI Renzo Martina
- DI\ue9guez Esther
- DIas Margarida
- DIercks Gabriele
- DIfruscolo Olimpia
- DIpple Heather
- Doherty Karen
- Dondaine Thibaut
- Donovan John O
- Dose Matthias
- Dougherty Andrew
- Downie Lorna
- Dramstad Elisabeth
- Dressler DIrk
- Duch\ue9 Charlotte
- Dugauquier Florence
- Duits Annelien
- Dujardin Kathy
- Dumas Eve M.
- Dunnett Stephen
- Dupuis Michel
- Durif Franck
- Durr Alexandra
- Duru C\ue9cile
- Dziadkiewicz Artur
- Ecker Daniel
- Eddy Charlotte
- Edwards Maureen
- Edwards Rachel
- Eklund Pia
- Ekwall Camilla
- Elifani Francesca
- Ellrichmann Gisa
- Esposito Federica
- Esteban Juan Carlos Gomez
- Eusebio Alexandre
- Evans Carole
- Ewenczyk Claire
- Fairtlough Helen
- Fannemel Madeleine
- Farewell Daniel
- Fasano Alfonso
- Fasquel V\ue9ronique
- Fernandez Cristina Melgar
- Ferraldeschi Michela
- Ferrandes Giovanna
- Ferreira Joaquim J
- Ferrer Pilar Quil\ue9z
- Figuerola Bego\uf1a Jeweinat
- Fillingham Kay
- Finisterra Ana Maria
- Fisher Kate
- Flament M\ue9lanie
- Fletcher Amy
- Fluchere Fr\ue9d\ue9rique
- Fortuna Lorenza
- Foster Jillian
- Foustanos Isabella
- Foy Kevin
- Frades Bel\ue9n
- Francis Flverly
- Francisque H\ue9l\ue8ne
- Franco Giovanni
- Frech Fernando Alonso
- Fredlund Gunnel
- Freire-Patino Dawn
- Frich Jan C.
- Frontali Marina
- Frost Julie
- Fullam Ruth
- Fuller Kathleen
- G\uf6ller Marie-Lousie
- G\uf6pfert Nicole
- G\uf8rvell Per F.
- Gago Miguel
- Gallassi Roberto
- Gallentree Deena
- Ganos Christos
- Garc\ueda Ana
- Garc\ueda Roc\uedo Garc\ueda-Ramos
- Garcia-Amigot Fermin
- Garde M\uf3nica Bascu\uf1ana
- Garrett Carolina
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- Gayde-Stephan Sabine
- Geitner Carolin
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- Gellera Cinzia
- Genitrini Silvia
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- Ghelli Elena
- Gil Acera
- Gill Paul
- Gillardin Anne-Fran\ue7oise
- Gilling Mette
- Ginestroni Andrea
- Girard Carole
- Giuliano Joe
- Godefroy Olivier
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- Gogol Anna
- Gohier B\ue9n\ue9dicte
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- Gonz\ue1lez Laura Vargas
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- Goodman Anna
- Gorzkowska Agnieszka
- Gorzolla Heike
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- Grabska Natalia
- Grosjean H\ue9l\ue8ne
- Gu\ue9rid Marie-Anne
- Guedes Leonor Correia
- Guia Dolors Badenes
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- Guimar\ue3es Joana
- Guisasola Luis Men\ue9ndez
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- Guzman Natalie Valle
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- H\uf8sterey-Ugander Ulrika
- Haider Salman
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- Hallam Caroline
- Hamer Stephanie
- Hametner Eva-Maria
- Handley Olivia J.
- Hannequin DIdier
- Hannier V\ue9ronique
- Harding Alison
- Hare Marianne
- Harris Kayla
- Harrison David
- Harrower Timothy
- Hart't Ellen P.
- Hartikainen Paivi
- Haug Marte Gj\uf8l
- Hauge Erik
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- Hermoso F\ue1tima Damas
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- Herranhof Brigitte
- Herrera Carmen Dur\ue1n
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- Hidding Ute
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- Idiago Jes\ufas Miguel Ruiz
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- Illmann Torsten
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- Irvine Sarah
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- Jack Roisin
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- Jameau Laetitia
- Jamieson Stuart
- Jamrozik Zygmunt
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- Johnson Liz
- Jones Lesley
- Jones Mary
- Jones Una
- Jourdain S\ue9verine
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- Justo Damian
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- Kassar Abdulrahman
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- Khalil Hanan
- Kipps Christopher
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- Klemp\ued\u159 Ji\u159\ued
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- Koivisto Susana Pro
- Komati Suresh
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- Kosinski Christoph Michael
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- Kwiecinski Hubert
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- Neleborn-Lingefj\ue4rd Liselotte
- Nemeth Andrea H
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- Peria\uf1ez Juan Manuel
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- Petersen Jens A.
- Peterson Maria
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- R\uf8sby Oddveig
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- Rakowicz Maryla
- Raman Ashok
- Ramesh Raviram
- Ramirez In\ue9s Legarda
- Ramos-Arroyo Maria Antonia
- Raseta Rolland
- Redondo Luis
- Redondo Mar\ueda Teresa C\ue1ceres
- Reetz Kathrin
- Regeur Lisbeth
- Reilmann Ralf
- Reisinger Karin
- Reiter Eva-Magdalena
- Retterst\uf8l Lars
- Riba\uef Pascale
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- Ribbat Michael
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- Rijntjes Michel
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- Ritchie Stuart
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- Rogers Dawn
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- Romero Sandra Gutierrez
- Romoli Anna Maria
- Roos Raymund A. C.
- Rose Sarah
- Rosser Anne
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- Roth Jan
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- Roze Emmanuel
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- Schrader Christoph
- Schwenk Daniela
- Sciruicchio Vittorio
- Sebasti\ue1n Ana Rojo
- Seliverstov Yury
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- Sempolowicz Justyna
- Seppi Klaus
- Serpino Claudia
- Sevilla Maria Ascension Zea
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- Sieradzan Kasia
- Sikiric Alma
- Silva Mark
- Simonelli Maria
- Simonin Cl\ue9mence
- Simpson Sheila A
- Simpson Steve
- Sinadinosa Daniela
- Singh Baldev
- Sipponen Marjett
- Sitek Emilia
- Siuda Gill
- Slawek Jaroslaw
- Smalley Sarah
- Snowden Julie
- Sol\ueds Pilar
- Soleti Francesco
- Solito Marcella
- Soliveri Paola
- Sollom Andrea
- Soltan Witold
- Soltysiak Beverley
- Sorbi Sandro
- Sorrentino Pierpaolo
- Spadaro Maria
- Spagnolo Francesca
- Spampinato Umberto
- Sprenger Fabienne
- Spruth Eike
- Squitieri Ferdinando
- St 9pniak Iwona
- St\ue4dtler Michael
- St\uf8rseth Hanna Haugan
- Staffen Wolfgang
- Stamm Christiane
- Stattin Eva-Lena
- Stebler Yanik
- Steinmetz Gis\ue9le
- Stenwak Agata
- Stockholm Jette
- Stokke Bodil
- Stompel Daniel
- Stopford Cheryl
- Storch Alexander
- Stubbe Lars
- Sulek Anna
- Summers Fiona
- Sundblom Jimmy
- Svenningsson Per
- Swain Rachel
- Szczudlik Andrzej
- Szczygiel Elzbieta
- Szinwelski Michal
- Tabrizi Sarah
- Tacik Pawel
- Tard C\ue9line
- Taroni Franco
- Tataru Alina
- Taylor Anne-Marie
- Taylor Cat
- Taylor Rachel
- Tchikviladz\ue9 Maya
- Thibault-Tanchou St\ue9phanie
- Thiel Silvia
- Thomas Gareth
- Thompson Jennifer
- Thomson Aileen
- Tidswell Katherine
- Timewell Erika
- Timings Leanne
- Tir M\ue9lissa
- Tomasello Chiara
- Tonner Alison
- Torlizzi Flavia
- Torres Mar\ueda Martirio Antequera
- Toscano Jean
- Townhill Jenny
- Tranchant Christine
- Trautmann Sonja
- Trender-Gerhard Iris
- Tucci Tecla
- Tuuha Katri
- Tyvoll Hilde
- Udaeta Beatriz
- Uhrova Tereza
- Ulla Miguel
- Ullah Jasmin
- Ure Alexandra
- Valadas Anabela
- Valentine Ruth
- Van De Wyngaerde Fran\ue7oise
- Van Den Bogaard Simon J. A.
- Van Hout Monique S. E.
- Van Oostrom Joost
- Van Paemel Dominique
- Van Reijen Dimphna
- Van Vugt Jeroen P. P.
- Van Walsem Marleen
- Vandenberghe Wim
- Vangsted-Hansen Christina
- Vaughan Vivien
- Ventura Marta Fat\ue1s
- Verellen-Dumoulin Christine
- Verhoeven Marloes
- Vernon Nathan
- Verny Christophe
- Verstappen Carla
- Verstraelen Nicola
- Vezza Maurizio
- Vidal Tiphaine
- Viladrich C\ue8lia Mareca
- Vilaplana Carmen Peir\uf3
- Villa Riballo Antonio
- Villa Carolina
- Villanueva Clara
- Villanueva Marina \uc1vila
- Vingerhoets Francois
- Vinther-Jensen Tua
- Vivancos Laura
- Vogel Melanie
- Vuillaume Isabelle
- W\uf3jcik Magdalena
- Waber Mirella
- Wagner Caroline
- Wahlstr\uf6m Jan
- Wallden Tina
- Walleczek Anna Maria
- Wannepain Sandrine
- Warner Thomas
- Wasielewska Anna
- Weber Nathalia
- Weekes Rebecca
- Wehus Ragnhild
- Weindl Adolf
- Wenning Gregor
- Wermuth Lene
- Werner Cornelius J.
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Wi\u15bniewski Bartlomiej
- Wider Christian
- Wikstr\uf6m Birgitta
- Wild Edward
- Wild Sue
- Williams Josh
- Winkelmann Juliane
- Winkler J\ufcrgen
- Witjes-An\ue9 Marie-Noelle
- Witkowski Grzegorz
- Wolz Annett
- Wolz Martin
- Wood Josh
- Wright Abigail
- Wright Jan
- Yardumian Pam
- Yates Shona
- Youssov Katia
- Yudina Elizaveta
- Zaremba Jacek
- Zaugg Sabine Weber
- Zdzienicka Elzbieta
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Eugeniusz
- Zimmermann Marie-Agathe
- Zinzi Paola
- Ziora-Jakutowicz Karolina
- Zittel Simone
- Zucker Birgit
- Publication venue
- 'IOS Press'
- Publication date
- 01/01/2018
- Field of study
Background: People with Huntington's disease (HD) have been observed to have lower rates of cancers. Objective: To investigate the relationship between age of onset of HD, CAG repeat length, and cancer diagnosis. Methods: Data were obtained from the European Huntington's disease network REGISTRY study for 6540 subjects. Population cancer incidence was ascertained from the GLOBOCAN database to obtain standardised incidence ratios of cancers in the REGISTRY subjects. Results: 173/6528 HD REGISTRY subjects had had a cancer diagnosis. The age-standardised incidence rate of all cancers in the REGISTRY HD population was 0.26 (CI 0.22-0.30). Individual cancers showed a lower age-standardised incidence rate compared with the control population with prostate and colorectal cancers showing the lowest rates. There was no effect of CAG length on the likelihood of cancer, but a cancer diagnosis within the last year was associated with a greatly increased rate of HD onset (Hazard Ratio 18.94, p < 0.001). Conclusions: Cancer is less common than expected in the HD population, confirming previous reports. However, this does not appear to be related to CAG length in HTT. A recent diagnosis of cancer increases the risk of HD onset at any age, likely due to increased investigation following a cancer diagnosis
A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial
- Author
- Abrams Judith
- Adda Mireille
- Adderley Jane
- Adhikari Neill K. J.
- Adhikari Neill K. J.
- Aissaoui Nadia
- Alam Ahsan
- Albrett Jonathan
- Albright Robert C.
- Alcuaz Victoria
- Allam Hayat
- Altarelli Marco
- Amaral Andre
- Amsbaugh Amy
- Anderson Felicity
- Andreu Pascal
- Antunes Veronica
- Arbane Gill
- Argaud Laurent
- Arias Castro
- Asehnoune Karim
- Attwood Ben
- Auld Fiona
- Ayas Najib
- Aycinena Juan Carlos
- Azais Marie-Ange
- Bachler Mirjam
- Backhouse Felicity
- Bagshaw Sean M.
- Bagshaw Sean M.
- Bagshaw Sean M.
- Bagshaw Sean M.
- Baharlo Behrad
- Bai Guoqiang
- Bai Jing
- Baig Nadia
- Baig Nadia
- Bailey Matthew
- Baker Nerilee
- Ball Ian M.
- Ball Jonathan
- Barbar Saber Davide
- Barbier François
- Barchard Jennifer
- Bass Frances
- Bates Samantha
- Baudry Thomas
- Beck James
- Beehre Nina
- Bellemare David
- Belley-Cote Emilie
- Bellmann Romuald
- Bellomo Rinaldo
- Bellomo Rinaldo
- Benettaib Fatna
- Benoit Luc
- Benton Jane
- Benzekri Dalila
- Bergin Colin
- Bihari Shailesh
- Bihorac Azra
- Bird Sarah
- Bitker Laurent
- Board Jasmin
- Bociek Aneta
- Bohé Julien
- Boisrame-Helms Julie
- Boivin Annick
- Bojic Andja
- Bone Allison
- Boschert Catherine
- Bouisse Camille
- Boulain Thierry
- Boulet Ăric
- Boumahni Dounia
- Bourchard Pierre-Alexandre
- Bowman Katie
- Bracke Stephanie
- Bradford Celia
- Brailsford Jane
- Brandtner Anna
- Bretagnol Anne
- Brickell Kathy
- Broadfield Emma
- Brodutch Shira
- Brooks Jenny
- Brown Gillian
- Brown Sherry
- Browne Troy
- Buehner Ulrike
- Buhr Heidi
- Burke Tara
- Burns Karen
- Buscher Hergen
- Butler Magdalena
- Butler Susie
- Cahill Hazel
- Cailhier Jean-François
- Callahan Jean Christophe
- Callender Owen
- Campbell Eileen
- Campbell Troy
- Campbell Victoria
- Campisi Josie
- Camporota Luigi
- Campos Sara
- Canet Emmanuel
- Cantien Marie
- Carbonnaeu Ălaine
- Carles Michel
- Carney Dominic
- Carney Gayle
- Carpentier Dorothée
- Carrera Ron
- Carrier François-Martin
- Carson Joshua
- Carter Joseph
- Carungcong Jaime
- Carvelli Paula
- Cegarra Santiago
- Cennamo Armando
- Chadbourn Indra
- Chadwick Lesley
- Chan Peter
- Chee Nigel
- Chen Man
- Chen Yan
- Chen Zhenzhen
- Chenaf Samir
- Cheung Winston
- Chevrel Guillaume
- Chiella Bianca
- Chimunda Tim
- Chudeau Nicolas
- Cinotti Raphaël
- Cirone Robert
- Clarey Emma
- Clark Amy
- Clark Edward
- Clark Michele
- Clarke France
- Cleophax Cedric
- Clere-Jehl Raphael
- Cloutier Eve
- Cohen Yves
- Cole Jade
- Cole Louise
- Coles Jennifer
- Colin Gwenhaël
- Collins Amy
- Combes Alain
- Commeureuc Morgane
- Condin Christopher
- Conner Louise
- Cooper Lauren
- Corcoran Eleanor
- Costa Patricia
- Costerousse Olivier
- Coupez Elisabeth
- Cour Martin
- Cowdrey Keri-Anne
- Creary Thais
- Crosby Laura
- Cross Rosalba
- Cunningham Mishell
- Cupka Julie
- da Costa Bruno R.
- Daniels Alison
- Dargent Auguste
- Davies Tracy Michelle
- De Crop Luc
- De La Salle Sylvie
- De Prost Nicolas
- De Watteville Aude
- Decalvele Maxens
- Dechanet Aline
- Dekeyser Thibault
- Delabranche Xavier
- Delaney Anthony
- Delecolle Lucie
- Delgado Carlos Castro
- Delisle-Thibault Charles
- Demeure Dominique
- Demiri Suela
- Demoule Alexandre
- Deng Fuxing
- Derrien Benoit
- Despy Liesl
- Dessap Armand Mekontso
- Devereaux Kelson
- Di Nella Michelle
- Diehl Jean-Luc
- Diel Naomi
- Dignam Gemma
- Dilawershah Maria
- Ding Lili
- Ding Ruiqi
- Ditlbacher Adelheid
- Dodek Peter
- Dominy Clive
- Dong Lei
- Dong Xin
- Dooley Natalie
- Doran Peter
- Dorfman Robert
- Dos Santos Sandra
- Dres Martin
- Dreyfuss Didier
- Dreyfuss Didier
- Drover John
- Du Bin
- Du Bin
- Duan Meili
- Duffy Jane
- Duffy Karina
- Dufour Nicolas
- Duggan Shelley
- Duke Graeme
- Dun Shijuan
- Dyett John
- DâAragon FrĂ©dĂ©rick
- Eastwood Glenn M.
- Eckert Philippe
- Efron Philip
- Elderkin Tania
- Elias Madona
- Elizabeth Wilcox M.
- Eller Philipp
- Ellis Karen
- Emery Malo
- Endre Zoltan
- Ensenyat-Martin Luis
- Eraldi Jean-Pierre
- Fadel Fouad
- Fan Jingqun
- Farnell-Ward Sarah
- Farrah Helen
- Faure Morgane
- Felix Luis
- Fellows Emma
- Fendt Lucia
- Fennessy Gerard
- Fiancette Maud
- Finfer Simon
- Finkenstedt Armin
- Finney Clare
- Fletcher Jason
- Forbes Loretta
- Forni Lui G.
- Forshaw Greg
- Foulkes Stephen
- Francoeur Charles Langis
- Franja Vincenta
- Freebairn Ross
- French Craig
- Friedrich Jan
- Fries Dietmar
- Fu Lijuan
- Fu Yongjian
- Fusco Kelly
- Gallagher Martin P.
- Gallagher Martin P.
- Gangopadhyay Himangsu
- Gantner Dashiell
- Gao Lan
- Garg Amit
- Gattas David
- Gatward Jonathan
- Gaudry Stéphane
- Gaudry Stéphane
- George Aparna
- Georgescu Ilinca
- Gernez Coralie
- Ghamraoui Ali
- Ghate Taneera
- Ghosh Angaj
- Giannakouros Panagiota
- Gibson Neil
- Giebel Shelley
- Gilder Eileen
- Glybina Anna
- Gomes Brigette
- Gomez Raquel
- Goodson Jennifer
- Gordon Boyd J.
- Goulart Joyce McKenney
- Goulart Joyce McKenney
- Goundry Stephanie
- Grainger Lia
- Grangé Steven
- Grant Alice
- Grant Caroline
- Gray Geraldine
- Grenier Stéphanie
- Gresham Rebecca
- Grillot Nicolas
- Guerot Emmanuel
- Guery Aurore
- Guilbault Gabrielle
- Guitton Christophe
- Guo Dongchen
- Guo Litao
- Gurung Babita
- Gutierrez David
- Guy Zoe
- Haljan Gregory
- Hall Adam
- Hallion Jane
- Haltia Paivi
- Hambrook Geraldine
- Hammond Naomi
- Hamshere Alexandra
- Hang Lele
- Harasemiw Oksana
- Harkett Samanth
- Harkins Margaret
- Harmon John
- Harris Claire-Louise
- Harrop Clare
- Hartig Frank
- Harvey Dan
- Hashemighouchani Haleh
- Haslam Nicole
- Hasslacher Julia
- Hauschild Caroline
- Hazelton Tracy
- He Xiandi
- He Xiaona
- Heidegger Claudia
- Heinonen Jonna
- Henderson Seton
- Henderson Steven
- Hendry Deborah
- Hernandez Clara
- Hernu Romain
- Herridge Margaret S.
- Higson Vicki
- Hill Dianne
- Hill Helen
- Hindle Julia
- Hiremath Swapnil
- Hirst Claire
- Hodder Jennifer
- Hodgson Luke E.
- Hopkins Philip
- Hoppu Sanna
- Hoste Eric
- Hou Guo
- Houghton James
- Howard Kate
- Howcroft Clare
- Howe Elizabeth
- Howlett Luisa
- Hu Chenghuan
- Hu Tingting
- Hu Xiaobo
- Huang Lili
- Huang Yingzi
- Hunt Anna
- Hunt Miranda
- Hunter Stephanie
- Hussain Nauman
- Hutch Debra
- Inkinen Outi
- Investigators STARRT-AKI
- Jackson Carolyn
- Jackson David
- Jagannathan Vijay
- Jalkanen Ville
- Jang Ryan
- Janin Pierre
- Ji Xiaojun
- Jim Kym
- Jin Xia
- Joannidis Michael
- Joannidis Michael
- Johnson Emily
- Johnston Andy
- Joseph Gipsy
- Judd Harriet
- Junge Andrea
- JĂ€rvisalo Mikko J.
- Kamel Toufik
- Kapoor Ritoo
- Karachi Tim
- Karlsson Sari
- Kashani Kianoush B.
- Kaufman Melissa
- Kaur Navjot
- Kavikondala Kanthi
- Kaye Callum
- Keet Owen
- Kentala Satu
- Kerr Deborah
- Khalid Imrana
- Ki Vincent
- Kiley Sean
- Kirkham Simon
- Kissling SĂ©bastien
- Klein David
- Klein Sebastian
- Knight David
- Knott Cameron
- Koglberger Paul
- Kokotsis Nicos
- Kol Mark
- Koottayi Sathyajith
- Korhonen Anna-Maija
- Kruger Peter
- Kuitunen Anne
- Kummerlen Christine
- Kutsogiannis Demetrios J.
- KĂŒllmar Mira
- Lacave Guillaume
- Lacherade Jean Claude
- Ladouceur MarilĂšne
- Lafrance Jean-Philippe
- Lagarrigue Matthieu Henry-
- Lakatos Louis
- Lakhal Karim
- Lambert Bridget
- Lamontagne François
- Lamontagne François
- Lamontagne François
- Landais Mickael
- Landoni Giovanni
- Lapinsky Stephen
- Lappi Eliria
- Large Audrey
- Latimer-Bell Charlotte
- Latta Laura
- Laurie Gordon
- Lauzier François
- Lawrence Cassie
- Le Moal CharlĂšne
- Leaver Susannah
- Lebert Christine
- LeBlanc Guillaume
- Lebrasseur Martine
- Lee Sandra
- Leivo Keijo
- Lellouche Francois
- Lembo Rosalba
- Lenga Ilan
- Lesona Eden
- Levoranta Markus
- Li Hao
- Li Jian
- Li Jianquan
- Li Jing
- Li Min
- Li Nan
- Li Rui
- Lian Yingtao
- Liangos Orfeas
- Licari Elisa
- Lim Rosario
- Lin Jin
- Lin Jincan
- Liu Airan
- Liu Cheng
- Liu Hongjuan
- Liu Jingfeng
- Liu Kathleen D.
- Liu Manli
- Liu Pei
- Liu Xingang
- Liu Yu
- Liu Zhongmin
- Liu Zhou
- Liu Zhuang
- Lizotte Patricia
- Lobaz Steve
- Lombardi Gaetano
- Long Dali
- Long Stephanie
- Lord Jenny
- Lowrey Julie
- Lu Kun
- Lu Liping
- Lyas Claretha
- Lynch Matthew
- Lynch Matthew
- LÄngsjö Jaakko
- Ma Hongye
- MacIntyre Erika
- Magder Sheldon
- Maguire Teena
- Maizel Julien
- Malila Kaisa
- Mallaird Samia Abed
- Mallet Maxime
- Manns Braden J.
- Manso Katarina
- Marceron Alina
- Marchalot Antoine
- Marchand Joannie
- Margalef Jordi
- Margarson Michael
- Marinoff Nicole
- Marios Clémence
- Marotti Martina
- Marque Sophie
- Martin Emma
- Martin-Lefevre Laurent
- Martino Frédéric
- Martins Laura
- Marzaroli Matteo
- Marzouk Mehdi
- Masi Paul
- Maslove David
- Mason Chris
- Mason Sophie
- Mason Tracy
- Masse Marie-HĂ©lĂšne
- Masters Kristy
- Matheson Elisha
- Mathonnet Armelle
- Mayaux Julien
- Mayette Michael
- Mazer David
- McArthur Colin
- McAuley Daniel F.
- McAuley Danny F.
- McCall Philip
- McClure Jason
- McConnochie Rachael
- McCoshen Lorena
- McCracken Phoebe
- McGain Forbes
- McGlone Philip
- McGloughlin Steve
- McGonigal Elizabeth
- McGuinness Shay
- McGuinness Shay
- McGuinness Shay P.
- McIntyre Lauralyn
- Mckay-Vucago Agnes
- McKerrow Elizabeth
- McLaughlan Derek
- Meehan Sharon
- Mehrtens Jan
- Mehta Navdeep
- Mehta Sangeeta
- Mei Huaxian
- Mei Jing
- Meng Zhaoli
- Merdji Hamid
- Meredith Megan
- Messika Jonathan
- Mew Louise
- Meyer Jason
- Meziani Ferhat
- Millen Tina
- Mitchell Wendy
- Mo Min
- Monnier Alexandra
- Monti Giacomo
- Montillier Philippe
- Moon Angela
- Mooney Owen
- Morawiec Elise
- Moreland Gayle
- Morgan Matt
- Morgan Rebecca
- Morgan Stacey
- Morizot Laura
- Morris Anna
- Moser Max
- Mu Sijie
- Mulder John
- Muller Grégoire
- Muller Lucie
- Murray Lauren
- Murray Patrick T.
- Muscedere John
- Musselwhite Janine
- Mwaura Esther
- Naeem Syed
- Naeem Syed
- Naud Jean-François
- Navarra Leanlove
- Nay Mai-Anh
- Neal Philippa
- Needham Matthew
- Neils Seigenthaller
- Newby Lynette
- Neyra Javier A.
- Nichol Alistair
- Nichol Alistair D.
- Nichol Alistair D.
- Nichol Alistair D.
- Nicholson Alice
- NiChonghaile Martina
- Nicolet Laurent
- Nieszkowska Ania
- Niven Alexander S.
- Niven Daniel J.
- Noble Harriet
- Noel Gibney R. T.
- Norris Sean
- Novellas Neus Grau
- Ogg Bethan
- Okubanjo Maryanne
- Olatunji Shaanti
- Omalay George
- Ordon Marie Amélie
- Orford Neil
- Ortiz-Soriano Victor M.
- Ostermann Marlies
- Ostermann Marlies
- Ostermann Marlies
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- Ovsenek Athena
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- Palevsky Paul M.
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- Patrick-Heselton Julie
- Paunovic Bojan
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- Reignier Jean
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- Rewa Oleksa
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- Ricard Jean-Damien
- Richard RĂ©gine
- Richardson Angus
- Richardson Max
- Rigatto Claudio
- RistimÀki Sanna
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- Robertson Yvonne
- Robine Adrien
- Robinson Chelsea
- Robinson Francesca
- Robinson Holly
- Rochwerg Bram
- Rochwerg Bram
- Rogers Paula
- Rokosh Ella
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- Romano Martin
- Romanovsky Adam S.
- Roodenburg Owen
- Rose Bernd Oliver
- Rosenberg Alex
- Rosenow Nadine
- Roshdy Ashraf
- Rossi Julie
- Roux Damien
- Roux Sylvie
- Roy Isabelle
- Rozec Bertrand
- Ruddell Stacey
- Ruddell Stacey
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- Said Simone
- Salamé Maya
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- Schneider Antoine G.
- Schneider Antoine G.
- Schnorf Madeleine
- Schwartz Kate
- Scott Teresa
- Sedillot Nicholas
- Seguin Amélie
- Sejourne Caroline
- Shah Asim
- Shah Sumesh
- Shami Aysha
- Shanmugasundaram Pradeep
- Sharif Sairah
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- Sharman Andrew
- Sharman Asheer
- Shaw David
- Shelley Ben
- Sheng Lulu
- Shi Qindong
- Shi Xianqing
- Shrestha Tapaswi
- Shuker Karen
- Sia Ying Tung
- Sibley Stephanie
- Sim Malcolm
- Simmonds Catherine
- Simon Marie
- Simon Mathieu
- Singh Gurmeet
- Skarzynski Marie
- Slack Andrew
- Smith John
- Smith Julie
- Smith Orla M.
- Snelson Catherine
- Sokolowski Colleen
- Soth Mark
- Souweine Bertrand
- Sparkes Simon
- Spruce Elaine
- Sridhar Kavita
- St-Arnaud Charles
- Staudinger Thomas
- Steele Andrew
- Stelfox Henry T.
- Stelfox Henry T.
- Stewart Richard
- Stoltenberg Anita
- Suen Gabriel
- Suhonen Taria
- Sun Jingjing
- Sutherland Sara-Beth
- Sutinen Sari
- Takaoka Alyson
- Tamion Fabienne
- Taneja Ravi
- Tchenio Xavier
- Thevenin Didier
- Thevenin Fabienne
- Thibault Michel
- Thiéry Guillaume
- Thomas Emma
- Thomas Liz
- Thome Fernando
- Thompson Patricia
- Thompson Tayne
- Thuong Marie
- Tiagarajah Abirami
- Tiller Esther
- Tilley Rosalinde
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- Titeca-Beauport Dimitri
- Tolibas Michael
- Tolwani Ashita
- Towns Miriam
- Tozzi Margherita
- Tridente Ascanio
- Trusson RĂ©mi
- Tung Ying
- Turgeon Alexis F.
- Törnblom Sanna
- Udy Andrew
- Vaara Suvi
- Vaara Suvi T.
- Vaara Suvi T.
- Vallance Shirley
- Vamplew Luke
- van Diepen Sean
- van Waegeningh Thomas
- Van Hoa Dang
- Vander Hayden Kymbalee
- Varila Simo
- Veenith Tonny
- Velez Laura
- Venz Ellen
- Verlay MĂ©lanie
- Vermeiren Daisy
- Vetro Joseph
- Vimpere Damien
- Vinatier Isabelle
- Vinsonneau Christophe
- Vitiello Michelangelo
- Vizcaychipi Marcela
- Vladic Chelsey
- Wagner Martin
- Walczak Karolina
- Wald Ron
- Wald Ron
- Wald Ron
- Wallace Samantha
- Wang Amanda Y.
- Wang Chuanyao
- Wang Chunting
- Wang Cunzhen
- Wang Dongxin
- Wang Haibo
- Wang Haiman
- Wang Jane
- Wang Jinlong
- Wang Kaiwu
- Wang Peng
- Wang Qizhi
- Wang Quihui
- Wang Xue
- Wang Yifeng
- Ward Geraldine
- Watpool Irene
- Watson Hayley
- Waugh Victoria
- Wax Randy
- Weir Matthew
- Weir Matthew A.
- Welsh Deborah
- Welters Ingeborg
- Wen Mingxiang
- Wetzig Krista
- White Peggy
- Whitehead Christina
- Whitehouse Tony
- Whitlock Richard P.
- Wilby Elizabeth
- Williams Erin
- Williams Karen
- Willox Fiona
- Wise Matthew
- Wittig Monika
- Wolverson Adam
- Wong Helen
- Wood Gordon
- Woolett Melissa
- Wootten Anna
- Wren Lynn
- Wu Changde
- Wu Jing
- Wun James
- Wyncoll Duncan
- Xu Hao
- Xu Song
- Yan Jie
- Yan Jinqi
- Yang Enyu
- Yang Jianxu
- Yang Juan
- Yang Yang
- Yang Yi
- Yang Ziqi
- Yao Han
- Yao Lan
- Yarad Elizabeth
- Ye Baning
- Yehia Aihem
- Young Helen
- Young Meredith
- Young Paul
- Youngs Nora
- Yu Zhui
- Zahirieh Alireza
- Zampieri Fernando G.
- Zangrillo Alberto
- Zarbock Alexander
- Zeng Qinjing
- Zhang Jichen
- Zhang Lei
- Zhang Meng
- Zhang Minwei
- Zhang Songsong
- Zhao Dan
- Zhao Mengya
- Zhao Shibing
- Zhao Shuangping
- Zhi Deyuan
- Zhou Qi
- Zhou Xiao
- Zhuang Haizhou
- Zotter Klemens
- Zuber Benjamin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Background
Timing of initiation of kidney-replacement therapy (KRT) in critically ill patients remains controversial. The Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial compared two strategies of KRT initiation (accelerated versus standard) in critically ill patients with acute kidney injury and found neutral results for 90-day all-cause mortality. Probabilistic exploration of the trial endpoints may enable greater understanding of the trial findings. We aimed to perform a reanalysis using a Bayesian framework.
Methods
We performed a secondary analysis of all 2927 patients randomized in multi-national STARRT-AKI trial, performed at 168 centers in 15 countries. The primary endpoint, 90-day all-cause mortality, was evaluated using hierarchical Bayesian logistic regression. A spectrum of priors includes optimistic, neutral, and pessimistic priors, along with priors informed from earlier clinical trials. Secondary endpoints (KRT-free days and hospital-free days) were assessed using zeroâone inflated beta regression.
Results
The posterior probability of benefit comparing an accelerated versus a standard KRT initiation strategy for the primary endpoint suggested no important difference, regardless of the prior used (absolute difference of 0.13% [95% credible interval [CrI]âââ3.30%; 3.40%],âââ0.39% [95% CrIâââ3.46%; 3.00%], and 0.64% [95% CrIâââ2.53%; 3.88%] for neutral, optimistic, and pessimistic priors, respectively). There was a very low probability that the effect size was equal or larger than a consensus-defined minimal clinically important difference. Patients allocated to the accelerated strategy had a lower number of KRT-free days (median absolute difference ofâââ3.55 days [95% CrIâââ6.38;âââ0.48]), with a probability that the accelerated strategy was associated with more KRT-free days of 0.008. Hospital-free days were similar between strategies, with the accelerated strategy having a median absolute difference of 0.48 more hospital-free days (95% CrIâââ1.87; 2.72) compared with the standard strategy and the probability that the accelerated strategy had more hospital-free days was 0.66.
Conclusions
In a Bayesian reanalysis of the STARRT-AKI trial, we found very low probability that an accelerated strategy has clinically important benefits compared with the standard strategy. Patients receiving the accelerated strategy probably have fewer days alive and KRT-free. These findings do not support the adoption of an accelerated strategy of KRT initiation