156 research outputs found

    Does case management improve outcomes for people with schizophrenia?

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    The Australian and New Zealand clinical practice guidelines recommend intensive case management for people with first-episode psychosis or an acute relapse of schizophrenia. Often initiated following discharge from hospital or transfer from community-based acute care, case management is a collaborative, community-based program designed to ensure people receive quality health care and integrated support services. Case management may provide substantial benefits for people suffering severe mental illnesses like schizophrenia, however, before case management services are made universally available, more work needs to be done to determine when, and for whom, these services are most effective

    Are our policies and laws leading to treatment delays for people with schizophrenia?

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    Under Australian mental health laws, people with schizophrenia can only be involuntarily committed to a mental health facility if they are assessed and it is determined that their illness is making them dangerous to themselves or others. To determine whether they are to undergo involuntary treatment, mental health workers must assess people against an ‘Obligatory Dangerousness Criterion’. This criterion is an advance on methods used prior to the mid-1970s, when many countries authorised involuntary commitment to a mental health facility on medical certification alone, without court approval or any proof of an emergency situation. An Obligatory Dangerousness Criterion is now widely used in Australia, the USA, and some areas of Canada and Europe as the means by which patients are assessed for the appropriateness of involuntary (compulsory) treatment. There is no doubt the policy underpinning its use was well intentioned; an Obligatory Dangerousness Criterion was originally developed in an attempt to bett er balance the rights of the mentally ill with the need to protect the public. However, over time some experts have begun to raise questions about the utility of this criterion, suggesting that it sometimes means patients don’t get access to necessary treatment as quickly as they should

    1997 Survey of Trademark Decisions by the Court of Appeals for the Federal Circuit

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    Does the theory of planned behaviour predict suicidal intent?

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    It is generally recognized that a variety of factors contribute to suicide. No single determinant is either necessary or sufficient to bring about suicide. A theoretical framework within which to consider how suicide becomes an acceptable option for some people is needed. The Theory of Planned Behaviour was applied to suicidal behaviour, and it was hypothesized that the attitude one holds towards suicide, the subjective norms one experiences regarding suicide, and the sense of perceived behavioral control that one has with regard to suicide would predict suicidal intent. Participants completed a survey measuring these variables based on a vignette about suicide. It was found that attitude towards suicide, subjective norm, and perceived behavioral control accounted for 72% of the variance in suicidal intent, with perceived behavioural control being primarily responsible. Further, these variables accounted for more of the variance than hopelessness or depression, which are generally considered to be highly predictive of suicidal intent. Implications for suicide prevention efforts are discussed.Dept. of Psychology. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis2000 .M39. Source: Dissertation Abstracts International, Volume: 62-10, Section: B, page: 4794. Adviser: Michael Kral. Thesis (Ph.D.)--University of Windsor (Canada), 2000

    RNA helicase EIF4A1-mediated translation is essential for the GC response

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    EIF4A1 and cofactors EIF4B and EIF4H have been well characterised in cancers, including B cell malignancies, for their ability to promote the translation of oncogenes with structured 5' untranslated regions. However, very little is known of their roles in nonmalignant cells. Using mouse models to delete Eif4a1, Eif4b or Eif4h in B cells, we show that EIF4A1, but not EIF4B or EIF4H, is essential for B cell development and the germinal centre response. After B cell activation in vitro, EIF4A1 facilitates an increased rate of protein synthesis, MYC expression, and expression of cell cycle regulators. However, EIF4A1-deficient cells remain viable, whereas inhibition of EIF4A1 and EIF4A2 by Hippuristanol treatment induces cell death.</p

    RNA helicase EIF4A1-mediated translation is essential for the GC response

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    EIF4A1 and cofactors EIF4B and EIF4H have been well characterised in cancers, including B cell malignancies, for their ability to promote the translation of oncogenes with structured 5' untranslated regions. However, very little is known of their roles in nonmalignant cells. Using mouse models to delete Eif4a1, Eif4b or Eif4h in B cells, we show that EIF4A1, but not EIF4B or EIF4H, is essential for B cell development and the germinal centre response. After B cell activation in vitro, EIF4A1 facilitates an increased rate of protein synthesis, MYC expression, and expression of cell cycle regulators. However, EIF4A1-deficient cells remain viable, whereas inhibition of EIF4A1 and EIF4A2 by Hippuristanol treatment induces cell death.</p

    Superconducting Cosmc Strings and Primordial Magnetic Fields

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    We consider grand unified theories with superconducting cosmic strings and which admit the mechanism for generating primordial magnetic fields recently discussed by Vachaspati. We show that these models are severely constrained by cosmological arguments. Quite generically, either stable springs or vortons will form. Provided the mass per unit length of the strings is sufficiently large, these stable configurations will overclose the Universe.Comment: BROWN-HET-830, 14 pages, use phyzz
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