SCIF-IRIS Framework: A framework to facilitate interoperability in supply chains

One approach that allows improving the collaboration among all the enterprises within a supply chain is interoperability. Interoperability allows the enterprises in the supply chain to collaborate in an efficient manner while preserving their own identities and their own ways of doing business through mechanisms that act as facilitators. However, there are few real practical examples of supply chain interoperability that can be used as a reference. In this paper, we present a framework that can facilitate supply chain interoperability and an example of how it can be applied to a food supply chain

Paleoenvironmental evolutionary history of the depocenter of the salar de Pozuelos (southern Puna).

Este trabajo presenta la historia evolutiva paleoambiental del depocentro del salar de Pozuelos (Puna Austral, Salta. Argentina). El salar, en base al análisis de datos de subsuelo consta de dos rellenos diferentes separadas por un paleosuelo yesífero, relacionado a la estabilidad tectónica en la cuenca. De base a techo, el primer relleno es de tipo inmaduro (facies clásticas o terrosas) que sugiere una depositación ligeramente más húmeda (pero todavía árida) y con mayor aporte de sedimento clástico. El segundo relleno del techo es de tipo maduro (facies evaporíticas o cristalinas), donde las facies evaporíticas son dominantes con escasos sedimentos detríticos, lo que indica condiciones climáticas áridas similares a las actuales en la Puna. Comprende así, un modelo de depositación típico de un ambiente de lago salino, perteneciente al subambiente lago salino efímero y dentro de él se identificaron dos depósitos diferentes y genéticamente interrelacionados saline mudflat y saline pan.In this paper, it is introduced the paleoenvironmental evolutionary history of the Pozuelos salar depocenter (Puna Austral, Salta. Argentina). In base of different drill holes, two different fillings are recognized and they are separated by a gypsum paleosoil related to the tectonic stability in the basin. The first filling is located at the salar base and consist of immature fill (clastic or muddy facies) suggesting a slightly more moist (but still arid) deposition and higher contribution of clastic sediment. The second filling is located at the salar top and consist of a mature fill (evaporitic or crystalline facies). The evaporitic facies are dominant with minor amount of detrital sediments, which indicates arid climatic conditions similar to the present-day in the Puna. This contribution identified two different and genetically interrelated deposits saline mudflat and saline pan; they correspond to an ephemeral saline lake sub environment. In this context, the described fill of the salar comprises a deposition model typical of a saline lake environment.Fil: Martínez, Verónica Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto Superior de Correlación Geológica. Grupo Vinculado al INSUGEO- Centro de Estudios Geologicos Andinos; ArgentinaFil: Alonso, Ricardo Narciso. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto Superior de Correlación Geológica. Grupo Vinculado al INSUGEO- Centro de Estudios Geologicos Andinos; ArgentinaFil: Galli, Claudia Inés. Universidad Nacional de Jujuy. Instituto de Ecorregiones Andinas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Ecorregiones Andinas; Argentin

Morfología de las costras evaporíticas del salar de Pozuelos, Puna Salteña

Los salares de la Puna Argentina son importantes reservorios de salmueras ricas en elementos alcalinos y alcalinos térreos, entre ellos el litio y potasio. Los estudios relacionados con sus evapofacies y costras superficiales son escasos. Este trabajo presenta las diferentes morfologías de las costras evaporíticas salinas del salar de Pozuelos (Puna Austral, Salta Argentina). Es una depresión salina a ~ 3760 m s.n.m., cuyas coordenadas geográficas aproximadas son 24º40’S y 66º45’O. Se elonga en sentido NE-SO, de unos ~ 13 km de largo y ~ 6 km ancho en promedio, con una superficie de ~ 84 km2. En este salar se reconocieron y mapearon seis tipos de costras evaporíticas salinas definidas según su morfología, estructuras y contenido clástico. Cada una de ellas está asociada a los cambios de facies laterales dentro del salar, relacionados con las condiciones y posición respecto al nivel freático, como así también, con los sistemas fluviales efímeros, con las diferentes zonas en que se encuentran en el salar y con la topografía. Se describe la relación existente entre las evapofacies, las costras evaporíticas, los recursos en sales y los elementos químicos de salmueras allí presentes.Morphology of evaporitical crusts of Salar de Pozuelos (Puna Salteña, Argentina). The saline lakes of Puna Argentina are important reservoirs of brines rich in alkaline and alkaline earth elements, including lithium and potassium. The related studies on their evapofacies and superficial crusts are scarce. This work presents the different morphologies of the evaporitic crusts in salar de Pozuelos (Puna Austral, Salta Argentina). It is a saline depression at ~ 3760 masl, whose approximate geographical coordinates are 24° 40´S and 66° 45´W, elongated on the NE-SW, about ~ 13 km long and ~ 6 km wide, with an area of ~ 84 km2. Different types of crusts were identified and mapped in this salar, according to their morphology, structures and clastic content. The evaporitic salt crusts are associated with changes of local side facies within the salar, interrelated to their conditions and position regarding the water table, as well as to the ephemeral streams, to their location in the salar and to the topography. This paper present the relationship between evapofacies, evaporitic crusts and resources in salts and chemical brine elements.Fil: Martínez, Verónica Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto Superior de Correlación Geológica. Grupo Vinculado al INSUGEO- Centro de Estudios Geologicos Andinos; ArgentinaFil: Galli, Claudia Inés. Universidad Nacional de Jujuy. Instituto de Ecorregiones Andinas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Ecorregiones Andinas; ArgentinaFil: Alonso, Ricardo Narciso. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto Superior de Correlación Geológica. Grupo Vinculado al INSUGEO- Centro de Estudios Geologicos Andinos; Argentin

Fungi Sensitization in Spain: Importance of the Alternaria alternata Species and Its Major Allergen Alt a 1 in the Allergenicity

Prevalence of allergy to fungi is around 3–10%. The most prevalent species involved in sensitizations are Alternaria alternata, Aspergillus fumigatus, Cladosporium herbarum, and Penicillium notatum. Our main objective was to estimate the prevalence of fungal sensitization and its variation across Spain. Following the ICH-GCP, we recruited 1156 patients from 15 allergy departments in Spain. Hospitals were selected by bioclimatic areas. Patients underwent a skin prick test (SPT) with fungi, pollens, house dust mites, and animal dander. Specific IgE to Alternaria alternata and Alt a 1 was assessed in patients with positive SPT to fungi. Of the 233 patients (20.2%) sensitized to at least one of the five fungi tested, 162 (69.5%) were sensitized to Alternaria alternata and Alt a 1, of whom 113 (69.8%) were children; 181 (77.7%) were also polysensitized to other allergens. Alternaria alternata and Alt a 1 sensitization was present in 25.4% of patients in the Continental area, 12.0% in the Mediterranean area, 7.0% in the Semidesertic area, and 2.3% in the Oceanic area. Prevalence of sensitization to the other tested sources was 63.8% to pollens, 60.5% to house dust mite, and 38.1% to animal dander. We concluded that the prevalence of fungal allergy is increasing. Fungi are still the fourth source of allergen sensitization. Alternaria alternata sensitization is the most prevalent in allergic patients to fungi. Alt a 1 is present in almost 90% of the patients sensitized to Alternaria alternata.This research was funded by Diater laboratorios S.A

Hypothermia prevents gliosis and angiogenesis development in an experimental model of ischemic proliferative retinopathy

PURPOSE: To develop a time course study of vascularization and glial response to perinatal asphyxia in hypoxic-ischemic animals, and to evaluate hypothermia as possible protective treatment. METHODS: We used retinas of 7-, 15-, 21-, and 30-day-old male Sprague-Dawley rats that were exposed to perinatal asphyxia at either 37°C (PA) or 15°C (HYP). Born to term animals were used as controls (CTL). We evaluated the thickness of the most inner layers of the retina (IR), including internal limiting membrane, the retinal nerve fiber layer, and the ganglion cell layer; and studied glial development, neovascularization, adrenomedullin (AM), and VEGF by immunohistochemistry, immunofluorescence, and Western blot. RESULTS: A significant increment in IR thickness was observed in the PA group from postnatal day (PND) 15 on. This alteration was concordant with an increased number of new vessels and increased GFAP expression. The immunolocalization of GFAP in the internal limiting membrane and perivascular glia of the IR and in the inner processes of Müller cells was coexpressed with AM, which was also significantly increased from PND7 in PA animals. In addition, VEGF expression was immunolocalized in cells of the ganglion cell layer of the IR and this expression significantly increased in the PA group from PND15 on. The retinas of the HYP group did not show differences when compared with CTL at any age. CONCLUSIONS: This work demonstrates that aberrant angiogenesis and exacerbated gliosis seem to be responsible for the increased thickness of the inner retina as a consequence of perinatal asphyxia, and that hypothermia is able to prevent these alterations.Fil: Rey Funes, Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia ; ArgentinaFil: Dorfman, Verónica Berta. Universidad Maimónides. Area de Investigaciones Biomédicas y Biotecnológicas. Centro de Estudios Biomédicos, Biotecnológicos, Ambientales y de Diagnóstico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ibarra, Mariano Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia ; ArgentinaFil: Peña, Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia ; ArgentinaFil: Contartese, Daniela Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia ; ArgentinaFil: Goldstein Raij, Jorge. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Acosta, Juan Manuel. Universidad Católica de Cuyo - Sede San Juan. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Larráyoz, Ignacio M.. Centro de Investigación Biomédica de La Rioja; EspañaFil: Martínez Murillo, Ricardo. Consejo Superior de Investigaciones Cientificas; España. Instituto Cajal. Departamento de Neurobiología Molecular, Celular y del Desarrollo; EspañaFil: Martínez, Alfredo. Centro de Investigación Biomédica de La Rioja; España. Consejo Superior de Investigaciones Cientificas; EspañaFil: Loidl, Cesar Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia ; Argentina. Universidad Católica de Cuyo - Sede San Juan. Facultad de Ciencias Médicas; Argentin

Reporte de un caso de carcinoma pancreático en canino: el aporte de la ultrasonofrafía

Un canino, Cocker Spaniel, hembra, de 10 años de edad es derivado al Servicio de Ecografía del Hospital Escuela de la Facultad de Ciencias Veterinarias de la UNLP, para realizar un estudio ultrasonográfico abdominal. La paciente presentaba un cuadro de adelgazamiento morboso, vómitos y diarrea crónica. El examen físico evidenció: Temperatura corporal de 39.5ºC, y palpación abdominal con dolor marcado en región epigástrica y mesogastrica craneal. Los resultados de laboratorio resaltaron leucocitosis marcada de 42.000 GB/ul con desvío a la izquierda, ALT de 79.4U/l, AST de 72.7 U/l, bilirrubina indirecta de 2,10 mg/% (elevada al triple del valor normal), FAS con valor de 1.422.5 U/l (mayor al doble de los valores de referencia), además de un suero ictérico. Una radiografía simple de abdomen en incidencia latero lateral realizada previamente había evidenciado una radiopacidad difusa con disminución de la visualización de las siluetas viscerales en región epigástrica, sugerente de efusión o inflamación de serosa peritoneal. Para definir esta imagen se indicó una ecografía abdominal con exploración focalizada en la zona descripta.Facultad de Ciencias Veterinaria

Research network on interoperability of applications and software for networked enterprises in the Valencian Region (INTERVAL)

Enterprise interoperability is a tool for enhancing the competitiveness of firms, and its importance is brought out by the fact one of the EC’s strategic aims is to accomplish interoperability among European firms by the year 2010. Nevertheless, in the particular case of the Valencian Region (Spain), research into enterprise interoperability is still badly structured, fragmented, overlapping and, in many cases, practically non-existent. The INTERVAL project has been set up in an attempt to solve this problem. The scheme plans to carry out a series of initiatives aimed at integrating research activities and applying them to the complicated Valencian business sector. By so doing these companies would benefit from the application of knowledge created specifically for them and adapted to fit their characteristics. In this paper we present the details of the project, including its goals, aims, activities, results achieved, the methodology used to accomplish them, the economic and/or technological advantages, as well as possible applications and future lines of research

Industry 4.0 and digitization towards job satisfaction of organizations in Tampico, Tamaulipas, Mexico

La industria 4.0 está relacionada en cada lugar y con el uso y la implementación de nuevas tecnologías para la mejora continua de los procesos administrativos. Como parte del crecimiento de una organización, es importante que día a día se adapte a los cambios tecnológicos que afectan las operaciones de los trabajadores o la seguridad laboral. Algunos de los elementos que abarca esta industria son el uso de equipos autónomos, robótica, simuladores de procesos, impresoras 3D, inteligencia artificial y equipos que comparten información en tiempo real. El objetivo de este artículo consiste en valorar los procesos de digitalización de las organizaciones de la ciudad de Tampico, Tamaulipas (México), desde el punto de vista del usuario, para identificar los factores determinantes de la satisfacción laboral. Se emplea la técnica multivariante de regresión de mínimos cuadrados parciales, considerando como factores de análisis de digitalización y su relación con el modelo de relación y colaboración, habilidades y competencias profesionales, formación digital y procesos de digitalización. Los resultados muestran que el grado de motivación aumenta con el incremento en la digitalización de los procesos y que la formación digital y las competencias profesionales necesitan aumentar gradualmente para tener un impacto positivo en relación con los procesos de digitalización.Industry 4.0 is related in each place and with the use and implementation of new technologies for the continuous improvement of administrative processes. As part of the growth of an organization, it is important that day by day it adapts to technological changes that affect worker operations or job security. Some of the elements that this industry encompasses are the use of autonomous equipment, robotics, process simulators, 3D printers, artificial intelligence and equipment that share information in real time. The objective of this article is to assess the digitization processes of organizations in the city of Tampico, Tamaulipas (Mexico), from the user's point of view, to identify the determining factors of job satisfaction. The multivariate technique of partial least squares regression (or PLS, by Partial Least Squares (or SEM, by Structural Equation Models) is used, considering as digitization analysis factors and their relationship with the relationship and collaboration model, skills and competencies professionals, digital training and digitization processes. The results show that the degree of motivation increases with the increase in the digitization of processes and that digital training and professional competencies need to increase gradually to have a positive impact in relation to the processes of digitization.Universidad Pablo de Olavid

Effect of Chronic L-Dopa or Melatonin Treatments after Dopamine Deafferentation in Rats: Dyskinesia, Motor Performance, and Cytological Analysis

The present study examines the ability of melatonin to protect striatal dopaminergic loss induced by 6-OHDA in a rat model of Parkinson's disease, comparing the results with L-DOPA-treated rats. The drugs were administered orally daily for a month, their therapeutic or dyskinetic effects were assessed by means of abnormal involuntary movements (AIMs) and stepping ability. At the cellular level, the response was evaluated using tyrosine hydroxylase immunoreactivity and striatal ultrastructural changes to compare between L-DOPA-induced AIMs and Melatonin-treated rats. Our findings demonstrated that chronic oral administration of Melatonin improved the alterations caused by the neurotoxin 6-OHDA. Melatonin-treated animals perform better in the motor tasks and had no dyskinetic alterations compared to L-DOPA-treated group. At the cellular level, we found that Melatonin-treated rats showed more TH-positive neurons and their striatal ultrastructure was well preserved. Thus, Melatonin is a useful treatment to delay the cellular and behavioral alterations observed in Parkinson's disease

Endothelial Progenitor Cells: Relevant Players in the Vasculopathy and Lung Fibrosis Associated with the Presence of Interstitial Lung Disease in Systemic Sclerosis Patients

Endothelial progenitor cells (EPC), which are key effectors in the physiologic vascular network, have been described as relevant players in autoimmune diseases. We previously showed that EPC frequency may help to identify the presence of interstitial lung disease (ILD) in rheumatoid arthritis patients. Given that ILD constitutes the main cause of mortality in systemic sclerosis (SSc) patients, we aimed to determine the EPC contribution to the pathogenic processes of vasculopathy and lung fibrosis in SSc-ILD+. EPC quantification was performed by flow cytometry on blood from 83 individuals: 21 SSc-ILD+ patients and subjects from comparative groups (20 SSc-ILD- and 21 idiopathic pulmonary fibrosis (IPF) patients and 21 healthy controls (HC)). EPC were considered as CD34+, CD45low, CD309+, and CD133+. A significant increase in EPC frequency was found in SSc-ILD+ patients when compared to HC (p < 0.001). SSc-ILD+ patients exhibited a higher EPC frequency than SSc-ILD- patients (p = 0.012), whereas it was markedly reduced compared to IPF patients (p < 0.001). EPC frequency was higher in males (p = 0.04) and negatively correlated to SSc duration (p = 0.04) in SSc-ILD+ patients. Our results indicate a role of EPC in the processes of vasculopathy and lung fibrosis in SSc-ILD+. EPC frequency may be considered as a biomarker of ILD in SSc patients.V.P.-C. is supported by a pre-doctoral grant from IDIVAL [PREVAL 18/01]. S.R.-M. is supported by funds from the RETICS Program [RD16/0012/0009, Instituto de Salud Carlos III (ISCIII), co-funded by the European Regional Development Fund (ERDF)]. B.A.-M. is a recipient of a ‘López Albo’ Post-Residency Programme funded by Servicio Cántabro de Salud. L.L.-G. is supported by funds from INNVAL20/06 (IDIVAL). R.P.-F. is supported by funds from the START project [FOREUM18/34]. O.G. is staff personnel of Xunta de Galicia (Servizo Galego de Saude (SERGAS) through a research-staff stabilization contract (ISCIII/SERGAS), and his work is funded by ISCIII and the ERDF [grants RD16/0012/0014 (RIER) and PI17/00409]. He is a beneficiary of project funds from the Research Executive Agency (REA) of the European Union in the framework of MSCA-RISE Action of the H2020 Programme, project 734899—Olive-Net. R.L.-M. is a recipient of a Miguel Servet type I fellowship [ISCIII, co-funded by the European Social Fund, ‘Investing in your future’, CP16/00033]