LA MEJORA DE PROCESOS EN LA EMPRESA SOFTEL

SOFTEL´s enterprise has a preponderant role in the social program related with the Computerization of the Cuban society, especially Health sector. In this enterprise, an Integrated Management System was designed that allows the enterprise to unify the internal processes, with the Cuban Law of Business Improvement, with the internal control components, taking into account the integration with ISO 9001: 2015, ISO 14001: 2015 and ISO 45001: 2018 standards and existing legislation for software development and the general operation of the enterprise.  Strategically, to reach a higher level of organization, the introduction of the tools Redmine, Alfresco and Diriger was established. When reaching a higher level of organization, the need arose to go up a new step in the performance of the organization to increase the efficiency and effectiveness of the processes, for which the preparation of tools was made to measure the effectiveness of the processes and the Integrated Management System.La Empresa SOFTEL tiene un papel preponderante en la Informatización de la sociedad cubana, especialmente en la salud. En esta empresa se diseñó un Sistema Integrado de Gestión que permite unificar los procesos internos, con el Decreto del Perfeccionamiento empresarial, los componentes del control interno, teniendo en cuenta la integración con las normas ISO 9001:2015, ISO 14001: 2015 y ISO 45001:2018, legislaciones existentes para el desarrollo de software y el funcionamiento general de la empresa. Estratégicamente para alcanzar un nivel superior de organización se estableció la introducción de las herramientas Redmine, Alfresco y  Diriger. Al alcanzar un nivel superior de organización, surgió la necesidad de elevar el desempeño de la organización y los procesos, por lo que se realizó la confección de herramientas que permitan medir la eficacia de los procesos y del Sistema Integrado de Gestión

Ethical Considerations in Research and Medical Care of Menopause

Menopause is the permanent cessation of menstruation, and among the main symptoms reported have been night sweats, heat waves, increased body fat at the central level, dyslipidemia, hypertension, osteoporosis, insulin resistance, diabetes, mild cognitive impairment, depression, periodontitis, varicose veins, apnea, urinary genital discomfort, as well as dryness in the mouth and eye. The diagnosis, study, and care of menopausal or postmenopausal women have had great advances, such as recognizing the sub-inclusion of women and female animal models in basic and clinical studies and proposing in the same design of the study the analysis by sex. Subsequently, the need for specialized ethical training was identified, beginning in undergraduate, postgraduate, and clinical practice. To achieve this, several actions were carried out, such as the foundation of Women’s Health Institutes, the implementation of the Institutional and Private Committees of Ethic, and the development of validated instruments to evaluate signs and symptoms. Currently, there is no consensus that meets the ethical requirements for care and research in these patients. Efforts have been made practically by pathology, without considering together the social and psychobiological condition. What is intended in this document is to present the ethical aspects related to the study and medical care of women in menopause

pH-responsive self-assembly of amyloid fibrils for dual hydrolase-oxidase reactions

Altres ajuts: ICREA Academia 2015There is an increasing interest in synthetic systems that can execute bioinspired chemical reactions without requiring the complex structures that characterize enzymes in their components. The hierarchical self-assembly of peptides provides a means to create catalytic microenvironments. Ideally, as it occurs in enzymes, the catalytic activity of peptide nanostructures should be reversibly regulated. In a typical enzyme mimetic design, the peptide's self-assembling and catalytic activities are segregated into different regions of the sequence. Here, we aimed to design minimal peptides in which the self-assembly and function were all encoded in the same amino acids. Moreover, we wanted to endow the resulting one-component nanomaterial with divergent, chemically unrelated, catalytic activities, a property not observed in natural enzymes. We show that short peptides consisting only of histidine and tyrosine residues, arranged in a binary pattern, form biocompatible amyloid-like fibrils and hydrogels combining hydrolytic and electrocatalytic activities. The nanofibers' mesoscopic properties are controlled by pH, the transition between assembled active β-sheet fibrils, and disassembled inactive random coil species occurring in a physiologically relevant pH range. The structure of one of such amyloid-like fibrils, as derived from molecular dynamic simulations, provides insights on how they attain this combination of structural and catalytic properties

Nueva estrategia didáctica para fomentar la participación del alumnado en el proceso de aprendizaje en el ámbito de la tecnología farmacéutica (continuación)

Depto. de Farmacia Galénica y Tecnología AlimentariaFac. de FarmaciaFALSEsubmitte

Creación de un nuevo recurso educativo virtual para estudiantes de grado en Farmacia

Depto. de Farmacia Galénica y Tecnología AlimentariaFac. de FarmaciaFALSEsubmitte

Formación de médicos y enfermeras para la detección temprana del cáncer de mama en méxico

Objetivo Analizar la formación académica que reciben los estudiantes de medicina y enfermería sobre el cáncer de mama (CaMa) durante el trascurso de su carrera universitaria. Materiales y Métodos Estudio exploratorio realizado en 2009. Basado en entrevistas semi-estructuradas a actores clave y revisión documental. Población de estudio: 199 Facultades/Escuelas de medicina y 108 Escuelas/Institutos de enfermería. Unidad de análisis: plan de estudios. Resultados En 16,8 % de los planes de estudio de medicina y  6,3 % de enfermería se encontró información específica de contenidos sobre CaMa. La capacitación que reciben los  médicos es predominantemente desarrollada por las áreas biomédica y clínica y en menor proporción en el área socio-médica. En enfermería los temas que más se desarrollan son en áreas comunitarias, abordando contenidos de promoción de la salud y prevención de la enfermedad (estilos de vida saludable e identificación de mujeres con alto riesgo de padecer CaMa). Discusión Se encontró escasa evidencia sobre entrenamiento específico para la detección y atención del cáncer de mama en los planes de estudio. Por los resultados encontrados es necesario fortalecer los currículos para formar a los futuros profesionales con capacidades para trabajar en la solución de los  problemas y necesidades específicos de salud de la población particularmente en acciones de prevención primaria y secundari

Corrigendum to: Preanalytical issues related to routine and diagnostic glucose tests: Results from a survey in Spain

This is a correction of Biochem Med (Zagreb) 2020;30(1):010704. DOI: https://doi.org/10.11613/ BM.2020.01070

Preanalytical issues related to routine and diagnostic glucose tests: Results from a survey in Spain

Introduction: Diabetes mellitus (DM) is one of the most prevalent diseases worldwide. The objective of this study was to find out under what preanalytical conditions routine and diagnostic glucose tests are performed across Spanish laboratories; and also what criteria are used for DM diagnosis. Materials and methods: An online survey was performed by the Commission on Quality Assurance in the Extra-Analytical Phase of the Spanish Society of Laboratory Medicine (SEQC-ML). Access to the questionnaire was available on the home page of the SEQC-ML website during the period April-July 2018. Data analysis was conducted with the IBM SPSS© Statistics (version 20.0) program. Results: A total of 96 valid surveys were obtained. Most laboratories were in public ownership, serving hospital and primary care patients, with high and medium workloads, and a predominance of mixed routine-urgent glucose testing. Serum tubes were the most used for routine glucose analysis (92%) and DM diagnosis (54%); followed by lithium-heparin plasma tubes (62%), intended primarily for urgent glucose testing; point-of care testing devices were used by 37%; and plasma tubes with a glycolysis inhibitor, mainly sodium fluoride, by 19%. Laboratories used the cut-off values and criteria recognized worldwide for DM diagnosis in adults and glucose-impaired tolerance, but diverged in terms of fasting plasma glucose and gestational DM criteria. Conclusion: Preanalytical processing of routine and DM diagnostic glucose testing in Spain does not allow a significant, non-quantified influence of glycolysis on the results to be ruled out. Possible adverse consequences include a delay in diagnosis and possible under-treatment

Antibodies against the flotillin-1/2 complex in patients with multiple sclerosis

Lleixa and Caballero-avila et al. report that antibodies targeting the flotillin-1/2 complex are present in a subgroup of patients with multiple sclerosis. Further studies are needed to understand the clinical and pathological relevance of anti-flotillin-1/2 autoantibodies in multiple sclerosis. Multiple sclerosis is a tissue-specific autoimmune disease of the central nervous system in which the antigen(s) remains elusive. Antibodies targeting the flotillin-1/2 complex have been described in 1-2% of the patients in a recent study. Other candidate antigens as anoctamin-2 or neurofascin-155 have been previously described in multiple sclerosis patients, although their clinical relevance remains uncertain. Our study aims to analyse the frequency and clinical relevance of antibodies against neurofascin-155, anoctamin-2 and flotillin-1/2 complex in multiple sclerosis. Serum (n = 252) and CSF (n = 50) samples from 282 multiple sclerosis patients were included in the study. The control group was composed of 260 serum samples (71 healthy donors and 189 with other neuroinflammatory disorders). Anti-flotillin-1/2, anti-anoctamin-2 and anti-neurofascin-155 antibodies were tested by cell-based assays using transfected cells. We identified six multiple sclerosis patients with antibodies against the flotillin-1/2 complex (2.1%) and one multiple sclerosis patient with antibodies against anoctamin-2 (0.35%). All multiple sclerosis patients were negative for anti-neurofascin-155 antibodies. Three of the anti-flotillin-1/2 positive patients showed anti-flotillin-1/2 positivity in other serum samples extracted at different moments of their disease. Immunoglobulin G subclasses of anti-flotillin-1/2 antibodies were predominantly one and three. We confirm that antibodies targeting the flotillin-1/2 complex are present in a subgroup of patients with multiple sclerosis. Further studies are needed to understand the clinical and pathological relevance of anti-flotillin-1/2 autoantibodies in multiple sclerosis

Sex differences in the impact of frailty in elderly outpatients with heart failure

Introduction: Frailty is common among patients with heart failure (HF). Our aim was to address the role of frailty in the management and prognosis of elderly men and women with HF. Methods and results: Prospective multicenter registry that included 499 HF outpatients ≥75 years old. Mean age was 81.4 ± 4.3 years, and 193 (38%) were women. Compared with men, women were older (81.9 ± 4.3 vs. 81.0 ± 4.2 years, p = 0.03) and had higher left ventricular ejection fraction (46 vs. 40%, p < 0.001) and less ischemic heart disease (30 vs. 57%, p < 0.001). Women had a higher prevalence of frailty (22 vs. 10% with Clinical Frailty Scale, 34 vs. 15% with FRAIL, and 67% vs. 46% with the mobility visual scale, all p-values < 0.001) and other geriatric conditions (Barthel index ≤90: 14.9 vs. 6.2%, p = 0.003; malnutrition according to Mini Nutritional Assessment Short Formulary ≤11: 55% vs. 42%, p = 0.007; Pfeiffer cognitive test's errors: 1.6 ± 1.7 vs. 1.0 ± 1.6, p < 0.001; depression according to Yesavage test; p < 0.001) and lower comorbidity (Charlson index ≥4: 14.1% vs. 22.1%, p = 0.038). Women also showed worse self-reported quality of life (6.5 ± 2.1 vs. 6.9 ± 1.9, on a scale from 0 to 10, p = 0.012). In the univariate analysis, frailty was an independent predictor of mortality in men [Hazard ratio (HR) 3.18, 95% confidence interval (CI) 1.29-7.83, p = 0.012; HR 4.53, 95% CI 2.08-9.89, p < 0.001; and HR 2.61, 95% CI 1.23-5.43, p = 0.010, according to FRAIL, Clinical Frailty Scale, and visual mobility scale, respectively], but not in women. In the multivariable analysis, frailty identified by the visual mobility scale was an independent predictor of mortality (HR 1.95, 95% CI 1.04-3.67, p = 0.03) and mortality/readmission (HR 2.06, 95% CI 1.05-4.04, p = 0.03) in men. Conclusions: In elderly outpatients with HF frailty is more common in women than in men. However, frailty is only associated with mortality in men