Implementación de los servicios de gestión de infraestructura IT bajo el servidor GNU/Linux Nethserver

En el presente artículo se evidencia la instalación y configuración como sistema operativo base a la distribución NethServer versión 7.9.2009, la cual fue instalada en una máquina virtual implementada en VirtualBox. Luego, se realiza la implementación de los servicios de gestión de infraestructura IT DHCP Server, DNS Server y Controlador de Dominio, Proxy, Cortafuegos, File Server y Print Server y VPN. Por lo anterior, el presente documento es construido con el paso a paso de la Implementación y configuración detallada de cada uno de los servicios descritos evidenciando el funcionamiento de los mismos.This article shows the installation and configuration as the base operating system of the NethServer version 7.9.2009 distribution, which was installed in a virtual machine implemented in VirtualBox. Then, the implementation of the IT infrastructure management services DHCP Server, DNS Server and Domain Controller, Proxy, Firewall, File Server and Print Server and VPN is carried out. Therefore, this document is constructed with a step-by-step implementation and detailed configuration of each of the services described, evidencing their operation

PREVALENCIA DE RESPIRACIÓN ORAL EN ESTUDIANTES UNIVERSITARIOS

INTRODUCCIÓN: El desarrollo del estudio giró en torno a la pregunta de investigación: ¿Cuál es la prevalencia de Respiración oral en estudiantes Universitarios?  MÉTODOS: Estudio transversal descriptivo, en el que se aplicaron los Cuestionarios de Autoexamen y Señales de alerta de respiración oral, desarrollados por el Departamento da Motricidade Orofacial da Sociedade Brasileira da Fonoaudiología, aplicados a 370 estudiantes de la Universidad de Pamplona. Las variables del estudio se clasificaron en dos grupos a partir de las señales de alerta de respiración oral: a) Obstrucción nasal, y, b) Trastornos de sueño. RESULTADOS: Con relación al análisis de anova multifactorial para cada uno de los ítems del cuestionario, se resalta la relación positiva para las variables “mejillas” y “cara alargada”, con la facultad a la cual pertenece el estudiante. Por otro lado para determinar el resultado de las formas de asociación en las preguntas de autoxamen y señales de alerta, se contó con un Dendograma usando distancias de ward y un Dendograma usando distancias promedio, arrojando cada uno 4 clulster de vecinos lejanos y de distancias promedio, respectivamente. ANÁLISIS Y DISCUSIÓN El estudio demuestra una alta prevalencia de signos y señales de alerta de Respiración Oral en la población. La evidencia gira en torno estudios en población menor a 17 años por lo que se deben seguir analizando las causas y consecuencias de esta situación en los jóvenes universitarios CONCLUSIONES: La prevalencia se califica como alta con una relación promedio de 1 de cada 3 estudiantes en cada variable

RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2 and GLI1

Mutations in the gene encoding Ras-associated binding protein 23 (RAB23) cause Carpenter Syndrome, which is characterized by multiple developmental abnormalities including polysyndactyly and defects in skull morphogenesis. To understand how RAB23 regulates skull development, we generated Rab23-deficient mice that survive to an age where skeletal development can be studied. Along with polysyndactyly, these mice exhibit premature fusion of multiple sutures resultant from aberrant osteoprogenitor proliferation and elevated osteogenesis in the suture. FGF10-driven FGFR1 signaling is elevated in Rab23(-/-) sutures with a consequent imbalance in MAPK, Hedgehog signaling and RUNX2 expression. Inhibition of elevated pERK1/2 signaling results in the normalization of osteoprogenitor proliferation with a concomitant reduction of osteogenic gene expression, and prevention of craniosynostosis. Our results suggest a novel role for RAB23 as an upstream negative regulator of both FGFR and canonical Hh-GLI1 signaling, and additionally in the non-canonical regulation of GLI1 through pERK1/2.Peer reviewe

Molecular diagnosis in patients and carriers of Hemophilia A and B [Diagn�stico molecular en pacientes y portadoras de hemofilia A y B]

[No abstract available

Molecular diagnosis in patients and carriers of Hemophilia A and B [Diagnóstico molecular en pacientes y portadoras de hemofilia A y B]

[No abstract available

Apert syndrome with preaxial polydactyly showing the typical mutation Ser252Trp in the FGFR2 gene

Apert syndrome with preaxial polydactyly showing the typical mutation Ser252 Trp in the FGFR2 gene: The Apert syndrome is characterized by craniosynostosis and syndactyly of hands and feet. Although most cases are sporadic, an autosomal dominant mode of inheritance is well documented. Two mutations in the FGFR2 gene (Ser252Trp and Pro253Arg) account for most of the cases. We report a patient with a rare form of Apert syndrome with polydactyly. The proposita has turribrachycephaly, complete syndactyly of 2nd to 5th digits ("mitten hands" and cutaneous fusion of all toes). The X-rays revealed craniosynostosis of the coronal suture and preaxial polydactyly of hands and feet with distal bony fusion. Molecular analysis found a C755G transversion (Ser252Trp) in the FGFR2 gene. Only eight patients with Apert syndrome and preaxial polydactyly have been reported and this is the first case In which molecular diagnosis is available. On the basis of the molecular findings in this patient, polydactyly should be considered part of the spectrum of abnormalities in the Apert syndrome. This assertion would establish the need for a new molecular classification of the acrocephalopolysyndactylies

Apert syndrome with preaxial polydactyly showing the typical mutation Ser252Trp in the FGFR2 gene

Apert syndrome with preaxial polydactyly showing the typical mutation Ser252 Trp in the FGFR2 gene: The Apert syndrome is characterized by craniosynostosis and syndactyly of hands and feet. Although most cases are sporadic, an autosomal dominant mode of inheritance is well documented. Two mutations in the FGFR2 gene (Ser252Trp and Pro253Arg) account for most of the cases. We report a patient with a rare form of Apert syndrome with polydactyly. The proposita has turribrachycephaly, complete syndactyly of 2nd to 5th digits ("mitten hands" and cutaneous fusion of all toes). The X-rays revealed craniosynostosis of the coronal suture and preaxial polydactyly of hands and feet with distal bony fusion. Molecular analysis found a C755G transversion (Ser252Trp) in the FGFR2 gene. Only eight patients with Apert syndrome and preaxial polydactyly have been reported and this is the first case In which molecular diagnosis is available. On the basis of the molecular findings in this patient, polydactyly should be considered part of the spectrum of abnormalities in the Apert syndrome. This assertion would establish the need for a new molecular classification of the acrocephalopolysyndactylies