A proposed bidirectional three-level DC-DC power converter for applications in smart grids: an experimental validation

The integration of renewable energy sources (RES), energy storage systems (ESS), and electric mobility into smart grids requires the use of DC-DC back-end power converters for adjusting voltage levels. Although a DC-DC converter applied for RES only operates in unidirectional mode, when applied to ESS or EM, the bidirectional mode is a fundamental requisite for exchanging power with the electrical power grid. In this context, this paper presents an experimental validation of a proposed bidirectional three-level DC-DC converter considering its application for smart grids. Traditionally, the DC-DC power converters of such applications are two-level converters. However, by employing a three-level topology, it is possible to improve the quality of the variables controlled by the power converter. Moreover, since the proposed DC-DC converter is controlled to produce a controlled current, the proposed current control and modulation strategies are introduced and described. A complete analysis of the operation principle of the proposed bidirectional three-level DC-DC power converter is presented, supported by experimental validation, employing a laboratory prototype.This work has been supported by FCT – Fundação para a Ciência e Tecnologia within the Project Scope: UID/CEC/00319/2019. This work has been supported by FCT Project DAIPESEV PTDC/EEI-EEE/30382/2017, and by the FCT Project newERA4GRIDs PTDC/EEI-EEE/30283/2017. Tiago Sousa is supported by the doctoral scholarship SFRH/BD/134353/2017 granted by FCT

Sliding mode control of an innovative single-switch three-level active rectifier

This paper presents the sliding mode control (SMC) applied to an innovative active rectifier. This proposed active rectifier is constituted by a single-switch, and operates with three voltage levels, evidencing a set of advantages when compared with conventional approaches of power factor correction topologies. Taking into account the diversity of applications for this type of power converter, the SMC is used in order to obtain a robust current tracking. Since the active rectifier is controlled according to the ac grid-side current, the error between such current and its reference is determined, and by employing the SMC, this error is minimized during each sampling period with the objective of selecting the state of the single-switch. A comprehensive description about the SMC implementation, supported by the overall operation of the active rectifier, is presented throughout the paper. The obtained computational results for a set of different operating conditions, comprising significant power ranges and sudden variations, confirm the accurate application of the SMC when applied to the proposed single-switch three-level active rectifier. A comparison is also established with other current control, allowing to confirm the precise application of the SMC strategy.This work has been supported by FCT – Fundação para a Ciência e Tecnologia within the Project Scope: UID/CEC/00319/2019. This work has been supported by FCT Project newERA4GRIDs PTDC/EEI-EEE/30283/2017, and by the FCT Project DAIPESEV PTDC/EEI-EEE/30382/2017. Tiago Sousa is supported by the doctoral scholarship SFRH/BD/134353/2017 granted by FCT

A novel multilevel converter for on-grid interface of renewable energy sources in smart grids

The on-grid interface of renewable energy sources involves a dc-ac converter for controlling the injected current. In this perspective, a novel topology of grid-tied converter is proposed, assuming as main feature the produced multilevel voltages (five-levels). The proposed grid-tied converter is intended for on-grid interfaces, which is controlled for guaranteeing sinusoidal currents for all grid voltage conditions. The dc-side can be linked directly to a dc-to-dc intermediary converter, responsible for interfacing renewable energy sources, as solar photovoltaic or wind power systems. Throughout the paper, a complete examination of the operation principle and the adopted control theory, including current control, as well as hardware project, are comprehensively presented. An accurate computational simulation validation is presented, comprising realistic operating conditions in terms of grid voltage disturbances and operating power. The obtained results prove the advantages of the proposed grid-tied multilevel converter, and establish a comparison with the classical solutions.This work has been supported by FCT – Fundação para a Ciência e Tecnologia within the Project Scope: UID/CEC/00319/2019. This work has been supported by FCT Project newERA4GRIDs PTDC/EEI-EEE/30283/2017, and by the FCT Project DAIPESEV PTDC/EEI-EEE/30382/2017. Tiago Sousa is supported by the doctoral scholarship SFRH/BD/134353/2017 granted by FCT

Comparative analysis of power electronics topologies to interface dc homes with the electrical ac power grid

This paper presents a comparative analysis of power electronics topologies that can be used to interface dc homes with a 230 V, 50 Hz ac power grid. Dc homes represent an essential asset for smart grids, since energy storage systems and renewable energy sources, such as photovoltaic solar panels, operate in dc, as well as most of the electrical appliances used in domestic scenario. However, since the power grid operates in ac, it is necessary to convert voltage from ac to dc to properly supply a dc home. This conversion can be accomplished in several ways, with different power conversion stages. In this context, this paper analyzes three different possibilities that can be used to perform the interface between the ac power grid and a dc home: (1) ac-dc converter using a low frequency transformer; (2) ac-dc and dc-dc converters using a high frequency transformer; (3) ac-ac and ac-dc converters using a medium frequency transformer. These three possibilities are compared in terms of efficiency, total power factor and total harmonic distortion of the ac power grid. The results were obtained by means of a simulation model based on the internal parameters of the power semiconductors.This work has been supported by FCT –Fundação para a Ciência e Tecnologia within the Project Scope: UID/CEC/00319/2019. This work has been supported by FCT Project DAIPESEV PTDC/EEI-EEE/30382/2017, and by the FCT ProjectnewERA4GRIDs PTDC/EEI-EEE/30283/2017. Mr. Tiago Sousa is supported by the doctoral scholarship SFRH/BD/134353/2017 granted by FCT

Determinants of intensive insulin therapeutic regimens in patients with type 1 diabetes: data from a nationwide multicenter survey in Brazil

Background: To evaluate the determinants of intensive insulin regimens (ITs) in patients with type 1 diabetes (T1D).Methods: This multicenter study was conducted between December 2008 and December 2010 in 28 public clinics in 20 Brazilian cities. Data were obtained from 3,591 patients (56.0% female, 57.1% Caucasian). Insulin regimens were classified as follows: group 1, conventional therapy (CT) (intermediate human insulin, one to two injections daily); group 2 (three or more insulin injections of intermediate plus regular human insulin); group 3 (three or more insulin injections of intermediate human insulin plus short-acting insulin analogues); group 4, basal-bolus (one or two insulin injections of long-acting plus short-acting insulin analogues or regular insulin); and group 5, basal-bolus with continuous subcutaneous insulin infusion (CSII). Groups 2 to 5 were considered IT groups.Results: We obtained complete data from 2,961 patients. Combined intermediate plus regular human insulin was the most used therapeutic regimen. CSII was used by 37 (1.2%) patients and IT by 2,669 (90.2%) patients. More patients on IT performed self-monitoring of blood glucose and were treated at the tertiary care level compared to CT patients (p < 0.001). the majority of patients from all groups had HbA1c levels above the target. Overweight or obesity was not associated with insulin regimen. Logistic regression analysis showed that economic status, age, ethnicity, and level of care were associated with IT (p < 0.001).Conclusions: Given the prevalence of intensive treatment for T1D in Brazil, more effective therapeutic strategies are needed for long term-health benefits.Farmanguinhos/Fundacao Oswaldo Cruz/National Health MinistryBrazilian Diabetes SocietyFundacao do Amparo a Pesquisa do Estado do Rio de JaneiroConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Estado Rio de Janeiro, Unit Diabet, BR-20551030 Rio de Janeiro, BrazilBaurus Diabet Assoc, São Paulo, BrazilFed Univ São Paulo State, Diabet Unit, São Paulo, BrazilFed Univ Hosp Porto Alegre, Porto Alegre, BrazilUniv Hosp São Paulo, Diabet Unit, São Paulo, BrazilUniv Fed Rio de Janeiro, Rio de Janeiro, BrazilUniv Fed Ceara, Fortaleza, Ceara, BrazilSanta Casa Misericordia, Belo Horizonte, MG, BrazilSanta Casa Misericordia São Paulo, São Paulo, BrazilUniv Fed Amazonas, Manaus, Amazonas, BrazilHosp Geral de Bonsucesso, Rio de Janeiro, BrazilHosp Univ Clementino Fraga Filho IPPMG, Rio de Janeiro, BrazilUniv Hosp São Paulo, São Paulo, BrazilFac Ciencias Med Santa Casa São Paulo, São Paulo, BrazilUniv São Paulo, Inst Crianca, Hosp Clin, São Paulo, BrazilUniv São Paulo, Fac Med Ribeirao Preto, Hosp Clin, Ribeirao Preto, BrazilAmbulatorio Fac Estadual Med Sao Jose Rio Preto, Ribeirao Preto, BrazilEscola Paulista Med, Ctr Diabet, Ribeirao Preto, BrazilClin Endocrinol Santa Casa Belo Horizonte, Belo Horizonte, MG, BrazilUniv Estadual Londrina, Londrina, BrazilUniv Fed Parana, Hosp Clin, Porto Alegre, RS, BrazilInst Crianca Com Diabet Rio Grande Sul, Rio Grande Do Sul, RS, BrazilGrp Hosp Conceicao, Inst Crianca Com Diabet, Porto Alegre, RS, BrazilHosp Univ Santa Catarina, Florianopolis, SC, BrazilInst Diabet Endocrinol Joinville, Joinville, BrazilHosp Reg Taguatinga, Brasilia, DF, BrazilHosp Geral Goiania, Goiania, Go, BrazilCtr Diabet & Endocrinol Estado Bahia, Goiania, Go, BrazilUniv Fed Maranhao, Sao Luis, BrazilCtr Integrado Diabet & Hipertensao Ceara, Fortaleza, Ceara, BrazilUniv Fed Sergipe, Aracaju, BrazilHosp Univ Alcides Carneiro, Campina Grande, BrazilHosp Univ Joao de Barros Barreto, Belem, Para, BrazilFed Univ São Paulo State, Diabet Unit, São Paulo, BrazilUniv Hosp São Paulo, Diabet Unit, São Paulo, BrazilUniv Hosp São Paulo, São Paulo, BrazilEscola Paulista Med, Ctr Diabet, Ribeirao Preto, BrazilWeb of Scienc

Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications

Superparamagnetic iron oxide nanoparticles can providemultiple benefits for biomedical applications in aqueous environments such asmagnetic separation or magnetic resonance imaging. To increase the colloidal stability and allow subsequent reactions, the introduction of hydrophilic functional groups onto the particles’ surface is essential. During this process, the original coating is exchanged by preferably covalently bonded ligands such as trialkoxysilanes. The duration of the silane exchange reaction, which commonly takes more than 24 h, is an important drawback for this approach. In this paper, we present a novel method, which introduces ultrasonication as an energy source to dramatically accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove the generic character, different functional groups were introduced on the surface including polyethylene glycol chains, carboxylic acid, amine, and thiol groups. Their colloidal stability in various aqueous buffer solutions as well as human plasma and serum was investigated to allow implementation in biomedical and sensing applications.status: publishe

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure &lt; 100 mmHg (n = 1127), estimated glomerular filtration rate &lt; 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Placental Aromatase Is Deficient in Placental Ischemia and Preeclampsia.

Preeclampsia is a maternal hypertensive disorder with uncertain etiology and a leading cause of maternal and fetal mortality worldwide, causing nearly 40% of premature births delivered before 35 weeks of gestation. The first stage of preeclampsia is characterized by reduction of utero-placental blood flow which is reflected in high blood pressure and proteinuria during the second half of pregnancy. In human placenta androgens derived from the maternal and fetal adrenal glands are converted into estrogens by the enzymatic action of placental aromatase. This implies that alterations in placental steroidogenesis and, subsequently, in the functionality or bioavailability of placental aromatase may be mechanistically involved in the pathophysiology of PE.Serum samples were collected at 32-36 weeks of gestation and placenta biopsies were collected at time of delivery from PE patients (n = 16) and pregnant controls (n = 32). The effect of oxygen tension on placental cells was assessed by incubation JEG-3 cells under 1% and 8% O2 for different time periods, Timed-mated, pregnant New Zealand white rabbits (n = 6) were used to establish an in vivo model of placental ischemia (achieved by ligature of uteroplacental vessels). Aromatase content and estrogens and androgens concentrations were measured.The protein and mRNA content of placental aromatase significantly diminished in placentae obtained from preeclamptic patients compared to controls. Similarly, the circulating concentrations of 17-β-estradiol/testosterone and estrone/androstenedione were reduced in preeclamptic patients vs. controls. These data are consistent with a concomitant decrease in aromatase activity. Aromatase content was reduced in response to low oxygen tension in the choriocarcinoma JEG-3 cell line and in rabbit placentae in response to partial ligation of uterine spiral arteries, suggesting that reduced placental aromatase activity in preeclamptic patients may be associated with chronic placental ischemia and hypoxia later in gestation.Placental aromatase expression and functionality are diminished in pregnancies complicated by preeclampsia in comparison with healthy pregnant controls

Aromatase is downregulated in JEG–3 cell line in response to hypoxia.

<p>JEG–3 cell line was exposed either to 8% or to 1% O₂ in an hypoxic chamber for 0, 4, 8, 16 and 24 h. <b>A</b>. Cells were collected at indicated times and protein lysates analyzed by western blot to determine the protein expression levels of aromatase, HIF–1α and β-Tubulin. Upper panel shows representative western blots and lower panels show aromatase and HIF–1α proteins densitometry data normalized to β-Tubulin loading control from n = 3 experiments. Data are shown in arbitrary units (A.U.) ±SEM. <b>B</b>. Cells were collected at indicated times and analyzed by qRT–PCR to determine aromatase mRNA transcript levels. Statistical analyses were performed using Student’s <i>t</i>-test and compared with the correspondent time point in the control, 8% O₂, cells. Columns are the mean of four independent experiments in duplicate; Data are reported as mean±SEM. *<i>P</i>≤0.05; **<i>P</i>≤0.01; *** <i>P</i>≤0.001, significant; n.s., non-significant.</p